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个人简介

学习经历 1990.09-1994.07 江西农业大学畜牧专业 农学学士 1994.09-1997.07 南京农业大学动物遗传育种专业 农学硕士 1999.09-2002.07 中国农业大学动物遗传育种与繁殖专业 农学博士 工作经历 1997.07-1999.09 南京农业大学动物科技学院 讲师 2002.10-2007.01 瑞典农业大学动物遗传育种系 博士后及项目研究员 2014.01-2015.01 美国康奈尔大学 访问学者 2007.02-至今 中国农业大学动物科技学院副教授 教授 科技奖励 教育部科技进步二等奖1项(排名第二),成果名称:中国家猪遗传演化与多样性分子评估 大北农科技特等奖1项(排名第三), 成果名称:中国家猪种质特征演化及分子育种应用 吴常信动物遗传育种科技成果奖(排名第一),成果名称:雄激素调控公猪脂肪沉积与肉质风味的分子机理研究 教育部科技进步一等奖1项(排名第八),成果名称:猪高产仔数FSH β基因发现及其应用研究 个人荣誉 教育部“新世纪优秀人才” 动物遗传学国家级优秀教学团队成员 校级优秀教师、溢多利育人奖、枣庄英才

研究领域

猪遗传资源与分子育种

近期论文

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HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia,Qiguo Tang, Qinqin Xu, Cui Ding, Hao Zhang, Yao Ling, Changxin Wu, and Meiying Fang,American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2021 320:5, R704-R713. Tang Q, Ding C, Xu Q, et al. Mitochondrial Fusion Potentially Regulates a Metabolic Change in Tibetan Chicken Embryonic Brain During Hypoxia. Frontiers in Cell and Developmental Biology. 2021;9:585166. Published 2021 Feb 9. doi:10.3389/fcell.2021.585166. Yang, W., Tang, Q., Bai, Y. et al. Bacterial magnetic particles-polyethylenimine vectors deliver target genes into multiple cell types with a high efficiency and low toxicity. Appl Microbiol Biotechnol (2020). https://doi.org/10.1007/s00253-020-10729-2. Wang J, Liu C, Chen J, Bai Y, Wang K, Wang Y, Fang M: Genome-Wide Analysis Reveals Human-Mediated Introgression from Western Pigs to Indigenous Chinese Breeds. Genes 2020, 11(3). Yang K, Wang J, Wang K, Luo Y, Tang Q, Liu X, Fang M: Integrated Analysis of miRNA-mRNA Network Reveals Different Regulatory Patterns in the Endometrium of Meishan and Duroc Sows during Mid-Late Gestation. Animals : an open access journal from MDPI 2020, 10(3). Wang K, Yang K, Xu Q, Liu Y, Li W, Bai Y, Wang J, Ding C, Liu X, Tang Q et al: Protein expression profiles in Meishan and Duroc sows during mid-gestation reveal differences affecting uterine capacity, endometrial receptivity, and the maternal–fetal Interface. BMC Genomics 2019, 20(1):991. Qiao Xu, Meiying Fang. Transcriptomic Analysis of Coding Genes and Non-Coding RNAs Reveals Complex Regulatory Networks Underlying the Black Back and White Belly Coat Phenotype in Chinese Wuzhishan Pigs[J]. Genes 2019, 10, 201. Liu Y, Zhang J, Xu Q, et al. Integrated miRNA-mRNA analysis reveals regulatory pathways underlying the curly fleece trait in Chinese tan sheep[J]. Bmc Genomics, 2018, 19(1):360. Wang K, Liu Y, Xu Q, et al. A post‐GWAS confirming GPAT3 gene associated with pig growth and a significant SNP influencing its promoter activity[J]. Animal Genetics, 2017. Kang X, Liu Y, Zhang J, et al. Characteristics and Expression Profile of KRT71 Screened by Suppression Subtractive Hybridization cDNA Library in Curly Fleece Chinese Tan Sheep[J]. DNA and cell biology, 2017. Liu Y, Kang X, Yang W, et al. Differential expression of KRT83 regulated by the transcript factor CAP1 in Chinese Tan sheep[J]. Gene, 2017, 614: 15-20. Wang K, Li W, Bai Y, et al. ssc-miR-7134-3p regulates fat accumulation in castrated male pigs by targeting MARK4 gene[J]. International journal of biological sciences, 2017, 13(2): 189. Meng Q, Wang K, Liu X, et al. Identification of growth trait related genes in a Yorkshire purebred pig population by genome-wide association studies[J]. Asian-Australasian journal of animal sciences, 2017, 30(4): 462. Yang W, Bai Y, Wang X, et al. Attaching biosynthesized bacterial magnetic particles to polyethylenimine enhances gene delivery into mammalian cells[J]. Journal of biomedical nanotechnology, 2016, 12(4): 789-799. Wang K, Liu D, Hernandez-Sanchez J, et al. Genome wide association analysis reveals new production trait genes in a male Duroc population[J]. PloS one, 2015, 10(9): e0139207. Bai Y, Zhang J B, Xue Y, et al. Differential expression of CYB5A in Chinese and European pig breeds due to genetic variations in the promoter region[J]. Animal genetics, 2015, 46(1): 16-22. Chen G, Bai Y, Ren L, et al. Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process[J]. PloS one, 2015, 10(1): e113194. Bai Y, Huang J M, Liu G, et al. A comprehensive microRNA expression profile of the backfat tissue from castrated and intact full-sib pair male pigs[J]. BMC genomics, 2014, 15(1): 47. Kang X, Liu G, Liu Y, et al. Transcriptome profile at different physiological stages reveals potential mode for curly fleece in Chinese tan sheep[J]. PloS one, 2013, 8(8): e71763. Yang W, Kang X, Yang Q, et al. Review on the development of genotyping methods for assessing farm animal diversity[J]. Journal of animal science and biotechnology, 2013, 4(1): 2. Kang X, Liu G, Liu Y, et al. Transcriptome profile at different physiological stages reveals potential mode for curly fleece in Chinese tan sheep[J]. PloS one, 2013, 8(8): e71763. Chen G, Li S, Dong X, et al. Investigation of testosterone, androstenone, and estradiol metabolism in HepG2 cells and primary culture pig hepatocytes and their effects on 17βHSD7 gene expression[J]. PloS one, 2012, 7(12): e52255. Dong X, Bai Y, Xin Y, et al. Investigation on the transcription factors of porcine 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase genes[J]. Gene, 2012, 499(1): 186-190. Huang J, Yang Y, Liu G, et al. Molecular cloning and characterization of the porcine FTO promoter and coding regions[J]. Molecular biology reports, 2011, 38(4): 2855-2862. Yang Y Z, Bai Y, Dong X X, et al. Expression Analysis of HIF-1 az and HIF-2az Genes in Tibetan Chicken under Normoxia and Hypoxia[J]. Journal of Animal and Veterinary Advances, 2011, 10(16): 2172-2175. Liu G, Liu Y, Zhang H, et al. Genetic variations and sequences analysis of MTATP6 and MTATP8 genes among different Chinese pig breeds[J]. Journal of Animal Breeding and Genetics, 2010, 127(6): 474-480. Huang J, Liu G, Liu Y, et al. Splice variant identification and expression analysis of the fat mass and obesity-associated (FTO) gene in intact and castrated male pigs[J]. DNA and cell biology, 2010, 29(12): 729-733. Fang M, Liu C, Zhao X, et al. Sequences and polymorphisms of exons 3 and 4 in porcine UCP~ 2 gene[J]. PROGRESS IN NATURAL SCIENCE, 2002, 12(7): 551-552. Fang M, Hu X, Jin W, et al. Genetic uniqueness of Chinese village pig populations inferred from microsatellite markers[J]. Journal of animal science, 2009, 87(11): 3445-3450. Fang M, Larson G, Ribeiro H S, et al. Contrasting mode of evolution at a coat color locus in wild and domestic pigs[J]. PLoS Genetics, 2009, 5(1): e1000341. Fang M, Andersson L. Mitochondrial diversity in European and Chinese pigs is consistent with population expansions that occurred prior to domestication[J]. Proceedings of the Royal Society of London B: Biological Sciences, 2006, 273(1595): 1803-1810. Fang M, Berg F, Ducos A, et al. Mitochondrial haplotypes of European wild boars with 2n= 36 are closely related to those of European domestic pigs with 2n= 38[J]. Animal genetics, 2006, 37(5): 459-464. Fang M, Braunschweig M, Hu X, Hu L, et al. Genetic variation of exon 2 of SLA-DQB gene in Chinese pigs[J]. Biochemical genetics, 2005, 43(3-4): 119-125. Fang M, Hu X, Jiang T, et al. The phylogeny of Chinese indigenous pig breeds inferred from microsatellite markers[J]. Animal genetics, 2005, 36(1): 7-13. Fang M, Zhao X, Li N, et al. Genetic analysis on 3′-terminal flanking region of uncoupling protein 3 in different pig breeds[J]. Chinese Science Bulletin, 2002, 47(18): 1541-1543. 王珏,刘成琨,刘德武,王克君,陈洁,吴珍芳,方美英.基于不同密度SNP芯片在杜洛克公猪中的全基因组选择效果分析[J].中国畜牧杂志,2019,55(12):75-79. 徐芹芹,刘玉芳,康晓龙,方美英.滩羊Eph A3基因克隆表达分析及生物信息学初步研究[J].中国畜牧杂志,2019,55(03):33-38. 刘玉芳, 康晓龙, 方美英. 滩羊 FGF21 基因 CDS 区克隆表达及生物信息学分析[J].中国畜牧杂志, 2016, 52(13): 23-28. 陈洁, 白莹, 徐芹芹, 等. 猪 PLSCR4 基因外显子区 PCR-RFLP 遗传多态性分析[J]. 中国畜牧杂志, 2013, 49(11): 1-4. 杨云周, 张吉斌, 方美英. 低氧诱导因子-1α 基因在藏鸡低氧适应机制中的研究进展[J]. 中国畜牧兽医, 2011, 38(12): 84-87. 张吉斌, 刘月平, 方美英. 线粒体 ATP 合酶基因组成及生化机制研究进展[J]. 中国畜牧杂志, 2010, 7: 64-68. 方美英, 刘剑锋, 张勤, 等. 加速优秀基因传递开辟动物遗传育种新时代[J]. 中国农村科技, 2016 (6): 61-63. 方美英. 中国地方猪种对世界猪种培育的贡献——来自分子遗传及进化数据的分析[J]. 中国地方猪种保护与利用第十届年会论文集, 2013. 方美英, 吴常信. 猪的毛色遗传[J]. 中国畜牧杂志, 2002, 38(2): 51-52. 方美英, 胡晓湘, 李宁, 等. 小梅山, 中梅山及大约克猪的 SLA—DQB 基因外显子 2 PCR—RFLP 多态性分析[J]. 遗传学报, 2002, 29(8): 685-687. 方美英, 吴常信. 猪品种遗传多样性的研究进展[J]. 畜牧与兽医, 2001, 33(5): 40-42. 著作 主编《家养动物驯化与品种培育》 参编“十二五”普通高等教育本科国家级规划教材《动物遗传学》(第二版) 参编《动物种业科技创新战略研究报告》(国家科技部组织)

学术兼职

国家畜禽遗传资源委员会猪专业委员会委员 第三次全国猪遗传资源普查技术专家组成员 全国科技平台标准化技术委员会委员 畜禽遗传改良北京市重点实验室副主任 中国动物遗传育种学会理事 全国动物生物技术学会理事

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