Hanrahan, Jane - University of Sydney

研究领域

Professor Hanrahan's research interests focuses on the understanding the role of GABA receptors in anxiety, sleep disorders, schizophrenia, epilepsy and learning and memory, including: Design and synthesis of conformationally restrained GABA analogues Developing molecules that allosterically modulate GABA receptor function Identifying and characterising natural products from traditional herbal medicines

近期论文

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Lee, H., Absalom, N., Hanrahan, J., van Nieuwenhuijzen, P., Ahring, J., Collins, M. (2016). A pharmacological characterization of GABA, THIP and DS2 at binary α4β3 and β3δ receptors: GABA activates β3δ receptors via the β3(+)δ(-) interface. Brain Research, 1644, 222-230. [More Information] Hamid, K., Ng, I., Tallapragada, V., Varadi, L., Hibbs, D., Hanrahan, J., Groundwater, P. (2016). An investigation of the differential effects of ursane triterpenoids from Centella asiatica, and their semi-synthetic analogues, on GABAA receptors. Chemical Biology & Drug Design, 88(3), 386-397. [More Information] Naffaa, M., Absalom, N., Solomon, V., Chebib, M., Hibbs, D., Hanrahan, J. (2016). Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of p1 GABAC Receptors via Site Mutation and Partial Agonism. PloS One, 11(5), 1-21. [More Information] Nematollahi, A., Sun, G., Harrop, S., Hanrahan, J., Church, W. (2016). Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 A Resolution. International Journal of Molecular Sciences, 17(4), 1-11. [More Information] Nematollahi, A., Sun, G., Jayawickrama, G., Hanrahan, J., Church, W. (2016). Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders. Molecules, 21(7), 1-9. [More Information] Carland, J., Yamamoto, I., Hanrahan, J., Abdel-Halim, H., Lewis, T., Absalom, N., Chebib, M. (2015). A Hydrophobic Area of the GABA p1 Receptor Containing Phenylalanine 124 Influences Both Receptor Activation and Deactivation. Journal of Molecular Neuroscience, 55(2), 305-313. [More Information] Abdelhalim, A., Karim, N., Chebib, M., Aburjai, T., Khan, I., Johnston, G., Hanrahan, J. (2015). Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. Journal of Pharmacy and Pharmaceutical Sciences, 18(4), 448-459. Naffaa, M., Chebib, M., Hibbs, D., Hanrahan, J. (2015). Comparison of templates for homology model of rho1 GABAC receptors: More insights to the orthosteric binding site's structure and functionality. Journal of Molecular Graphics and Modelling, 62, 43-55. [More Information] Hanrahan, J., Chebib, M., Johnston, G. (2015). Interactions of flavonoids with ionotropic GABA receptors. Advances in Pharmacology, 72, 189-200. [More Information] Jayawickrama, G., Sadig, R., Sun, G., Nematollahi, A., Nadvi, N., Hanrahan, J., Gorrell, M., Church, W. (2015). Kynurenine aminotransferases and the prospects of inhibitors for the treatment of schizophrenia. Current Medicinal Chemistry, 22(24), 2902-2918. [More Information] Rae, C., Nasrallah, F., Balcar, V., Rowlands, B., Johnston, G., Hanrahan, J. (2015). Metabolomic Approaches to Defining the Role(s) of GABAI Receptors in the Brain. Journal of Neuroimmune Pharmacology, 10(3), 45-456. [More Information] Bui, J., Day, C., Hanrahan, J., Winstock, A., Chaar, B. (2015). Senior nurses' perspectives on the transfer of opioid substitution treatment clients from clinics to community pharmacy. Drug and Alcohol Review, 34(5), 495-498. [More Information] Hamid, K., Ng, I., Tallapragada, V., Hibbs, D., Hanrahan, J., Groundwater, P. (2015). The Differential Effects of Resveratrol and trans-e-Viniferin on the GABA-Induced Current in GABAA Receptor Subtypes Expressed in Xenopus Laevis Oocytes. Journal of Pharmacy and Pharmaceutical Sciences, 18(4), 328-338. Chua, H., Absalom, N., Hanrahan, J., Viswas, R., Chebib, M. (2015). The Direct Actions of GABA, 2’-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries. PloS One, 10(10), 1-19. [More Information] Samad, A., Adeel, M., Khan, D., Badshah, S., Muhammad, Z., Khan, S., Hanrahan, J. (2015). Two New Bioactive Furoquinoline Alkaloids from Zanthoxylum armatum. Asian Journal of Chemistry, 27(7), 2468-2472. [More Information] Abdelhalim, A., Chebib, M., Aburjai, T., Johnston, G., Hanrahan, J. (2014). GABAA Receptor Modulation by Compounds Isolated from Salvia triloba L. Advances in Biological Chemistry, 4(2), 148-159. [More Information] Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff-Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, G., Chebib, M., et al (2014). GABAA Receptors Containing p1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. PloS One, 9(1), 1-16. [More Information] Hall, B., Karim, N., Chebib, M., Johnston, G., Hanrahan, J. (2014). Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone. Neurochemical Research, 39, 1068-1078. [More Information] Samad, A., Badshah, S., Khan, D., Ali, F., Amanullah, M., Hanrahan, J. (2014). New prenylated carbazole alkaloids from Zanthoxylum armatum. Journal of Asian Natural Products Research, 16(12), 1126-1131. [More Information] Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Chebib, M., Hanrahan, J. (2013). Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. ACS Medicinal Chemistry Letters, 4(4), 402-407. [More Information]