王波 - 中国农业大学 - 动物科学技术学院

个人简介

王波，男，动物营养与饲料科学系，副教授，中国共产党党员。近年来，系统阐明了维生素A在脂肪发育过程中的作用和机制，为防治肥胖及其相关的代谢疾病提供了理论依据。通过研究维生素A在怀孕期和哺乳期对后代脂肪的沉积的程序化作用，揭示了早期营养因素对抗肥胖能力的长远影响。同时，揭示了血管调控脂肪细胞发育并提供脂肪前体细胞的作用机理，为防治肥胖相关代谢疾病以及改善动物肉品质提供了新的靶点。分析了环境中有害化学物质对脂肪细胞代谢能力的抑制作用，发现农业生产中常用的杀虫剂毒死蜱能够抑制褐色脂肪细胞的产热能力，可能对全球肥胖的流行起到了促进作用。在畜牧学领域，通过研究维生素A对肉牛肌间脂肪和肌肉发育的影响，提出了在动物生长早期增加肌内脂肪前体细胞库以增加肌内脂肪细胞数目，从而针对性地增加肌内脂肪的沉积潜力。此外，构建了诱导反刍动物细胞体外3D培养和诱导脂肪分化的方法，为反刍动物脂肪发育研究提供了急需的实验手段。累计发表论文50多篇，其中以第一和通讯作者身份在Nature Communications、Cell Discovery、Ebiomedicine、FASEB J、JMCB、JN、JASB等生命科学和畜牧学重要杂志发表了十几篇SCI论文。相关研究获得了国内外几十家媒体的报道，在新网络媒体上也获得了广泛的关注。获得奖励与荣誉北京市科协2020-2022年度青年人才托举工程 Michael G. DeGroote Fellowship Awards, McMaster University, 2017-2019 Frasier Fred W. Memorial Scholarship, Washington State University, 2016 - 2017 GPSA Travel Grant, Washington State University, 2016 CRB travel award, Washington State University, 2015-2016 Edward & Sally A. Veenhuizen S Scholarship, Washington State University, 2014 – 2015 Frasier Fred W. Memorial Scholarship, Washington State University, 2013 – 2014

研究领域

脂肪细胞分化机理；胎儿程序化；营养、环境等因素对脂肪及肌肉发育和代谢的调控作用

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Bo Wang, Evangelia Tsakiridis, Shuman Zhang, Andrea Llanos, Eric Dejardins, Julian Yabut, Alexander Green, Emily Day, Brennan Smith, James Lally, Jianhan Wu, Mr Amogelang Raphenya, Krishna Srinivasan, Andrew McArthur, Shingo Kajimura, Jagdish Suresh Patel, Michael Wade, Katherine Morrison, Alison Holloway, Gregory Steinberg. 2021. The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue. Nature Communications 12, 5163. Wang, Y., Y. Wu, J. Chen, X. Guo, L. Yan, Y. Guo, B. Wang*, and J. Yuan*. 2021. The duration of food withdrawal affects the intestinal structure, nutrients absorption, and utilization in broiler chicken. FASEB J 35(1):e21178. Li, S., J. You, Z. Wang, Y. Liu, B. Wang, M. Du, and T. Zou. 2021. Curcumin alleviates high-fat diet-induced hepatic steatosis and obesity in association with modulation of gut microbiota in mice. Food Res. Int. 143:110270. Zhao, L., J. S. Son, B. Wang, Q. Tian, Y. Chen, X. Liu, J. M. de Avila, M.-J. Zhu, and M. Du. 2020. Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration. EBioMedicine 60:103020. Ayansola, H., C. Liao, Y. Dong, X. Yu, B. Zhang, and B. Wang*. 2020. Prospect of early vascular tone and satellite cell modulations on white striping muscle myopathy. Poult. Sci. Wang B, Fu X, Liang XW, Wang ZX, Zhao L, Tian QY, Zhao JX, Gomez NA, Trombetta SC, Avila JM, Zhu MJ, and Du M. Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors. Cell discovery, 2017, 3:17036. Wang B, Wang ZX, Avila JM, Zhu MJ, Zhang FY, Gomez NA, Zhao L, Tian QY, Zhao JX, Maricelli J, Zhang H, Rodgers BD and Du M. Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB J, 2017 Vol.31. Wang B, Fu X, Zhu MJ, Du M. Retinoic acid inhibits white adipogenesis by disrupting GADD45A mediated Zfp423 DNA demethylation. Journal of molecular cell biology, 2017, 9(4):338-349. Wang B, Fu X, Liang XW, Wang ZX, Yang QY, Zou TD, Nie W, Zhao JX, Gao PF, Zhu MJ, Avila JM, Maricelli J, Rodgers BM, and Du M. Maternal Retinoids Increase PDGFRα+ Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development. EbioMedicine, 2017, 18: 288-299. Wang B, Zhang FY, Wang ZX, Zhang H, Du M. Alcohol aggravate cancer induced cachexia via inducing adipose browning and skeletal muscle atrophy. Oncotarget, 2017. Wang B, Min Z, Yuan JM, Zhang BK, Guo YM. Effects of dietary tryptophan and stocking density on the performance, meat quality, and metabolic status of broilers. Journal of Animal Science and Biotechnology 2014, 5(1): 44. Wang B, Yang G, Liang XW, Zhu MJ, and Du M. Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice. BMC-Complementary and Alternative Medicine, 2014, (14): 162. Wang B., Q. Yang, C. L. Harris, M. L. Nelson, J. R. Busboom, M. J. Zhu, and Du M. Nutrigenomic regulation of aidpose tissue development – role of retinoic acid. Meat Science, 2016, 120: 100-106. Wang B, Nie W, Fu X, de Avila JM, Ma Y, Zhu MJ, Maquivar M, Parish SM, Busboom JR, Nelson ML, Du M: Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers. Journal of Animal Science and Biotechnology 2018, 9:82. Wang, B., Qu, Y., Wang, Y., Ma, Y., Xu, C., Li, F., Liu, C., Lu, X., Wang, B., Xiu, P. and Gao, Y., 2019. Triplet Male Lambs Are More Susceptible than Twins to Dietary Soybean Oil–Induced Fatty Liver. The Journal of nutrition, 149(6), pp.989-995. C. L. Harris#, B. Wang#, J. M. Deavila, J. R. Busboom, M. Maquivar, S. M. Parish, B. McCann, M. L. Nelson, M. Du, Vitamin A administration at birth promotes calf growth and marbling fat development in Angus beef cattle. Journal of animal science and biotechnology, 2018. (co-first author) Ma YN#, Wang B#, Wang ZX, Zhu MJ, Du M. Adipogenic differentiation of bovine stromal vascular cells in organoid culture. Animal, 2018. (co-first author) Wang B, Min Z, Yuan JM. Apparent ileal digestible tryptophan requirements of 22-to 42-day-old broiler chicks. The Journal of Applied Poultry Research, 2015: pfv061. Maricelli JA, Bishaw YM, Wang B, Du M and Rodgers BD. Systemic smad7 gene therapy increases striated muscle mass and enhances exercise capacity in a dose-dependent manner. Human gene therapy, 2017. Fu X, Yang QY, Wang B, Zhao JX, Zhu MJ, Parish SM, Du M. Reduced satellite cell density and myogenesis in Wagyu compared with Angus cattle as a possible explanation of its high marbling. Animal, 2017. Yang Q, Liang X, Sun X, Zhang L, Fu X, Rogers CJ, Berim A, Zhang S, Wang S, Wang B, Foretz M, Viollet B, Gang DR, Rodgers BD, Zhu MJ, Du M. AMPK/α-ketoglutarate axis dynamically mediates DNA demethylation in the Prdm16 promoter and brown adipogenesis. Cell metabolism. 2016. Zou T, Chen D, Yang Q, Wang B, Zhu MJ, Nathanielsz PW, Du M: Resveratrol supplementation to high fat diet‐fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. The Journal of physiology. 2017. Liang, X., Yang Y, Fu X, Rogers CJ, Wang B, Pan H, Zhu MJ, Nathanielsz PW, and Du M. Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. The Journal of Physiology, 2016, 594 (15): 4453-4466. Du M, Wang B, Fu X, Yang Q, Zhu MJ. Fetal programming in meat production. Meat science, 2015 (109): 40-47. Huang C, Wang B, Min Z, Yuan JM. Dietary inclusion level and time effects of taurine on broiler performance, meat quality, oxidative status and muscle taurine content. British poultry science, 2014, 55 (5), 598-604. Yuan JM, Wang B, Huang Z, Fan Y, Huang C, Hou Z. Comparisons of egg quality traits, egg weight loss and hatchability between striped and normal duck eggs. British Poultry Science 54.2 (2013): 265-269. Xing, T., Y. Kang, X. Xu, B. Wang, M. Du, and M. J. Zhu*. Raspberry supplementation improves insulin signaling and promotes brown-like adipocyte development in white adipose tissue of obese mice. Molecular Nutrition and Food Research, 2018. Zou T, Wang B, Yang Q, de Avila JM, Zhu MJ, You J, Chen D, Du M. Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1. The Journal of Nutritional Biochemistry. 2018. Zhao L, Zou TD, Gomez N, Wang B, Zhu MJ, and Min D. Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1. Nutrition & Diabetes, 2018. Zou, T., Wang, B., Li, S., Liu, Y. and You, J., 2020. Dietary apple polyphenols promote fat browning in high-fat diet-induced obese mice through activation of adenosine monophosphate-activated protein kinase α. Journal of the Science of Food and Agriculture. Yabut, J.M., Desjardins, E.M., Chan, E.J., Day, E.A., Leroux, J.M., Wang, B., Crane, E.D., Wong, W., Morrison, K.M., Crane, J.D. and Khan, W.I., 2020. Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance. Nature communications, 11. Zhao, L., Wang, B., Gomez, N.A., de Avila, J.M., Zhu, M.J. and Du, M., 2020. Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice. International Journal of Obesity, 44(1), pp.226-234. Zou, T., Kang, Y., Wang, B., de Avila, J.M., You, J., Zhu, M.J. and Du, M., 2019. Raspberry supplementation reduces lipid accumulation and improves insulin sensitivity in skeletal muscle of mice fed a high-fat diet. Journal of Functional Foods, 63, p.103572. Tian, Q., Zhao, J., Yang, Q., Wang, B., Deavila, J.M., Zhu, M.J. and Du, M., 2019. Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice. Aging cell, p.e13059. 王波,闵芝智,呙于明,袁建敏. 1-21日龄雄性肉鸡表观回肠可消化色氨酸需要量研究.中国畜牧杂志，2015,11:27-33. 王璐，易路，王波，尹晓楠，闵芝智，梁恒之，袁建敏.家禽不同料重比测定方法的比较研究. 中国家禽，2015,37（17）：31-34. 王波，闵芝智，李晓明，李庆云，袁建敏，呙于明.1-21日龄肉鸡色氨酸适宜水平研究.中国家禽，2014,36（11）：31-34. 梁恒之，王波，尹达菲，侯卓成，袁建敏.不同饲料转化率的北京鸭和枫叶鸭消化器官发育及盲肠微生物菌群的比较研究. 中国畜牧杂志,2013,49(19):42-46. 王波，何龙，黄春喜,袁建敏.螺纹蛋发生特点及产螺纹蛋母鸭生理指标比较研究，水禽世界，2011，增刊：214-219. 黄春喜,袁建敏，周淑亮，王波.牛磺酸对肉仔鸡生长性能、消化器官和免疫器官的影响，动物营养学报，2011，23（5）：854-861 王波，袁建敏.鸭饮水习性及饮水用具研究进展. 水禽世界，2010,2:41-43. 王波，秦春华，周佳，蒋纪才，初芹，史远刚，王雅春.宁夏几个肉牛杂交群体与秦川牛的BPI比较研究.中国牛业科学,2010，36(004):9-11. 宗宁远，徐威，周伟华，王波，袁建敏.产螺纹蛋鸭与正常鸭消化器官及输卵管形态和组织学比较. 水禽世界，2009，增刊，162-165. 黄志敏，范彧，王波，袁建敏.螺纹蛋蛋白特性的研究. 水禽世界，2009，增刊，181-183. 王波，袁建敏，阎磊，陈瑶.螺纹蛋对孵化性能的影响，中国家禽，2009，31（8）：46-47. 公开发表会议摘要 Wang, B., Zhang, S., Llanos, A., Tsakiridis, E.E., Desjardins, E.M., Yabut, J.M., Green, A.E., Day, E.A., Smith, B.K., Lally, J.S. and Raphenya, A.R., 2021. The Pesticide Chlorpyrifos Promotes Obesity by Inhibiting Diet-Induced Thermogenesis. Journal of the Endocrine Society, 5(Supplement_1), pp.A59-A60. Wang, B., X. Fu, S. M. Zhang, X. W. Liang, M. J. Zhu, and M. Du. Maternal Vitamin A Supplementation Expands Adipose Progenitor Population through Promoting Vascular Development. Experimental Biology Meeting, San Diego, California, April 1-5, 2016. Wang, B., M. J. Zhu, and M. Du. All-trans-Retinoic Acid Inhibits Adipogenesis by Interrupting Gadd45α Induced Zfp423 Demethylation. Experimental Biology Meeting, San Diego, California, April 1-5, 2016. Wang B., M. Du. Maternal obesity sets offspring adipose development. Center for Reproductive Biology Annual Retreat, Moscow, ID, August 7, 2015. Wang, B., G. Yang, X. Wei, M. J. Zhu, and M. Du. Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice [M]. The Annual Meeting of Institute for Food Technologists, New Orleans, LA, June 21-24, 2014. Yuan J, D Liu, Wang B, Z Huang, Y Fan, C Huang. Comparative of egg quality, minerals content, albumen characteristics and weight loss between luowen egg and normal egg of duck. World’s Poultry Science Journal, Egg Meat Symposia 2011, b-044, (67):40-41. Yuan J, C Huang, Wang B, S Zhou. Effects of Cage Versus Floor Litter Environments on Blood Parameters and Meat Quality in Broilers. Poult Sci. 2011, Vol 89, E-Suppl.1. Huang C, Yuan JM, Zhou SL, Wu J, Wang B. Effect of Dietary Taurine on Growth Performance and Development of Structure and Function of Digestive Organs in Broiler Chicken. Proceedings of the 6th National Symposium on Feed Nutrition, 2010. Yuan J, Liu D, Wang B, Huang Z, Fan Y, Huang C. Comparative of egg quality, minerals content, albumen characteristics and weight loss between luowen egg and normal egg of duck. World’s Poultry Science Journal, Egg Meat Symposia 2011, b-044, (67):40-41. 王波，袁建敏，闵芝智，黄春喜. 色氨酸对不同饲养密度下肉鸡生产性能、肉品质和抗氧化能力的影响. 畜牧兽医年会. 2011.