个人简介

Professor of Biochemistry & Molecular Biology Diplom, 1994, Technical Univ. of Berlin Ph.D., 1999, Univ. of Houston Postdoc, 1999-2003, The Scripps Research Institute. AwardOrganizationDivisionLevel CodeType CodeStart DateEnd Date Alfred P. Sloan Research FellowshipAlfred P. Sloan FoundationProfessionalFellowship2005 Junior Faculty AwardSigma Xi Honor SocietyMichigan State UniversityProfessionalHonors2005 Science at the Edge seminar series organizerCenter for Biological ModelingProfessionalAdministration20032004 Ph.D.University of HoustonChemistryGraduateDegree1999 Research Excellence AwardShellGraduateHonors1998 Graduate Fellowship AwardBayer Inc. FoundationGraduateFellowship1997 Graduate FellowshipRobert A. Welch FoundationGraduateFellowship1996 Student Challenge AwardUniversity of Houston Alumni AssociationGraduateHonors1995 Diplom (M.S.)Technical University of BerlinPhysicsGraduateDegree1994 Chemistry Graduate ScholarshipUniversity of HoustonGraduateFellowship1994 VordiplomTechnical University of BerlinComputer ScienceUndergraduateDegree1990

研究领域

Biological Physical Theoretical and Computational

(Research Description PDF - 1946 kb) Multiscale modeling of biological macromolecules Computer simulations. of biological macromolecules allow detailed mechanistic studies of how structure and dynamics relate to biological function. We are interested both in the development of new simulation methods and their application to challenging biophysical problems. In particular we are focused on employing multi-scale simulation methodologies that combine fully atomistic descriptions with coarse-grained models and implicit mean-field descriptions of solvent environments. Such methods allow us to explore conformational dynamics over long time scales and across large spatial scales ranging from supramolecular assemblies all the way to cellular scales. The ultimate goal of our research is to bridge between our current understanding of single-molecule dynamics and biological function at the cellular level. MSH2-MSH6 and RNA polymerase structures. One area of specific interest involves protein-nucleic acid complexes that are involved in replica-tion and transcription. We are studying the recognition of post-replication DNA mismatches by MutS and the human homolog MSH2-MSH6 and subse-quent initiation of DNA repair. A detailed un-derstanding of the DNA mismatch repair system is relevant for many types of cancer that often result from DNA mutations that are left un-repaired. We are also interested in mechanistic details of how transcription is carried out by RNA polymerase because of its fundamental importance in biology. SERCA Ca2+ pump regulated by phospholamban. A second area of emphasis is the study of membrane-bound proteins and peptides. Specific systems of interest are the regulation of Ca2+ transport in heart muscle by SERCA through interactions with phosholamban and the structure and dynamics of viral fusion peptides. Especially in the case of fusion peptides we are also interested in aggregation in the context of the membrane since oligomers appear to be critical for fusion activity. Structure refinement with lattice-based sampling. A third area of interest is the prediction of protein structures from its amino acid sequence at levels of accuracy similar to experimental data. While it has become relatively easy to generate native-like models if structural templates are available from related proteins, such models often lack detailed features of amino acid side chain packing in the native structure. We are applying enhanced sampling techniques in combination with accurate energy functions in order to refine approximate protein structures towards the actual native conformation.

近期论文

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Jaewoon Jong, Takakaru Mori, Chigusa Kobayashi, Yasuhiro Matsunaga, Takao Yoda, Michael Feig, Yuji Sugita: GENESIS: A hybrid-parallel and multi-scale molecular dynamics simulator with enhanced sampling algorithms for biomolecular and cellular simulations WIREs Computational Molecular Science (2015) in press Michael Feig, Ryuhei Harada, Takaharu Mori, Isseki Yu, Koichi Takahashi, Yuji Sugita: Complete Atomistic Model of a Bacterial Cytoplasm Integrates Physics, Biochemistry, and Systems Biology Journal of Molecular Graphics and Modeling (2015) in press Vahid Mirjalil, Michael Feig: Interactions of Amino Acid Side-Chain Analogs within Membrane Environments Journal of Physical Chemistry B (2015) in press Beibei Wang, Kristopher Opron, Zachary F. Burton, Robert I. Cukier, Michael Feig: Five checkpoints maintaining the fidelity of transcription by RNA polymersases in structural and energetic detail Nucleic Acids Research (2015) in press Vahid Mirjalili, Michael Feig: Density-biased sampling: A robust computational method for studying pore formation in membranes Journal of Chemical Theory and Computation (2015) in press Asli Yildirim, Monika Sharma, Bradley Varner, Liang Fang, Michael Feig: Conformational Preferences of DNA in Cellular Environments Journal of Physical Chemistry B (2014) in press Parimal Kar, Michael Feig: Recent Advances in Transferable Coarse-Grained Modeling of Proteins Advances in Protein Chemistry & Structural Biology: Biomolecular Modelling and Simulations (2014) 10, 3459-3472 Parimal Kar, Srinivasa Murthy Gopal, Yi-Ming Cheng, Afra Panahi, Michael Feig: Transferring the PRIMO Coarse-Grained Force Field to the Membrane Environment: Simulation of Proteins and Helix-Helix Association Journal of Chemical Theory and Computation (2014) in press Liang Fang, Hyun Ju Cho, Christina Chan, Michael Feig: Binding site multiplicity with fatty acid ligands: Implications for the regulation of PKR kinase autophosphorylation with palmitate Proteins (2014) in press Monika Sharma, Alexander V. Predeus, Nicholas Kovacs, Michael Feig: Differential mismatch recognition specificities of eukaryotic MutS homologs, MutSα and MutSβ Biophysical Journal (2014) 106, 375-382 Vahid Mirjalili, Kennan Noyes, Michael Feig: Physics Based Protein Structure Refinement through Multiple Molecular Dynamics Trajectories and Structure Averaging Proteins (2014) 82 (Supplement S2), 196-207 Michael Feig, Yuji Sugita: Reaching New Levels of Realism in Modeling Biological Macromolecules in Cellular Environments Journal of Molecular Graphics and Modeling (2013) 45, 144-156 Beibei Wang, Michael Feig, Robert Cukier, Zachary Burton: Computational simulation strategies for analysis of multi-subunit RNA polymerases Chemical Reviews (2013) 113, 8546-8566 Cheol Choi, Suyong Re, Mohammad Rashid, Hui Li, Michael Feig, Yuji Sugita: Solvent Electronic Polarization Effects on Na+-Na+ and Cl--CL- pair associations in aqueous solution Journal of Physical Chemistry B (2013) 117, 9273-9279 Parimal Kar, Srinivasa Murthy Gopal, Yi-Ming Cheng, Alexander Predeus, Michael Feig: PRIMO: A transferable coarse-grained force field for proteins Journal of Chemical Theory and Computation (2013) 9, 3769-3788 Beibei Wang, Alexander Predeus, Zachary Burton, Michael Feig: Energetic and Structural Details of Trigger Loop Closing Transition in RNA Polymerase II Biophysical Journal (2013) 105, 767-775 Monika Sharma, Alexander Predeus, Shayantani Mukherjee, Michael Feig: DNA Bending Propensity in the Presence of Base Mismatches: Implications for DNA Repair Journal of Physical Chemistry B (2013) 117, 6194-6205 Afra Panahi, Michael Feig: Dynamic Heterogeneous Dielectric Generalized Born (DHDGB): An implicit membrane model with a dynamically varying bilayer thickness Journal of Chemical Theory and Computation (2013) 9, 1709-1719 Ryuhei Harada, Naoya Tochio, Takanori Kigawa, Yuji Sugita, Michael Feig: Reduced Native State Stability in Crowded Cellular Environment Due to Protein-Protein Interactions Journal of the American Chemical Society (2013) 135, 3696-3701