个人简介

Brett received his B.Sc. in chemistry from McMaster University (Canada) in 2006. He began his graduate studies with Professor Timothy M. Swager at the Massachusetts Institute of Technology as an NSERC graduate fellow, where he developed new syntheses of conjugated polymers for applications in biosensing and conductive materials. After receiving his Ph.D. in 2011, he moved to the University of Wisconsin–Madison as a Canadian Institutes of Health Research Postdoctoral Fellow working with Professor Ronald T. Raines. At UW–Madison he studied secondary molecular orbital interactions that contribute to the stability of proteins, as well as boronic acids and thiol reducing agents for protein chemistry applications. In collaboration with Professor Patricia J. Keely at UW–Madison, he also developed molecular probes to monitor the progression of breast cancer. Brett joined the faculty in August 2014 as an Assistant Professor.

研究领域

Organic and Bioorganic Chemistry/Self-assembly/Materials

Chemists possess an unparalleled understanding of how the complexity of macroscopic matter emerges from the relative simplicity of atoms and molecules; we seek to employ these insights to investigate the widening interface of chemistry and biology. Our research program aims to develop tools and biomimetic materials to interrogate, understand, and manipulate the interactions that occur between biological building blocks. Synthetic chemistry and the develpoment of new methods underpin all aspects of our research, and we apply the principles of chemistry towards the precise molecular-level design and engineering of these systems. Students and podoctoral researchers experience a diverse range of topics and techniques, including organic and bioorganic chemistry, synthesis, protein chemistry, materials and macromolecular science.

近期论文

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Signatures of n→π* interactions in proteins Newberry, R. W.; Bartlett, G. J.; VanVeller, B.; Woolfson, D. N.; Raines, R. T. Protein Sci. 2014, 23, 284-288. DOI: 10.1002/pro.2413 Interplay of hydrogen bonds and n→π* interactions in proteins Bartlett, G. J.; Newberry, R. W.; VanVeller, B.; Raines, R. T.; Woolfson, D. N. J. Am. Chem. Soc. 2013, 135, 18682-18688. DOI: 10.1021/ja4106122 Thiols and selenols as relay catalysts for disulfide-bond reduction Lukesh, J. C. III; VanVeller, B.; Raines, R. T. Angew. Chem. Int. Ed. 2013, 52, 12901-12904. DOI: 10.1002/anie.201307481 - Cover Article, DOI: 10.1002/anie.201309405 A divalent protecting group for benzoxaboroles VanVeller, B.; Aronoff, M. A.; Raines, R. T. RSC Adv. 2013, 3, 21331-21334. DOI: 10.1039/c3ra44385j A Selective detection of boronic acids through ESIPT fluorescence Aronoff, M. A.; VanVeller, B.; Raines, R. T. Org. Lett. 2013, 15, 5382-5385. DOI: 10.1021/ol402714k n→π* Interactions of amides and thioamides: implications for protein stability Newberry, R. W.; VanVeller, B.; Guzei, I. A.; Raines, R. T. J. Am. Chem. Soc. 2013, 135, 7843-7846. DOI: 10.1021/ja4033583 - JACS Spotlight J. Am. Chem. Soc. 2013, 135, 8431. DOI: 10.1021/ja405586p - Chemical & Engineering News 2012, 90 (36), 68-71. Link: Tweeks Boost Protein Stability Synthesis and properties of triptycene-containing polyetherolefins via acyclic diene metathesis polymerization Sydlik, S. A.; Delgado, P. A.; Inomata, S.; VanVeller, B.; Yang, Y.; Swager, T. M.; Wagener, K. B. J. Polym. Sci. Part A: Polym. Chem. 2013, 51, 1695-1706. DOI: 10.1002/pola.26557 Polycyclic aromatic triptycenes: oxygen substitution cyclization strategies VanVeller, B.; Schipper, D. J.; Swager, T. M. J. Am. Chem. Soc. 2012, 134, 7282-7285. DOI: 10.1021/ja3018253 Fluorescent amphiphiles: a novel tool for designing mild topical conference Seto, J.; Polat, B.; VanVeller, B.; Lopez, R.; Langer, R.; Blankschtein, D. J. Control. Release 2012, 158, 85-92. DOI: 10.1016/j.jconrel.2011.10.018 Triptycene diols: a strategy for synthesizing planar π-systems VanVeller, B.; Robinson, D.; Swager, T. M. Angew. Chem. Int. Ed. 2012, 51, 1182-1186. DOI: 10.1002/anie.201106985 Absolute rate constants for 5-deazariboflavin triplet excited state in one-electron transfer processes Barra, M.; VanVeller, B.; Verberne, C. J. Photochem. Photobiol., A 2011, 225, 113-116. DOI: 10.1016/j.jphotochem.2011.10.007 An experimental and molecular dynamics investigation into the amphiphilic nature of sulforhodamine B Polat, B. E.; Lin, S.; Mendenhall, J. D.; VanVeller, B.; Langer, R.; Blankschtein, D. J. Phys. Chem. B 2011, 115, 1394-1402. DOI: 10.1021/jp109866q Synthesis of azaperylene-9,10-dicarboximides Andrew, T. L.; VanVeller, B.; Swager, T. M. Synlett 2010, 3045-3048. DOI: 10.1055/s-0030-1259060 Biocompatible post-polymerization functionalization of a water soluble poly(p-phenylene ethynylene) VanVeller, B.; Swager, T. M. Chem. Commun. 2010, 5761–5763. DOI: 10.1039/c0cc01456g Poly(aryleneethynylene)s VanVeller, B.; Swager, T. M. Design and Synthesis of Conjugated Polymers,Leclerc, M.; Morin, J., Eds. Wiley-VCH: Weinheim, 2010; Chapter 5 DOI: 10.1002/9783527629787 Rigid hydrophilic structures for improved properties of conjugated polymers and nitrotyrosine sensing in water VanVeller, B.; Miki, K.; Swager, T. M. Org. Lett. 2010, 12, 1292–1295. DOI: 10.1021/ol1001768