Kayser, Veysel - University of Sydney

研究领域

Associate Professor Kayser’s research focuses on protein folding and aggregation, biopharmaceutical formulation development – particularly of therapeutic monoclonal antibodies (mAbs), the development and application of experimental based methods to biopharmaceutical products and processes, virus and vaccine characterization and formulation – in particular for rabies and influenza. Since 2006, he has focused on the development of biopharmaceuticals (mAbs and vaccines), formulation of biologics, and molecular engineering for biotherapeutics. He has worked with several pharmaceutical companies including Sanofi-Pasteur in research or consulting. He has published numerous papers on the subject in reputed journals, supervised HDR students, and serves as a reviewer for many journals. Areas of interest include: protein folding and aggregation vaccine and biopharmaceutical manufacturing stabilization and formulation of biotherapeutics and vaccines molecular level design of biologicals and processes nucleation and crystallization

近期论文

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Sahin, Z., Demir, Y., Kayser, V. (2016). Global kinetic analysis of seeded BSA aggregation. European Journal of Pharmaceutical Sciences, 86, 115-124. [More Information] Özer İlhan, �., Akkoc, S., Gok, Y., Upadhyay, P., Kayser, V. (2016). In vitro cytotoxic activities of new silver and PEPPSI palladium N-heterocyclic carbene complexes derived from benzimidazolium salts. Inorganica Chimica Acta, 449, 75-81. [More Information] Akkoc, S., Gok, Y., Ilhan, I., Kayser, V. (2016). N-Methylphthalimide-substituted Benzimidazolium salts and PEPPSI Pd-NHC complexes: Synthesis, characterization and catalytic activity in carbon-carbon bond-forming reactions. Beilstein Journal of Organic Chemistry, 12, 81-88. [More Information] Kayser, V., Chennamsetty, N., Voynov, V., Helk, B., Forrer, K., Trout, B. (2012). A screening tool for therapeutic monoclonal antibodies: Identifying the most stable protein and its best formulation based on thioflavin T binding. Biotechnology Journal, 7(1), 127-132. [More Information] Kayser, V., Chennamsetty, N., Voynov, V., Helk, B., Trout, B. (2011). Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding. mAbs, 3(4), 408-411. [More Information] Kayser, V., Chennamsetty, N., Voynov, V., Helk, B., Forrer, K., Trout, B. (2011). Evaluation of a Non-Arrhenius Model for Therapeutic Monoclonal Antibody Aggregation. Journal of Pharmaceutical Sciences, 100(7), 2526-2542. [More Information] Kayser, V., Chennamsetty, N., Voynov, V., Forrer, K., Helk, B., Trout, B. (2011). Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies. Biotechnology Journal, 6(1), 38-44. [More Information] Chennamsetty, N., Voynov, V., Kayser, V., Helk, B., Trout, B. (2011). Prediction of protein binding regions. Proteins: Structure, Function, and Bioinformatics, 79(3), 888-897. [More Information] Kayser, V., Chennamsetty, N., Voynov, V., Helk, B., Trout, B. (2011). Tryptophan-Tryptophan Energy Transfer and Classification of Tryptophan Residues in Proteins Using a Therapeutic Monoclonal Antibody as a Model. Journal of Fluorescence, 21(1), 275-288. [More Information] Voynov, V., Chennamsetty, N., Kayser, V., Wallny, H., Helk, B., Trout, B. (2010). Design and Application of Antibody Cysteine Variants. Bioconjugate Chemistry, 21(2), 385-392. [More Information] Chennamsetty, N., Voynov, V., Kayser, V., Helk, B., Trout, B. (2010). Prediction of Aggregation Prone Regions of Therapeutic Proteins. Russian Journal of Physical Chemistry B, 114(9), 6614-6624. [More Information] Chennamsetty, N., Helk, B., Voynov, V., Kayser, V., Trout, B. (2009). Aggregation-Prone Motifs in Human Immunoglobulin G. Journal of Molecular Biology, 391(2), 404-413. [More Information] Chennamsetty, N., Voynov, V., Kayser, V., Helk, B., Trout, B. (2009). Design of therapeutic proteins with enhanced stability. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(29), 11937-11942. [More Information] Voynov, V., Chennamsetty, N., Kayser, V., Helk, B., Forrer, K., Zhang, H., Fritsch, C., Heine, H., Trout, B. (2009). Dynamic Fluctuations of Protein-Carbohydrate Interactions Promote Protein Aggregation. PloS One, 4(12), 1-10. [More Information] Voynov, V., Chennamsetty, N., Kayser, V., Helk, B., Trout, B. (2009). Predictive tools for stabilization of therapeutic proteins. mAbs, 1(6), 580-582. [More Information]