Grewal, Thomas - University of Sydney

研究领域

Regulation of EGFR/Ras signalling and trafficking. Ras signaling and stimulation of cholesterol efflux in atherosclerosis. Role of Annexin A6 in cholesterol export from late endosomes and caveolae/lipid raft formation.

近期论文

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Tran, J., Magenau, A., Rodriguez, M., Rentero, C., Royo, T., Enrich, C., Thomas, S., Grewal, T., Gaus, K. (2016). Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. PloS One, 11(3), 1-20. [More Information] Garcia-Melero, A., Reverter, M., Hoque, M., Meneses-Salas, E., Koese, M., Conway, J., Johnsen, C., Alvarez-Guaita, A., Morales-Paytuvi, F., Elmaghrabi, Y., Grewal, T., et al (2016). Annexin A6 and late endosomal cholesterol modulates integrin recycling and cell migration. The Journal of Biological Chemistry, 291(3), 1320-1335. [More Information] Meier, E., Rein-Fischboeck, L., Pohl, R., Wanninger, J., Hoy, A., Grewal, T., Eisinger, K., Krautbauer, S., Liebisch, G., Weiss, T., et al (2016). Annexin A6 protein is downregulated in human hepatocellular carcinoma. Molecular and Cellular Biochemistry, 418(1-2), 81-90. [More Information] Cornley, R., Pollock, A., Rentero, C., Norris, S., Alvarez-Guaita, A., Grewal, T., Mitchell, T., Enrich, C., Moss, S., Parton, R., et al (2016). Annexin A6 regulates interleukin-2-mediated T-cell proliferation. Immunology and Cell Biology, 94(6), 543-553. [More Information] Chan, T., Cheung, F., Zheng, J., Lu, X., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2016). Casein Kinase 2 Is a Novel Regulator of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Trafficking. Molecular Pharmaceutics, 13(1), 144-154. [More Information] Munoz, L., Yeung, Y., Grewal, T. (2016). Oncogenic Ras modulates p38 MAPK-mediated inflammatory cytokine production in glioblastoma cells. Cancer Biology and Therapy, 17(4), 355-363. [More Information] Lasrich, D., Bartelt, A., Grewal, T., Heeren, J. (2015). Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes. Experimental Cell Research, 337(1), 94-102. [More Information] Alvarez-Guaita, A., Vila de Muga, S., Owen, D., Williamson, D., Magenau, A., Garcia-Melero, A., Reverter, M., Hoque, M., Cairns, R., Cornely, R., Grewal, T., et al (2015). Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. British Journal of Pharmacology, 172(7), 1677-1690. [More Information] Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information] Chan, T., Zheng, J., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2015). Putative Transmembrane Domain 6 of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Influences Transporter Substrate Binding, Protein Trafficking, and Quality Control. Molecular Pharmaceutics, 12(1), 111-119. [More Information] Enrich, C., Rentero, C., Hierro, A., Grewal, T. (2015). Role of cholesterol in SNARE-mediated trafficking on intracellular membranes. Journal of Cell Science, 128(6), 1071-1081. [More Information] Hoque, M., Rentero, C., Conway, J., Murray, R., Timpson, P., Enrich, C., Grewal, T. (2015). The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann Pick Type C1 mutation and altered integrin trafficking. Cell adhesion & migration, 9(5), 384-391. [More Information] Gurgis, F., Yeung, Y., Tang, M., Heng, B., Buckland, M., Ammit, A., Haapasalo, J., Haapasalo, H., Guillemin, G., Grewal, T., Munoz, L. (2015). The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells. Oncogene, 34(22), 2934-2942. [More Information] Hoque, M., Rentero, C., Cairns, R., Tebar, F., Enrich, C., Grewal, T. (2014). Annexins - scaffolds modulating PKC localization and signaling. Cellular Signalling, 26(6), 1213-1225. [More Information] Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., de Muga, S., Alvarez-Guaita, A., Conway, J., Wood, P., Cairns, R., Lykopoulou, L., Grewal, T., et al (2014). Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries. Cell Reports, 7(3), 883-897. [More Information] Koese, M., Rentero, C., Kota, B., Hoque, M., Cairns, R., Wood, P., Vila de Muga, S., Reverter, M., Alvarez-Guaita, A., Monastyrskaya, K., Grewal, T., et al (2013). Annexin A6 is a scaffold for PKC(alpha) to promote EGFR inactivation. Oncogene, 32(23), 2858-2872. [More Information] Musiol, A., Gran, S., Ehrhardt, C., Ludwig, S., Grewal, T., Gerke, V., Rescher, U. (2013). Annexin A6-Balanced Late Endosomal Cholesterol Controls Influenza A Replication and Propagation. MBIO, 4(6), 1-11. [More Information] Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information] Poeter, M., Radke, S., Koese, M., Hessner, F., Hegemann, A., Musiol, A., Gerke, V., Grewal, T., Rescher, U. (2013). Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signaling. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1833 (7), 1700-1711. [More Information] Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K., Reverter, M., Alvarez-Guaita, A., Rye, K., Grewal, T., et al (2013). Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PloS One, 8(4), 1-10. [More Information]