Huang, Jin - University of Sydney - Discipline of Biomedical Science

研究领域

Glaucoma is the leading cause of irreversible blindness worldwide. It is a group of eye diseases where raised intraocular pressure (IOP) occurs over time, leading to visual impairment, and eventually blindness. This raised IOP causes the progressive death of the output nerve cells (neurons) of the eye called retinal ganglion cells. Despite substantial research on this disease, the pathophysiology of glaucoma is not fully understood. The retina is made up of light sensitive tissue located at the back of the eye. It contains neurons that are important in the first stage of visual perception and visual processing. One of these neurons is called ganglion cells. They project from the retina to other regions within the brain (such as the lateral geniculate nucleus), and are important in the modification of complex visual signals. To understand the pathophysiological changes in the properties of ganglion cells in glaucoma, we are using a mouse model. Techniques involved are intracellular recording techniques such as patch clamp and confocal microscopy. We will examine the properties of ganglion cells at different time points to allow comparisons before the development of glaucoma and during glaucoma with peak IOP. We will focus on the large alpha ganglion cells and characterise their basic physiological responses, which provide information about their health and behaviour such as spontaneous activity, contrast sensitivity and receptive field organisation. Thus, this project will contribute to our understanding of the effects of raised IOP characteristic of glaucoma on ganglion cell properties that ultimately leads to their death.

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Huang, J., Protti, D. (2016). The impact of inhibitory mechanisms in the inner retina on spatial tuning of RGCs. Scientific Reports, 6, 1-13. [More Information] Protti, D., Di Marco, S., Huang, J., Vonhoff, C., Nguyen, V., Solomon, S. (2014). Inner retinal inhibition shapes the receptive field of retinal ganglion cells in primate. The Journal of Physiology, 592(1), 49-65. [More Information] Huang, J., Stiefel, K., Protti, D. (2013). Implementing dynamic clamp with synaptic and artificial conductances in mouse retinal ganglion cells. Journal of Visualized Experiments, 75, 1-7. [More Information] Wang, C., Huang, J., Bardy, C., Fitzgibbon, T., Dreher, B. (2010). Influence of 'feedback' signals on spatial integration in receptive fields of cat area 17 neurons. Brain Research, 1328, 34-48. [More Information] Bardy, C., Huang, J., Wang, C., Fitzgibbon, T., Dreher, B. (2009). 'Top-down' influences of ipsilateral or contralateral postero-temporal visual cortices on the extra-classical receptive fields of neurons in cat's striate cortex. Neuroscience, 158(2), 951-968. [More Information] Wang, C., Bardy, C., Huang, J., Fitzgibbon, T., Dreher, B. (2009). Contrast dependence of center and surround integration in primary visual cortex of the cat. Journal of Vision, 9(20), 1-15. [More Information] Huang, J., Wang, C., Dreher, B. (2007). The effects of reversible inactivation of postero-temporal visual cortex on neuronal activities in cat's area 17. Brain Research, 1138, 111-128. [More Information] Bardy, C., Huang, J., Wang, C., Fitzgibbon, T., Dreher, B. (2006). 'Simplification' of responses of complex cells in cat striate cortex: suppressive surrounds and 'feedback' inactivation. The Journal of Physiology, 574(3), 731-750. [More Information]