McLachlan, Andrew - University of Sydney

研究领域

The impact of ageing on drug disposition and response to medicines. Includes clinical pharmacological studies in older people, assessing the manner in which age affects response to medicines, age-related patterns of using medications, and how these factors inform the quality use of medicines. Currently he is involved in a trial of deprescribing (i.e. judicious and appropriate cessation of) medications in older individuals. Ethnic differences in drug response. Collaborations with GSK studying the impact of geographical ancestry on the response to medicines, to help inform the safe use of medications and new drug development. Herb-drug interactions. Investigates the impact of herbal medicines on conventional medicines including insights related to the mechanism and consequences of these interactions. Therapeutic drug monitoring as a tool for optimised drug therapy. Current research focuses on antifungal treatments, aiming to individualise and guide optimal pharmacological endpoints by accounting for individual variability in response to these medications. Optimal anticoagulant use in older people. Includes the development and assessment of a collaborative model of home-based post-discharge warfarin management service, which was associated with a significantly reduced rate of readmissions and adverse events and improved persistence with therapy, and studies of herb-drug interactions with warfarin. Optimal treatment of low back pain. Series of collaborations on the efficacy of various interventions including physiotherapy, NSAIDs and paracetamol in low back pain, which led to two publications in the Lancet (2007 and 2014). The research is now being extended to explore interventions in the management of sciatica and in defining the management model that best serves patients with acute low back pain in the primary care setting. Optimising anticancer therapies by understanding pharmacokinetic and pharmacodynamic variability. Quality use of medicines. Including the patterns of medicines use and how this relates to quality care and health outcomes in the area of mental health, cardiovascular disease and cancer. Quality and safety in medication management.

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Eassey, D., Smith, L., Krass, I., McLachlan, A., Brien, J. (2016). Consumer perspectives of medication-related problems following discharge from hospital in Australia: a quantitative study. International Journal for Quality in Health Care, 28(3), 391-397. [More Information] Mekonnen, A., Welch, S., Medeiros, C., Sandaradura, I., Nair, P., McLachlan, A., Brien, J. (2016). Documenting antibiotic use in transition from intensive care unit to wards. Journal of Pharmacy Practice and Research, 46(1), 91-92. [More Information] Mekonnen, A., McLachlan, A., Brien, J. (2016). Effectiveness of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions: a systematic review and meta-analysis. BMJ Open, 6(2), 1-14. [More Information] Shaheed, C., Maher, C., Williams, K., Day, R., McLachlan, A. (2016). Efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain a systematic review and meta-analysis. JAMA Internal Medicine, 176(7), 958-968. [More Information] Barnes, J., McLachlan, A., Sherwin, C., Enioutina, E. (2016). Herbal medicines: challenges in the modern world. Part 1. Australia and New Zealand. Expert Review of Clinical Pharmacology, 9(7), 905-915. [More Information] Nath, C., Trotman, J., Tiley, C., Presgrave, P., Joshua, D., Kerridge, I., Kwan, Y., Gurney, H., McLachlan, A., Earl, J., Shaw, P., et al (2016). High melphalan exposure is associated with improved overall survival in myeloma patients receiving high dose melphalan and autologous transplantation. British Journal of Clinical Pharmacology, 82(1), 149-159. [More Information] Mekonnen, A., Abebe, T., McLachlan, A., Brien, J. (2016). Impact of electronic medication reconciliation interventions on medication discrepancies at hospital transitions: A systematic review and meta-analysis. BMC Medical Informatics and Decision Making, 16(1), 1-14. [More Information] Abdel Shaheed, C., McFarlane, B., Maher, C., Williams, K., Bergin, J., Matthews, A., McLachlan, A. (2016). Investigating the primary care management of low back pain: A simulated patient study. The Journal of Pain, 17(1), 27-35. [More Information] Lin, C., McLachlan, A., Latimer, J., Day, R., Billot, L., Koes, B., Maher, C. (2016). OPAL: A randomised, placebo-controlled trial of opioid analgesia for the reduction of pain severity in people with acute spinal pain. Trial protocol. BMJ Open, 6(8), 1-8. [More Information] Abdel Shaheed, C., Maher, C., Williams, K., McLachlan, A. (2016). Pharmacists' views on implementing a disease state management program for low back pain. Australian Journal of Primary Health, 22(3), 211-217. [More Information] Yata, M., McLachlan, A., Forster, D., Page, S., Beijerink, N. (2016). Pharmacokinetics and cardiovascular effects following a single oral administration of a nonaqueous pimobendan solution in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics, 39, 45-53. [More Information] Mekonnen, A., McLachlan, A., Brien, J. (2016). Pharmacy-led medication reconciliation programmes at hospital transitions: A systematic review and meta-analysis. Journal Of Clinical Pharmacy And Therapeutics, 41(2), 128-144. [More Information] Le Couteur, D., McLachlan, A., Hilmer, S. (2016). Polypharmacy in older people: When should you deprescribe? Medicine Today, 7(6), 16-24. Mathieson, S., Billot, L., Maher, C., McLachlan, A., Latimer, J., Koes, B., Hancock, M., Harris, I., Day, R., Pik, J., Jan, S., Lin, C. (2016). PRECISE - pregabalin in addition to usual care: statistical analysis plan. Trials, 17(1), 1-10. [More Information] Kaur, G., Phillips, C., Wong, K., McLachlan, A., Saini, B. (2016). Timing of Administration: For Commonly-Prescribed Medicines in Australia. Pharmaceutics, 8(2), 1-18. [More Information] Jansen, J., Naganathan, V., Carter, S., McLachlan, A., Nickel, B., Irwig, L., Bonner, C., Doust, J., Colvin, J., Heaney, A., McCaffery, K., et al (2016). Too much medicine in older people? Deprescribing through shared decision making. BMJ, 353, 1-6. [More Information] He, S., Busfield, S., Ritchie, D., Hertzberg, M., Durrant, S., Lewis, I., Marlton, P., McLachlan, A., Kerridge, I., Bradstock, K., Iland, H., et al (2015). A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia. Leukemia & Lymphoma, 56(5), 1406-1415. [More Information] Lowres, N., Krass, I., Neubeck, A., Redfern, J., McLachlan, A., Bennett, A., Freedman, S. (2015). Atrial fibrillation screening in pharmacies using an iPhone ECG: a qualitative review of implementation. International Journal of Clinical Pharmacy, 37(6), 1111-1120. [More Information] Saqf el Hait, S., Chaar, B., McLachlan, A., Overland, J., Basheti, I. (2015). Clinical Pharmacist-led Diabetes Management and Education Program Effect on the Arabic-speaking People in Australia: A Pilot Study. Jordan Journal of Pharmaceutical Sciences, 8(1), 1-11. Mathieson, S., Kasch, R., Maher, C., Pinto, R., McLachlan, A., Koes, B., Lin, C. (2015). Combination drug therapy for low back pain. Cochrane Database of Systematic Reviews, 2015 (12), 1-13. [More Information]