个人简介
2020.05-至今:中国农业大学,优秀人才引进,副教授
2016.05-2020.04:北京食品营养与人类健康高精尖创新中心,岗位科学家
2014.12-2016.04:中国科学院生物物理研究所,副研究员
2012.07-2014.11:中国科学院生物物理研究所,助理研究员
2007.09-2012.06:中国科院生物物理研究所,细胞生物学,理学博士
2003.09-2007.06:四川大学,生命科学学院,生物科学,学士
课题项目
北京市自然科学基金面上项目,7222111,平滑肌肌酸代谢调控肺动脉高压的机制研究,2022-2024,20万,在研,主持
国家自然科学基金面上项目,82170429,巨噬细胞与平滑肌代谢互作调控肺动脉高压的机制研究,2022-2025,58万,在研,主持
中国农业大学科创项目,2021TC114,15051003,动脉粥样硬化斑块中微生物的研究,2021-2021,1万,结题,主持
国家自然科学基金面上项目,31970717,细胞膜受体调控mTORC2活化的新机制研究,2020-2023,58万,在研,主持
中国农业大学基本科研业务费专项资金项目,2020TC015,CD146调控mTOR复合物促进细胞增殖的作用机制研究,2020-2020,6万,结题,主持
国家自然科学基金青年基金,31300729,CD146在动脉粥样硬化发展中的作用机制研究,2014.01-2016.12,23万,结题,主持
横向项目,QQ星原生DHA牛奶营养优势研究,2021.12-2022.08,185万,在研,主持
国家自然科学基金面上项目,31871792,乳铁蛋白在维生素D促进钙吸收过程中的协同效应与作用机制,2019.01-2022.12,60万,在研,骨干参与
国家自然科学基金重大研究计划,91529306,CD146调控肝炎恶性转化的网络研究,2015.01-2017.12,299.4万,已结题,骨干参与
国家自然科学基金重大研究计划,91329102,CD146作为关键节点调控非可控性炎症恶性转化分子机制研究,2012.01-2014.12,150万,已结题,骨干参与
国家自然科学基金重大研究计划,91329732,CD146作为关键节点调控非可控性炎症恶性转化分子机制研究,2009.01-2011.12,150万,已结题,骨干参与
国家自然科学基金面上项目,81371330,CD146介导的淋巴细胞迁移在多发性硬化症中的作用和机制,2014.01-2017.12,80万,已结题,骨干参与
国家自然科学基金面上项目,81272409,EMET:肿瘤转移新机制,2013.01-2016.12,100万,已结题,骨干参与
国家自然科学基金面上项目,81371025,CD146在眼底新生血管疾病中的作用及机制,2013.01-2016.12,100万,已结题,骨干参与
近期论文
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Peng An, Wenyi Xu, Junjie Luo#, Yongting Luo#. Expanding mTOR complex 2 signaling-emerging regulators and new connections. Frontiers in Cell and Developmental Biology. 2021 Jul 30;9:713806
Xuan Wang, Peng An, Zhenglong Gu, Yongting Luo#, Junjie Luo#. Mitochondrial Metal Ion Transport in Cell Metabolism and Disease, Int J Mol Sci. 2021 Jul 14;22(14):7525
Xu T, Zhang X, Liu Y, Wang H, Luo J#, Luo Y#, An P#. Effects of dietary polyphenol supplementation on iron status and erythropoiesis: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2021 Apr 19:nqab068
Yongting Luo#, Xiao Teng, Lingling Zhang, Jianan Chen, Zheng Liu, Xuehui Chen, Shuai Zhao, Sai Yang, Jing Feng, Xiyun Yan#. CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension. Nature Communications. 2019, 7;10(1):3551.
Wenyi Xu, Huijuan Hua, Yueh-Ho Chiu, Guannan Li, Huihan Zhi, Zhengquan Yu, Fazheng Ren, Yongting Luo#, Wei Cui#. CD146 regulates growth factor-induced mTORC2 activity independent of PI3K and mTORC1 pathways. Cell Reports. 2019.
Yongting Luo#, Wenyi Xu, Guannan Li, Wei Cui#. Weighing in on mTOR complex 2 signaling: the expanding role in cell metabolism. Oxidative Medicine and Cellular Longevity. 2018, Article ID 7838647.
Lingling Zhang*, Yongting Luo*, Xiao Teng, Zhenzhen Wu, Mengtao Li, Dong Xu, Qian Wang, Fei Wang, Jing Feng#, Xiaofeng Zeng#, Xiyun Yan#. CD146: a potential therapeutic target for systemic sclerosis. Protein & Cell, 2018 ;9(12):1050-1054.
Jianan Chen*, Yongting Luo*, Hongxin Huang, Shuilong Wu, Jing Feng, Jingjing Zhang, Xiyun Yan#. CD146 is essential for PDGFRβ-induced pericyte recruitment. Protein & Cell, 2018;9(8):743-747.
Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang F, Feng J, Yang D, Qin Z, Yan X#. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Research. 2017;27(3):352-372.
Selected as Cover Story (封面文章)
Jianan Chen*, Yongting Luo*, Hui Hui, Tanxi Cai, Hongxin Huang, Fuquan Yang, Jing Feng, Jingjing Zhang#, Xiyun Yan#. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci U S A. 2017;114(36):E7622-E7631.
被国际著名专家在Faculty 1000 Prime上推荐为新发现及新药靶点
Xing S*, Luo Y*, Liu Z, Bu P, Duan H, Liu D, Wang P, Yang J, Song L, Feng J, Yang D, Qin Z, Yan X#. Targeting endothelial CD146 attenuates colitis and prevents colitis associated carcinogenesis. Am J Pathol. 2014. 184(5):1604-16.
被标注为“继续医学教育”文章 (CME Program)
被专题评述Highlighted by: Adhesion Molecule Shows Promise for Treating Colitis [Am J Pathol. 2014]
Qian YN*, Luo YT*, Duan HX, Feng LQ, Bi Q, Wang YJ, Yan XY#. Adhesion Molecule CD146 and its Soluble Form Correlate Well with Carotid Atherosclerosis and Plaque Instability. CNS Neurosci Ther., 2014. 20(5):438-45.
Duan H*, Xing S*, Luo Y*, Feng L, Gramaglia I, Zhang Y, Lu D, Zeng Q, Fan K, Feng J, Yang D, Qin Z, Couraud PO, Romero IA, Weksler B, Yan X#. Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS. Sci Rep. 2013;3:1687.
Duan H*, Luo Y*, Hao H*, Feng L*, Zhang Y, Lu D, Xing S, Feng J, Yang D, Song L, Yan X#. Soluble CD146 in cerebrospinal fluid of active multiple sclerosis. Neuroscience. 2013;235:16-26.
Luo Y*, Zheng C*, Zhang J, Lu D, Zhuang J, Xing S, Feng J, Yang D, Yan X#. Recognition of CD146 as an ERM-binding protein offers novel mechanisms for melanoma cell migration. Oncogene. 2012;31(3):306-21.