连正兴 - 中国农业大学 - 动物科学技术学院

个人简介

学习经历 1992/09-1996/06：东北农业大学，动物科技学院动物遗传育种与繁殖系，博士 1986/09-1989/06：东北农学院畜牧系，硕士 1982/09-1986/06：东北农学院畜牧系，学士工作经历 2003/07-至今：中国农业大学，动物科技学院，动物遗传育种与繁殖系，教授 1996/07-2003/07：中国农业大学，动物科技学院，动物遗传育种与繁殖系，副教授 1989/07-1992/07：东北农业大学，动物科技学院，动物遗传育种与繁殖系，讲师其中： 2008/01-2008/12：英国Institute of Animal Health in UK，访问学者 2000/01-2000/04：法国农业科学院（INRA），合作研究获得奖励与荣誉 2006年度教育部科学技术进步二等奖，高效表达重组人乳铁蛋白和a-乳清白蛋白的奶牛生物反应器 2005年度北京市科学技术进步一等奖，应用体细胞克隆技术生产和拯救优质种牛 2003年度国家技术发明二等奖，猪高产仔数FSHβ基因的发现及其应用研究

研究领域

动物分子与细胞工程育种

近期论文

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Yu D, Wang J, Zou H, Feng T, Chen L, Li J, Qi X, Li Z, Duan X, Xu C, Zhang L, Long X, Lan J, Chen C, Wang C, Xu X, Ren J, Zhao Y, Hu X, Lian Z, Men H, Pan D, Li N, Capecchi MR, Du X, Zhao Y, Wu S. Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning. PNAS. 2018 Shoulong Deng et al. Melatonin promotes sheep Leydig cell testosterone secretion in a co-culture with Sertoli cells. Theriogenology. 2018 Jingling Tao et al. Effects of AANAT overexpression on the inflammatory responses and autophagy activity in the cellular and transgenic animal levels Autophagy. 2018 Sutian Wang et al. Overexpression of Toll-like Receptor 4-linked Mitogen-activated Protein Kinase Signaling Contributes to Internalization of Escherichia coli in Sheep. International Journal of Biological Sciences. 2018 Yitong Yuan et al. Dwarf chickens with low monocytes/macrophages phagocytic activity show low antibody titers but greater performance. Animal Reproduction Science. 2018 Yitong Yuan et al. Interferon-γ acts as a regulator in the trade-off between phagocytosis and production performance in dwarf chickens. Journal of Animal Science and Biotechnology. 2018 Li Zhang et al. An Alternative Method for Long-Term Culture of Chicken Embryonic Stem Cell In Vitro. Stem Cells International. 2018 Shoulong Deng et al. Erratum to: Over-expression of Toll-like receptor 2 up-regulates heme oxygenase-1 expression and decreases oxidative injury in dairy goats Journal. of Animal Science and Biotechnology. 2017 Shoulong Deng et al. In vitro production of functional haploid sperm cells from male germ cells of Saanen dairy goat. Theriogenology. 2017 Shoulong Deng et al. Over-expression of Toll-like receptor 2 up-regulates heme oxygenase-1 expression and decreases oxidative injury in dairy goats. Journal of Animal Science and Biotechnology. 2017 Shoulong Deng et al. RNAi combining Sleeping Beauty transposon system inhibits ex vivo expression of foot-and-mouth disease virus VP1 in transgenic sheep cells. Science Report. 2017 Teng Ma et al. An AANAT/ASMT transgenic animal model constructed with CRISPR/Cas9 system serving as the mammary gland bioreactor to produce melatonin-enriched milk in sheep. Journal of Pineal Research. 2017 Xiuzhi Tian et al. Beneficial Effects of Melatonin on the In Vitro Maturation of Sheep Oocytes and Its Relation to Melatonin Receptors. International Journal of Molecular Sciences. 2017 Xiuzhi Tian et al. Melatonin Promotes the In Vitro Development of Microinjected Pronuclear Mouse Embryos via Its Anti-Oxidative and Anti-Apoptotic Effects. International Journal of Molecular Sciences. 2017 Hongping Wu et al. The evolutionary characteristics and structural biology of Gallus toll‐like receptor 21 Journal of Molecular Recognition 2017 Mingming Wu et al. Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system. Science Report. 2016 Yan Li et al. Efficient production of pronuclear embryos in breeding and nonbreeding season for generating transgenic sheep overexpressing TLR4. Journal of Animal Science and Biotechnology. 2016 Hai Wang et al. Expression of recombinant human lysozyme in transgenic chicken promotes the growth of Bifidobacterium in the intestine and improves postnatal growth of chicken. AMB Express. 2016 Kun Yu et al. Small interfering RNA expression inhibits avian infectious bronchitis virus replication and inflammatory response Antiviral Therapy. 2016 Shi JM Effects of seasonal changes on the ovulation rate and embryo quality in superovulated Black Suffolk ewes. Neuro endocrinology letters. 2015 Yuanhong Xie et al. Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat. Brazilian journal of microbiology. 2015 Zhang Y et al. Endothelial Cells Regulate Cardiac Myocyte Reorganisation Through β1-Integrin Signalling. Cellular Physiology and Biochemistry. 2015 Hai Bai et al. A 90-day toxicology study of meat from genetically modified sheep overexpressing TLR4 in Sprague-Dawley rats. Plos One. 2015 Shoulong Deng et al. Melatonin reduces oxidative damage and upregulates heat shock protein 90 expression in cryopreserved human semen. Free Radical Biology and Medicine. 2015 Shoulong Deng et al. Toll-Like Receptor 4 Promotes NO Synthesis by Upregulating GCHI Expression under Oxidative Stress Conditions in Sheep Monocytes/Macrophages. Oxidative Medicine and Cellular Longevity. 2015 Shoulong Deng et al. Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep Oxidative Medicine and Cellular Longevity. 2015 Wenting Li et al. Tongue Epithelium Cells from shRNA Mediated Transgenic Goat Show High Resistance to Foot and Mouth Disease Virus. Science Report. 2015 Zhang L et al. Effects of melatonin on superovulation and transgenic embryo transplantation in small-tailed han sheep (Ovis aries). Neuro endocrinology letters. 2013 Shoulong Deng et al. Transgenic cloned sheep overexpressing ovine toll-like receptor 4. Theriogenology. 2013 Miaoying Yu et al. Four recombinant pluripotency transcriptional factors containing a protein transduction domain maintained the in vitro pluripotency of chicken embryonic stem cells. Science China Life Sciences. 2013

学术兼职

中国农业生物技术学会，副秘书长中国农业生物技术学会动物生物技术分会，秘书长中国畜牧兽医学会动物遗传育种学分会，理事全国农业转基因生物安全管理标准化技术委员会，委员