余建东 - 暨南大学 - 粤港澳中枢神经再生研究院

个人简介

余建东，男，博士，粤港澳中枢神经再生研究院副教授。2003年毕业于北京师范大学生命科学学院生物技术系，获理学学士学位；2009年毕业于中国科学院生物物理研究所，获生物物理学博士学位。2010至2015年在美国罗格斯大学新泽西医学院从事博后研究，主要研究癫痫发病机制，并获美国Epilepsy Foundation的fellowship。2015年加入暨南大学。科研项目 1. 2017/1-2020/12 国家自然科学基金（面上基金），项目名：电突触在颞叶癫痫海马抑制性神经元死亡中的作用及其分子机制研究（81671288）；资助金额：57万元。项目负责人。

研究领域

主要研究方向为癫痫，大脑损伤后的修复和亨廷顿舞蹈症，帕金森综合症以及阿尔兹海默症等神经退行性疾病的细胞转化治疗。

近期论文

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1. Jiandong Yu, Bogumila Swietekb, Archana Prodduturb, Vijayalakshmi Santhakumar (2016). Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. Neurobiol Dis. 89, 23-35. 2. Jiandong Yu, Archana Proddutur, Bogumila Swietek, Fatima S. Elgammal and Vijayalakshmi Santhakumar(2016). Functional reduction in Cannabinoid-Sensitive Heterotypic Inhibition of Dentate Basket Cells in Epilepsy: Impact on Network Rhythms. Cerebral Cortex. 26(11): 4299-4314. （封面文章） 3. Jiandong Yu, Bogumila Swietek, Archana Proddutur, and Vijayalakshmi Santhakumar (2015). Dentate total molecular layer interneurons mediate cannabinoid-sensitive inhibition. Hippocampus. 25(8):884-9. 4. Archana Proddutur, Jiandong Yu, Fatima S. Elgammal, and Vijayalakshmi Santhakumar (2013) Seizure-induced alterations in fast-spiking basket cell GABA currents modulate frequency and coherence of gamma oscillation in network simulations. Chaos: An Interdisciplinary Journal of Nonlinear Science 23 (4), 046109. （封面文章） 5. Jiandong Yu*, Archana Proddutur*, Fatima S. Elgammal, Takahiro Ito, and Vijayalakshmi Santhakumar (2013) Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells. J. Neurophysiology 109 (7), 1746-1763.(* Co-first author) 6. Jiandong Yu, Jinhui Wang (2012) Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes. Mol Brain. Aug 1; 5:26. 7. Jiandong Yu, Hao Qian, Na Chen, Jinhui Wang (2011) Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks. PLoS ONE. Sep 20; 6(9): e25219. 8. Na Chen, Jiandong Yu, Qian H, Ge R and Jinhui Wang (2010) Axons amplify somatic incomplete spikes into uniform amplitudes in mouse cortical pyramidal neurons. PLoS ONE. Jul 29; 5(7):e11868. 9. Jinhui Wang, Jian Wei, Xin Chen, Jiandong Yu, Na Chen, Jack Shi (2008) Gain and fidelity of transmission patterns at cortical excitatory unitary synapses improve spike encoding. J Cell Science 121(17) 2951-2960. 10. Na Chen, Xin Chen, Jiandong Yu and Jinhui Wang (2006) Afterhyperpolarization improves spike programming through lowering threshold potentials and refractory periods mediated by voltage-gated sodium channels. Biochemical and Biophysical Research Communications, 346(3), 938-945.