个人简介
学习经历
2003年9月-2008年6月 中国农业大学 博士
1999年9月-2003年6月 湖南农业大学 学士
工作经历
2013年1月-至今 中国农业大学动物科技学院 副研究员
2013年1月-2014年6月 美国芝加哥大学生命医学部 访问学者
2008年6月-2012年12月 中国农业大学动物科技学院 助理研究员
社会服务工作
中国畜牧兽医学会动物营养分会 理事、副秘书长
北京畜牧兽医学会 理事
获得奖励与荣誉
张炳坤，袁建敏.以雏鹰俱乐部作为技术依托的创新创业人才培养模式. 全国农业专业学位研究生实践教学成果奖二等奖. 全国农业专业学位研究生教育指导委员会.2018
呙于明(#); 张日俊; 李绍钰; 吕明斌; 袁建敏; 郝国庆; 杨鹰; 魏凤仙; 张炳坤; 王忠. 肉鸡健康养殖的营养调控与饲料高效利用技术. 国家科技进步二等奖. 国家科学技术奖励工作办公室, 2011
近期论文
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Bian Yifei, Jiaqi Lei, Jia Zhong, Bo Wang, Yan Wan, Jinxin Li, Chaoyong Liao, Yang He, Zhongjie Liu, Koichi Ito, and Bingkun Zhang*. Kaempferol reduces obesity, prevents intestinal inflammation, and modulates gut microbiota in high-fat diet mice. Journal of Nutritional Biochemistry. 2022. 99: 108840.
Liao Chaoyong, Ayansola Hammed, Yanbo Ma, Koichi Ito, Yuming Guo and Bingkun Zhang*. Advances in enhanced menaquinone-7 production from Bacillus subtilis. Frontiers in Bioengineering and Biotechnology. 2021. 9: 695526.
He Yang #, Xuan Liu#, Yuanyang Dong, Jiaqi Lei, Koichi Ito, Bingkun Zhang*. Enterococcus faecium PNC01 isolated from the intestinal mucosa of chicken as an alternative for antibiotics to reduce feed conversion rate in broiler chickens. Microbial Cell Factories. 2021. 20:122.
He Yang, Hammed Ayansola, Yujiao Lai, Qihang Hou, Chaoyong Liao, Jiaqi Lei, Qiuyu Jiang, Hori Masatoshi, Bingkun Zhang*. Genistein inhibits colonic goblet cell loss and colorectal inflammation induced by Salmonella typhimurium infection. Molecular Nutrition & Food Research. 2021, 65(16), 202100209.
Hou Qihang, Jingxi Huang, Hammed Ayansola, Masatoshi Hori, Bingkun Zhang*. Intestinal stem cells and immune cells relationships: potential therapeutic targets for inflammatory bowel diseases. Frontiers in Immunology. 2021. 11:623691.
He Yang#, Yanyan Yang#, Yuanyang Dong, Koichi Ito, Bingkun Zhang*. Highly nutritious diet resists Salmonella Typhimurium infections by improving intestinal microbiota and morphology in broiler chickens. Poultry Science. 2020. 99(12): 7055-7065. December 2020. https://doi.org/10.1016/j.psj.2020.09.073.
Sun Jingjing, Cheng Zhang, Bingkun Zhang*. Effects of organic zinc on broiler intestinal permeability and integrity in Clostridium perfringens–challenged condition. Poultry Science. 2020. 99(12): 6653-6656.
Hou Qihang, Yuanyang Dong, Jingxi Huang, Chaoyong Liao, Jiaqi Lei, Youli Wang, Yujiao Lai, Yifei Bian, Yang He, Jingjing Sun, Meng Sun, Qiuyu Jiang, Bo Wang, Zhengquan Yu, Yuming Guo, Bingkun Zhang*. Exogenous L-arginine increases intestinal stem cell function through CD90+ stromal cells producing mTORC1-induced Wnt2b. Communications Biology. 2020. 3: 611.
Dong Yuanyang, Jiaqi Lei, Bingkun Zhang*. Dietary Quercetin Alleviated DSS-induced Colitis in Mice through Several Possible Pathways by Transcriptome Analysis. Current Pharmaceutical Biotechnology. 2020. 21(15): 1666 - 1673.
Dong Yuanyang, Jiaqi Lei, Bingkun Zhang*. Effects of dietary quercetin on the antioxidative status and cecal microbiota in broiler chickens fed with oxidized oil. Poultry Science. 2020. 99(10): 4892-4903.
Hou Qihang, Yuanyang Dong, Qinghua Yu, Bo Wang, Shen Le, Yuming Guo, Bingkun Zhang*. Regulation of the Paneth cell niche by exogenous L-arginine couples the intestinal stem cell function. The FASEB Journal. 2020. 34: 10299–10315.
Dong Yuanyang, Qihang Hou, Meng Sun, Jingjing Sun, Bingkun Zhang*. Targeted Isolation of Antioxidant Constituents from Plantago asiatica L. and In Vitro Activity Assay. Molecules. 2020. 25(8): 1825.
Dong Yuanyang, Qihang Hou, Jiaqi Lei, Patricia G. Wolf, Hammed Ayansola, Bingkun Zhang*. Quercetin alleviates intestinal oxidative damage induced by H2O2 via modulation of GSH: In vitro screening and in vivo evaluation in a colitis model of mice. ACS Omega. 2020. 5(14): 8334-8346.
Bian Yifei, Yuanyang Dong, Jingjing Sun, Meng Sun, Qihang Hou, Yujiao Lai, Bingkun Zhang*. Protective effect of kaempferol on LPS-induced inflammation and barrier dysfunction in a coculture model of intestinal epithelial cells and intestinal microvascular endothelial cells. Journal of Agricultural and Food Chemistry. 2020. 68(1): 160-167.
He Yang, Yanyan Yang, Yuanyang Dong, Changling Yan, Bingkun Zhang*. The Effects of flavomycin and colistin sulfate pre-treatment on ileal bacterial community composition, the response to Salmonella typhimurium and host gene expression in broiler chickens. Microorganisms 2019. 7(11): 574.
Wei Wu, Zhibin Xiao, Wenyi An, Yuanyang Dong, Bingkun Zhang*. 2018. Dietary sodium butyrate improves intestinal development and function by modulating the microbial community in broilers. PLoS ONE 13(5): e0197762.
Shao Yu-Xin, Zhao Lei, Patricia G Wolf, Yan Gao, Yu-Ming Guo, and Bing-Kun Zhang*. 2017. Zinc supplementation, via GPR39, upregulates PKC zeta to protect intestinal barrier integrity in caco-2 cells challenged by Salmonella enterica Serovar Typhimurium. The Journal of Nutrition. 2017. 147(7):1282-1289.
Tsai Peiyun#, Bingkun Zhang#, Weiqi He, Juanmin Zha, Matthew A. Odenwald, Gurminder Singh, Atsushi Tamura, Le Shen, Anne Sailer, Sunil Yeruva, Weiting Kuo, Yangxin Fu, Sachiko Tsukita, and Jerrold R. Turner. 2017. IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance. Cell Host & Microbe. 2017. 21(6): 671–681.
Shao Yuxin, Patricia G. Wolf, Shuangshuang Guo, Yuming Guo, H. Rex Gaskinsc, Bingkun Zhang*. 2017. Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells. Journal of Nutritional Biochemistry. 2017. 43: 18–26.
张炳坤，呙于明，赵丽红，马秋刚，袁建敏. “案例式”课程在线教学实践与思考.教育现代化. 2021. 8（57）：1-5.
江秋雨，武威，呙于明，班志彬, 张炳坤*. 不同比例豆粕组合的营养价值及肉仔鸡代谢能预测模型的建立. 动物营养学报. 2021. 33（7）: 3799-3809.
孙静静, 张炳坤*. 家禽微量元素敏感指标研究进展. 动物营养学报. 2021，33(4)：1841-1850.
万妍，邵玉新，张炳坤*.不同阶段日粮锌营养对肉鸡生长性能及肠黏膜屏障功能的影响. 中国家禽. 2020.42(9) : 54-61.
江秋雨，何阳，呙于明，张炳坤*. 家禽净能体系的构建及其在饼粕类饲料上的应用. 动物营养学报. 2020. 32(9) : 4020-4028.
万妍，许彦飞，董元洋，张炳坤*. 超微粉碎车前对沙门氏菌感染肉仔鸡生长性能、免疫功能和抗氧化功能的影响. 动物营养学报. 2020. 32 (8): 3636-3653.
安文艺，雷佳琦，董元洋，武威，刘璇，邵玉新，张炳坤*. 壳寡糖与屎肠球菌对肉仔鸡生长性能、免疫功能及肠道短链脂肪酸含量的影响. 中国畜牧杂志. 2019. 55(08):110-117.
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