个人简介

Dr. Lee joined the faculty in August 2008. Before joining Iowa State, he worked at the Genome Center, University of California-Davis as a staff scientist, and at the Department of Chemistry, Indiana University as a post-doctoral fellow with Prof. David E. Clemmer. He received his PhD from Seoul National Univeristy in 1997 with Prof. Myung Soo Kim, and worked for LG Semicon and Hyndai Electronics before coming to United States. His mass spectrometry expertise covers wide disciplines including fundamentals, instrumentation, proteomics, and ion mobility. His current research interest include MALDI-based high-spatial resolution mass spectrometry imaging, mass spectrometry analysis of biomass pyrolysis, and use of nanoparticle matrices for forensic and microbiome analysis.

研究领域

Biological Mass Spectrometry

Lee group is working on biological and engineering application of mass spectrometry. The two major research themes have been Mass Spectrometry Imaging of Plant Metabolites and High-resolution Bio-oil analysis. Recently, we expanded our research interests to forensic applications, particularly MALDI imaging of Latent Fingerprints, and High-throughput Metabolite Analysis from microbiome or drug-resistant bacteria. Mass Spectrometry Imaging of Plant Metabolites Chemical Imaging of Latent Fingerprints Bio-oil Analysis High-throughput MALDI Metabolomics

近期论文

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"Cellular and Sub-cellular Level Localization of Maize Lipids and Metabolites Using High Spatial Resolution MALDI Mass Spectrometry Imaging", Maria Emilia Dueñas, Adam D. Feenstra, Andrew R. Korte, Paige Hinners, and Young Jin Lee, In 'Maize: Methods and Protocols', edited by Mark Lagrimini, 217-231, 2018. ​ "Single cell metabolomics by mass spectrometry imaging", Maria E. Dueñas, Young Jin Lee, In: Shen Hu (eds), Cancer Metabolomics: Technologies and Applications. submitted on Jul 8, 2019. “Potential of triacylglycerol profiles in latent fingerprints to reveal individual diet, exercise, or health information for forensic evidence" Kelly C. O’Neill, Paige Hinners, and Young Jin Lee*, Analytical Methods, 2020, 12, 792, https://doi.org/10.1039/C9AY02652E. "Editorial: Single Plant Cell Metabolomics", Aleš Svatoš*, Young Jin Lee, Zhibo Yang, Frontiers in Plant Science, accepted on Feb 3, 2020, doi: 10.3389/fpls.2020.00161. "Determining fingerprint age with mass spectrometry imaging via ozonolysis of triacylglycerols", Paige Hinners, Madison Thomas, Young Jin Lee*, Analytical Chemistry, 2020, 92(4), 3125-3132 (selected as a supplementary journal cover), https://doi.org/10.1021/acs.analchem.9b04765. "Towards Mass Spectrometry Imaging in the Metabolomics Scale: Increasing Metabolic Coverage through Multiple On-Tissue Chemical Modifications", Maria Emilia Dueñas and Young Jin Lee*, Frontiers in Plant Science, 2019, 10, 860, DOI: 10.3389/fpls.2019.00860, contribution to a research topic "single cell plant metabolomics". "Transcriptional and chemical changes in soybean leaves in response to long-term aphid colonization", Jessica Hohenstein, Matthew E. Studham, Adam Klein, Nikola Kovinich, Kia Barry, Young Jin Lee, and Gustavo C MacIntosh*, Frontiers in Plant Science, 2019, 10, 310, DOI: 10.3389/fpls.2019.00310. "Structural Analysis of Polyurethane Monomers by Pyrolysis GC TOFMS via Dopant-Assisted Atmospheric Pressure Chemical Ionization", Evan Larson, Junghyun Lee, Young Jin Lee*, J. Am. Soc. Mass Spectrom. 2019, 30, 1046-1058 (invited contribution for 2018 ASMS John B. Fenn Distinguished Contribution Awards), DOI: 10.1007/s13361-019-02165-y. "Study of the Cyanoacrylate Fuming Mechanism by Matrix Assister Laser Desorption/ Ionization Mass Spectrometry", Kelly C. O’Neill, Young Jin Lee*, J. Mass Spectrom. 2019, 54(3), 222-226. doi: 10.1002/jms.4325. “Carbon-Based Fingerprint Powder as a One-Step Development and Matrix Application for High-Resolution Mass Spectrometry Imaging of Latent Fingerprints”, Paige Hinners, Young Jin Lee*, J. Forensic Science, in print. https://doi.org/10.1111/1556-4029.13981 “Novel instrumentation for tracking molecular products in fast pyrolysis of carbohydrates with sub-second temporal resolution”, Carolyn Hutchinson, D. Paul Cole, Erica Dalluge, Evan Larson, Young Jin Lee*, J. Anal. Appl. Pyrolysis. 2018, 136, 107-114. https://doi.org/10.1016/j.jaap.2018.10.017 "Nanoparticle Microarray for High-throughput Microbiome Metabolomics using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry", Rebecca L. Hansen, Maria Emilia Dueñas, Torey Looft, and Young Jin Lee*, Anal. Bioanal. Chem. 2019, 1, 147-156 (published as Paper in Forefront), https://doi.org/10.1007/s00216-018-1436-5. "FERONIA Mutation Induces High Levels of Chloroplast-Localized Arabidopsides which are involved in Root Growth", Rebecca L. Hansen, Hongqing Guo, Yanhai Yin, Young Jin Lee*, The Plant J., 2019, 97, 341-351, https://doi.org/10.1111/tpj.14123. "Sputter Coated Metal Screening for Small Molecule Analysis and High-Spatial Resolution Imaging in Laser Desorption Ionization Mass Spectrometry", Rebecca L. Hansen, Maria Emilia Dueñas, Young Jin Lee*, J. Am. Soc. Mass Spectrom. 2019, 30, 299. "Gas Chromatography-Tandem Mass Spectrometry of Lignin Pyrolyzates with Dopant-Assisted Atmospheric Pressure Chemical Ionization and Molecular Structure Search with CSI:FingerID", Evan A. Larson, Carolyn P. Hutchinson, Young Jin Lee*, J. Am. Soc. Mass Spectrom. 2018, 29(9), 1908-1918. "Characterizing Virus-Induced Gene Silencing at the Cellular Level with In Situ Multimodal Imaging", Sadie J. Burkhow, Nicole M. Stephens, Yu Mei, Maria Emilia Dueñas, Daniel J. Freppon, Geng Ding, Shea C. Smith, Young-Jin Lee, Basil J. Nikolau, Steven A. Whitham, Emily A. Smith*, Plant Methods, 2018, 14:37. "Revealing Individual Lifestyles through Mass Spectrometry Imaging of Chemical Compounds in Fingerprints", Paige Hinners, Kelly C. O’Neill, and Young Jin Lee*, Scientific Reports, 2018, 8:5149. "Chemical Imaging of Cyanoacrylate Fumed Fingerprints by Matrix Assisted Laser Desorption Ionization Mass Spectrometry Imaging", Kelly C. O’Neill, Paige Hinners, Young Jin Lee, J. Forensic Science, 2018, 63(3), 1854-1857. doi: 10.1111/1556-4029.13773. "High-Spatial Resolution Mass Spectrometry Imaging: Toward Single Cell Metabolomics in Plant Tissues", Rebecca L. Hansen and Young Jin Lee*, Chemical Records (invited mini review), 2018, 18, 65-77. "Effect of Aging and Surface Interactions on the Diffusion of Endogenous Compounds in Latent Fingerprints", Kelly C. O’Neill and Young-Jin Lee*, J. Forensic Science, 2018. 63, 708-713. "3D MALDI Mass Spectrometry Imaging of a Single Cell: Spatial Mapping of Lipids in the Embryonic Development of Zebrafish", Maria Emilia Dueñas, Jeffrey J. Essner and Young Jin Lee*, Scientific Reports, 2017, 7, 14946. ​