Balle, Thomas - University of Sydney

研究领域

Computational and medicinal chemistry applied to ligand gated ion channels Structure and function of ligand gated ion channels Structure, ligand and fragment based drug design Development of radioligands for noninvasive brain imaging by positron emission tomography

近期论文

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Shahsavar, A., Gajhede, M., Kastrup, J., Balle, T. (2016). Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate. Basic and Clinical Pharmacology and Toxicology, 118(6), 3999-407. [More Information] Shahsavar, A., Ahring, J., Olsen, J., Krintel, C., Kastrup, J., Balle, T., Gajhede, M. (2015). Acetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity. Molecular Pharmacology, 88(4), 697-707. [More Information] De La Fuente Revenga, M., Balle, T., Jensen, A., Frølund, B. (2015). Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations. European Journal of Medicinal Chemistry, 102, 352-362. [More Information] Ahring, J., Olsen, J., Nielsen, E., Peters, D., Pedersen, M., Rohde, L., Kastrup, J., Shahsavar, A., Indurthi Venkata, D., Chebib, M., Balle, T., et al (2015). Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface. Neuropharmacology, 92, 135-145. [More Information] Bach, T., Jensen, A., Petersen, J., Sorensen, T., Della Volpe, S., Liu, J., Blaazer, A., Van Muijlwijk-Koezen, J., Balle, T., Frolund, B. (2015). Exploration of the molecular architecture of the orthosteric binding site in the alpha4beta2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane. European Journal of Medicinal Chemistry, 102, 425-444. [More Information] Shahsavar, A., Balle, T. (2015). From Shellfish Poisoning to Neuroscience. Structure, 23(6), 979-980. [More Information] Krall, J., Balle, T., Krogsgaard-Larsen, N., Sorensen, T., Krogsgaard-Larsen, P., Kristiansen, U., Frolund, B. (2015). GABAA Receptor Partial Agonists and Antagonists: Structure, Binding Mode, and Pharmacology. Advances in Pharmacology, 72, 201-227. [More Information] Neumann, S., Shields, N., Balle, T., Chebib, M., Clarkson, A. (2015). Innate Immunity and Inflammation Post-Stroke: An alpha7-Nicotinic Agonist Perspective. International Journal of Molecular Sciences, 16(12), 29029-29046. [More Information] Hellyer, S., Indurthi Venkata, D., Balle, T., Runder-Varga, V., Selwood, A., Tyndall, J., Chebib, M., Rhodes, L., Kerr, S. (2015). Pinnatoxins E, F and G target multiple nicotinic receptor subtypes. Journal of Neurochemistry, 135(3), 479-491. [More Information] Gallagher, R., Chebib, M., Balle, T., McLeod, M. (2015). Thiol-Reactive Analogues of Galanthamine, Codeine, and Morphine as Potential Probes to Interrogate Allosteric Binding within Nicotinic Acetylcholine Receptors. Australian Journal of Chemistry, 68(12), 1834-1841. [More Information] Petersen, I., Crestey, F., Jensen, A., Indurthi Venkata, D., Pedersen, H., Andreasen, J., Balle, T., Kristensen, J. (2015). Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. ACS Medicinal Chemistry Letters, 6(4), 472-475. [More Information] Krall, J., Kongstad, K., Nielsen, B., Sorensen, T., Balle, T., Jensen, A., Frolund, B. (2014). 5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric gamma-Aminobutyric Acid Type A Receptor Binding Site. ChemMedChem: chemistry enabling drug discovery, 9(11), 2475-2485. [More Information] Olsen, J., Balle, T., Gajhede, M., Ahring, J., Kastrup, J. (2014). Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors. PloS One, 9(3), 1-8. [More Information] Petersen, J., Bergmann, R., Krogsgaard-Larsen, P., Balle, T., Frolund, B. (2014). Probing the Orthosteric Binding Site of GABAA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres. Neurochemical Research, 39(6), 1005-1015. [More Information] Krogsgaard-Larsen, N., Harpsoe, K., Kehler, J., Christoffersen, C., Brosen, P., Balle, T. (2014). Revision of the Classical Dopamine D2 Agonist Pharmacophore Based on an Integrated Medicinal Chemistry, Homology Modelling and Computational Docking Approach. Neurochemical Research, 39(10), 1997-2007. [More Information] Olsen, J., Ahring, J., Kastrup, J., Gajhede, M., Balle, T. (2014). Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at a4B2 Nicotinic Acetylcholine Receptors. The Journal of Biological Chemistry, 289(36), 24911-24921. [More Information] Petersen, J., Soerensen, T., Damgaard, M., Nielsen, B., Jensen, A., Balle, T., Bergmann, R., Frølund, B. (2014). Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABAA receptor agonists. European Journal of Medicinal Chemistry, 84, 404-416. [More Information] Bergmann, R., Kongsbak, K., Sørensen, P., Sander, T., Balle, T. (2013). A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites. PloS One, 8(1), 1-13. [More Information] Absalom, N., Quek, G., Lewis, T., Qudah, T., von Arenstorff, I., Ambrus, J., Harpsøe, K., Karim, N., Balle, T., McLeod, M., Chebib, M. (2013). Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. Journal of Biological Chemistry, 288(37), 26521-26532. [More Information] Crestey, F., Jensen, A., Borch, M., Andreasen, J., Andersen, J., Balle, T., Kristensen, J. (2013). Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists. Journal of Medicinal Chemistry, 56(23), 9673-9682. [More Information]