段新华 - 西安交通大学

个人简介

教育经历 2002 – 2007 Ph.D., Organic Chemistry, Lanzhou University, Lanzhou, China. (Supervisor:Prof. Yong-Min Liang) 1997 – 2001 B.S., Applied Chemistry, Ningxia University, Yinchuan, China. 科研经历 2020 – 至今教授西安交通大学化学学院 2016 – 2020 教授西安交通大学理学院 2010 – 2015 副教授西安交通大学理学院 2008 – 2010 博士后德国慕尼黑大学化学学院 (指导老师: Prof. Herbert Mayr) 2007 – 2008 博士后法国国家科学研究中心(CNRS)自然物质化学研究所(ISCN)(指导老师: Prof. Jieping Zhu)

研究领域

Our group current research interests are the development of new synthetic methodologies, strategies and transition-metal catalyzed tandem processes for the rapid construction of biologically active heterocycles. (1) Transition-metal Catalyzed Decarboxylative Cross-coupling Reaction Transition-metal catalyzed decarboxylative cross-coupling reactions using simple carboxylic acids as coupling partners have emerged as a new type of C-C bond formation reaction. In these reactions, using readily available and stable carboxylic acids instead of organometallic reagents enabled the decarboxylative cross-coupling reactions to proceed with good selectivities and tolerance of functional groups (2) Synthesis of Heterocycles Heterocycles represent a larger group of organic compounds and play a significant role in life processed and in all aspects of pure and applied chemistry. Nitrogen-containing heterocycles are an component of not only some of the most interesting and biologically important natural products, such as alkaloids, carbohydrates, nucleic acids, and antibiotics but include numerous potent pharmaceutical drugs and a large amount of synthetic organic compounds

近期论文

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Zhao, Y.; Shan, Q.-C.; Xin, H.; Gao, P.; Yang, X.; Duan, X.-H.; Guo, L.-N.* Nickel-Catalyzed Carbonylative Four-Component 1,4-Dicarbofunctionalization of 1,3-Enynes. Sci. China Chem. 2024, DOI: 10.1007/s11426-024-1973-2. Xin, H.; Yang, M.; Guan, C.; Li, J.; Gao, P.; Yang, X.; Duan, X.-H.; Guo, L.-N.* Iron-Catalyzed Cyanide-Free Synthesis of Alkyl Nitriles: Oxidative Deconstruction of Cycloalkanones with Ammonium Salts and Aerobic Oxidation. Org. Lett. 2024, DOI: 10.1021/acs.orglett.4c00458. Tao, J.-Q.; Liu, S.; Zhang, T.-Y.; Xin, H.; Gao, P.; Yang, X.; Duan, X.-H.; Guo, L.-N.* Photoinduced Copper-Catalyzed Alkoxyl Radical-Triggered Ring-Expansion/Aminocarbonylation Cascade. Chinese Chemical Letters, 2024, DOI: 10.1016/j.cclet.2023.109263. Miao, H.-J.; Zhang, J.-H.; Li, W.; Yang, W.; Xin, H.; Gao, P.; Duan, X.-H.; Guo, L.-N.* Aromatization-Driven Deconstructive Functionalization of Spiro Dihydroquinazolinones via Dual Photoredox/Nickel Catalysis. Chem. Sci. 2024, DOI: 10.1039/d4sc01111b. Zhang, J.-H.; Miao, H.-J.; Xin, H.; Wang, G.; Yang, X.; Wang, X.; Gao, P.; Duan, X.-H.; Guo, L.-N.* Photoredox-Catalyzed Alkylarylation of Activated Alkenes via a Ring-Opening/Truce–Smiles Rearrangement Cascade. Chem. Commun. 2024, DOI: 10.1039/d4cc01324g. Shan, Q.-C.; Zhao, Y.; Liu, S.; Wang, S.-T.; Xu, Y.; Liu, H.-F.; Duan, X.-H.; Guo, L.-N.* Nickel-Catalyzed Modular Four-Component 1,4-Alkylcarbonylation of 1,3-Enynes to Tetra-Substituted CF3-Allenyl Ketones. ACS Catal. 2024, DOI: 10.1021/acscatal.3c05776. Guo, Q.; Zhang, J.-D.; Chen, Y.-J.; Zhang, K.-Y.; Guo, L.-N.; Shan, Q.-C.; Lu, J.-L.; Duan, X.-H.* ; Wu, L.-Z. Enhanced Hydrogen Evolution Activity of CsPbBr3 Nanocrystals Achieved by Dimensionality Change. Chem. Commun. 2023, DOI: 10.1039/d2cc06731e. Xin, H.; Guo, L.-N.; Yang, M.; Guan, C.; Yuan, Z.-H.; Duan, X.-H.* Photoredox-Catalyzed Sequential Dowd–Beckwith Ring Expansion and C–H Functionalization of THIQs Org. Chem. Front. 2023, DOI: 10.1039/d2qo02001g. Zhang, L.; Liu, S.; Ma, M.; Shen, Y.; Gao, P.; Guo, L.-N.; Duan, X.-H.* Metal-Free and Visible Light-Induced Difunctionalizations of α-CF3 Styrenes with Aryl Diazonium Salts and Hetero Nucleophiles. Eur. J. Org. Chem. 2023, DOI: 10.1002/ejoc.202300846. Miao, H.-J.; Zhang, J.-H.; Liu, S.; Wang, W.-H.; Xu, Y.; Duan, X.-H.; Xin, H.; Liu, L.; Guo, L.-N.* Alkoxyl Radical-Mediated Ring Expansion/1,4-Difunctionalization of 1,3-Enynes upon Copper Catalysis. Org. Lett. 2023, DOI: 10.1021/acs.orglett.3c01809. Bai, M.; Liu, S.; Xin, H.; Xu, Y.; Duan, X.-H.; Xin, H.; Liu, L.; Guo, L.-N.* Iron-Catalyzed Alkoxyl Radical-Mediated C–C Bond Cleavage/Phosphorothiolation: A New Approach to Functionalized S-Alkyl Phosphorothioates. Org. Biomol. Chem. 2023, DOI: 10.1039/d3ob00673e. Ma, Y.-J.; Yuan, Z.-H.; Gao P.; Duan, X.-H.; Xin, H.; Liu, L.; Guo, L.-N.* Divergent Construction of Azaheterocycles via Alkoxyl Radical-Triggered C−C Bond Cleavage/Cyclization of N‑Functionalized Acrylamides. J. Org. Chem. 2023, DOI: 10.1021/acs.joc.3c00695. Yuan, Z.-H.; Xin, H.; Zhang, L.; Gao P.; Yang X.; Liu, L.; Duan, X.-H.; Guo, L.-N.* Metal-Free, Visible-Light Driven α-C(sp3)–H gem-Diﬂuoroallylation of Glycine Derivatives with Triﬂuoromethyl Alkenes and 1,3-Enynes Green Chem. 2023, DOI: 10.1039/d3gc01750h. Liu, S.; Ma, P.; Zhang, L.; Shen, S.; Miao, H.-J.; Liu, L.; Houk, K. N.; Duan, X.-H.; Guo, L.-N.* A Cheap Metal Catalyzed Ring Expansion/Cross-Coupling Cascade: A New Route to Functionalized Medium-Sized and Macrolactones. Chem. Sci. 2023, DOI: 10.1039/d2sc06157k. Zhang, T.-Y.; Wu, Y.; Liu, S.; Tao, J.-Q.; Yang, X.; Wang, X.-Q.; Duan, X.-H.; Guo, L.-N.* Iron-Catalyzed Alkoxyl Radical-Induced C–C Bond Cleavage/gem-Difluoroalkylation Cascade. Org. Lett. 2023, DOI: 10.1021/acs.orglett.3c01427. Liu, S.; Zhang, L.; Xu, L.; Gao, P.; Duan, X.-H.; Guo, L.-N.* Fe-Catalyzed Alkylazidation of α-Trifluoromethylalkenes: An Access to Quaternary Stereocenters Containing CF3 and N3 Groups. Org. Lett. 2023, DOI: 10.1021/acs.orglett.3c00439. Shan, Q.-C.; Liu, S.; Shen, Y.; Ma, M.; Duan, X.-H.; Gao, P.; Guo, L.-N.* Switchable In Situ SO2 Capture and CF3 Migration of Enol Triflates with Peroxyl Compounds under Iron Catalysis. Org. Lett. 2022, DOI: 10.1021/acs.orglett.2c02663. Yuan, Z.-H.; Xin, H.; Tao, J.-Q.; Ma, Y.-J.; Duan, X.-H.; Guo, L.-N.* Thermo-Induced Decarboxylative α-C(sp3)–H Fluoroalkylation of Glycine Derivatives with Fluorinated Peroxy Esters. Org. Chem. Front. 2022, DOI: 10.1039/d2qo00613h. Liu, L.; Duan, X.-H.; Guo, L.-N.* Recent Advance in Iminyl Radical Triggered C–H and C–C Bond Functionalization of Oxime Esters via 1,5-HAT and β-Carbon Scission. Synthesis 2021, DOI: 10.1055/a-1545-6874. Chen, H.; Guo, L.-N.*; Sun, Q.-X.; Chen, L.; Tao, J.-Q.; Gao, P.* Copper-Catalyzed Redox Neutral Ketoalkylation of Csp2–H Bonds via C–C Bond Cleavage. Org. Chem. Front. 2021, DOI: 10.1039/d1qo00882j. Sun, Q.-X.; Chen, H.; Liu, S.; Wang, X.-Q.; Duan, X.-H.; Guo, L.-N.* Iron-Catalyzed Thiolation and Selenylation of Cycloalkyl Hydroperoxides via C–C Bond Cleavage. J. Org. Chem. 2021, 86, 11987 Visible Light-Driven, Copper-Catalyzed Aerobic Oxidative Cleavage of Cycloalkanones. Hong Xin, Xin-Hua Duan, Mingyu Yang, Yiwen Zhang, and Li-Na Guo J. Org. Chem. 2021, 86, 8263. Sulfonamide as Photoinduced Hydrogen-Atom Transfer Catalyst for Regioselective Alkylation of C(sp 3 )−H Bonds Adjacent to Heteroatoms Zhi-Yong Ma, Mengyang Li, Li-Na Guo, Le Liu, Dongdong Wang, and Xin-Hua Duan Org. Lett. 2021, 23, 474. Visible-Light-Driven Palladium-Catalyzed Dowd–Beckwith Ring Expansion/C–C Bond Formation Cascade. Li Chen, Li-Na Guo, Shuai Liu, Le Liu, and Xin-Hua Duan Chem. Sci. 2021, 12, 1791. Visible-Light-Induced anti-Markovnikov Hydrosulfonation of Styrene Derivatives Yinan Zheng, Ying You, Qianqian Shen, Junjie Zhang, Le Liu, and Xin-Hua Duan Org. Chem. Front. 2020, 7, 2069. Metal-Free, Visible-Light-Induced Selective C-C Bond Cleavage of Cycloalkanones with Molecular Oxygen. Hong Xin, Xin-Hua Duan, Le Liu, and Li-Na Guo Chem. Eur. J. 2020, 26, 11690. Copper-Catalyzed Alkylarylation of Vinylarenes with Cycloalkylsilyl Peroxides and Boronic Acids. Shuo Yang, Pin Gao, Meng-Ting Suo, Shu-Xin Gao, Xin-Hua Duan, and Li-Na Guo Chem. Commun. 2020, 56, 10714. Nickel-catalyzed Suzuki Coupling of Cycloalkyl Silyl Peroxides with Boronic Acids. Lei Chen, Jun-Cheng Yang, Pengfei Xu, Jun-Jie Zhang, Xin-Hua Duan, and Li−Na Guo J. Org. Chem. 2020, 85, 7515. Iron(II)-Catalyzed Direct C-H Cyanoalkylation of 2H-indazoles and Coumarins via Radical C-C Bond Cleavage. Pin Gao, Yuan-Bo Cheng, Fan Yang, Li-Na Guo, and Xin-Hua Duan