Low, Siew Kee - University of Sydney

研究领域

Genetic factors play a vital role in affecting inter-individual variability of drug response. My main research interest is in the field of clinical genomics, which I study the contributions of genetic variations and clinical factors in the development of complex diseases and the mechanism of drug responses. The details of my research focus include: Identification of genetic variations which are associated with drug response and drug-induced adverse events through candidate gene approach, genome-wide association study as well as next generation sequencing. Establishment of functional analysis to evaluate the impact of genetic variations/genes associated with complex diseases, drug response and drug-induced adverse events identified from genomic analysis. Development of prediction models by utilizing genetic and clinical risk factors and implementation of genotype-guided drug therapy into clinical setting. Pharmaco-economic studies to evaluate the usefulness of genetic intervention in clinical settings. Pharmaco-ethnicity study to examine the pharmacogenetics/pharmacogenomics differences in various populations. Implementation of personalized medicine for better drug treatment.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Sapkota, Y., Low, S., Attia, J., Gordon, S., Henders, A., Holliday, E., MacGregor, S., Martin, N., McEvoy, M., Morris, A., et al (2015). Association between endometriosis and the interleukin 1A (IL1A) locus. Human Reproduction, 30(1), 239-248. [More Information] Kim, Y., Oh, J., Kim, Y., Hwang, M., Moon, S., Low, S., Takahashi, A., Matsuda, K., Kubo, M., Lee, J., et al (2015). Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach. BioMed Research International, 2015 (Article ID 914965), 1-9. [More Information] Komatsu, M., Wheeler, H., Chung, S., Low, S., Wing, C., Delaney, S., Gorsic, L., Takahashi, A., Kubo, M., Kroetz, D., et al (2015). Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy. Clinical Cancer Research, 21(19), 4337-4346. [More Information] Cai, Q., Zhang, B., Sung, H., Low, S., Kweon, S., Lu, W., Shi, J., Long, J., Wen, W., Choi, J., et al (2014). Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. Nature Genetics, 46(8), 886-890. [More Information] Low, S., Takahashi, A., Mushiroda, T., Kubo, M. (2014). Genome-Wide Association Study: A Useful Tool to Identify Common Genetic Variants Associated with Drug Toxicity and Efficacy in Cancer Pharmacogenomics. Clinical Cancer Research, 20(10), 2541-2552. [More Information] Chung, S., Low, S., Zembutsu, H., Takahashi, A., Kubo, M., Sasa, M., Nakamura, Y. (2013). A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Breast Cancer Research, 15(5), 1-10. [More Information] Low, S., Takahashi, A., Ashikawa, K., Inazawa, J., Miki, Y., Kubo, M., Nakamura, Y., Katagiri, T. (2013). Genome-Wide Association Study of Breast Cancer in the Japanese Population. PloS One, 8(10), 1-8. [More Information] Low, S., Chung, S., Takahashi, A., Zembutsu, H., Mushiroda, T., Kubo, M., Nakamura, Y. (2013). Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer science, 104(8), 1074-1082. [More Information] Osman, W., Low, S., Takahashi, A., Kubo, M., Nakamura, Y. (2012). A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. Human Molecular Genetics, 21(12), 2836-2842. [More Information] Nyholt, D., Low, S., Anderson, C., Painter, J., Uno, S., Morris, A., MacGregor, S., Gordon, S., Henders, A., Martin, N., et al (2012). Genome-wide association meta-analysis identifies new endometriosis risk loci. Nature Genetics, 44(12), 1355-1359. [More Information] Low, S., Takahashi, A., Cha, P., Zembutsu, H., Kamatani, N., Kubo, M., Nakamura, Y. (2012). Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. Human Molecular Genetics, 21(9), 2102-2110. [More Information] Cha, P., Takahashi, A., Hosono, N., Low, S., Kamatani, N., Kubo, M., Nakamura, Y. (2011). A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. Nature Genetics, 43(5), 447-451. [More Information] Yasuno, K., Bakircioglu, M., Low, S., Bilguvar, K., Gaal, E., Ruigrok, Y., Niemela, M., Hata, A., Bijlenga, P., Kasuyai, H., et al (2011). Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 108(49), 19707-19712. [More Information] Low, S., Zembutsu, H., Takahashi, A., Kamatani, N., Cha, P., Hosono, N., Kubo, M., Matsuda, K., Nakamura, Y. (2011). Impact of LIMK1, MMP2 and TNF-a variations for intracranial aneurysm in Japanese population. Journal of Human Genetics, 56(3), 211-216. [More Information] Yasuno, K., Bilguvar, K., Bijlenga, P., Low, S., Krischek, B., Auburger, G., Simon, M., Krex, D., Arlier, Z., Nayak, N., et al (2010). Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nature Genetics, 42(5), 420-425. [More Information] Yasuno, K., Bilguvar, K., Bijlenga, P., Low, S., Krischeck, B., Auburger, G., Simon, M., Krex, D., Arlier, Z., Nayak, N., et al (2010). Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nature Genetics, 42(5), 420-425. [More Information] Low, S., Kuchiba, A., Zembutsu, H., Saito, A., Takahashi, A., Kubo, M., Daigo, Y., Kamatani, N., Chiku, S., Totsuka, H., et al (2010). Genome-Wide Association Study of Pancreatic Cancer in Japanese Population. PloS One, 5(7), 1-7. [More Information] Low, S., Kuchiba, A., Zembutsu, H., Saito, A., Takahashi, A., Kubo, M., Daigo, Y., Kamatani, N., Chiku, S., Totsuka, H., et al (2010). Genome-wide association study of pancreatic cancer in Japanese population. Brain, 5(7), e11824-e11824. [More Information] Low, S., Kiyotani, K., Mushiroda, T., Daigo, Y., Nakamura, Y., Zembutsu, H. (2009). Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients. Journal of Human Genetics, 54(10), 564-571. [More Information] Low, S., Kiyotani, K., Mushiroda, T., Daigo, Y., Nakamura, Y., Zembutsu, H. (2009). Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients. Journal of Human Genetics, 54(10), 564-571. [More Information]