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学习经历 2008/9-2011/12,中国农业大学动物科技学院动物营养与饲料科学专业,博士,导师:谯仕彦教授 2006/9-2008/6,中国农业大学动物科技学院动物营养与饲料科学专业,硕士,导师:王凤来教授 2002/9-2006/7,中国农业大学动物科技学院动物科学专业,本科,导师:富俊才副教授 工作经历 2021/3-至今,中国农业大学动物科技学院,教授 2016/1-2021/3,中国农业大学动物科技学院,副教授 2013/06-2015/12,中国农业大学动物科技学院,讲师 2012/2-2013/5,美国俄克拉荷马州立大学动物科学系分子营养实验室,博士后

研究领域

母猪营养与繁殖

近期论文

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Qianhong Ye, Xiangzhou Zeng, Shuang Cai, Shiyan Qiao, and Xiangfang Zeng. Mechanisms of lipid metabolism in uterine receptivity and embryo development. Trends in Endocrinology & Metabolism.2021.1642(通讯作者). Qianhong Ye,Xiangfang Zeng,Shuai Wang,Xiangzhou Zeng,Guangxin Yang,Changchuan Ye,Shuang Cai,Meixia Chen,Siyu Li,Shiyan Qiao.Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPARγ and PGC1α pathways in ovarian granulosa cells. The FASEB Journal. 2021;35:e21316(通讯作者). Meixia Chen,Jie Li,Bo Zhang,Xiangfang Zeng,Xiangzhou Zeng, Shuang Cai,Qianhong Ye, Guangxin Yang, Changchuan Ye, Lijun Shang, and Shiyan Qiao.Uterine Insulin Sensitivity Defects Induced Embryo Implantation Loss Associated with Mitochondrial Dysfunction-Triggered Oxidative Stress. Oxidative Medicine and Cellular Longevity.2021;2021:6655685(通讯作者). Shuang Cai,Qianhong Ye,Xiangzhou Zeng,Guangxin Yang,Changchuan Ye,Meixia Chen,Haitao Yu,Yuming Wang,Gang Wang,Shuo Huang,Shuang Quan,Xiangfang Zeng,Shiyan Qiao. CBS and MAT2A improve methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation. Cell Proliferation. 2021;54:e12950(通讯作者). Shuang Cai, Shuang Quan, Guangxin Yang, Qianhong Ye, Meixia Chen, Haitao Yu,Gang Wang, Yuming Wang, Xiangfang Zeng, and Shiyan Qiao. One Carbon Metabolism and Mammalian Pregnancy Outcomes. Mol. Nutr. Food Res. 2021; 65:2000734(通讯作者). Shuang Cai,Shuang Quan,Guangxin Yang,Meixia Chen, Qianhong Ye,Gang Wang,Haitao Yu, Yuming Wang,Shiyan Qiao, and Xiangfang Zeng. Nutritional Status Impacts Epigenetic Regulation in Early Embryo Development: A Scoping Review. Adv Nutr. 2021;00:1–16(通讯作者). Junyan Zhou, Yuming Wang, Xiangzhou Zeng, Tao Zhang, Peili Li, Bingqian Yao, Lu Wang, Shiyan Qiao, and Xiangfang Zeng*. Effect of antibiotic-free, low-protein diets with specific amino acid compositions on growth and intestinal flora in weaned pigs. Food Funct. 2020. 11:493(通讯作者). Hongbin Liu, Chengli Hou, Ning Li, Xiaoya Zhang, Guolong Zhang, Feiyun Yang, Xiangfang Zeng*, Zuohua Liu, and Shiyan Qiao. Microbial and metabolic alterations in gut microbiota of sows during pregnancy and lactation. FASEB J. 2019.33:4490-4501(通讯作者). Qianhong Ye, Shuang Cai, Shuai Wang, Xiangzhou Zeng, Changchuan Ye, Meixia Chen, Xiangfang Zeng*, Shiyan Qiao. Maternal short and medium chain fatty acids supply during early pregnancy improves embryo survival through enhancing progesterone synthesis in rats. J Nutr Biochem. 2019. 69:98-107(通讯作者). Meixia Chen, Bo Zhang, Shuang Cai, Xiangfang Zeng*, Qianhong Ye, Xiangbing Mao, Shihai Zhang, Xiangzhou Zeng, Changchuan Ye, Shiyan Qiao. Metabolic disorder of amino acids, fatty acids and purines reflects the decreases in oocyte quality and potential in sows. J Proteomics. 2019.doi.org/10.1016/j.jprot.2019.03.015(通讯作者). Man Ren, Shuang Cai, Tong Zhou, Shihai Zhang, Shenghe Li, Erhui Jin, Chuanyan Che, Xiangfang Zeng*, Tao Zhang and Shiyan Qiao. Isoleucine attenuates infection induced by E. coli challenge through the modulation of intestinal endogenous antimicrobial peptide expression and the inhibition of the increase in plasma endotoxin and IL-6 in weaned pigs. Food Funct., 2019, DOI: 10.1039/c9fo00218a(通讯作者). Shuang Cai, Jinlong Zhu, Xiangzhou Zeng, Qianhong Ye, Changchuan Ye, Xiangbing Mao, Shihai Zhang, Shiyan Qiao, and Xiangfang Zeng*. Maternal N?carbamylglutamate supply during early pregnancy enhanced pregnancy outcomes in sows through modulations of targeted genes and metabolism pathways. J Agr Food Chem. 2018.66:5845-5852(通讯作者). Xiaoya Zhang, Xutong Liu, Hongmin Jia, Pingli He, Xiangbing Mao, Shiyan Qiao, and Xiangfang Zeng*. Valine supplementation in a reduced protein diet regulates growth performance partially through modulation of plasma amino acids profile, metabolic responses, endocrine, and neural factors in piglets. J Agr Food Chem. 2018.66:3161-3168(通讯作者). Changchuan Ye, Xiangzhou Zeng, Jinlong Zhu, Ying Liu, Qianhong Ye, Shiyan Qiao, and Xiangfang Zeng*. Dietary N?carbamylglutamate supplementation in a reduced protein diet affects carcass traits and the profile of muscle amino acids and fatty acids in finishing pigs. J Agr Food Chem. 2017.65:5751-5758 (通讯作者). Bo Zhang, Licui Chu, Hong Liu, Chunyuan Xie, Shiyan Qiao, Xiangfang Zeng*. Leucine supplementation in a chronically protein-restricted diet enhances muscle weight and postprandial protein synthesis of skeletal muscle by promoting the mTOR pathway in adult rats. Engineering. 2017.3:1-6 (通讯作者). Shihai Zhang, Xiangfang Zeng*, Man Ren, Xiangbing Mao, and Shiyan Qiao. Novel metabolic and physiological functions of branched chain amino acids: a review. J Anim Sci Biotechnol. 2017.8:10 (通讯作者). Man Ren, Shihai Zhang, Xutong Liu, Shenghe Li, Xiangbing Mao, Xiangfang Zeng*, and Shiyan Qiao. Different lipopolysaccharide branched-chain amino acids modulate porcine intestinal endogenous β-defensin expression through the Sirt1/ERK/90RSK pathway. J Agr Food Chem. 2016.64:3371-3379 (通讯作者). Shihai Zhang, Licui Chu, Shiyan Qiao, Xiangbing Mao, Xiangfang Zeng*. Effects of dietary leucine supplementation in low crude protein diets on performance, nitrogen balance, whole body protein turnover, carcass characteristics and meat quality of finishing pigs. Anim Sci J. 2016.87:911-920(通讯作者). Shihai Zhang, Qing Yang, Man Ren, Shiyan Qiao, Pingli He, Defa Li, and Xiangfang Zeng*. Effects of isoleucine on glucose uptake through the enhancement of muscular membrane concentrations of GLUT1 and GLUT4 and intestinal membrane concentrations of Na+ /glucose co-transporter 1 (SGLT-1) and GLUT2. Brit J Nutr. 2016.116: 593-602 (通讯作者). Xiangfang Zeng*, Zhimin Huang, Fengrui Zhang, Xiangbing Mao, Shihai Zhang, ShiyanQiao. 2015. Oral administration of N-carbamylglutamate might improve growth performance and intestinal function of suckling piglets. Livest Sci. 2015.181:242-248. Jinlong Zhu, Xiangfang Zeng*, Qian Peng, Shenming Zeng, Haiyi Zhao, Hexiao Shen, Shiyan Qiao. 2015. Maternal N-carbamylglutamate supplementation during early pregnancy enhances embryonic survival and development through modulation of the endometrial proteome in gilts. J Nutr. 2015.145:2212-2220 (通讯作者). Man Ren, Xutong Liu, Xu Wang, Guijie Zhang, Shiyan Qiao, Xiangfang Zeng*. Increased levels of standardized ileal digestible threonineattenuate intestinal damage and immune responses in Escherichia coli K88+ challenged weaned piglets. Anim Feed Sci Technol. 2014.195: 67-75(通讯作者). Man Ren,Chuang Liu, Xiangfang Zeng*, Longyao Yue, Xiangbing Mao, Shiyan Qiao, Junjun Wang. Amino acids modulates the intestinal proteome associated with immune and stress response in weaning pig. Mol Biol Rep. 2014.41(6) (通讯作者). Shihai Zhang, Man Ren, Xiangfang Zeng*, Pingli He, Xi Ma, Shiyan Qiao. Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2)through PI3K/Akt/mTOR and ERK signaling pathways. Amino Acids. 2014.46: 2633-2642. (通讯作者). Xiangfang Zeng, Lakshmi T. Sunkara, Weiyu Jiang,Megan Bible, Scott Carter, Xi Ma, Shiyan Qiao, Guolong Zhang. Induction of porcine host defense peptide gene expression by short-chain fatty acids and their analogs. PLoS ONE. 2013.8(8): e72922. doi:10.1371/journal.pone.0072922. Xiangfang Zeng, Xiangbing Mao, Zhimin Huang,Fenglai Wang, GuoyaoWu, Shiyan Qiao. Arginine enhances embryo implantation in rats through PI3K/PKB/mTOR/NO Signaling pathway during early pregnancy. Reproduction. 2013.145:1-7. Xiangfang Zeng, Zhimin Huang, Xiangbing Mao, Junjun Wang, Guoyao Wu, Shiyan Qiao. N-carbamylglutamate enhances pregnancy outcome in rats through activation of the PI3K/PKB/mTOR signaling pathway. PLoS ONE. 2012. 7(7): e41192. doi:10.1371/journal.pone.0041192. Xiangfang Zeng, Fenglai Wang, Xia Fan, Wenjun Yang, Bo Zhou, Pengfei Li, Yulong Yin, Guoyao Wu, and Junjun Wang. Dietary arginine supplementation during early pregnancy enhances embryonic survival in rats. J Nutr. 2008.138: 1421-1425. Weiwei Wang, Xiangfang Zeng, Xiangbing Mao, Guoyao Wu and Shiyan Qiao. Optimal dietary true ileal digestible threonine for supporting the mucosal barrier in small intestine of weanling pigs. J Nutr. 2010.140:981-986(并列第一作者). Xiangbing Mao, Xiangfang Zeng, Zhimin Huang, Junjun Wang,Shiyan Qiao. Leptin and leucine synergistically regulate protein metabolism in c2c12 myotubes and mouse skeletal muscles. Brit J Nutr. 2013.110:256-264(并列第一作者). 蔡爽, 叶倩红, 曾祥芳*. 蛋氨酸对畜禽繁殖性能的影响及机制. 动物营养学报. 2018. (03): 881-887. 周相超, 杨凤娟, 霍应峰, 曾祥芳*. 低氮日粮条件下生长猪标准回肠可消化异亮氨酸需要量研究. 中国畜牧杂志. 2018. (05): 67-73. 张博, 蔡爽, 叶倩红, 曾祥芳*, 谯仕彦. 营养物质调节母猪卵母细胞质量与繁殖性能的研究进展. 动物营养学报. 2017. (10): 3436-3443.

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