斯大勇 - 中国农业大学 - 动物科学技术学院

个人简介

学习经历 2009.04-2012.03 日本京都大学，博士,导师：Jun Ogawa 教授，Michihiko Kataoka 教授 2008.10-2009.03 日本京都大学，研究生,导师：Sakayo Shimizu 教授 2007.10-2008.08 中国赴日本国留学生预备学校，日语学习 2005.09-2007.06 中国农业大学动物科技学院，硕士,导师：张日俊教授 2001.09-2005.06 中国农业大学生物学院，学士工作经历 2016.07-至今中国农业大学动物科技学院，讲师、副教授 2014.04-2016.05 夏威夷大学蛋白质研究中心，博士后；导师：Qingxiao Li 教授 2012.04-2014.03 日本京都大学，博士后；导师：Jun Ogawa教授获得奖励与荣誉中国农业大学研究生教育成果奖一等奖，2018

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Li, Z., Cheng, Q., Guo, H., Zhang, R., Si, D. (2020) Expression of Hybrid Peptide EF-1 in Pichia pastoris, Its Purification, and Antimicrobial Characterization. Molecules 25(23):5538. Si, D., Shang, T., Liu, X., Zheng, Z., Hu, Q., Hu, C., Zhang, R. (2020) Production and characterization of functional wheat bran hydrolysate rich in reducing sugars, xylooligosaccharides and phenolic acids. Biotechnol Rep 27: e00511. Ahmad, B., Hanif, Q., Wei, X., Zhang, L., Shahid, M., Si, D.*, Zhang, R. (2019) Expression and Purification of Hybrid LL-37T alpha 1 Peptide in Pichia pastoris and Evaluation of Its Immunomodulatory and Anti-inflammatory Activities by LPS Neutralization. Front Immunol 10:1365. Wei, X., Wu, R., Zhang, L., Ahmad, B., Si, D.*, Zhang, R. (2018) Expression, Purification, and Characterization of a Novel Hybrid Peptide with Potent Antibacterial Activity. Molecules 23(6):1491. Shang, T., Si, D., Zhang, D., Liu, X., Zhao, L., Hu, C., Fu, Y., Zhang, R. (2017) Enhancement of thermoalkaliphilic xylanase production by Pichia pastoris through novel fed-batch strategy in high cell-density fermentation. BMC Biotechnol 17；55 (共同一作) Si, D., Urano, N., Nozaki, S., Honda, K., Shimizu, S., Kataoka, M. (2012) L-Pantoyl lactone dehydrogenase from Rhodococcus erythropolis: genetic analyses and application to the stereospecific oxidation of L-pantoyl lactone. Appl Microbiol Biotechnol 95: 431-440. Si, D., Urano, N., Shimizu, S., Kataoka, M. (2012) LplR, a Repressor Belonging to TetR Family, Regulates Expression of the L-Pantoyl Lactone Dehydrogenase Gene in Rhodococcus erythropolis. Appl Environ Microbiol78:7923-7930. Si, D., Urano, N., Shimizu, S., Kataoka, M. (2011) Cloning and overexpression of ketopantoic acid reductase gene from Stenotrophomonas maltophilia and its application to stereospecific production of D-pantoic acid. Appl Microbiol Biotechnol 93:1619-1625. Cheng, J., Wu, M., Zhong, R., Si, D., Meng, G., Zhang, R., Zhang, Y. (2021) Rapid Golden Gate assembly of exons from genomic DNA for protein expression in Escherichia coli and Pichia pastori. Biotechniques 71(2). Zhang, L.,Wei, X., Zhang, R., Petitte, J N., Si, D., Li, Z., Cheng, J., Du, M. (2019) Design and Development of a Novel Peptide for Treating Intestinal Inflammation. Frontiers in Immunology 10:1841. Wei, X., Zhang, L., Zhang, Ri., Wu, R., Petitte, J N., Hou, Y., Si, D., Ahmad, B., Guo, H., Zhang, M., Cheng, Q., Tong, Y. (2021) Targeting the TLR2 Receptor With a Novel Thymopentin-Derived Peptide Modulates Immune Responses. Frontiers in Immunology 12:620494. Zhang, L., Wei, X., Zhang, R., Mozdziak, P E., Si, D., Ahmad, B., Cheng, Q., Tong, Y. (2021) Design and Immunological Evaluation of a Hybrid Peptide as a Potent TLR2 Agonist by Structure-Based Virtual Screening. Frontiers in Cell and Developmental Biology 9:620370. Zhang, L., Wei, X., Zhang, R., Koci, M., Si, D., Ahmad, B., Guo, H., Hou, Y. (2021) C-Terminal Amination of a Cationic Anti-Inflammatory Peptide Improves Bioavailability and Inhibitory Activity Against LPS-Induced Inflammation. Frontiers in Immunology 11:618312. Wei, X., Zhang, L., Zhang, R., Wu, R., Si, D., Ahmad, B., Petitte, J N., Mozdziak, P E., Li, Zh., Guo, H., Zhang, M. (2020) A highly efficient hybrid peptide ameliorates intestinal inflammation and mucosal barrier damage by neutralizing lipopolysaccharides and antagonizing the lipopolysaccharide-receptor interaction. FASEB Journal 34(12): 16049-72. Wei, X., Zhang, L., Zhang, R., Koci, M., Si, D., Ahmad, B., Cheng, J., Wang, J., Aihemaiti, M., Zhang, M. (2020) A Novel Cecropin-LL37 Hybrid Peptide Protects Mice Against EHEC Infection-Mediated Changes in Gut Microbiota, Intestinal Inflammation, and Impairment of Mucosal Barrier Functions. Frontiers in Immunology 11:1361. Ahmad, B., Hanif, Q., Wei, X., Zhang, L., Sabir, N., Li, Z., Cheng, J., Khan, S A., Basit, A., Shahid, M., Rehman, Amin U., Si, D., Zhang, R. (2020) In vitro Impact of Yeast Expressed Hybrid Peptide CATH-2TP5 as a Prophylactic Measure Toward Sepsis and Inflammation. Frontiers in Bioengineering and Biotechnology 8:454. Ahmad, B., Li, Z., Hanif, Q., Hu, Q., Wei, X., Zhang, L., Khan, S A., Aihemaiti, M., Gulzar, H., Shahid, M., Si, D., Zhang, R. (2020) A Hybrid Peptide DEFB-TP5 Expressed in Methylotrophic Yeast Neutralizes LPS With Potent Anti-inflammatory Activities. Frontiers in Pharmacology 11:461. Zhang, L., Wei, X., Zhang, R., Koci, M., Si, D., Ahmad, B., Cheng, J., Wang, J. (2019) Development of a Highly Efficient Hybrid Peptide That Increases Immunomodulatory Activity Via the TLR4-Mediated Nuclear Factor-kappa B Signaling Pathway. International Journal of Molecular Sciences 20(24):6161. Zhang, L., Wei, X., Zhang, R., Si, D., Petitte, J N., Ahmad, B., Zhang, M. (2019) A Novel Peptide Ameliorates LPS-Induced Intestinal Inflammation and Mucosal Barrier Damage via Its Antioxidant and Antiendotoxin Effects. International Journal of Molecular Sciences 20(16):3974 Zheng, Z., Si, D., Ahmad, B., Li, Z., Zhang, R. (2018) A novel antioxidative peptide derived from chicken blood corpuscle hydrolysate. Food Research International 106:410-419. Poole, A. M., Horinouchi, N., Catchpole, R. J., Si, D., Hibi, M., Tanaka, K., Ogawa, J. (2014) The Case for an Early Biological Origin of DNA. J Mol Evol 79:204-212. 李仲玄，程强，姚蒙蒙，胡聪，买尔哈巴·艾合买提，王晓冰，张日俊，斯大勇*. 乳酸链球菌素（Nisin）的特性及应用. 饲料工业 , 2020, 41(24):8-11. 杜孟思, 王晓冰, 姚蒙蒙, 斯大勇*. 产氢抗氧化丁酸梭菌高效发酵工艺参数的优化. 饲料工业, 2020, 41(20):6-11. 张璐璐, 卫旭彪, 李仲玄, 胡庆勇, 斯大勇, 张日俊. 单胃动物肠道细菌对氨基酸的代谢作用. 中国畜牧杂志, 2018, 54(11):17-20. 胡聪, 李仲玄, 斯大勇, 张日俊. 解淀粉芽孢杆菌在畜禽养殖中的应用. 饲料工业, 2018, 39(06):56-60. 李仲玄, 胡聪, 胡庆勇, 斯大勇, 张日俊. 肠道微生物对猪肌内脂肪的影响. 饲料工业, 2017, 38(24):29-32. 胡庆勇, 卫旭彪, 张璐璐, 斯大勇, 张日俊. 抗菌抗病毒杂合肽M-L发酵液的抑菌谱及生物稳定性研究. 中国农业大学学报, 2017, 22(12):110-116. 胡庆勇, 胡聪, 斯大勇, 张日俊. 益生菌对蛋品质的调控及作用机理. 饲料工业, 2017, 38(20):57-61. 张璐璐, 卫旭彪, 斯大勇, 张日俊. 肠道微生物与宿主膳食蛋白代谢的影响. 饲料工业, 2017, 38(18):58-61. 卫旭彪, 张璐璐, 斯大勇, 张日俊. 肠道菌群对氨基酸的分解及其产物对宿主的作用. 饲料工业, 2017, 38(16):41-44. 胡聪, 李仲玄, 斯大勇, 张日俊. 果渣的利用现状及开发动向. 饲料工业, 2017, 38(13):44-46. 张璐璐, 卫旭彪, 斯大勇, 郑召君, 马广, 张日俊. 产纤维素酶芽孢杆菌的筛选及鉴定. 饲料工业, 2016, 37(18):45-50. 崔学平, 斯大勇, 崔扬健. 大豆异黄酮的生理功能. 饲料与畜牧, 2009, 2:17-19. 崔学平, 斯大勇, 崔扬健. 叶酸在畜禽生产中的应用. 家禽科学, 2008, 10:42-44. 斯大勇, 张日俊. 乳酸菌粘附的机制、特点、生物学作用. 中国微生态学杂志, 2008, 03:294-297.

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