Polson, Jaimie - University of Sydney - Discipline of Biomedical Science

研究领域

How does the brain control blood pressure and what are the mechanisms underlying neurogenic hypertension (high blood pressure)? Recent studies have re-ignited interest in the role of the brain as a major cause of hypertension. There is also increasing interest in foetal or developmental origins of hypertension, in which an adverse "in utero" environment can predispose the offspring to develop high blood pressure in later life. My current research focus looks at whether raised steroid levels during gestation alters the normal functioning of the autonomic nervous system in the offspring, such that they are at increased risk of developing hypertension as adults. One possibility is that alterations in the physiological responses to normal, everyday stressors may lead to chronic raised levels of sympathetic nerve activity and ultimately raised blood pressure. I also have close collaborations with Professor Roger Dampney in the Discipline of Physiology, where we study the neural mechanisms underlying the cardiovascular responses to psychological stress and exercise. The central neural pathways mediating cardio-respiratory responses to stress and exercise are poorly understood. We use a combination of physiological and anatomical techniques to try to identify these pathways.

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Furlong, T., McDowall, L., Horiuchi, J., Polson, J., Dampney, R. (2014). The effect of air puff stress on c-Fos expression in rat hypothalamus and brainstem: central circuitry mediating sympathoexcitation and baroreflex resetting. European Journal of Neuroscience, 39(9), 1429-1438. [More Information] Iigaya, K., Horiuchi, J., McDowall, L., Lam, A., Sediqi, Y., Polson, J., Carrive, P., Dampney, R. (2012). Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 303(10), R1011-R1022. [More Information] Kenny, D., Polson, J., Martin, R., Paton, J., Wolf, A. (2011). Hypertension and coarctation of the aorta: an inevitable consequence of developmental pathophysiology. Hypertension Research, 34(5), 543-547. [More Information] Kenny, D., Polson, J., Martin, R., Caputo, M., Wilson, D., Cockroft, J., Paton, J., Wolf, A. (2011). Relationship of aortic pulse wave velocity and baroreceptor reflex sensitivity to blood pressure control in patients with repaired coarctation of the aorta. American Heart Journal, 162(2), 398-404. [More Information] Kenny, D., Polson, J., Martin, R., Wilson, D., Caputo, M., Cockcroft, J., Paton, J., Wolf, A. (2010). Surgical Approach for Aortic Coarctation Influences Arterial Compliance and Blood Pressure Control. The Annals of Thoracic Surgery, 90(2), 600-604. [More Information] Kenny, D., Polson, J., Martin, R., Paton, J., Wolf, A. (2009). Normalization of Autonomic Function in Children With Coarctation of the Aorta After Surgical Correction in Infancy. Hypertension, 54(3), e21-e22. [More Information] Sun, C., Zubcevic, J., Polson, J., Potts, J., Diez-Freire, C., Zhang, Q., Paton, J., Raizada, M. (2009). Shift to an involvement of phosphatidylinositol 3-kinase in angiotensin ii actions on nucleus tractus solitarii neurons of the spontaneously hypertensive rat. Circulation Research, 105(12), 1248-1255. [More Information] Waki, H., Shimizu, T., Yamasaki, M., Katahira, K., Katsuda, S., Polson, J., Maeda, M. (2008). Ramp rate of blood pressure changes does not affect aortic afferent sensitivity in anesthetized rats. Neuroscience Letters, 448(1), 37-40. [More Information] Paton, J., Wang, S., Polson, J., Kasparov, S. (2008). Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension. Journal of Molecular Medicine, 86(6), 705-710. [More Information] Polson, J., Dampney, R., Boscan, P., Pickering, A., Paton, J. (2007). Differential baroreflex control of sympathetic drive by angiotensin II in the nucleus tractus solitarii. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 293(5), R1954-R1960. [More Information] Waki, H., Katahira, K., Polson, J., Kasparov, S., Murphy, D., Paton, J. (2006). Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats. Experimental Physiology, 91(1), 201-213. [More Information] Waki, H., Katahira, K., Polson, J., Kasparov, S., Murphy, D., Paton, J. (2006). Erratum: Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats (Experimental Physiology (2006) 91 (201-213)). Experimental Physiology, 91(2), 482-482. [More Information] Polson, J., McCallion, N., Waki, H., Thorne, G., Tooley, M., Paton, J., Wolf, A. (2006). Evidence for Cardiovascular Autonomic Dysfunction in Neonates With Coarctation of the Aorta. Circulation, 113(24), 2844-2850. [More Information] Marsh, A., Fontes, M., Killinger, S., Pawlak, D., Polson, J., Dampney, R. (2003). Cardiovascular responses evoked by Leptin acting on neurons in the ventromedial and dorsomedial hypothalamus. Hypertension, 42(4), 488-493. Dampney, R., Polson, J., Potts, P., Hirooka, Y., Horiuchi, J. (2003). Functional organization of brain pathways subserving the baroreceptor reflex: studies in conscious animals using the immediate early gene expression. Cellular and Molecular Neurobiology, 23(4/5), 597-616. Dampney, R., Horiuchi, J., Tagawa, T., Fontes, M., Potts, P., Polson, J. (2003). Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone. Acta Physiologica, 177(3), 209-218. Dampney, R., Coleman, M., Fontes, M., Hirooka, Y., Horiuchi, J., Li, Y., Polson, J., Potts, P., Tagawa, T. (2002). Central mechanisms underlying short and long term regulation of the cardiovascular system. Clinical and Experimental Pharmacology and Physiology, 29(4), 261-268. Polson, J., Mrljak, S., Potts, P., Dampney, R. (2002). Fos expression in spinally projecting neurons after hypotension in the conscious rabbit. Autonomic Neuroscience: Basic and Clinical, 100(1-2), 10-20. Fontes, M., Tagawa, T., Polson, J., Dampney, R., Cavanagh, S. (2001). Descending pathways mediating cardiovascular response from dorsomedial hypothalamic nucleus. American Journal of Physiology: Heart and Circulatory Physiology, 280(6), H2891-H2901.