个人简介

Aaron Rossini, Assistant Professor of Chemistry, received his B.Sc. in 2005 and Ph.D. in 2010 from the University of Windsor where he worked in the group of Prof. Robert W. Schurko on the development and application of solid-state NMR spectroscopy of unreceptive and exotic nuclei. From 2011 to 2014 he worked with Prof. Lyndon Emsley and Dr. Anne Lesage at the École Normale Supérieure de Lyon/CRMN Lyon as a Marie Curie post-doctoral fellow on the development and application of dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy. Following postdoctoral work at the École Polytechnique Fédérale de Lausanne with Prof. Lyndon Emsley he will join the chemistry faculty at Iowa State University in August 2015.

研究领域

Solid-State NMR Spectroscopy/Dynamic Nuclear Polarization and Materials Characterization

The comprehensive atomic level characterization of systems such as heterogeneous catalysts, pharmaceuticals, nanoparticles, functional materials, etc. often presents a considerable challenge due to disorder and/or dilution of the species of interest. Research in our group centers on utilizing solid-state NMR to investigate the structure and composition of systems that are challenging to characterize with conventional techniques. In particular, we will explore the development and application of dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy for the characterization of materials. In a DNP experiment the high polarization of unpaired electrons is transferred to magnetic nuclei. DNP represents a revolution for NMR spectroscopy since it can enhance the sensitivity of NMR experiments by several orders of magnitude. This enables NMR experiments previously considered impossible or infeasible and allows the application of NMR to previously intractable systems. For example, I have previously employed DNP enhanced solid-state NMR to improve the characterization of surfaces/interfaces of inorganic materials, observe dilute species and active sites, characterize the solid phases (polymorphs) of pharmaceuticals and to enable the fast acquisition of NMR spectra of unreceptive and challenging isotopes (e.g., 2H, 14N, 15N, etc.). However, there is much room for the improvement of DNP by developing sample preparation methods, theoretical models, extending DNP to new classes of materials, polarizing agents etc. In collaboration with the Prof. Marek Pruski’s group we will utilize the state of the art 400 MHz/263 GHz DNP solid-state NMR spectrometer that was recently installed at the Ames Laboratory. In addition to work on DNP enhanced solid-state NMR we are also interested in developing and applying conventional high resolution solid-state NMR techniques. Students and researchers in my group will primarily work on the applications and/or development of NMR techniques. However, they also gain experience in basic synthetic and sample preparation techniques and other characterization and modeling techniques such as EPR spectroscopy, quantum chemical calculations, X-ray diffraction, etc.

近期论文

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Amplifying Dynamic Nuclear Polarization of Frozen Solutions by Incorporating Dielectric Particles, J. Am. Chem. Soc., 2014, 135, 15711-15718. Kubicki D.J., Rossini A.J., Purea A., Zagdoun A., Ouari O., Tordo P., Engelke F., Lesage A., Emsley L. Spectral Signatures of the Active Sites in Sn–β Zeolite, Angew. Chem. Int. Ed., 2014, 53, 10179-10183. Wolf P., Valla M., Rossini A.J., Comas-Vives A., Núñez-Zarur F., Malaman B., Lesage A., Emsley L., Copéret C., Hermans I. DNP Enhanced NMR Spectroscopy for Pharmaceutical Formulations, J. Am. Chem. Soc., 2014, 136, 2324-2334. Rossini A.J., Widdifield C.M., Zagdoun A., Lelli M., Schwarzwälder M., Copéret C., Lesage A., Emsley L. Dynamic Nuclear Polarization Enhanced 14N Overtone Spectroscopy, Phys.Chem. Chem. Phys., 2014, 16, 12890-12899. Rossini A.J., Emsley L., O’Dell L.A. Dynamic Nuclear Polarization Surface Enhanced NMR Spectroscopy, Acc. Chem. Res., 2013, 46, 1942-1951. Rossini A.J., Zagdoun A., Lelli M., Lesage A., Copéret C., Emsley L. (Special Issue on Solid-state NMR) Dynamic Nuclear Polarization NMR Spectroscopy of Microcrystalline Solids, J. Am. Chem. Soc., 2012, 134, 16899-16908. Rossini A.J., Zagdoun A., Hegner F.S., Schwarzwälder M., Gajan D., Copéret C., Lesage A., Emsley L. (JACS Spotlight, J. Am. Chem. Soc., 2012, 134, 17840-17841.) Dynamic Nuclear Polarization Enhanced Solid-State NMR Spectroscopy of Functionalized Metal-Organic Frameworks, Angew. Chem-Int. Ed., 2012, 51, 123-127. Rossini A.J., Zagdoun A., Lelli M., Canivet J., Aguado S., Ouari O., Tordo P., Rosay M., Maas W.E., Copéret C., Farrusseng D., Emsley L., Lesage A.