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研究领域

Molecular Modelling and Computational Chemistry Biological and Medicinal Chemistry Drug Design Solid state chemistry High resolution X-ray and neutron diffraction Experimental charge density distributions. ab initio and DFT calculations

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Hamid, K., Ng, I., Tallapragada, V., Varadi, L., Hibbs, D., Hanrahan, J., Groundwater, P. (2016). An investigation of the differential effects of ursane triterpenoids from Centella asiatica, and their semi-synthetic analogues, on GABAA receptors. Chemical Biology & Drug Design, 88(3), 386-397. [More Information] Luo, J., Jin, T., Varadi, L., Perry, J., Hibbs, D., Groundwater, P. (2016). Evaluation of fluorogenic aminonaphthalenesulfonamides and 6-hydrazinobenz[de]isoquinoline-1,3-diones for the detection of bacteria. Dyes and Pigments, 125, 15-26. [More Information] Panda, D., Bhattacharya, D., Gao, Q., Oza, P., Lin, H., Hawkins, B., Hibbs, D., Groundwater, P. (2016). Identification of agents targeting FtsZ assembly. Future Medicinal Chemistry, 8(10), 1111-1132. [More Information] Naffaa, M., Absalom, N., Solomon, V., Chebib, M., Hibbs, D., Hanrahan, J. (2016). Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of p1 GABAC Receptors via Site Mutation and Partial Agonism. PloS One, 11(5), 1-21. [More Information] Groundwater, P., Xu, S., Lai, F., Varadi, L., Tan, J., Perry, J., Hibbs, D. (2016). New Delhi metallo-β-lactamase-1: structure, inhibitors and detection of producers. Future Medicinal Chemistry, 8(9), 993-1012. [More Information] Naffaa, M., Chebib, M., Hibbs, D., Hanrahan, J. (2015). Comparison of templates for homology model of rho1 GABAC receptors: More insights to the orthosteric binding site's structure and functionality. Journal of Molecular Graphics and Modelling, 62, 43-55. [More Information] Banister, S., Stuart, J., Kevin, R., Edington, A., Longworth, M., Wilkinson, S., Beinat, C., Buchanan, A., Hibbs, D., Glass, M., McGregor, I., Kassiou, M., et al (2015). Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135. ACS Chemical Neuroscience, 6(8), 1445-1458. [More Information] Du, J., Varadi, L., Tan, J., Zhao, Y., Groundwater, P., Platts, J., Hibbs, D. (2015). Experimental and theoretical charge density distribution in Pigment Yellow 101. Physical Chemistry Chemical Physics, 17, 4677-4686. [More Information] Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information] Roper, A., Leverett, P., Murphy, T., Williams, P., Hibbs, D. (2015). Klebelsbergite, Sb4O4SO4(OH)2: Stability relationships, formation in Nature, and refinement of its structure. American Mineralogist, 100(2-3), 602-607. [More Information] Merlot, A., Sahni, S., Lane, D., Fordham, A., Pantarat, N., Hibbs, D., Richardson, V., Doddareddy, M., Ong, J., Huang, M., Richardson, D., Kalinowski, D. (2015). Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells. Oncotarget, 6(12), 10374-10398. Ho, S., McLachlan, A., Chen, T., Hibbs, D., Fois, R. (2015). Relationships Between Pharmacovigilance, Molecular, Structural, and Pathway Data: Revealing Mechanisms for Immune-Mediated Drug-Induced Liver Injury. CPT: Pharmacometrics and Systems Pharmacology, 4(7), 426-441. [More Information] Wong, C., Ho, S., Saini, B., Hibbs, D., Fois, R. (2015). Standardisation of the FAERS database: a systematic approach to manually recoding drug name variants. Pharmacoepidemiology and drug safety, 24(7), 731-737. [More Information] Banister, S., Stuart, J., Conroy, T., Longworth, M., Manohar, M., Beinat, C., Wilkinson, S., Kevin, R., Hibbs, D., Glass, M., McGregor, I., Kassiou, M., et al (2015). Structure-activity relationships of synthetic cannabinoid designer drug RCS-4 and its regioisomers and C4 homologues. Forensic Toxicology, 33(2), 355-366. [More Information] Hamid, K., Ng, I., Tallapragada, V., Hibbs, D., Hanrahan, J., Groundwater, P. (2015). The Differential Effects of Resveratrol and trans-e-Viniferin on the GABA-Induced Current in GABAA Receptor Subtypes Expressed in Xenopus Laevis Oocytes. Journal of Pharmacy and Pharmaceutical Sciences, 18(4), 328-338. Zhang, W., Ning, F., Varadi, L., Hibbs, D., Platts, J., Nyerges, M., Anderson, R., Groundwater, P. (2014). An investigation of the scope of the 1,7-electrocyclization of alpha, beta: gamma, delta-conjugated azomethine ylides. Tetrahedron, 70(22), 3621-3629. [More Information] Beinat, C., Reekie, T., Hibbs, D., Xie, T., Olson, T., Xiao, Y., Harvey, A., O'Connor, S., Coles, C., Tsanaktsidis, J., Kassiou, M. (2014). Investigations of amide bond variation and biaryl modification in analogues of alpha7 nAChR agonist SEN12333. European Journal of Medicinal Chemistry, 84, 200-205. [More Information] Austin, C., Kahlert, J., Issa, F., Reed, J., Smith, J., Ioppolo, J., Ong, J., Jamie, J., Hibbs, D., Rendina, L. (2014). The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane. Dalton Transactions, 43(28), 10719-10724. [More Information] Gu, R., Hibbs, D., Ong, J., Edwards, R., Murray, M. (2014). The multikinase inhibitor axitinib is a potent inhibitor of human CYP1A2. Biochemical Pharmacology, 88(2), 245-252. [More Information] Raguine, L., Ali, M., Bender, V., Diefenbach, E., Doddareddy, M., Hibbs, D., Manolios, N. (2013). Alanine Scan of an Immunosuppressive Peptide (CP): Analysis of Structure-Function Relationships. Chemical Biology & Drug Design, 81(2), 167-174. [More Information] Ng, N., Leverett, P., Hibbs, D., Yang, Q., Bulanadi, J., Wu, M., Aldrich-Wright, J. (2013). The antimicrobial properties of some copper(ii) and platinum(ii) 1,10-phenanthroline complexes. Dalton Transactions, 42(9), 3196-3209. [More Information]

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