个人简介

Arthur received his PhD at the University of Maryland, 2007 and was a post-doc at the Ohio State University in 2008. Arthur joined the Chemistry Department in 2009. Honors and Awards: 2015 Liberal Arts and Sciences Early Achievement in Research Award 2015 Chemical Communications Emerging Investigator 2014 ACS Organic Young Investigator Award 2014 Thieme Chemistry Journal Award 2013 Cottrell Scholar Award 2013 ISU Early Achievement in Teaching Award 2013 Cassling Family Faculty Early Achievement in Teaching Award 2012 Wilkinson Undergraduate Teaching Award 2010 Carlyle Caldwell Endowed Chair in Chemistry James Stewart Excellence in Teaching Award University of Maryland Excellence in Teaching Award William-Bailey Fellow Ronald E. McNair Scholar

研究领域

Synthesis of chemical tools for biological and medical applications

My lab uses techniques in physical organic chemistry to tackle challenging problems in medicine. Theory and experiment are used in concert to develop robust, widely applicable tools for biological and biomedical applications. A particular interest of my lab is the development of 'smart' chemical mediators for use in targeted drug delivery. Such mediators can be thought of as transporters for moving potent, yet inactivated, drugs to the site of the disease. When the mediator comes in contact with the diseased tissue, the efficacious drug is released in its potent form, either through activation by a non-covalent binding event or through light irradiation. This targeted approach to drug delivery holds the promise of selectively releasing drugs in diseased tissues while leaving healthy tissues unscathed. For example, the terrible side effects of cancer chemotherapies derive from the simultaneous destruction of healthy cells as well as tumor cells. The development of a mediator that selectively delivers toxic chemotherapy compounds to the site of a tumor could permit more aggressive drug dosing while minimizing the side effects of such treatments. These types of mediators could also function as chemical sensors, releasing a chemical reporter upon interaction of the mediator with a toxic metal, explosive, poison, or a chemical/biological agent. Students in my group will use organic synthesis, high-level computational studies, mechanistic studies, non-covalent host-guest chemistry, photochemistry, and ultrafast laser spectroscopy to develop these technologies.

近期论文

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Slanina, T., Shrestha, P., Palao, E., Kand, D., Peterson, J., Dutton, A., Rubinstein, N., Weinstain, R., Winter, A.H., Klan, P. “In Search of the Perfect Photocage: Structure-Reactivity Relationships in meso-Methyl BODIPY Photoremovable Protecting Groups.” 2017, J. Am. Chem. Soc. 137 (11), pp 3783–3786 bodipy photocage photoremovable protecting group Du, L., Qiu, Y., Lan, X., Zhu, R., Phillips, D., Li, M-D., Dutton, A., Winter, A.H. “Direct Detection of the Open-shell Singlet Phenyloxenium Ion: An Atom-Centered Diradical Reacts as an Electrophile.” 2017, J. Am. Chem. Soc. 139 (42), pp 15054–15059. open shell oxenium ion Geraskina, M., Dutton, A., Juetten, M., Wood, S., Winter, A.H. “The Viologen Cation Radical Pimer: A Case of Dispersion‐Driven Bonding.” Angew. Chem, 2017, 129 (32), 9563-9567. radical pimer Fischer, L., Dutton, A., Winter, A.H. “Anomalous Effect of Non-Alternant Hydrocarbons on Carbocation and Carbanion Electronic Configurations.” Chem. Sci., 2017, 8, 4231-4241. (Article featured on cover). diradical spin crossover Peterson, J., Geraskina, M., Zhang., R., Winter, A.H. “Effect of Substituents on the Bond Strength of Air Stable Dicyanomethyl Radical Thermochromes.” 2017, J. Org. Chem. 82 (12), 6497-6501. diradical spin crossover Qui, Y., Winter, A.H. “New Photoheterolysis Precursors to Study Oxenium ions: Combining Experiment and Theory”. Org. Biomol. Chem. 2017, 15 (13), 2666-2671. oxenium Qiu, Y., Fischer, L., Dutton, A., Winter, A.H. “Aryl Nitrenium and Oxenium Ions with Unusual High-Spin π,π* States: Exploiting Hückel/Baird (Anti)Aromaticity.” 2017, J. Org. Chem. nitrenium oxenium Dutton, A., Winter, A.H. “Computationally Modeling Non-Adiabatic Dynamics and Surface Crossings in Organic Photoreactions”. Applied Theoretical Chemistry (Ed, Dean Tantillo), 2017, in press (scheduled for printing March 2018). nitrenium oxenium Reinig, R. R.; Mukherjee, D.; Weinstein, Z. B.; Xie, W.; Albright, T.; Baird, B.; Gray, T. S.; Ellern, A.; Miller, G. J.; Winter, A. H.; Bud'ko, S. L.; Sadow, A. D. "Synthesis and Oxidation Catalysis of Tris(oxazolinyl)borate Cobalt(II) Scorpionate" Eur. J. Inorg. Chem. 2016, 2486-2494. Goswami, P., Syed, A., Beck, C., Zessin, T., Mahoney, K., Unash, R.,Smith, E.A., Winter, A.H. " BODIPY-Derived Photoremovable Protecting Groups Unmasked with Green Light."2015, J. Am. Chem. Soc. In press.. Albright, T.R., Winter, A.H. "A Fine Line Separates Carbocations from Diradical Ions in Donor-Unconjugated Cations" 2015, J. Am. Chem. Soc. In press. Juetten, M., Buck, A., Winter, A.H. "A Radical Spin on Viologen Polymers: Organic Spin Crossover Materials in Water." 2015, Chem. Commun. (Invited article for Emerging Investigators Issue) In press. Li, M, Hanway, P.J. , Albright, T.R., Winter, A.H, Phillips, D.L. "Direct Spectroscopic Observation of Open-shell Singlet, Closed-shell Singlet, and Triplet p-Biphenylyloxenium Ion". 2014, J. Am. Chem. Soc. 136 (35), pp 12364–12370 Buck, A.T., Beck, C.L., Winter, A.H. "Inverted Substrate Preferences for Photochemical Heterolysis Arises from Conical Intersection Control." 2014, J. Am. Chem. Soc. 136 (25), pp 8933–8940 Mahoney, K.M., Goswami, P., Syed, A., Kolker, P., Shannan, B., Smith, E.A, Winter, A.H. "Self-Immolative Phthalate Esters Sensitive to Hydrogen Peroxide and Light" 2014,J. Org. Chem., 79 (23), pp 11740–11743. Geraskina, M.R., Buck, A.T., Winter, A.H. An Organic Spin Crossover Material in Water Based on a Covalently Linked Radical Dyad". 2014, J. Org. Chem. 79 (16), 7723–7727. Geraskina, M.R., Juetten, M.J., Winter, A.H. " Access to Aryl Mellitic Acid Esters via a Surprising Oxidative Esterification Reaction". J. Org. Chem. 2014, 79 (11), pp 5334–5337 Bhattacharjee, U., Beck, C.L., Winter, A.H., Petrich, J.W. . "Tryptophan and ATTO 590: Mutual Fluorescence Quenching and Exciplex Formation" J. Phys. Chem. 2014, 118 (29), pp 8471–8477 Beck, C.L, Winter, A.H. "Non-Covalent Catch and Release of Carboxylates in Water". J.Org. Chem. 2014, 79 (7), pp 3152–3158 Buck, A.T., Paletta, J.T., Khindurangala, S., Beck, C.L, Winter, A.H. "A Non-Covalently Reversible Paramagnetic Switch in Water". J. Am. Chem. Soc. 2013, 135 (29), pp 10594–10597. Hanway, P.J., Xue, J., Bhattacharjee, U., Milot, M., Phillips, D.L., Winter, A.H., "Direct Detection and Reactivity of the Short-Lived Phenyloxenium Ion." J. Am. Chem. Soc. 2013, 135 (24), pp 9078–9082. Beck, C.L., Berg, S., Winter, A.H. "Pincher Ferrocene-Derived Cation Carboxylate Ion Pairs in Aqueous DMSO" Organic & Biomolecular Chemistry. 2013, 11, 5827-5835. Kraus, G. A., Pollock, G., R., Beck, C.L., Palmer, K., Winter, A.H. "Aromatics from Pyrones: Esters of Terephthalic Acid and Isophthalic Acid from Methyl Coumalate". RSC Advances, 2013, 3, 12721-12725. Mahoney, K., Goswami, P., Winter, A. "Self-Immolative Aryl Phthalate Esters" J. Org. Chem. 2013, 78 (2), pp 702–705 . Hanway, P., Winter, A. "Heteroaryl Oxenium Ions Have Diverse and Unusual Low-energy Electronic States" .J. Phys. Chem. A 2012, 116(37):9398-403 Hanway, P., Winter, A. "Phenyloxenium Ions: More Like Phenylnitrenium Ions than Isoelectronic Phenylnitrenes?.J. Am. Chem. Soc., 2011, 133 (13), pp 5086–5093 Vyas, S., Winter, A., Hadad., C. "Theory and computation in the study of nitrenes and their excited state photoprecursors." Nitrenes and Nitrenium Ions . Ed: Anna Gudmundsdottir. 2013, In press. Weeks, Daniel. Pushing Electrons (Edited by Arthur Winter). 4th ed. Spring, 2014. Winter, Arthur. Organic Chemistry I Workbook for Dummies,. Hoboken, NJ: Wiley Publishing Inc, 2013. A hands-on workbook containing problem-solving guides and hundreds of problems with detailed solutions. Translated into German. Winter, Arthur. Organic Chemistry I for Dummies, 2nd Ed. Hoboken, NJ: Wiley Publishing Inc., 2014. A practical textbook complement for first-semester undergraduate organic chemistry students with a focus on concept comprehension and problem solving techniques. Translated into German (including short version) and Portugese. Prior publications (Ph.D./Postdoctoral): Research Papers Prior to ISU: Perrotta, R., Winter, A., Coldren, W., Falvey, D. "2-(3,5-dinitrophenyl)-1,3-dithiane Carbanion: A Benzylic Anion with a Low Energy Triplet State." J. Am. Chem. Soc. 2011, 133 (39), 15553-15558. Xue, JD, Vyas, S., Dyu, Y., Luk, H., Chuang, Y., But, T., Toy, P., Wang, J., Winter, A., Phillps,D., Hadad, C., Platz, M. ".Time-resolved Resonance Raman and Computational Investigation of the Influence of 4-Acetamido and 4-N-Methylacetamido Substituents on the Chemistry of Phenylnitrene" . J. Phys. Chem. A. 2011, 115 (26), 7521-7530.. Perrotta, R., Winter, A., Falvey, D. "Photochemical Heterolysis of 3,5-Bis(dimethylamino)benzyl Alcohols and Esters: Generation of a Benzyl Cation with a Low-Energy Triplet State. Org. Lett. 2011, 13 (2), 212-215.