Chrzanowski, Wojtek - University of Sydney

研究领域

Biointerface is understood as an interconnection between a synthetic or natural material and tissue, microorganism, cell, virus or biomolecule. Biointerface often refers to the surface of biomaterials that dictates responses of cell and tissue. Therefore, through the engineering of this surface it is possible to regulate biological responses. Dr Chrzanowski's research develops multifunctional surfaces that regulated cell attachment and differentiation. The regulation is achieved using biointerfaces with immobilised protein/peptide that modulated cell responses in a controlled manner. His work focuses also on drug delivery systems that are capable of modulating drug uptake. In particular his research centres around responsive materials that can target disease and control drug release upon external activation. Drug carriers are design to sensitise cells and upregulate drug adsorption. Nano/molecular characterisation of materials. In Dr Chrzanowski's laboratory, he uses state-of-art imaging and probing facilities nanoIR (nanoTA, SThM, LCR), Scanning Ion Conductance Microscope and Molecular Probe equipped in nanopro toolbox used for nanocharacterisation of mechanical properties of materials. Both techniques are fully integrated with fluorescence and light microscope to provide unique combination of 2D and 3D integrated images of various types of materials. Current projects look closely on cell mechanics and real time changes to the cell membrane and cells morphology upon specific stimuli.

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Bahramian, B., Ma, Y., Rohanizadeh, R., Chrzanowski, W., Dehghani, F. (2016). A new solution for removing metal-based catalyst residues from a biodegradable polymer. Green Chemistry, 18(13), 3740-3748. [More Information] Khanal, D., Kondyurin, A., Hau, H., Knowles, J., Levinson, O., Ramzan, I., Fu, D., Marcott, C., Chrzanowski, W. (2016). Biospectroscopy of Nanodiamond-Induced Alterations in Conformation of Intra- and Extracellular Proteins: A Nanoscale IR Study. Analytical Chemistry, 88(15), 7530-7538. [More Information] Posadowska, U., Brzychczy-Włoch, M., Drozdz, A., Krok-Borkowicz, M., Włodarczyk-Biegun, M., Dobrzynski, P., Chrzanowski, W., pamula, E. (2016). Injectable hybrid delivery system composed of gellan gum, nanoparticles and gentamicin for the localized treatment of bone infections. Expert Opinion on Drug Delivery, 13(5), 613-620. [More Information] , , Kondyurin, A., Chrzanowski, W., McKenzie, D., Bilek, M. (2016). Plasma immersion ion implantation of a two-phase blend of polysulfone and polyvinylpyrrolidone. Materials and Design, 95, 381-391. [More Information] Baek, S., Singh, R., Kim, T., Seo, J., Shin, U., Chrzanowski, W., Kim, H. (2016). Triple Hit with Drug Carriers: pH- and Temperature-Responsive Theranostics for Multimodal Chemo- and Photothermal Therapy and Diagnostic Applications. ACS Applied Materials and Interfaces, 8(14), 8967-8979. [More Information] Haghi, M., Traini, D., Wood, L., Oliver, B., Young, P., Chrzanowski, W. (2015). A 'soft spot' for drug transport: Modulation of cell stiffness using fatty acids and its impact on drug transport in lung model. Journal of Materials Chemistry B, 3(13), 2583-2589. [More Information] Hanaor, D., Chrzanowski, W., Gan, Y. (2015). An approach for the in-situ specific surface area assessment of aqueous oxide particles. Journal of the Australian Ceramics Society, 51(2), 88-93. Negahi Shirazi, A., Chrzanowski, W., Khademhosseini, A., Dehghani, F. (2015). Anterior cruciate ligament: Structure, injuries and regenerative treatments. Advances in Experimental Medicine and Biology, 881(2015), 161-186. [More Information] Bazaka, K., Jacob, M., Chrzanowski, W., Ostrikov, K. (2015). Anti-bacterial surfaces: natural agents, mechanisms of action, and plasma surface modification. RSC Advances, 5(60), 48739-48759. [More Information] Ghadiri, M., Chrzanowski, W., Rohanizadeh, R. (2015). Biomedical applications of cationic clay minerals. RSC Advances, 5(37), 29467-29481. [More Information] Kim, S., Naskar, D., Kundu, S., Bishop, D., Doble, P., Boddy, A., Chan, K., Wall, I., Chrzanowski, W. (2015). Formulation of Biologically-Inspired Silk-Based Drug Carriers for Pulmonary Delivery Targeted for Lung Cancer. Scientific Reports, 5, 1-13. [More Information] Khanal, D., Dillon, E., Hau, H., Fu, D., Ramzan, I., Chrzanowski, W. (2015). Lorentz contact resonance spectroscopy for nanoscale characterisation of structural and mechanical properties of biological, dental and pharmaceutical materials. Journal of Materials Science: Materials in Medicine, 26(12), 1-10. [More Information] Singh, R., Jin, G., Mahapatra, C., Patel, K., Chrzanowski, W., Kim, H. (2015). Mesoporous Silica-Layered Biopolymer Hybrid Nanofibrous Scaffold: A Novel Nanobiomatrix Platform for Therapeutics Delivery and Bone Regeneration. ACS Applied Materials and Interfaces, 7(15), 8088-8098. [More Information] Won, J., Yun, Y., Jang, J., Yang, S., Kim, J., Chrzanowski, W., Wall, I., Knowles, J., Kim, H. (2015). Multifunctional and stable bone mimic proteinaceous matrix for bone tissue engineering. Biomaterials, 56, 46-57. [More Information] Chrzanowski, W., Lee, J., Kondyurin, A., Lord, M., Jang, J., Kim, H., Bilek, M. (2015). Nano-Bio-Chemical Braille for Cells: The Regulation of Stem Cell Responses using Bi-Functional Surfaces. Advanced Functional Materials, 25(2), 193-205. [More Information] Kosobrodova, E., Jones, R., Kondyurin, A., Chrzanowski, W., Pigram, P., McKenzie, D., Bilek, M. (2015). Orientation and conformation of anti-CD34 antibody immobilised on untreated and plasma treated polycarbonate. Acta Biomaterialia, 19, 128-137. [More Information] Lee, W., Loo, J., Chrzanowski, W., Rohanizadeh, R. (2015). Osteoblast response to the surface of amino acid-functionalized hydroxyapatite. Journal of Biomedical Materials Research. Part A, 103A (6), 2150-2160. [More Information] Baek, S., Singh, R., Khanal, D., Patel, K., Lee, E., Leong, K., Chrzanowski, W., Kim, H. (2015). Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles. Nanoscale, 7(34), 4191-4216. [More Information] Neel, E., Chrzanowski, W. (2015). Surface topography and mechanical properties of flax fibres modified glass ionomer restorative materials. Journal of Biomedical Engineering and Informatics, 1(1), 82-92. [More Information] Kim, S., Wong, A., Neel, E., Chrzanowski, W., Chan, K. (2015). The future perspectives of natural materials for pulmonary drug delivery and lung tissue engineering. Expert Opinion on Drug Delivery, 12(6), 869-887. [More Information]