Wang, Wei - The University of Arizona

个人简介

As Co-Director of the Arizona Center for Drug Discovery and professor in the Department of Pharmacology and Toxicology, Dr. Wang is responsible for advancing the mission of drug discovery at the UA Health Sciences, main campus and the Phoenix Biomedical Campus. By uniting the UA’s state-of-the-art facilities, expertise and resources, he will help facilitate drug discovery and development while enhancing translational research collaboration. Dr. Wang received his doctorate in organic chemistry from North Carolina State University in Raleigh and completed a post-doctoral fellowship in chemistry at the UA. Before joining the UA, he was a professor in the Department of Chemistry and Chemical Biology at the University of New Mexico in Albuquerque. Dr. Wang is in the top 5 percent of authors cited in the field of chemistry with an h-index of 70, an indicator of his productivity and influence in research. His research interests include organic synthesis, molecular imaging and recognition, chemical biology and medicinal chemistry (drug discovery). He is an author or co-author of more than 240 original research papers and 17 books/book chapters. He has six scientific patents and is a peer reviewer for more than 60 national and international journals. Education & Post Graduate Training: Post-Doctoral, Chemistry, University of Arizona, 2000 PhD, Chemistry, North Carolina State University, 2000 MS, Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 1993 BS, Chemistry, Nanjing Normal University, 1988

研究领域

Synthetic methodology development Probe/drug design and development Anti-cancer agents Protein-protein interaction Fluorescence sensors Chemical biology Synthetic biology

近期论文

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Fang, K., Dong, G., Li, Y., He, S., Wu, Y., Wu, S., Wang, W., & Sheng, C. (2018). Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors. ACS medicinal chemistry letters, 9(4), 312-317. Fang, K., Dong, G., Wang, H., He, S., Wu, S., Wang, W., & Sheng, C. (2018). Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA. ChemMedChem, 13(1), 30-36. He, S., Dong, G., Wu, S., Fang, K., Miao, Z., Wang, W., & Sheng, C. (2018). Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents. Journal of medicinal chemistry, 61(16), 7245-7260. Huang, X. F., Jiang, W. T., Liu, L., Song, F. C., Zhu, X., Shi, G. L., Ding, S. M., Ke, H. M., Wang, W., O'Donnell, J. M., Zhang, H. T., Luo, H. B., Wan, Y. Q., Song, G. Q., & Xu, Y. (2018). A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling. CNS neuroscience & therapeutics, 24(10), 889-896. Li, J., Zheng, H., Wang, W., Miao, Y., Sheng, Y., & Feng, C. (2018). Role of an isoform-specific residue at the calmodulin-heme (NO synthase) interface in the FMN - heme electron transfer. FEBS letters, 592(14), 2425-2431. Qin, C., Liu, Y., Yu, Y., Fu, Y., Li, H., & Wang, W. (2018). α-Functionalization of 2-Vinylpyridines via a Chiral Phosphine Catalyzed Enantioselective Cross Rauhut-Currier Reaction. Organic letters, 20(5), 1304-1307. Tong, M., Wang, S., Zhuang, J., Qin, C., Li, H., & Wang, W. (2018). Direct Access of the Chiral Quinolinyl Core of Cinchona Alkaloids via a Brønsted Acid and Chiral Amine Co-catalyzed Chemo- and Enantioselective α-Alkylation of Quinolinylmethanols with Enals. Organic letters, 20(4), 1195-1199. Wang, W., Chen, X., Xu, H., Ma, S., Tong, H., & Lou, K. Y. (2018). A Simple Two-photon Turn-on Fluorescent Probe for Selective Detection of Cysteine Based on Dual PeT/ICT Mechanism. RCS Advances, 8, 13388-13392. Wang, W., Fan, H., Pan, P., & Zhang, Y. (2018). Facile Synthesis of 2-Quinolinones via Hypervalent Iodine(III)-Mediated Intramolecular Decarboxylative-Heck Reaction at Room Temperature. Organic Letters, 20, 7929-7932. Wang, W., Mao, Y., Liu, Y., Hu, W., Wang, L., & Zhang, S. L. (2018). Pd-catalyzed Debenzylation and Deallyation of Ethers and Esters with Sodium Hydride. ACS Catalysis, 8(4), 3016-3020. Wang, W., Shao, L. Y., Xing, L. H., Guo, Y., Yu, K. K., Liu, H. W., Liao, D. H., & Ji, Y. F. (2018). Catalytic Cascade Access to Biaryl-2-Methyl Acetates from Pyruvate O-Arylmethyl Ketoximes via the Palladium-Catalyzed C(sp2)-H Bond Arylation and C-O Bond Solvolysis. Advanced Synthesis & Catalysis, 360(15), 2925-2937. Wang, W., Tong, M., Zhang, Y., Qin, C., Fu, Y., Liu, Y., & LI, H. (2018). Alkenylazaarenes as Dipolarophiles in 1,3-Dipolar Cycloaddition of Nitrones: Regioselectivity-Switchable and Highly Diastereoselective Synthesis of Multisubstituted Isoxazolidines. Organic Chemical Frontiers, 5(20), 2945-2949. Wang, W., Xu, H., & Wang, X. L. (2018). Monomethylarsonous Acid: Induction of DNA Damage and Oxidative Stress in Mouse Natural Killer Cells at Environmentally-relevant Concentrations. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 832-833, 1-6. Xu, H., Xu, H., Ma, S., Chen, X., Huang, L., Chen, J., Gao, F., Wang, R., Lou, K., & Wang, W. (2018). Analyte Regeneration Fluorescent Probes for Formaldehyde Enabled by Regiospecific Formaldehyde-Induced Intramolecularity. Journal of the American Chemical Society. Zhou, D., Yu, X., Zhang, J., Wang, W., & Xie, H. (2018). Organocatalytic Asymmetric Formal [4 + 2] Cycloaddition of in Situ Oxidation-Generated ortho-Quinone Methides and Aldehydes. Organic letters, 20(1), 174-177.