个人简介

Adjunct Professor of Physics B.A. & M.A., 1985, Brandeis Univ. Ph.D., 1991, California Institute of Technology Postdoctoral Research Fellow, 1991-1993, California Institute of Technology. AwardOrganizationDivisionLevel CodeType CodeStart DateEnd Date MSU Innovator of the Year awardProfessionalHonors2013 Science and Technology Awards from Corp! magazineBiophotonic SolutionsProfessionalProfessional Activities20102010 Distinguished Faculty AwardProfessionalHonors2008 Featured in articleACS 125th Anniversary Issue of Chemical and Engineering NewsProfessionalHonors2001 Alfred P. Sloan FellowshipAlfred P. Sloan FoundationProfessionalFellowship1998 Teacher-Scholar AwardCamille and Henry Dreyfus FoundationProfessionalHonors1998 Eli Lilly Teaching FellowshipMichigan State UniversityProfessionalFellowship1996 Beckman Young Investigator AwardBeckman FoundationProfessionalHonors1995 Packard Fellowship for Science and EngineeringThe David and Lucile Packard FoundationProfessionalFellowship1995 General Electric Foundation Faculty AwardGeneral ElectricProfessionalHonors1994 New Faculty AwardCamille and Henry Dreyfus FoundationProfessionalHonors1993 Nobel Laureate Signature award for Graduate Education in ChemistryAmerican Chemical SocietyProfessionalHonors1992 Postdoctoral Research FellowCalifornia Institute of TechnologyPostdoctoralFellowship19911993 The Herbert Newby McCoy AwardCalifornia Institute of TechnologyGraduateHonors1991 Ph.D.California Institute of TechnologyGraduateDegree1991 Milton and Francis Clauser Doctoral PrizeCalifornia Institute of TechnologyGraduateHonors1991 Melvin M. Snider Prize in ChemistryBrandeis University, Waltham, MAUndergraduateHonors1985 Bachelor of ArtsBrandeis University, Waltham, MAUndergraduateDegree1985 Earl C. Anthony FellowshipCalifornia Institute of TechnologyGraduateFellowship1985 Phi Beta KappaPhi Beta KappaBrandeis University, Waltham, MAUndergraduateHonors1985 Bachelor of Arts Magna Cum LaudeBrandeis University, Waltham, MAUndergraduateDegree1985 M.A.Brandeis University, Waltham, MAGraduateDegree1985

研究领域

Analytical Biological Chemical Physics Physical

(Research Description PDF - 1620 kb) Ultrashort laser pulses are considered photonic reagents that can be used to study and control chemistry by our group. We are engaged in developing the laser technology as well as the novel applications that become available in areas such as biomedical imaging, molecular detection and identification and proteomic analysis. Our group has six state-of-the-art femtosecond laser systems with MIIPS pulse shaping technology available for our projects. Some of our challenging projects include: Development of multidimensional spectroscopic methods for standoff identification of chemicals in solid, liquid and gaseous states; Exploring novel biomedical applications of nonlinear photonic control for selective two-photon microscopy and imaging through tissue; Exploring the behavior of molecules under intense laser fields; Development of fiber laser technology coupled to automated phase optimization for biomedical applications; Development of femtosecond laser induced dissociation for proteomic and metabolomic analysis. These images illustrate the use of ultrashort (~10 fs) shaped pulses in two-photon microscopy. Selective excitation of subcellular structures such as actin (blue) and mitochondria (green) in HeLa (human cervical cancer) cells is illustrated in the top two images, obtained without fluorescence filters. The bottom figure is a combination of the top two images. Ultrafast Lasers and Imaging. The laser pulses in our laboratory are short enough to “freeze” the motion of atoms and allow us to see chemical reactions as they take place. Using a pulse shaper, we are able to tailor the phase of the individual wavelength components. These shaped pulses can be used to control the quantum-mechanical aspects of laser-molecule interactions. For example, we can control which molecules absorb energy and which do not, an aspect we have used to achieve selective two-photon microscopy. Our group has a number of inter-disciplinary interests (Physics, Chemistry, Biology, Medicine, and Engineering) that lead to collaborations with other universities, agencies, and companies. The teamwork we practice leads to a high level of productivity, shared responsibility and success. You can expect to be involved in the preparation of several manuscripts. The creativity and forward-thinking that we encourage has led to 7 issued patents and 29 patent applications. We are constantly pushing the boundaries of new technology and ideas. All research ideas are welcomed and pursued, as we have ongoing work that ranges from fundamental science to applications. One of the more challenging real world problems is the remote identification of hazardous molecules. Here, we couple the multidimensionality of femtosecond pulse shaping with CARS (Coherent Anti-Stokes Raman Scattering) spectroscopy to develop a fast and reliable laser-based method for remote detection of explosive materials

近期论文

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G. J. Parker, D. E. Parker, B. Nie, V. V. Lozovoy and M. Dantus, "LIBS and ablation threshold analysis using a megahertz Yb fiber laser oscillator," Spectrochimica Acta Part B: Atomic Spectroscopy (2015). M. Nairat, A. Konar, M. Kaniecki, V. V. Lozovoy and M. Dantus, "Investigating the Role of Human Serum Albumin Protein Pocket on the Excited State Dynamics of Indocyanine Green Using Shaped Femtosecond Laser Pulses," Phys. Chem. Chem. Phys 17, 5872-5877 (2015). I. Saytashev, B. Xu, M.T. Bremer, and M. Dantus, "Simultaneous Selective Two-Photon Microscopy Using MHz Rate Pulse Shaping and Quadrature Detection of the Time-Multiplexed Signal," Ultrafast Phenomena XIX, K. Yamanouchi et al., Eds. (Springer Proceedings in Physics 162, 2015). B. Nie, I. Saytashev, and M. Dantus, "Towards a Compact Fiber Laser for Multimodal Imaging," Ultrafast Phenomena XIX, K. Yamanouchi et al., Eds. (Springer Proceedings in Physics 162, 2015). A. Konar, V.V. Lozovoy, and M. Dantus, "Solvent Environment Revealed by Positively Chirped Pulses," Ultrafast Phenomena XIX, K. Yamanouchi et al., Eds. (Springer Proceedings in Physics 162, 2015). A. Konar, Y. Shu, V.V. Lozovoy, J.E. Jackson, B.G. Levine, and M. Dantus, "Polyatomic Molecules under Intense Femtosecond Laser Irradiation," J. Phys. Chem. A 118, 11433-11450 (2014). A. Ryabtsev, S. Pouya, M. Koochesfahani, and M. Dantus, "Vortices in the wake of a femtosecond laser filament," Optics Express 22, 26098-26102 (2014). M. Dantus and K. Monro, "Ultrafast Temporal Shaping Is Coming of Age," Biophotonics 21, 24-28 (2014). S. Pouya, A. Van Rhijn, M. Dantus, M. Koochesfahani, "Multi-photon molecular tagging velocimetry with femtosecond excitation (FemtoMTV)," Experiments in Fluids 55 (2014). I. Saytashev, and M. Dantus "Multimodal Imaging of highly pigmented tissues," in Biomedical Optics 2014, OSA Technical Digest, paper BT3A.18 (2014). G. Rasskazov, A. Ryabtsev, V.V. Lozovoy and M. Dantus, "Laser-induced dispersion control," Optics Letters 39 (2014). H. Liu; W. Renninger; B. Nie; M. Dantus; F. Yu; J. Knight; A. Chong; F. Wise "High-power femtosecond fiber lasers based on self-similar pulse evolution," Proc. SPIE 9136, Nonlinear Optics and Its Applications VIII; and Quantum Optics III, 91360W (2014). B. Nie, I. Saytashev, and M. Dantus "Towards a compact fiber laser for multimodal imaging," Proc. SPIE 8948, 89480A (2014). I. Saytashev, B. Xu, M.T. Bremer and M. Dantus "Simultaneous selective two-photon microscopy using MHz rate pulse shaping and quadrature detection of the time-multiplexed signal," Proc. SPIE 8948, 89482F (2014). A. Konar, V.V. Lozovoy, and M. Dantus, "Electronic dephasing of molecules in solution measured by nonlinear spectral interferometry," ScienceJet 4 (2015). A. Konar, V.V. Lozovoy, and M. Dantus, "Solvent Environment Revealed by Positively Chirped Pulses," J. Phys. Chem. Lett. 5, 924–928 (2014). D. Pestov, A. Ryabtsev, G. Rasskazov, V.V. Lozovoy, and M. Dantus, "Real-time single-shot measurement and correction of pulse phase and amplitude for ultrafast lasers," Opt. Eng. 53, 051511 (2014). M. Dantus and C.L. Kalcic, "Ultrafast Ionization and Fragmentation: From Small Molecules to Proteomic Analysis", Ultrafast Phenomena in Molecular Sciences, R. Nalda and L. Banares, Eds. (Springer Series in Chemical Physics 107, 2014) p. 171-201 R.M. Bowman, M. Dantus, A.H. Zewail, Jennifer L. Herek, "Historical perspective on: Femtosecond transition-state spectroscopy of iodine—From strongly bound to repulsive surface dynamics", Chem Phys Lett 589, 42-45 (2013). B. Nie, G.Parker, V.V.Lozovoy and M. Dantus, "Energy scaling of Yb fiber oscillator producing clusters of femtosecond pulses", Optical Engineering 53, 051505 (2013).