Chan, Kim - University of Sydney - Faculty of Pharmacy

研究领域

Professor Chan is a world leader in respiratory drug delivery. Over a decade since joining the University of Sydney, he has developed a leading research program on aerosol drug delivery, ranging from in vitro, ranging from powder production by novel processes, particle engineering and aerosol formulation, to scintigraphic imaging of lung deposition and clinical outcome. He played a pivotal role in the development of Aridol™ (inhaled mannitol for diagnosis of asthma), which was approved by the FDA in the United States, 14 European Union countries, Singapore, Malaysia, South Korea, Australia and New Zealand. He has more than 280 scientific publications on pharmaceutical formulation and drug delivery (including 175 original research papers, 45 book chapters and reviews and 40 full-length conference articles, with over 5,000 citations and H-index of 38) and holds seven patents in these areas.

近期论文

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Leung, S., Parumasivam, T., Tang, P., Chan, K. (2016). A Proof-of-Principle Setup for Delivery of Relenza® (Zanamivir) Inhalation Powder to Intubated Patients. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(1), 30-35. [More Information] Chen, L., Okuda, T., Lu, X., Chan, K. (2016). Amorphous powders for inhalation drug delivery. Advanced Drug Delivery Reviews, 100, 102-115. [More Information] Leung, S., Chiow, A., Ukkonen, A., Chan, K. (2016). Applicability of Bipolar Charge Analyzer (BOLAR) in Characterizing the Bipolar Electrostatic Charge Profile of Commercial Metered Dose Inhalers (MDIs). Pharmaceutical Research, 33(2), 283-291. [More Information] Wong, J., Kwok, P., Niemela, V., Heng, D., Crapper, J., Chan, K. (2016). Bipolar electrostatic charge and mass distributions of powder aerosols – Effects of inhaler design and inhaler material. Journal of Aerosol Science, 95, 104-117. [More Information] Tong, Z., Zhong, W., Yu, A., Chan, K., Yang, R. (2016). CFD–DEM investigation of the effect of agglomerate–agglomerate collision on dry powder aerosolisation. Journal of Aerosol Science, 92, 109-121. [More Information] Seto, Y., Suzuki, G., Leung, S., Chan, K., Onoue, S. (2016). Development of an Improved Inhalable Powder Formulation of Pirfenidone by Spray-Drying: In Vitro Characterization and Pharmacokinetic Profiling. Pharmaceutical Research, 33(6), 1447-1455. [More Information] Parumasivam, T., Chang, R., Abdelghany, S., Ye, T., Britton, W., Chan, K. (2016). Dry powder inhalable formulations for anti-tubercular therapy. Advanced Drug Delivery Reviews, 102, 83-101. [More Information] Wang, W., Zhou, Q., Sun, S., Denman, J., Gengenbach, T., Barraud, N., Rice, S., Li, J., Yang, M., Chan, K. (2016). Effects of Surface Composition on the Aerosolisation and Dissolution of Inhaled Antibiotic Combination Powders Consisting of Colistin and Rifampicin. The AAPS Journal, 18(2), 372-384. [More Information] Cipolla, D., Wu, H., Salentinig, S., Boyd, B., Rades, T., Vanhecke, D., Fink-Petri, A., Rothin-Rutishauser, B., Eastman, S., Redelmeier, T., Chan, K., et al (2016). Formation of drug nanocrystals under nanoconfinement afforded by liposomes. RSC Advances, 6(8), 6223-6233. [More Information] Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, K., Li, J., Zhou, F. (2016). Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins. Journal of Antimicrobial Chemotherapy, 71(2), 403-412. [More Information] Parumasivam, T., Chan, J., Pang, A., Quan, D., Triccas, J., Britton, W., Chan, K. (2016). In Vitro Evaluation of Inhalable Verapamil-Rifapentine Particles for Tuberculosis Therapy. Molecular Pharmaceutics, 13(3), 979-989. [More Information] Parumasivam, T., Chan, J., Pang, A., Quan, D., Triccas, J., Britton, W., Chan, K. (2016). In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment. European Journal of Pharmaceutics and Biopharmaceutics, 107, 205-214. [More Information] Sugianto, T., Chan, K. (2016). Inhaled antibiotics in the treatment of non-cystic fibrosis bronchiectasis: Clinical and drug delivery perspectives. Expert Opinion on Drug Delivery, 13(1), 7-22. [More Information] Li, L., Sun, S., Parumasivam, T., Denman, J., Gengenbach, T., Tang, P., Mao, S., Chan, K. (2016). l-Leucine as an excipient against moisture on in vitro aerosolization performances of highly hygroscopic spray-dried powders. European Journal of Pharmaceutics and Biopharmaceutics, 102, 132-141. [More Information] Leung, S., Parumasivam, T., Gao, F., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Britton, W., Kutter, E., Chan, K. (2016). Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections. Pharmaceutical Research, 33(6), 1486-1496. [More Information] Jin, L., Zhou, Q., Chan, K., Larson, I., Pennington, M., Morales, R., Boyd, B., Norton, R., Nicolazzo, J. (2016). Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases. Journal of Pharmaceutical Sciences, 105(2), 650-656. [More Information] Leung, S., Parumasivam, T., Tang, P., Chan, K. (2016). Response to Letter to the Editor: Pulmonary Delivery of Dry Powders During Invasive Mechanical Ventilation: Innovations Are Required. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(2), 217-217. [More Information] Parumasivam, T., Leung, S., Quan, D., Triccas, J., Britton, W., Chan, K. (2016). Rifapentine-loaded PLGA microparticles for tuberculosis inhaled therapy: Preparation and in vitro aerosol characterization. European Journal of Pharmaceutical Sciences, 88, 1-11. [More Information] Lee, S., Teo, J., Heng, D., Zhao, Y., Ng, W., Chan, K., Tan, L., Tan, R. (2015). A novel inhaled multi-pronged attack against respiratory bacteria. European Journal of Pharmaceutical Sciences, 70, 37-44. [More Information] D'Sa, D., Chan, K. (2015). A Review of Methods for Evaluating Particle Stability in Suspension Based Pressurized Metered Dose Inhalers. Current Pharmaceutical Design, 21(27), 3955-3965.