Groundwater, Paul - University of Sydney

研究领域

The design, synthesis and testing of novel agents for the treatment of cancer and psoriasis. New chromogenic methods for the detection of bacteria. The identification of the active principle of medicinal plants.

近期论文

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Hamid, K., Ng, I., Tallapragada, V., Varadi, L., Hibbs, D., Hanrahan, J., Groundwater, P. (2016). An investigation of the differential effects of ursane triterpenoids from Centella asiatica, and their semi-synthetic analogues, on GABAA receptors. Chemical Biology & Drug Design, 88(3), 386-397. [More Information] Luo, J., Jin, T., Varadi, L., Perry, J., Hibbs, D., Groundwater, P. (2016). Evaluation of fluorogenic aminonaphthalenesulfonamides and 6-hydrazinobenz[de]isoquinoline-1,3-diones for the detection of bacteria. Dyes and Pigments, 125, 15-26. [More Information] Panda, D., Bhattacharya, D., Gao, Q., Oza, P., Lin, H., Hawkins, B., Hibbs, D., Groundwater, P. (2016). Identification of agents targeting FtsZ assembly. Future Medicinal Chemistry, 8(10), 1111-1132. [More Information] Groundwater, P., Xu, S., Lai, F., Varadi, L., Tan, J., Perry, J., Hibbs, D. (2016). New Delhi metallo-β-lactamase-1: structure, inhibitors and detection of producers. Future Medicinal Chemistry, 8(9), 993-1012. [More Information] Frost, L., Suryadevara, P., Cannell, S., Groundwater, P., Hambleton, P., Anderson, R. (2016). Synthesis of diacylated y-glutamyl-cysteamine prodrugs, and in vitro evaluation of their cytotoxicity and intracellular delivery of cysteamine. European Journal of Medicinal Chemistry, 109, 206-215. [More Information] Du, J., Varadi, L., Tan, J., Zhao, Y., Groundwater, P., Platts, J., Hibbs, D. (2015). Experimental and theoretical charge density distribution in Pigment Yellow 101. Physical Chemistry Chemical Physics, 17, 4677-4686. [More Information] Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information] Hamid, K., Alqahtani, A., Kim, M., Cho, J., Cui, P., Li, C., Groundwater, P., Li, G. (2015). Tetracyclic triterpenoids in herbal medicines and their activities in diabetes and its complications. Current Topics in Medicinal Chemistry, 15(23), 2406-2430. [More Information] Hamid, K., Ng, I., Tallapragada, V., Hibbs, D., Hanrahan, J., Groundwater, P. (2015). The Differential Effects of Resveratrol and trans-e-Viniferin on the GABA-Induced Current in GABAA Receptor Subtypes Expressed in Xenopus Laevis Oocytes. Journal of Pharmacy and Pharmaceutical Sciences, 18(4), 328-338. Zhang, W., Ning, F., Varadi, L., Hibbs, D., Platts, J., Nyerges, M., Anderson, R., Groundwater, P. (2014). An investigation of the scope of the 1,7-electrocyclization of alpha, beta: gamma, delta-conjugated azomethine ylides. Tetrahedron, 70(22), 3621-3629. [More Information] Yan, Z., Liu, J., Lu, D., Narlawar, R., Groundwater, P., Li, P. (2014). Two new ceramides from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms. Natural Product Research, 28(3), 144-149. [More Information] Bedernjak, A., Groundwater, P., Gray, M., James, A., Orenga, S., Perry, J., Anderson, R. (2013). Synthesis and evaluation of halogenated nitrophenoxazinones as nitroreductase substrates for the detection of pathogenic bacteria. Tetrahedron, 69(39), 8456-8462. [More Information] Matin, A., Doddareddy, M., Gavande, N., Nammi, S., Groundwater, P., Roubin, R., Hibbs, D. (2013). The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists. Bioorganic and Medicinal Chemistry, 21(3), 766-778. [More Information] Alqahtani, A., Hamid, K., Kam, A., Wong, K., Abdelhak, Z., Razmovski-Naumovski, V., Chan, K., Li, K., Groundwater, P., Li, G. (2013). The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications. Current Medicinal Chemistry, 20(7), 908-931. [More Information] George, S., Anderson, R., Hambleton, P., Groundwater, P. (2012). A Simple RP-HPLC Method for the Determination of the Anti-Psoriatic Drug Dithranol and its Application in an In Vitro Cell Uptake Study. Current Pharmaceutical Analysis, 8(1), 75-82. [More Information] Petch, D., Anderson, R., Cunningham, A., George, S., Hibbs, D., Liu, R., Mackay, S., Paul, A., Small, D., Groundwater, P. (2012). Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis. Bioorganic & Medicinal Chemistry Letters, 20(19), 5901-5914. [More Information] Zhao, Y., Hibbs, D., Groundwater, P., Wassef, A. (2012). Diethyl 4-(4-acetamidophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. Acta Crystallographica. Section E: Structure Reports Online, 68(8), 1-8. [More Information] Nguyen, T., Howard, S., Hanrahan, J., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and Theoretical Charge Density Distribution in a Host-Guest System: Synthetic Terephthaloyl Receptor Complexed to Adipic Acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116, 5618-5628. [More Information] Nguyen, T., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and theoretical charge density studies of 8-hydroxyquinoline cocrystallized with salicylic acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116(13), 3420-3427. [More Information] Kottakota, S., Evangelopoulos, D., Alnimr, A., Bhakta, S., McHugh, T., Gray, M., Groundwater, P., Marrs, E., Perry, J., Spilling, C., et al (2012). Synthesis and biological evaluation of purpurealidin E-derived marine sponge metabolites: aplysamine-2, aplyzanzine A, and suberedamines A and B. Journal of Natural Products, 75(6), 1090-1101. [More Information]