Duke, Colin - University of Sydney

研究领域

Investigation of biologically-active substances from natural and synthetic sources for therapeutic purposes and/or research tools. Use of specific biological tests and screens are used to detect biologically active substances potentially useful for the treatment of viral, neurological, cardiovascular, cancer and other diseases. Isolation of bioactive substances detected in extracts of selected plants, their identification and evaluation as potential drugs, lead substances for drug development and/or research tools. Syntheses of biologically-active natural products and analogues, structure-activity relationships and drug design. Investigation of the chemical profiles of selected medicinal herbs by extraction, analysis, identification and quantification of chemical constituents. Evaluation of medicinal effects attributed to herbs by examining published information about the pharmacological activity of the constituents, or by subjecting extracts or isolated constituents to relevant analytical, chemical and/or biological assays. Discovery of Australian plants with medicinal potential.

近期论文

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Chan, J., Tyne, A., Pang, A., McLachlan, A., Perera, V., Chan, J., Britton, W., Chan, K., Duke, C., Young, P., Traini, D. (2015). Murine pharmacokinetics of rifapentine delivered as an inhalable dry powder. International Journal of Antimicrobial Agents, 45(3), 319-323. [More Information] Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information] Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information] Li, Y., Tran, V., Kota, B., Nammi, S., Duke, C., Roufogalis, B. (2014). Preventative Effect of Zingiber officinale on Insulin Resistance in a High-Fat High-Carbohydrate Diet-Fed Rat Model and its Mechanism of Action. Basic and Clinical Pharmacology and Toxicology, 115(2), 209-215. [More Information] Li, Y., Tran, V., Koolaji, N., Duke, C., Roufogalis, B. (2013). (S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i. Journal of Pharmacy and Pharmaceutical Sciences, 16(2), 304-312. [More Information] Kamato, D., Rezaei, H., Getachew, R., Thach, L., Guidone, D., Osman, N., Roufogalis, B., Duke, C., Tran, V., Zheng, W., et al (2013). (S)-[6]-Gingerol inhibits TGF-Beta-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65(7), 1026-1036. [More Information] Li, X., McGrath, K., Tran, V., Li, Y., Duke, C., Roufogalis, B., Heather, A. (2013). Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells. Evidence-Based Complementary and Alternative Medicine, 2013, 1-8. [More Information] Li, X., McGrath, K., Tran, V., Li, Y., Mandadi, S., Duke, C., Heather, A., Roufogalis, B. (2013). Identification of a Calcium Signalling Pathway of S-[6]-Gingerol in HuH-7 Cells. Evidence-Based Complementary and Alternative Medicine, 2013, 1-7. [More Information] Koolaji, N., Abu-Mellal, A., Tran, V., Duke, R., Duke, C. (2013). Synthesis of C- and O-prenylated tetrahydroxystilbenes and O-prenylated cinnamates and their action towards cancer cells. European Journal of Medicinal Chemistry, 63, 415-422. [More Information] Cui, P., Rawling, T., Bourget, K., Kim, T., Duke, C., Doddareddy, M., Hibbs, D., Zhou, F., Tattam, B., Petrovic, N., Murray, M. (2012). Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. Journal of Medicinal Chemistry, 55(16), 7163-7172. [More Information] Li, Y., Tran, V., Duke, C., Roufogalis, B. (2012). Gingerols of Zingiber officinale Enhance Glucose Uptake by Increasing Cell Surface GLUT4 in Cultured L6 Myotubes. Planta Medica: natural products and medicinal plant research, 78(14), 1549-1555. [More Information] Abu-Mellal, A., Koolaji, N., Duke, R., Tran, V., Duke, C. (2012). Prenylated cinnamate and stilbenes from Kangaroo Island propolis and their antioxidant activity. Phytochemistry, 77, 251-259. [More Information] Li, Y., Tran, V., Duke, C., Roufogalis, B. (2012). Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review. Evidence-Based Complementary and Alternative Medicine, 2012, 1-10. [More Information] Tran, V., Duke, R., Abu-Mellal, A., Duke, C. (2012). Propolis with high flavonoid content collected by honey bees from Acacia paradoxa. Phytochemistry, 81, 126-132. [More Information] Duke, C., van Haaften, C., Tran, V. (2011). Efficient Isolation of an Anti-Cancer Sesquiterpene Lactone from Calomeria amaranthoides by Steam Distillation. Green and Sustainable Chemistry, 1, 123-127. [More Information] Tran, V., Marks, D., Duke, R., Bebawy, M., Duke, C., Roufogalis, B. (2011). Modulation of P-glycoprotein-Mediated Anticancer Drug Accumulation, Cytotoxicity, and ATPase Activity by Flavonoid Interactions. Nutrition and Cancer: an international journal, 63(3), 435-443. [More Information] van Haaften, C., Duke, C., Weerheim, A., Smit, N., van Haard, P., Darroudi, F., Trimbos, B. (2011). Potent cytotoxic effects of Calomeria amaranthoides on ovarian cancers. Journal of Experimental and Clinical Cancer Research, 30(1), 29-1-29-6. [More Information] Li, Z., Yang, D., Duke, C., Dong, W. (2011). Synthesis and MS/NMR characterization of the isomers of di-hydroxylated fatty acid. Zhongshan Daxue Xuebao (Acta Scientiarum Naturalium Universitatis Sunyatseni), 50(5), 75-78. Rawling, T., Duke, C., Cui, P., Murray, M. (2010). Facile and Stereoselective Synthesis of (Z)-15-Octadecenoic Acid and (Z)-16-Nonadecenoic Acid: Monounsaturated Omega-3 Fatty Acids. Lipids, 45(2), 159-165. [More Information] Cole, N., Sou, P., Ngo, A., Tsang, K., Severino, J., Arun, S., Duke, C., Reeve, V. (2010). Topical 'Sydney' Propolis Protects against UV-Radiation-Induced Inflammation, Lipid Peroxidation and Immune Suppression in Mouse Skin. International Archives Of Allergy And Immunology, 152(2), 87-97. [More Information]