Zhao, Yan - IOWA State University - Department of Chemistry

个人简介

Yan Zhao, professor of chemistry, received his B.S. in chemistry from Lanzhou University in 1992, his Ph.D. from Northwestern University in 1996, was a postdoctoral fellow at the University of Illinois from 1996-1998, and was a Senior Scientist at the Procter & Gamble Company until July 2002. Dr. Zhao's areas of interest include synthesis of molecules capable of controllable conformational changes, and their usage as "smart" sensors, materials, and catalysts; self-assembling in water; biomimetic chemistry in materials synthesis and catalysis; design and construction of nanoscale structures; amphiphilic molecules and polymers; multifunctional surfactants.

研究领域

The biological world has unparalleled abilities to control structures, functions, reactions, and energy transfer with great efficiency and accuracy. We are interested in biomimetic chemistry to “abstract good design from nature.” One of our main research goals is to design molecules that functionally mimic certain biological systems, and in turn to prepare molecules, polymers, and materials that have useful and superior properties. Our imprinted nanoparticles mimic natural antibodies in their molecular recognition of small-molecule drugs, peptides, and carbohydrates. They serve as excellent supramolecular hosts, specific biomimetic sensors, and smart materials useful for chemistry and biology. Our enzyme-mimetic catalysts carry out highly selective chemical transformations in water under mild conditions. With tunable chiral space near the catalytic center, our synthetic aldolase enables poor chiral (prolinamide) catalysts to achieve up to 99% ee and even racemic catalysts >70% ee.

近期论文

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Ishani Bose and Yan Zhao* “Tandem Aldol Reaction from Acetal Mixtures by an Artificial Enzyme with Site-Isolated Acid and Base Functionality,” submitted for publication. Ishani Bose and Yan Zhao* “Selective Hydrolysis of Aryl Esters under Acidic and Neutral Conditions by a Synthetic Aspartic Protease Mimic,” ACS Catal. 2021, 11, 3938–3942. https://doi.org/10.1021/acscatal.1c00371 Xiaowei Li, Milad Zangiabadi, and Yan Zhao* “Molecularly Imprinted Synthetic Glucosidase for the Hydrolysis of Cellulose in Aqueous and Nonaqueous Solutions,” J. Am. Chem. Soc. 2021, 143, 5172–5181. https://doi.org/10.1021/jacs.1c01352 Xiaowei Li, Kaiqian Chen, and Yan Zhao* “Sequence-Selective Protection of Peptides from Proteolysis,” Angew. Chem. Int. Ed. 2021, 133, in press. https://doi.org/10.1002/anie.202102148 Xiaowei Li, Tania M. Palhano Zanela, Eric S. Underbakke, and Yan Zhao* “Controlling Kinase Activities by Selective Protection of Peptide Substrates,” J. Am. Chem. Soc. 2021, 143, 639–643. https://doi.org/10.1021/jacs.0c11566 Ishani Bose, Shixin Fa, and Yan Zhao* “A Tunable Artificial Enzyme–Cofactor Complex for Selective Hydrolysis of Acetals,” J. Org. Chem. 2021, 86, 1701–1711. https://doi.org/10.1021/acs.joc.0c02519 Xiaowei Li and Yan Zhao,* “Synthetic Glycosidase for the Precise Hydrolysis of Oligosaccharides and Polysaccharides,” Chem. Sci. 2021, 12, 374–383. https://doi.org/10.1039/D0SC05338D Likun Duan and Yan Zhao,* “Molecularly Imprinted Micelles for Fluorescent Sensing of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs),” React. Funct. Polym. 2021, 156, 104759. https://doi.org/10.1016/j.reactfunctpolym.2020.104759 Ishani Bose and Yan Zhao,* “pH-Controlled Nanoparticle Catalysts for Highly Selective Tandem Henry Reaction from Mixtures,” ACS Catal. 2020, 10, 13973–13977. https://doi.org/10.1021/acscatal.0c03468 Xiaowei Li and Yan Zhao,* “Synthetic Glycosidase Distinguishing Glycan and Glycosidic Linkage in Its Catalytic Hydrolysis,” ACS Catal. 2020, 10, 13800–13808. https://doi.org/10.1021/acscatal.0c04038 Likun Duan, Milad Zangiabadi, and Yan Zhao,* “Synthetic Lectins for Selective Binding of Glycoproteins in Water,” Chem. Commun. 2020, 56, 10199–10202. https://doi.org/10.1039/D0CC02892D Milad Zangiabadi and Yan Zhao,* “Molecularly Imprinted Polymeric Receptors with Interfacial Hydrogen Bonds for Peptide Recognition in Water,” ACS Appl. Polym. Mater. 2020, 2, 3171–3180. https://doi.org/10.1021/acsapm.0c00354 Milad Zangiabadi and Yan Zhao,* “Selective Binding of Complex Glycans and Glycoproteins in Water by Molecularly Imprinted Nanoparticles,” Nano Lett. 2020, 20, 5106–5110. http://dx.doi.org/10.1021/acs.nanolett.0c01305 Likun Duan and Yan Zhao,* “Zwitterionic Molecularly Imprinted Cross-Linked Micelles for Alkaloid Recognition in Water,” Chem. Asian. J. 2020, 15, 1035–1038. http://dx.doi.org/10.1002/asia.201901783 Likun Duan and Yan Zhao,* “Zwitterionic Molecularly Imprinted Cross-Linked Micelles for Alkaloid Recognition in Water,” J. Org. Chem. 2019, 84, 13457–13464. http://dx.doi.org/10.1021/acs.joc.9b01629 Kaiqian Chen and Yan Zhao,* “Effects of Nano-Confinement and Conformational Mobility on Molecular Imprinting of Cross-Linked Micelles,” Org. Biomol. Chem. 2019, 17, 8611–8617. http://dx.doi.org/10.1039/C9OB01440C Xiaowei Li and Yan Zhao,* “Chiral Gating for Size-Selective Asymmetric Catalysis in Water,” 2019, J. Am. Chem. Soc. 2019, 141, 13749–13752. Featured on JACS cover and highlighted on ChemistryViews. https://doi.org/10.1021/jacs.9b06619 Shixin Fa and Yan Zhao,* “A General Method for Peptide Recognition in Water through Bioinspired Complementarity,” Chem. Mater. 2019, 31, 4889–4896. https://doi.org/10.1021/acs.chemmater.9b01613 Lan Hu, MD Arifuzzaman, and Yan Zhao,* “Controlling Product Inhibition through Substrate-Specific Active Sites in Nanoparticle-Based Phosphodiesterase and Esterase,” ACS Catal. 2019, 9, 5019–5024. http://dx.doi.org/10.1021/acscatal.9b00630 Roshan W. Gunasekara and Yan Zhao,* “Binding and Protection of Glycosphingolipids by Synthetic Nanoparticles,” Chem. Commun. 2019, 55, 4773–4776. http://dx.doi.org/10.1039/C9CC01694E