个人简介
浙江师范大学2013年度引进人才,校聘教授。2000年于复旦大学医学神经生物国家重点实验室获得神经生物学博士学位。2000至2007年在美国康奈尔大学医学院麻醉系做博士后和研究员，从事麻醉剂在神经系统的机制研究，对于疼痛中枢机制、出血性中风及麻醉剂中枢机制均有出色研究。目前主要从事运动性相关的脑创伤及骨骼肌损伤机制研究，截止2018年发表SCI论文30余篇。
课题：
1.运动对创伤性脑损伤导致的幼龄大鼠皮层神经元损伤及运动功能缺陷影响的机制研究 国家体育总局
2.创伤性脑损 导致幼龄小鼠皮层神经元进行伤的机制研究 省自然科学基金
近期论文
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Modified device for fluid percussion injury in rodents. Journal of Neuroscience Research J Neuro Res. 2018;00:1–18.
Effect of fluoride exposure on mRNA expression of cav1.2 and calcium signal pathway apoptosis regulators in PC12 cells. Environ Toxicol Pharmacol. 2017 Sep;54:74-79.
Effects of Different Levels of Calcium Intake on Brain Cell Apoptosis in Fluorosis Rat Offspring and Its Molecular Mechanism. Biol Trace Elem Res. 2017 Apr;176(2):355-366.
The molecular mechanisms of the renal injury in fluorosis induced by drinking water with a high fluoride ion content and the effects of selenium intervention. Fluoride. 2017 50(1 Pt 2)105–120
Moderate injury in motor-sensory cortex causes behavioral deficits accompanied by electrophysiological changes in mice adulthood. PLoS One. 2017 Feb 14;12(2):e0171976.
Effects of Sodium Fluoride on Lipid Peroxidation and PARP, XBP-1 Expression in PC12 Cell. Biol Trace Elem Res. 2016 Sep;173(1):161-7.
Molecular mechanism of brain impairment caused by drinking-acquired fluorosis and selenium intervention. Environ Toxicol Pharmacol. 2016 Apr;43:134-9.
Activity-dependent depression of neuronal sodium channels by the general anaesthetic isoflurane. Br J Anaesth. 2015 Jul;115(1):112-21.
Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment. Br J Pharmacol. 2012, 165: 1424–1441.
Effects of Halogenated Inhaled Anesthetics on Voltage-gated Na+ Channel Function. Anesthesiology 2009, 110:582-590.
Inhibits Tetrodotoxin-resistant Voltage-gated Sodium Channel Nav1.8. Anesthesiology 2009, 111:591-599.
Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel. J Pharmacol Exp Ther 2007, 322:1076-1083.
Isoform-selective effects of isoflurane on voltage-gated Na+ channels. Anesthesiology 2007, 107:91-98.
Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminals. J Pharmacol Exp Ther. 2005, 312:801-808.
Distinct rat neurohypophysial nerve terminal populations identified by size, electrophysiological properties and neuropeptide content. Brain Research 2004, 1024: 203-211.
Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals. Molecular Pharmacology 2003, 64:373-381.
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