研究领域

SPECT/CT (Single Photon Emission Computred Tomography) Lung imaging of ventilation and perfusion PET/CT (Positron Emission Tomography) Analysis of reconstructed image characteristics and variance properties

My interests are in the development of quantitative techniques using imaging of in vivo radionuclide tracers and development of multi-modality imaging methodology. I have extensive experience in both single photon tomography (SPECT) and positron emission tomography (PET). Contributions include developing simultaneous emission/transmission scanning on the gamma camera using the scanning radionuclide line source approach, which has now been implemented by nearly all manufacturers and, more recently, leading a team in developing an in-house SPECT/CT scanner. I have had numerous clinical collaborations most notably in functional neuro-imaging and in respiratory medicine. I was actively involved in developing techniques to measure cerebral activation in PET, assessing aerosol distribution in vivo using 3D methods, measuring changes in mucus clearance rates after therapeutic interventions, and in mapping airways ventilation patterns. More recently, I have been involved in developing techniques and instrumentation for SPECT/CT multimodality imaging and investigating novel methods of measuring and utilising measures of error variance in reconstructed SPECT & PET images.

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Dylke, E., Schembri, G., Bailey, D., Bailey, E., Ward, L., Refshauge, K., Beith, J., Black, D., Kilbreath, S. (2016). Diagnosis of upper limb lymphedema: development of an evidence-based approach. Acta Oncologica, In press. [More Information] Eslick, E., Bailey, D., Harris, B., Kipritidis, J., Stevens, M., Li, B., Bailey, E., Gradinscak, D., Pollock, S., Htun, C., Keall, P., et al (2016). Measurement of preoperative lobar lung function with computed tomography ventilation imaging: progress towards rapid stratification of lung cancer lobectomy patients with abnormal lung function. European Journal Of Cardio-Thoracic Surgery, 49(4), 1075-1082. [More Information] Carlier, T., Willowson, K., Fourkal, E., Bailey, D., Doss, M., Conti, M. (2015). 90Y -PET imaging: Exploring limitations and accuracy under conditions of low counts and high random fraction. Medical Physics, 42(7), 4295-4309. [More Information] Willowson, K., Tapner, M., Bailey, D. (2015). A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: The QUEST Phantom Study. European Journal of Nuclear Medicine and Molecular Imaging, 42(8). [More Information] Schembri, G., Roach, P., Bailey, D., Freeman, L. (2015). Artifacts and anatomical variants affecting ventilation and perfusion lung imaging. Seminars in Nuclear Medicine, 45(5), 373-391. [More Information] Bailey, D., Antoch, G., Bartenstein, P., Barthel, H., Beer, A., Bisdas, S., Bluemke, D., Boellaard, R., Claussen, C., Franzius, C., et al (2015). Combined PET/MR: The Real Work Has Just Started. Summary Report of the Third International Workshop on PET/MR Imaging; February 17-21, 2014, Tubingen, Germany. Molecular Imaging and Biology, 17(3), 297-312. [More Information] Bailey, D., Pichler, B., Guckel, B., Barthel, H., Beer, A., Bremerich, J., Czernin, J., Drzezga, A., Franzius, C., Goh, V., et al (2015). Combined PET/MRI: Multi-modality Multi-parametric Imaging Is Here: Summary Report of the 4th International Workshop on PET/MR Imaging; February 23–27, 2015, Tubingen, Germany. Molecular Imaging and Biology, 17(5), 595-608. [More Information] Park, W., Li, B., Maher, R., Samra, J., Clarke, S., Bernard, E., Bailey, D., Pavlakis, N. (2015). Dramatic response to selective internal radiation therapy for unresectable hepatocellular carcinoma. Oxford Medical Case Reports, 2015 (2), 194-195. [More Information] Bailey, D., Hennessy, T., Willowson, K., Henry, E., Chan, D., Aslani, A., Roach, P. (2015). In vivo quantification of (177)Lu with planar whole-body and SPECT/CT gamma camera imaging. EJNMMI Physics, 2(1), 1-17. [More Information] Li, M., Chan, D., Pavlakis, N., Kneebone, A., Bailey, D., Clarke, S. (2014). Enduring complete metabolic response in metastatic adenocarcinoma of the gastro-oesophageal junction. Oxford Medical Case Reports, 2014 (6), 105-106. [More Information] Lau, E., Bailey, D., Bailey, E., Torzillo, P., Roach, P., Schembri, G., Corte, T., Celermajer, D. (2014). Pulmonary hypertension leads to a loss of gravity dependent redistribution of regional lung perfusion: a SPECT/CT study. Heart, 100(1), 47-53. [More Information] Attarwala, A., Molina-Duran, F., Busing, K., Schonberg, S., Bailey, D., Willowson, K., Glatting, G. (2014). Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging. PloS One, 9(11), 1-7. [More Information] Bailey, D., Willowson, K. (2014). Quantitative SPECT/CT: SPECT joins PET as a quantitative imaging modality. European Journal of Nuclear Medicine and Molecular Imaging, 41(1), S17-S25. [More Information] Bailey, D., Willowson, K. (2013). An evidence-based review of quantitative SPECT imaging and potential clinical applications. The Journal of Nuclear Medicine, 54(1), 83-89. [More Information] Bailey, D., Barthel, H., Beyer, T., Boellaard, R., Gückel, B., Hellwig, D., Herzog, H., Pichler, B., Quick, H., Sabri, O., et al (2013). Summary Report of the First International Workshop on PET/MR Imaging, March 19-23, 2012, Tubingen, Germany. Molecular Imaging and Biology, 15(4), 361-371. [More Information] Bailey, E., Bailey, D., Hunyor, S., Ladd, L., Bautovich, G. (2013). Translation of Methodology Used In Human Myocardial Imaging to a Sheep Model of Acute Myocardial Infarction. Asia Oceania Journal of Nuclear Medicine & Biology, 1(2), 10-21. Roach, P., Schembri, G., Bailey, D. (2013). V/Q Scanning Using SPECT and SPECT/CT. Journal of Nuclear Medicine, 54(9), 1588-1596. [More Information] Willowson, K., Bailey, E., Bailey, D. (2012). A retrospective evaluation of radiation dose associated with low dose FDG protocols in whole-body PET/CT. Australasian Physical and Engineering Sciences in Medicine, 35(1), 49-53. [More Information] Farrow, C., Salome, C., Harris, B., Bailey, D., Bailey, E., Berend, N., Young, I., King, G. (2012). Airway closure on imaging relates to airway hyperresponsiveness and peripheral airway disease in asthma. Journal of Applied Physiology, 113(6), 958-966. [More Information] Willowson, K., Bailey, D., Schembri, G., Baldock, C. (2012). CT-based quantitative SPECT for the radionuclide 201TI: experimental validation and a standardized uptake value for brain tumour patients. Cancer Imaging, 12, 31-40. [More Information]