段新华 - 西安交通大学

个人简介

Education 2002-2007 Ph.D., Organic Chemistry, Lanzhou University, Lanzhou, China. (Supervisor: Prof. Yong-Min Liang) 1997-2001 B.S., Applied Chemistry, Ningxia University, Yinchuan, China. Research Experience 2016-present Professor 2010-2015 Associate Professor Department of Chemistry, School of Science, Xi'an Jiaotong University 2008-2010 Postdoctoral Fellow Department of Chemistry, Ludwit-Maximilians-Universit ä t M ü nchen, Germany. (Supervisor: Prof. Herbert Mayr) 2007-2008 Postdoctoral Fellow Institut de Chimie des Substances Naturelles (ISCN), Centre National de la Recherche Scientifique (CNRS), France. (Supervisor: Prof. Jieping Zhu) Awards and Honors The Second-Class Award for Progress in Science and Technology of Gansu Province, 2008 "Haizheng" Graduate Award, Lanzhou University, 2006 段新华，西安交通大学理学院化学系，教授，博士生导师。2007年博士毕业于兰州大学功能有机分子化学国家重点实验室。获理学博士学位。主要从事过渡金属催化的杂环化合物合成研究。2007-2008年在法国国家科学研究中心(CNRS)下属的天然物质化学研究所(ICSN)从事博士后研究，师从有机合成化学家Jieping Zhu教授。从事具有重要药物活性羟吲哚化合物的合成研究。2008-2010年在德国慕尼黑大学化学系从事博士后研究，师从Herbert Mayr 教授。2010年入职西安交通大学，现任理学院副院长

研究领域

Our group current research interests are the development of new synthetic methodologies, strategies and transition-metal catalyzed tandem processes for the rapid construction of biologically active heterocycles. (1) Transition-metal Catalyzed Decarboxylative Cross-coupling Reaction Transition-metal catalyzed decarboxylative cross-coupling reactions using simple carboxylic acids as coupling partners have emerged as a new type of C-C bond formation reaction. In these reactions, using readily available and stable carboxylic acids instead of organometallic reagents enabled the decarboxylative cross-coupling reactions to proceed with good selectivities and tolerance of functional groups (2) Synthesis of Heterocycles Heterocycles represent a larger group of organic compounds and play a significant role in life processed and in all aspects of pure and applied chemistry. Nitrogen-containing heterocycles are an component of not only some of the most interesting and biologically important natural products, such as alkaloids, carbohydrates, nucleic acids, and antibiotics but include numerous potent pharmaceutical drugs and a large amount of synthetic organic compounds

近期论文

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Vsible Light Driven Alkylation of C(sp3)−H Bonds Enabled by 1,6-Hydrogen Atom Transfer/Radical Relay Addition . Zhi-Yong Ma, Li-Na Guo, Ying You, Fan Yang, Mingyou Hu, and Xin-Hua Duan Org. Lett. 2019, DOI: 10.1021/acs.orglett.9b01804 Copper-Catalyzed Cyanoalkylation of Amines via C–C Bond Cleavage: An Approach for C(sp3)–N Bond Formations. Lin Yang, Jia-Yu Zhang, Xin-Hua Duan, Pin Gao, Jiao Jiao, and Li-Na Guo J. Org. Chem. 2019, DOI: 10.1021/acs.joc.9b01084 Iminyl Radical-Triggered 1,5-Hydrogen-Atom Transfer/Heck-Type Coupling by Visible-Light Photoredox Catalysis. Li Chen, Li-Na Guo, Zhi-Yong Ma, Yu-Rui Gu, Junjie Zhang, and Xin-Hua Duan J. Org. Chem. 2019, 84, 6475. DOI: 10.1021/acs.joc.9b00525 Iminyl Radical-Triggered Intermolecular Distal C(sp3)−H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade. Yu-Rui Gu, Xin-Hua Duan, Li Chen, Zhi-Yong Ma, Pin Gao, and Li-Na Guo Org. Lett. 2019, 21, 917. DOI: 10.1021/acs.orglett.8b03865 Transition-Metal Free C–C Bond Cleavage/Borylation of Cycloketone Oxime Esters. Jin-Jiang Zhang, Xin-Hua Duan, Yong Wu, Jun-Cheng Yang and Li-Na Guo Chem. Sci. 2019, 10, 161. DOI: 10.1039/c8sc03315c Iminyl Radical-Mediated Controlled Hydroxyalkylation of Remote C(sp3)-H Bond via Tandem 1,5-HAT and Difunctionalization of Aryl Alkenes. Zhi-Yong Ma, Li-Na Guo, Yu-Rui Gu, Li Chen, and Xin-Hua Duan Adv. Synth. Catal. 2018, 360, 4341. DOI: 10.1002/adsc.201801198 Iron-Catalyzed Decarboxylative Olefination of Cycloketone Oxime Esters with α,β-Unsaturated Carboxylic Acids via C-C Bond Cleavage. Jing-Feng Zhao, Xin-Hua Duan, Yu-Rui Gu, Pin Gao, and Li-Na Guo Org. Lett. 2018, 20, 4614. DOI: 10.1021/acs.orglett.8b01901 Redox-Neutral Cyanoalkylation/Cyclization of Olefinic 1,3‑Dicarbonyls with Cycloketone Oxime Esters: Access to Cyanoalkylated Dihydrofurans. Jia-Yu Zhang, Xin-Hua Duan, Jun-Cheng Yang, and Li-Na Guo J. Org. Chem. 2018, 83, 4239. DOI: 10.1021/acs.joc.8b00271 Iron-Catalyzed Ring-Opening/Allylation of Cyclobutanone Oxime Esters with Allylic Sulfones. Jing-Feng Zhao, Pin Gao, Xin-Hua Duan, and Li-Na Guo Adv. Synth. Catal. 2018, 360, 1775. DOI: 10.1002/adsc.201701630 Metal-Free, Visible-Light-Promoted Decarboxylative Radical Cyclization of Vinyl Azides with N‑Acyloxyphthalimides. Jun-Cheng Yang, Jia-Yu Zhang, Jin-Jiang Zhang, Xin-Hua Duan, and Li-Na Guo J. Org. Chem. 2018, 83, 1598. DOI: 10.1021/acs.joc.7b02861 Direct C−H Cyanoalkylation of Quinoxalin-2(1H)‑ones via Radical C−C Bond Cleavage. Lin Yang, Pin Gao, Xin-Hua Duan, Yu-Rui Gu, and Li−Na Guo Org. Lett. 2018, 20, 1034. DOI: 10.1021/acs.orglett.7b03984 Direct C–H Functionalization of Heteroarenes via Redox-Neutral Radical Process: A Facile Route to C–C Bonds Formation. Pin Gao, Yu-Rui Gu, Xin-Hua Duan Synthesis 2017, 49, 3407. Invited Article DOI: 10.1055/s-0036-1588493 Visible-Light-Mediated Dual Decarboxylative Coupling of Redox-Active Esters with α,β-Unsaturated Carboxylic Acids. Jin-Jiang Zhang, Jun-ChengYang, Li-Na Guo,and Xin-Hua Duan Chem. Eur. J. 2017, 23,10259. Hot Paper DOI: 10.1002/chem.201702200 Recent Advances in Persulfates-Promoted Radical Reaction. Jing-Feng Zhao, Xin-Hua Duan, and Li-Na Guo Chin. J. Org. Chem. 2017, 37, 2498. Invited Article DOI: 10.6023/cjoc201705003 Direct C−H Cyanoalkylation of Heteroaromatic N-Oxides and Quinones via C−C Bond Cleavage of Cyclobutanone Oximes. Yu-Rui Gu, Xin-Hua Duan, Lin Yang, and Li-Na Guo, Org. Lett. 2017, 19, 5908. DOI: 10.1021/acs.orglett.7b02902 Recent Advances in Catalytic Decarboxylative Acylation Reactions via a Radical Process Li-Na Guo, Hua Wang, and Xin-Hua Duan Org. Biomol. Chem. 2016, 14, 7380. Invited Article DOI: 10.1093/c6ob01113f Palladium-Catalyzed Alkylarylation of Acrylamides with Unactivated Alkyl Halides Hua Wang, Li-Na Guo, and Xin-Hua Duan J. Org. Chem. 2016, 81, 860. DOI: 10.1021/acs.joc.5b02433 Transition-Metal-Free Oxyfluorination of Olefinic Amides for the Synthesis of Fluorinated Heterocycles Jing-Feng Zhao, Xin-Hua Duan, Hua Yang, and Li-Na Guo J. Org. Chem. 2015, 80, 11149. DOI: 10.1021/acs.joc.5b01909 Alkynylation of Tertiary Cycloalkanols via Radical C−C Bond Cleavage: A Route to Distal Alkynylated Ketones Shun Wang, Li-Na Guo, Hua Wang and Xin-Hua Duan Org. Lett. 2015, 17, 4798. DOI: 10.1021/acs.orglett.5b02353 Decarboxylative Alkynylation of alpha-Keto Acids and Oxamic Acids in Aqueous Media Hua Wang, Li-Na Guo, Shun Wang and Xin-Hua Duan Org. Lett. 2015, 17, 3054. DOI: 10.1021/acs.orglett.5b01336