个人简介

Edward I. Stiefel award in Bioinorganic Chemistry, 2012 NSF CAREER, 2012 Earle C. Anthony Fellowship, University of California, Berkeley, 2002-2003 Rhône-Alpes Fellowship, France, 2000-2001 Leonardo Fellowship, European Union, 1999-2000

研究领域

Inorganic & Organometallic Chemistry/Analytical & Bioanalytical Chemistry/Chemical Biology/Organic Chemistry

Our group studies the role of metal ions in biological systems and design metal complexes as biological and medical probes. Using analytical, inorganic and organic synthetic techniques we develop lanthanide complexes as responsive luminescent sensors for nucleotides, and iron oxide nanoparticles as contrast agents for medical MRI. Another project is directed toward elucidating the recognition and uptake of heme by gram-negative bacteria. The heme-transport proteins will be studied both from a structural, a chemical biology and an inorganic perspective.

近期论文

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Wickramaratne, T. M.; Pierre, V. C.* “Turning an aptamer into a light-switch probe with a single bioconjugation” Bioconjugate Chem. ASAP DOI: 10.1021/bc5003899 Peterson, K. L.; Dang, J. L; Weitz, E. A.; Lewandowski, C.; Pierre, V. C.* “Effect of lanthanide complex structure on cell viability and association” Inorg. Chem. 2014, 53, 6013-6021. Pierre, V. C.*; Allen, M. J.*; Caravan, P.* “Contrast Agents for Magnetic Resonance Imaging: 30+ Years and Where are We Going?” J. Biol. Inorg. Chem. 2014, 19, 127-131. (pdf) Weitz, E. A.; Chang, J.; Rosenfield, A. H.; Morrow, E.; Pierre, V. C.* “The Basis for the Molecular Recognition and the Selective Time-Gated Luminescent Detection of ATP and GTP by a Lanthanide Complex” Chem. Sci. 2013, 4, 4052-4060. (pdf) (supporting information) Peterson, K. L.; Margherio, M. J.; Doan, P.; Wilke, K. T.; Pierre, V. C.* "The Basis for Sensitive and Selective Time-Delayed Luminescence Detection of Hydroxyl Radical by Lanthanide Complexes" Inorg. Chem. 2013, 52, 9390-9398. (pdf) (supporting information) Weitz, E. A.; Lewandowski, C.; Smolensky, E. D.; Marjanska, M.; Pierre, V. C.* "A Magnetoplasmonic Agent fo Copper(I) with Dual Response by MRI and Dark Field Microscopy" ACS Nano 2013, 7, 5842-5849. (pdf) Smolenksy, E. D.; Peterson, K. L.; Weitz, E. A.; Lewandowski, C.; Pierre, V. C.* “Magnetoluminescent Light-Switches: Dual Modality in DNA Detection” J. Am. Chem. Soc. 2013, 135, 8966-8972. (pdf) Smolensky, E. D.; Park, H.-Y. E.; Zhou, Y.; Rolla, G. A.; Marjanska, M.; Botta, M.; Pierre, V. C.* “Scaling Laws at the Nano Size: the Effect of Particle Size and Shape on the Magnetism and Relaxivity of Iron Oxide Nanoparticle Contrast Agents” J. Mat. Chem. B, 2013, 1, 2818-2828. (pdf) Pierre, V. C. U.S. Patent Application No. 14/022,962 “LUMINESCENT PROBES HAVING A PHENATHRIDINYL ANTENNA, AND METHODS OF USE” (Corresponding U.S. Preliminary Patent Application No. 61/701,248) Weitz, E. A.; Chang, J. Y.; Rosenfield, A. H.; Pierre, V. C.* "A Selective Luminescent Probe for the Direct Time-Gated Detection of Adenosine Triphosphate" J. Am. Chem. Soc. 2012, 134, 16099-16102.. (pdf) (supporting information) Smolensky, E. D.; Marjanska, M.; Pierre, V. C.* “A Responsive Particulate MRI Contrast Agent for Copper(I): a Cautionary Tale” Dalton Trans. 2012, 41, 8039-8046. Invited contribution – special issue on “New Talent in the Americas” (pdf) (supporting information) Smolensky, E. D.; Zhou, Y.; Pierre, V. C.* “Magnetoluminescent Agents for Dual MRI and Time-Gated Fluorescence Imaging” –Eur. J. Inorg. Chem. 2012, 12, 2141-2147. Invited contribution – special issue on “Metal-Based MRI probes”. Featured in ChemistryView (pdf) Floyd, W.; Klemm, P.; Smiles, D.; Kohlgruber, A.; Pierre, V. C.; Mynar, J.; Frechet, J.-M. J.; Raymond, K. N.* “Conjugation Effects of Various Linkers on Gd(III) MRI Contrast Agents with Dendrimers: Optimizing the Hydroxypyridinonate (HOPO) Ligands with Nontoxic, Degradable Esteramide (EA) Dendrimers For High Relaxivity” J. Am. Chem. Soc. 2011, 133, 2390-2393. Smolensky, E. D.; Neary, M. C.; Zhou, Y.; Berquo, T. S.; Pierre, V. C.* “Fe3O4@organic@Au: High Saturation Magnetization Core-Shell Nanocomposites as Magnetoplasmonic MRI Contrast Agents” Chem. Commun. 2011, 47, 2149-2151. (pdf) (supporting information) Weitz, E. A.; Pierre, V. C.* “A Ratiometric Probe for the Time-Gated Luminescence Detection of Potassium in Water” Chem. Commun. 2011, 47, 541-543. Invited contribution – special issue on emerging investigators. (pdf) (supporting information) Smolensky, E. D.; Park, H.-Y. E.; Berquo, T. S.; Pierre, V. C.* “Surface Functionalization of Iron Oxide Nanoparticles for MRI Applications: Effect of Anchoring and Ligand Exchange Protocol” Contrast Media Molecular Imaging 2011, 6, 189-199. (pdf) (supporting information) Page, S. E.; Wilke, K.; Pierre, V. C.* “Sensitive and Selective Time-Gated Detection of Hydroxyl Radical in Water" Chem. Commun. 2010, 46, 2423-2425. (pdf) (supporting information) Thibon, A.; Pierre, V. C.* “Principles of Responsive Lanthanide-Based Luminescent Probes” Anal. Bioanal. Chem. 2009, 394, 107-120. invited contribution (pdf) Thibon, A.; Pierre, V. C.* “A Highly Selective Luminescence Sensor for the Time-Gated Detection of Potassium” J. Am. Chem. Soc. 2009, 131, 434-435. (pdf) (supporting information) Zeglis, B. M.; Pierre, V. C.; Kaiser, J. T.; Barton, J. K. “A Bulky Rhodium Complex Bound to an Adenosine-Adenosine DNA Mismatch: General Architecture of the Metalloinsertion Binding Mode” Biochemistry 2009, 48, 4247-4253.