个人简介

B.S., 1981, Bates College Ph.D., 1985, Univ. of Wisconsin-Madison Member of Technical Staff, 1985-91, Bell Communications Research Award Organization Division Level Code Type Code Start Date End Date Gold Medal Award from the New York Section of the Society for Applied Spectroscopy Professional Honors 2011 Member National Institutes of Health NIH Repairative Medicine Study Section Professional Professional Activities 2004 Member International Conference on Electode Processes Scientific Committee Professional Professional Activities 2004 Discussion Leader Gordon Research Conference Analytical Chemistry Professional Administration 2001 Member NASA NASA Crystal Growth Review Panel Professional Professional Activities 2001 Member American Chemical Society ACS Award in Chemical Instrumentation Jury Professional Professional Activities 2001 2002 Organizer American Chemical Society Symposia on Polymer Characterization and Interface Characterization, Fall National Meeting Professional Administration 1999 Member National Science Foundation NSF-CCLI Review Panel Professional Professional Activities 1999 Member NASA Environmental Health Review Panel Professional Administration 1998 NSF pecial Creativity Extension National Science Foundation Professional Honors 1998 Special Creativity Award National Science Foundation Professional Honors 1998 Member Optical Society of America International Organizing Committee, Optical Society of America Fall Meeting Professional Professional Activities 1997 Organizer FACSS Molecular Spectroscopy, Materials and Interfaces Program Professional Administration 1997 Organizer National Science Foundation Keystone Conference on Reconnecting the Academic and Industrial Analytical Communities - GOALI Workshop Professional Administration 1996 Member Findeis Award Jury Professional Professional Activities 1995 1996 Member National Science Foundation NSF SBIR Review Panels Professional Professional Activities 1995 1996 Ph.D. University of Wisconsin-Madison Graduate Degree 1985 DuPont Departmental Fellowship Graduate Fellowship 1983 Graduate with Honors (Chemistry) Bates College, Lewiston, ME Undergraduate Honors 1981 Bachelor of Science Bates College, Lewiston, ME Undergraduate Degree 1981 Summer Internship American Chemical Society Analytical Division Undergraduate Honors 1980 Eastern Analytical Symposium Student Award Undergraduate Honors 1980

研究领域

Analytical Biological Materials

(Research Description PDF - 1948 kb) Controlling the physical properties and chemical selectivity of an interface is an issue central to areas of science ranging from cellular function to heterogeneous catalysis and chemical sensing. The Blanchard group works on the design and synthesis of interfaces with an eye toward achieving this control. We are currently focusing our energies on catalytic and biomimetic systems because of their broad utility. Biomimetic Interfaces. The creation of interfacial structures that can function biomimetically is a gateway to the design of biosensors. We have been actively involved in the creation of such structures where we deposit a lipid bilayer structure, with fluorescent and electrochemical probes imbedded at specific locations within the interface. Our efforts are aimed at probing local organization and fluidity in the bilayer, so that we will be able to incorporate transmembrane proteins into these interfaces for use as sensing elements. Schematic of a chemically-bound, fluid lipid bilayer interface. Lipid Layer Binding to Surfaces. We have recently devised a means of creating lipid mono- and bilayer structures that can be bound to surfaces, are stable in air and retain fluid behavior. This work represents a novel effort aimed at creating robust, fluid bio-interfaces. We create these interfaces in a two-step process, modifying a gold surface with a hydroxyl-terminated molecule, then reacting the hydroxyl end group to create a phosphate. The surface phosphate group is complexed with a metal ion, which can then complex with phospholipid head groups to chemically bind the lipid molecule to the interface. The structural details and fluid behavior of this novel bio-interface depend on the metal ion and phospholipid structure, allowing us to “tune” the properties of the interface for specific applications. Supramolecular Assemblies. Catalysis is central to processes ranging from petroleum refining to the functioning of living organisms. We are concerned with creating a structural “scaffold” on which molecular catalysts can be bound and reactant streams can be flowed through. Bound heterogeneous catalytic systems have the benefits of minimizing post-reaction cleanup, structural stabilization of the catalyst and the ability to reuse catalysts efficiently. We are interested in understanding how the immobilization of catalytic species influences their ability to function. While the immobilization of catalysis is not new, there is no real understanding of how catalytic activity can be mediated by support structures. We aim to impose a new level of structural control over the catalyst support by using inverse opal nanostructures for this purpose. Support properties such as pore size and surface chemical functionality have a significant influence on the catalytic behavior of enzymes. Supported inverse opal structure grown on a porous alumina substrate.

近期论文

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Iwan Setiawan and G. J. Blanchard, "Structural disruption of phospholipid bilayers over a range of length scales by n-butanol," Journal of Physical Chemistry B, 118, 3085-3093 (2014). Thomas R. Bartlett, Safeer Ahmed, Floriana Tuna, David Collison, Gary J. Blanchard and Frank Marken, "Liquid | Liquid Interfacial Photoelectrochemistry of Chromoionophore I Immobilised in 4-(3-Phenylpropyl)-Pyridine Microdroplets," ChemElectroChem, 1, 400-406 (2014). Iwan Setiawan and G. J. Blanchard, "Ethanol-Induced Perturbations to Planar Lipid Bilayer Structures," Journal of Physical Chemistry B, 118, 537-546 (2014). Hannah E. Mize and G. J. Blanchard "State-Dependent Rotational Diffusion of Tetracene in n-Alkanes. Evidence for a Dominant Energy Relaxation Pathway," Journal of Physical Chemistry B, 117, 16260-16265 (2013). Dorota Nieciecka, Aleksandra Joniec, G. J. Blanchard, and Paweł Krysiński, "Interactions of Doxorubicin with Organized Interfacial Assemblies. 1. Electrochemical Characterization," Langmuir, 29, 14560-14569 (2013). Dorota Nieciecka, Agata Krolikowska, Iwan Setiawan, Paweł Krysiński, and G. J. Blanchard, "Interactions of Doxorubicin with Organized Interfacial Assemblies. 2. Spectroscopic Characterization," Langmuir, 29, 14570-14579 (2013). Daria Kępińska, Adam Budniak, Krystyna Kijewska, G. J. Blanchard, and Maciej Mazur, "Encapsulation of Nile Red in polypyrrole microvessels," Polymer, 54, 4538-4544 (2013). Krzysztof Nawara, John L. McCracken, Paweł Krysiński, and G. J. Blanchard, "Structure-Dependent Complexation of Fe3+ by Anthracyclines. 1. The Importance of Pendent Hydroxyl Functionality," Journal of Physical Chemistry B, 117, 6859-6867 (2013). Krzysztof Nawara, Hillary Beeckman, Paweł Krysiński, and G. J. Blanchard, "Structure-Dependent Complexation of Fe3+ by Anthracyclines. 2. The Roles of Methoxy and Daunosamine Functionalities," Journal of Physical Chemistry B, 117, 6868-6873 (2013). Chen Qiu and G. J. Blanchard, "Phospholipid vesicle stability and temporal variations in acyl chain organization," Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 110, 383-390 (2013). S. M. Baumler and G. J. Blanchard, "Lipid adlayer organization mediated by a liquid overlayer," Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 98, 429-435 (2012). Douglas B .Gornowich and G. J. Blanchard, "Enhancement of Enzyme Activity by Confinement in an Inverse Opal Structure," Journal of Physical Chemistry C, 116, 12165-12171 (2012). Krzysztof Nawara, Paweł Krysiński and G. J. Blanchard, "An Examination of the Photoinduced Reactivity of Doxorubicin: Catalysis and Degradation," Journal of Physical Chemistry A, 116, 4330-4337 (2012). Krzysztof Nawara, Paweł Krysiński and G. J. Blanchard, "Doxorubicin is a Photocatalyst for the Generation of H2O2," RSC Advances, 2, 4059-4061 (2012). Andrew M. Collins, G. J. Blanchard and Frank Marken, "Spectroelectrochemical Investigation of Tetraphenyl-porphyrinato-Mn(III/II)-Driven Liquid | Liquid | Electrode ClO4-, CO3H-, Cl-, and F- Anion Transfer into 4-(3-Phenylpropyl)-Pyridine," Electroanalysis, 24, 246-253 (2012). Krystyna Kijewska, G. J. Blanchard, Jakub Szlachetko, Jarosław Stolarski, Anna Kisiel, Agata Michalska, Krzysztof Maksymiuk, Marcin Pisarek, Paweł Majewski, Paweł Krysiński and Maciej Mazur, "Photopolymerized polypyrrole microvessels," Chemistry - A European Journal, 18, 310-320 (2012). Iwan Setiawan and G. J. Blanchard, "Evaluating the Sensitivity of Lipid Headgroup-Bound Chromophores to their Local Environment," Journal of Physical Chemistry B, 116, 966-973 (2012). Daria Kępińska, G. J. Blanchard, Paweł Krysiński, Jarosław Stolarski, Krystyna Kijewska and Maciej Mazur, "Pyrene-loaded polypyrrole microvessels," Langmuir, 27, 12720-12729 (2011). Margaretta M. Dimos and G. J. Blanchard, "Examining the Electro-Catalytic Oxidation of Selected Diols at Nanoporous and Planar Pt Electrodes," Journal of Physical Chemistry C, 115, 11247-11256 (2011). Andrew M. Collins, G. J. Blanchard, Jonathan Hawkett, David Collison and Frank Marken, "Liquid | Liquid | Electrode Triple Phase Boundary Photovoltammetry of Pentoxyresorufin in 4-(3-Phenylpropyl)pyridine," Langmuir, 27, 6471-6477 (2011).