王友军 - 北京师范大学 - 生命科学学院

个人简介

烟台大学生物化学学士（1997），北京大学神经生理学硕士（2000），美国马里兰大学帕克分校神经与认知生物学博士（2007）。之后在美国天普大学Gill实验室先后以博士后及助理科学家的身份工作（2007-2013）。2013年5月正式入职北京师范大学生命科学学院抗性基因资源与分子发育北京市重点实验室，并入选教育部2013年度“新世纪人才支持计划”，获得了国家自然科学基金面上、重大研发计划以及科技部重大研究计划等的资助。

研究领域

课题组研究领域为钙信号转导机制及其生理病理作用。近年主要关注细胞器（内质网-质膜）互作过程中的钙信号通路，致力于揭示STIM-Orai蛋白介导的钙池操纵钙内流（SOCE）的激活及调控机制。还合作开发各种光遗传及光化学工具，通过光控胞内钙信号，来重建细胞或模式生物在病理过程中失衡的钙稳态，进而探究钙信号在老年痴呆等神经退行性疾病中的防治作用。

近期论文

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代表性论著(#: 共同第一作者；*: 共同通讯作者) Xie J#, Ma G#*, Zhou L#, He L, Zhang Z, Tan P, Huang Z, Fang S, Wang T, Lee YT, Wen S, Siwko S, Wang L, Liu J, Du Y, Zhang N, Liu X, Han L, Huang Y, Wang R, Wang Y*, Zhou Y*, Han W*. (2022) Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth. Adv Sci (Weinh). 9(11):e2103940. doi: 10.1002/advs.202103940. He L#, Wang L#, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Dou F, Siwko S, Huang Y*, Wang Y*, Zhou Y*. (2021) Engineering of a bona fide light-operated calcium channel. Nature Communications. 12(1):164. doi: 10.1038/s41467-020-20425-4 Yang X#, Ma G#, Zheng S#, Qin X, Li X, Du L, Wang Y*, Zhou Y*, Li M*. (2020) Optical control of CRAC channels using photoswitchable azopy-razoles. J Am Chem Soc., 142(20):9460-9470. doi: 10.1021/jacs.0c02949. Dong H#*, Zhang Y#, Song R, Xu J, Yuan Y, Liu J, Li J, Zheng S, Liu T, Lu b*, Wang Y*, Klein ML* (2019)Towards a model for activation of Orai channel. iscience. 16:356-367. doi: 10.1016/j.isci.2019.05.041 Zheng S#, Ma G#, He L#, Zhang T, Li J, Yuan X, Nguyen NT, Huang Y, Zhang X, Gao P, Nwokonko R, Gill DL, Dong H, Zhou Y*, Wang Y*. (2018) Identification of molecular determinants that govern distinct STIM2 activation dynamics. PLoS Biol. 16(11):e2006898. doi: 10.1371/journal.pbio.2006898. Ma G#, Liu J#, Ke Y#, Liu X, Huang Y, Li M, Wang Y*, Zhou Y*.(2018).Optogenetic Control of Voltage Gated Calcium Channels. Angew Chem Int Ed. 57(24):7019-7022. Jing J#, He L#, Sun A#, Quintana A#, Ding Y#, Ma G, Tan P, Liang X, Zheng X, Chen L, Shi X, Zhang SL, Zhong L, Huang Y, Dong MQ, Walker CL, Hogan PG, Wang Y*, Zhou Y*. (2015) Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx. Nat Cell Biol. 17(10):1339-47 Ma G#, Wei M#, He L#, Liu C#, Wu B, Zhang SL, Jing J, Liang X, Senes A, Tan P, Li S, Sun A, Bi Y, Zhong L, Si H, Shen Y, Li M, Lee MS, Zhou W, Wang J*, Wang Y*, Zhou Y*. (2015) Inside-out Ca2+ signalling prompted by STIM1 conformational switch. Nature Communications.6:7826 doi: 10.1038/ncomms8826 Wang X#, Wang Y#*, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS, Soboloff J, Gill DL*. (2014) Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site. Nature Communications. 5,3183. Wang Y, Deng X, Mancarella S, Hendron E, Eguchi S, Soboloff J, Tang X and Gill DL. (2010) The calcium store-sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science. 330(6000):105-9. Wang Y, Deng X, Zhou Y, Hendron E, Ritchie MF, Tang XD, Mancarella S, Kurosaki T, Mori Y, Soboloff J and Gill DL. (2009) STIM Protein Coupling in the Activation of Orai Channels. Proc Natl. Acad. Sci. USA 106(18):7391-6. 评论 (#: 共同第一作者；*: 共同通讯作者) Jing J*, Zhou Y, Wang Y*. (2021) Dimming the donor to brighten up FRET-based biosensors. Cell Calcium. 99:102474. doi: 10.1016/j.ceca.2021.102474. Ma G, Liu J, Zhou Y*, Wang Y* (2018) Let there be light: a bright future for Ca2+ signaling. Science Bulletin. 63 (2018) 1029–1031 Rothberg BS, Wang Y, and Gill DL (2013). Orai Channel Pore Properties and Gating by STIM: Implications from the Orai Crystal Structure. Science Signaling. 6(267):pe9. Mancarella S, Wang Y, Gill DL. (2011) SIGNAL TRANSDUCTCTION STIM1 senses both Ca2+ and heat. Nature Chemical Biology. 7(6):344-5 Wang Y, Deng X, Gill DL. (2010) Calcium signaling by STIM and Orai: intimate coupling details revealed. Sci Signal. 3(148):pe42 Mancarella S, Wang Y, Gill DL. (2009) Calcium signals: STIM dynamics mediate spatially unique oscillations. Curr Biol. 19(20):R950-2. 综述 (#: 共同第一作者；*: 共同通讯作者) Ma G, Wen S, He L, Huang Y, Wang Y*, Zhou Y*. (2017) Optogenetic toolkit for precise control of calcium signaling. Cell Calcium. 64:36-46. doi: 10.1016/j.ceca.2017.01.004. Deng X, Wang Y, Zhou Y, Soboloff J, Gill DL. (2009). STIM and Orai: dynamic intermembrane coupling to control cellular calcium signals. J Biol Chem. 284(34): 22501-5. Wang Y, Deng X, Hewavitharana T, Soboloff J and Gill DL. (2008) Stim, ORAI and TRPC channels in the control of calcium entry signals in smooth muscle. Clin. Exp. Pharmacol. Physiol. 35(9):1127-33 书籍章节(#: 共同第一作者；*: 共同通讯作者) Zhou Y, Wang Y, Gill DL. (2018) Assessing the Molecular Nature of the STIM1/Orai1 Coupling Interface Using FRET Approaches. Calcium Entry Channels in Non-Excitable Cells. Chapter 7. Zhang Y, Zheng S, Zhou Y, Gill DL, Wang Y*. (2018) Patch-Clamp Recording of the CRAC Channel Current in STIM-Orai Overexpressing Cells. Methods Mol Biol. 1843:1-16. doi: 10.1007/978-1-4939-8704-7_1. Zhang S, He L, Zhou Y, Wang Y*. (2018) Fluorescence-Based Ratiometric Measurement of CRAC Channel Activity in STIM-Orai-Overexpressing HEK-293 Cells. Methods Mol Biol. 1843:17-39. doi: 10.1007/978-1-4939-8704-7_2. Payne R, Wang Y. (2010) Phototransduction in Limulus Photoreceptors, Encyclopedia of the Eye, Dartt DA, Elsevier Ltd，381-388