个人简介

Jason first became interested in organic chemistry while preparing for the 1996 and 1997 International Chemistry Olympiad competitions. He received A.B. and A.M. degrees in 2001 from Harvard University, where he worked with Matthew D. Shair. After two years as a medicinal chemist at Enanta Pharmaceuticals (Watertown, MA), he joined K. C. Nicolaou’s group at The Scripps Research Institute. In 2008, he completed Ph.D. studies on the total synthesis and biological evaluation of uncialamycin. After postdoctoral research in the Nicolaou group and co-authoring Classics in Total Synthesis III, he joined the faculty in 2011.

研究领域

Organic synthesis and Chemical biology

Multi-step synthesis of complex organic molecules provides a demanding test of synthetic reactions and strategies, serving both to inspire development of useful transformations and to measure progress in the field. Equally importantly, organic synthesis is a powerful tool for accessing potentially-useful molecules, both natural and designed. For example, a flexible synthesis allows access to analogues for comparative studies (e.g., biological assays). Systematic probing of the effects of structural modifications leads to an atomic-level understanding of structure-property relationships, enabling the design of compounds with tailored properties. One area of research in the Chen group is the synthesis and evaluation of compounds with potential applications in biology or medicine. Our targets are scarce marine natural products with structures that draw attention to shortcomings in the synthetic toolbox. We are inspired by the need for flexible selectivity; rather than focus on one stereo- or regioisomer of a product, we design synthetic approaches that should be amenable to flexible analoguing. Current targets include an immunostimulant, an anticancer agent, and a structurally-unprecedented alkaloid. Another research thrust in the group is the development of practical biorenewable monomeric and polymeric materials. We are interested in practical and scalable syntheses of molecularly well-defined materials with interesting and tunable properties. Of particular interest are materials that can respond to environmental cues in a pre-defined manner, either reversibly or irreversibly. Current interests include the design and synthesis of biorenewable diisocyanates and polyurethanes (see our ChemSusChem paper in 2013).

近期论文

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M. D. Zenner, Y. Xia, J. S. Chen, M. R. Kessler, Polyurethanes from isosorbide-based diisocyanates, ChemSusChem 2013, 6, 1182 – 1185. X. Jiang, L. Shi, H. Liu, A. H. Khan, J. S. Chen, Gas extrusion in natural products total synthesis, Org. Biomol. Chem. 2012, 10, 8383 – 8392. K. C. Nicolaou, N. L. Simmons, Y. Ying, P. M. Heretsch, J. S. Chen, Enantioselective dichlorination of allylic alcohols, J. Am. Chem. Soc. 2011, 133, 8134 – 8137. K. C. Nicolaou, J. S. Chen, H. Zhang, A. Montero, Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin, Angew. Chem., Int. Ed. 2008, 47, 185 – 189. K. C. Nicolaou, H. Zhang, J. S. Chen, J. J. Crawford, L. Pasunoori, Total synthesis and stereochemistry of uncialamycin, Angew. Chem., Int. Ed. 2007, 46, 4704 – 4707.