Leung, Sharon - University of Sydney

研究领域

Sharon is keen to incorporate her engineering and microfluidics background for the production of inhalable drug powders with engineered features, such as using of particles with controlled porosity as therapeutic carriers and polymer encapsulation for control release of active ingredients. She is also interested in examining the mechanisms responsible for stabilisation of bacteriophages in powder formulations to enable optimization of process parameters for production of phage powders.

近期论文

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Leung, S., Parumasivam, T., Tang, P., Chan, K. (2016). A Proof-of-Principle Setup for Delivery of Relenza® (Zanamivir) Inhalation Powder to Intubated Patients. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(1), 30-35. [More Information] Leung, S., Chiow, A., Ukkonen, A., Chan, K. (2016). Applicability of Bipolar Charge Analyzer (BOLAR) in Characterizing the Bipolar Electrostatic Charge Profile of Commercial Metered Dose Inhalers (MDIs). Pharmaceutical Research, 33(2), 283-291. [More Information] Seto, Y., Suzuki, G., Leung, S., Chan, K., Onoue, S. (2016). Development of an Improved Inhalable Powder Formulation of Pirfenidone by Spray-Drying: In Vitro Characterization and Pharmacokinetic Profiling. Pharmaceutical Research, 33(6), 1447-1455. [More Information] Leung, S., Parumasivam, T., Gao, F., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Britton, W., Kutter, E., Chan, K. (2016). Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections. Pharmaceutical Research, 33(6), 1486-1496. [More Information] Leung, S., Parumasivam, T., Tang, P., Chan, K. (2016). Response to Letter to the Editor: Pulmonary Delivery of Dry Powders During Invasive Mechanical Ventilation: Innovations Are Required. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(2), 217-217. [More Information] Parumasivam, T., Leung, S., Quan, D., Triccas, J., Britton, W., Chan, K. (2016). Rifapentine-loaded PLGA microparticles for tuberculosis inhaled therapy: Preparation and in vitro aerosol characterization. European Journal of Pharmaceutical Sciences, 88, 1-11. [More Information] Tang, P., Leung, S., Hor, E., Ruzycki, C., Carrigy, N., Finlay, W., Brannan, J., Devadason, S., Anderson, S., Sly, P., Samnick, K., Chan, K. (2015). An Apparatus to Deliver Mannitol Powder for Bronchial Provocation in Children Under Six Years Old. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28(6), 452-461. [More Information] Leung, S., Tang, P., Zhou, Q., Tong, Z., Leung, C., Decharaksa, J., Yang, R., Chan, K. (2015). De-agglomeration Effect of the US Pharmacopeia and Alberta Throats on Carrier-Based Powders in Commercial Inhalation Products. The AAPS Journal, 17(6), 1407-1416. [More Information] Zhou, Q., Leung, S., Tang, P., Parumasivam, T., Loh, Z., Chan, K. (2015). Inhaled formulations and pulmonary drug delivery systems for respiratory infections. Advanced Drug Delivery Reviews, 85, 83-89. [More Information] Chan, J., Wong, J., Zhou, Q., Leung, S., Chan, K. (2014). Advances in Device and Formulation Technologies for Pulmonary Drug Delivery. AAPS PharmSciTech, 15(4), 882-897. Zhou, Q., Tang, P., Leung, S., Chan, J., Chan, K. (2014). Emerging inhalation aerosol devices and strategies: Where are we headed? Advanced Drug Delivery Reviews, 75, 3-17. [More Information] Leung, S., Gupta, R., Fletcher, D., Haynes, B. (2014). Experimental Investigation of Taylor and Intermittent Slug-annular/Annular Flow in Microchannels. Experimental Heat Transfer, 27(4), 360-375. [More Information] Gupta, R., Leung, S., Manica, R., Fletcher, D., Haynes, B. (2013). Hydrodynamics of liquid-liquid Taylor flow in microchannels. Chemical Engineering Science, 92, 180-189. [More Information] Gupta, R., Leung, S., Manica, R., Fletcher, D., Haynes, B. (2013). Three Dimensional Effects in Taylor Flow in Circular Microchannels. La Houille Blanche, 2, 60-67. [More Information] Cheung, W., Lau, S., Leung, S., Ip, A., McKay, G. (2012). Characteristics of Chemical Modified Activated Carbons from Bamboo Scaffolding. Chinese Journal of Chemical Engineering, 20(3), 515-523. [More Information] Leung, S., Gupta, R., Fletcher, D., Haynes, B. (2012). Effect of flow characteristics on Taylor flow heat transfer. Industrial and Engineering Chemistry Research, 51(4), 2010-2020. [More Information] Leung, S., Gupta, R., Fletcher, D., Haynes, B. (2012). Gravitational effect on Taylor flow in horizontal microchannels. Chemical Engineering Science, 69(1), 553-564. [More Information] Asadolahi, A., Gupta, R., Leung, S., Fletcher, D., Haynes, B. (2012). Validation of a CFD model of Taylor flow hydrodynamics and heat transfer. Chemical Engineering Science, 69(1), 541-552. [More Information] Leung, S., Liu, Y., Fletcher, D., Haynes, B. (2010). Heat Transfer in Well-Characterised Taylor Flow. Chemical Engineering Science, 65(24), 6379-6388. [More Information] Leung, S., Cheung, A., McKay, G. (2009). Acid Dyes Adsorption onto Activated Carbon from Waste Tyre. International Journal of Environment and Waste Management (IJEWM), 3(3-4), 286-296. [More Information]