Dehghani, Fariba - University of Sydney - School of Chemical and Biomolecular Engineering

研究领域

Professor Fariba Dehghani's work in bioengineering research focuses on developing technologies for processing biomaterials, with particular emphasis on tissue engineering and regenerative medicine. "My research aims to develop sustainable, low-energy, benign processes for manufacturing bio-products and to reduce organic solvent consumption. For instance, currently I am looking into developing bio-inspired materials and technologies to engineer tissues and organs, and investigating whether these can translate to clinical outcomes. This involves novel materials and implant devices as well as compounds for the treatment and prevention of cardiovascular disease, viral infections, cancer, osteoporosis and a range of other health issues. "My work focuses on synthesising biodegradable polymers, bioglasses, and hybrids with unique feature for tissue engineering. I also aim to develop materials for minimally invasive surgery and overcome current issues for injectable formulations including degradability, injectability and mechanical strength. Overcoming these will have a major impact on developing materials that can resolve many health issues, including sport injuries and bone defects. I am currently investigating applications of these new classes of biomaterials for drug delivery and cartilage and bone repair. "Another example of my research is the use of nano- and micro-particles for targeted drug delivery - such as in the treatment of cancer. The use of such small particles as an avenue for drug delivery can improve bioavailability by enabling drugs to permeate cell walls, minimising necessary doses and side effects. "My bioengineering research has resulted in developing a fermentation process that led to producing an oil rich in vitamin K, with greater bioavailability. The concentration of this compound is 25-fold higher than any commercially available food on the market. This oil can be used in the formulation of food products to reduce the risk of osteoporotic fractures and cardiovascular disease. "I've been working in this field since 1998, and joined the University of Sydney in 2006. Working here provides a collegial environment where I can collaborate with other disciplines and internationally prominent research teams."

近期论文

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Bahramian, B., Ma, Y., Rohanizadeh, R., Chrzanowski, W., Dehghani, F. (2016). A new solution for removing metal-based catalyst residues from a biodegradable polymer. Green Chemistry, 18(13), 3740-3748. [More Information] Negahi Shirazi, A., Fathi, A., Suarez, F., Wang, Y., Maitz, P., Dehghani, F. (2016). A Novel Strategy for Softening Gelatin-Bioactive-Glass Hybrids. ACS Applied Materials and Interfaces, 8(3), 1676-1686. [More Information] Talaei Zanjani, N., Miranda Saksena, M., Valtchev, P., Diefenbach, R., Hueston, L., Diefenbach, E., Sairi, F., Gomes, V., Cunningham, A., Dehghani, F. (2016). Abalone Hemocyanin Blocks the Entry of HSV-1 into Cells: a Potential New Antiviral Strategy. Antimicrobial Agents and Chemotherapy, 60(2), 1003-1012. [More Information] Karahan, H., Wei, L., Goh, K., Liu, Z., Birer, O., Dehghani, F., Xu, C., Wei, J., Chen, Y. (2016). Bacterial physiology is a key modulator of the antibacterial activity of graphene oxide [In Press]. Nanoscale. [More Information] Manavitehrani, I., Fathi, A., Badr, H., Daly, S., Negahi Shirazi, A., Dehghani, F. (2016). Biomedical applications of biodegradable polyesters. Polymers, 8(1), 1-32. [More Information] Wu, J., Cunningham, A., Dehghani, F., Diefenbach, R. (2016). Comparison of Haliotis rubra hemocyanin isoforms 1 and 2. Gene Reports, 4, 123-130. [More Information] Ebrahimi, A., Saffari, M., Dehghani, F., Langrish, T. (2016). Incorporation of acetaminophen as an active pharmaceutical ingredient into porous lactose. International Journal of Pharmaceutics, 499(1-2), 217-227. [More Information] Yu, N., Fathi, A., Murphy, C., Mikulec, K., Peacock, L., Cantrill, L., Dehghani, F., Little, D., Schindeler, A. (2016). Local co-delivery of rhBMP-2 and cathepsin K inhibitor L006235 in poly(D,L-lactide-co-glycolide) nanospheres [In Press]. Journal of Biomedical Materials Research. Part B: Applied Biomaterials. [More Information] Goh, K., Heising, J., Yuan, Y., Karahan, H., Wei, L., Zhai, S., Koh, J., Htin, N., Zhang, F., Wang, R., Dehghani, F., Chen, Y., et al (2016). Sandwich-Architectured Poly(lactic acid)-Graphene Composite Food Packaging Films. ACS Applied Materials and Interfaces, 8(15), 9994-10004. [More Information] Marshall, G., Valtchev, P., Dehghani, F., Gomes, V. (2016). Thermal denaturation and protein stability analysis of Haliotis rubra hemocyanin. Journal of Thermal Analysis and Calorimetry, 123(3), 2499-2505. [More Information] Paini, M., Daly, S., Aliakbarian, B., Fathi, A., Arab-Tehrany, E., Perego, P., Dehghani, F., Valtchev, P. (2015). An efficient liposome based method for antioxidants encapsulation. Colloids And Surfaces B: Biointerfaces, 136, 1067-1072. [More Information] Negahi Shirazi, A., Chrzanowski, W., Khademhosseini, A., Dehghani, F. (2015). Anterior cruciate ligament: Structure, injuries and regenerative treatments. Advances in Experimental Medicine and Biology, 881(2015), 161-186. [More Information] Ravarian, R., Murphy, C., Schindeler, A., Rawal, A., Hook, J., Dehghani, F. (2015). Bioactive poly(methyl methacrylate) for bone fixation. RSC Advances, 5(75), 60681-60690. [More Information] Cheng, T., Murphy, C., Ravarian, R., Dehghani, F., Little, D., Schindeler, A. (2015). Bisphosphonate-adsorbed ceramic nanoparticles increase bone formation in an injectable carrier for bone tissue engineering. Journal of Tissue Engineering, 6, 1-9. [More Information] Sairi, F., Valtchev, P., Gomes, V., Dehghani, F. (2015). Distribution and Characterization of Rhogocyte Cell Types in the Mantle Tissue of Haliotis laevigata. Marine Biotechnology, 17(2), 168-179. [More Information] Ravarian, R., Craft, M., Dehghani, F. (2015). Enhancing the biological activity of chitosan and controlling the degradation by nanoscale interaction with bioglass. Journal of Biomedical Materials Research. Part A, 103(9), 2898-2908. [More Information] Wakelin, E., Fathi, A., Kracica, M., Yeo, G., Wise, S., Weiss, A., McCulloch, D., Dehghani, F., McKenzie, D., Bilek, M. (2015). Mechanical Properties of Plasma Immersion Ion Implanted PEEK for Bioactivation of Medical Devices. ACS Applied Materials and Interfaces, 7(41), 23029-23040. [More Information] Manavi Tehrani, I., Fathi, A., Wang, Y., Maitz, P., Dehghani, F. (2015). Reinforced Poly(Propylene Carbonate) Composite with Enhanced and Tunable Characteristics, an Alternative for Poly(lactic Acid). ACS Applied Materials and Interfaces, 7(40), 22421-22430. [More Information] Wang, Y., Mithieux, S., Kong, Y., Wang, X., Chong, C., Fathi, A., Dehghani, F., Panas, E., Kemnitzer, J., Daniels, R., Maitz, P., Li, Z., Weiss, A., et al (2015). Tropoelastin incorporation into a dermal regeneration template promotes wound angiogenesis. Advanced Healthcare Materials, 4(4), 577-584. [More Information] Berenjian, A., Mahanama, R., Kavanagh, J., Dehghani, F. (2015). Vitamin K series: current status and future prospects. Critical Reviews in Biotechnology, 35(2), 199-208. [More Information]