陈功 - 暨南大学 - 粤港澳中枢神经再生研究院

个人简介

陈功( Gong Chen )博士于1987 年毕业于上海复旦大学，随后师从中国科学院上海生理研究所冯德培院士攻读博士学位。先后在耶鲁大学和斯坦福大学进行博士后研究。2002年加入宾夕法尼亚州立大学( Pennsylvania State University )，2013年升任维恩魏勒曼冠名主任教授。2019年辞去宾夕法尼亚州立大学的终身教授席位，全职加入暨南大学粤港澳神经再生研究院，建立大脑修复中心，为解决重大脑疾病探索神经再生的新途径。主要成就陈功教授是国际上最早在成年哺乳类动物上运用大脑内源性胶质细胞原位直接转分化为功能性神经元的先驱者之一。近年来发表了一系列的大脑原位神经再生工作，包括首次在非人灵长类的大脑里实现原位胶质细胞向神经元的直接转分化。陈功教授团队还创造性地发明了小分子组合物将体外培养的人脑胶质细胞直接转化为功能性神经元。2014 年，陈功教授在华盛顿神经科学大会上主持了世界上首次“在体细胞转化” 的专题报告会，标志着再生医学领域的一个新的里程碑。2016年受邀 Neuron 杂志发表了关于大脑原位神经再生技术的前瞻性综述，为这一新领域的发展指明了方向。

研究领域

大脑原位神经再生技术在治疗脑中风，老年痴呆症，帕金森综合症，亨廷顿舞蹈症，脑损伤，脊髓损伤，脊髓侧索硬化症（ALS），以及脑胶质瘤等一系列重大中枢神经疾病中的应用。

近期论文

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Liu MH, Li W, Zheng JJ, Xu YG, He Q, Chen G. Differential neuronal reprogramming of astrocytes in the grey matter and white matter. Neural Regen Res. 2020 Feb;15(2):342-351. Lei W, Li W, Ge L, Chen G. Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains. Front Neurosci. 2019 Feb 21;13:131. Yu-Chen Chen, Ning-Xin Ma, Zi-Fei Pei, Zheng Wu, Fabricio H. Do-Monte, Susan Keefe, Emma Yellin, Miranda S. Chen, Jiu-Chao Yin, Grace Lee, Angélica Minier- Toribio , Yi Hu, Yu-Ting Bai, Kathryn Lee, Gregory J. Quirk, Gong Chen. (2019) A NeuroD1 AAV-Based Gene Therapy For Functional Brain Repair After Ischemic Injury Through In Vivo Astrocyte-To-Neuron Conversion. Molecular Therapy, Sept. 6, 2019 online published. News Press: https://scienmag.com/gene-therapy-helps-functional-recovery-after-stroke/ Long-Jiao Ge, Fu-Han Yang, Jie Feng, Nan-Hui Chen, Min Jiang, Jian-Hong Wang, Xin-Tian Hu, Gong Chen. In Vivo Neuroregeneration to Treat Ischemic Stroke in Adult Non-Human Primate Brains through NeuroD1 AAV-based Gene Therapy. BioRxiv preprint first posted online Nov. 1, 2019. DOI: http://dx.doi.org/10.1101/816066 Brendan Puls, Yan Ding, Mengjie Pan, Lei Zhang, Cody Forsyth, Morgan Metzger, Tanvi Rana, Xiaoyun Ding, Matthew Keefe, Alice Cai, Austin Redilla, Michael Lai, Hedong Li, Gong Chen. Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion. BioRxiv preprint first posted online Oct. 31, 2019. DOI: http://dx.doi.org/10.1101/818823 Yin, J.C., Zhang, L., Ma, N.X., Wang, Y., Lee, G., Hou, X.Y., Lei, Z.F., Zhang, F.Y., Dong, F.P., Wu, G.Y., and Chen, G. (2019) Chemical Conversion of Human Fetal Astrocytes into Neurons through Modulation of Multiple Signaling Pathways. Stem Cell Reports, Feb. 7, 2019, online publication. DOI:https://doi.org/10.1016/j.stemcr.2019.01.003 News press: https://science.psu.edu/news-and-events/2019-news/Chen2-2019 Ma N.X., Yin J.C., Chen G. (2019) Transcriptome analysis of small molecule-mediated astrocyte-to-neuron reprogramming. Frontiers in Cell and Developmental Biology, accepted May 1, 2019. (https://www.frontiersin.org/articles/10.3389/fcell.2019.00082/abstract) Lei Zhang, Zhuofan Lei, Ziyuan Guo, Zifei Pei, Yuchen Chen, Fengyu Zhang, Alice Cai, Yung Kin Mok, Grace Lee, Vishal Swaminnathan, Fan Wang, Yuting Bai, Gong Chen. (2018) Reversing Glial Scar Back To Neural Tissue Through NeuroD1-Mediated Astrocyte-To-Neuron Conversion. BioRxiv, February 7th, 2018 online publishing. Hedong Li and Gong Chen. (2016) In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells. Neuron, 91:728-738. (Invited Review) Xin Tang, Julie Kim, Li Zhou, Eric Wengert, Lei Zhang, Zheng Wu, Cassiano Carromeu, Alysson R. Muotri, Maria C. N. Marchetto, Fred H. Gage, and Gong Chen. (2016) KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Proc Natl Acad Sci USA. Epub: 2016 Jan 5. Lei Zhang, Jiu-Chao Yin, Hana Yeh, Ning-Xin Ma, Grace Lee, Xiangyun Amy Chen, Yanming Wang, Li Lin, Li Chen, Peng Jin, Gang-Yi Wu* and Gong Chen*. (2015) Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons. Cell Stem Cell, 17:1-13, E-Pub on Oct. 15, 2015. Ziyuan Guo, Lei Zhang, Zheng Wu, Yuchen Chen, Fan Wang, and Gong Chen. (2014) In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model. Cell Stem Cell, 14: 188-202. E-pub on Dec. 19, 2013. Selected as one of the BEST of 2014 articles by Cell Stem Cell. Zhexing Wen*, Ha Nam Nguyen*, Ziyuan Guo*, Matthew Lalli, Xinyuan Wang, Yijing Su, Nam-Shik Kim, Ki-Jun Yoon, Jaehoon Shin, Ce Zhang, Georgia Makri, David Nauen, Humei Yu, Cheng-Hsuan Chiang, Nadine Yoritomo, Kozo Kaibuchi, Christopher Ross, Jizhong Zou, Kimberly Christian, Linzhao Cheng, Russell Magolis, Gong Chen, Kenneth Kosik, Elmer Guzman, Hongjun Song, and Guo-li Ming. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature, E-pub Aug. 17, 2014. Zheng Wu, Ziyuan Guo, Marla Gearing, Gong Chen. (2014) Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer's disease model. Nature Communications, June 13, 2014. Brennand, K., A. Simone, J. Jou, C. Gelboin-Burkhart, N. Tran, S. Sangar, Y. Li, Y. Mu, G. Chen, D. Yu, S. McCarthy, J. Sebat, and F. Gage. (2011) Modeling schizophrenia using human induced pluripotent stem cells. Nature 473: 221-225. Fan, Y., X. Tang, E. Vitriol, G. Chen, and J. Q. Zheng. (2011) Actin capping protein is required for dendritic spine development and synapse formation. Journal of Neuroscience 31(28): 10228-10233. Marchetto, M. C. N., C. Carromeu, A. Acab, D. Yu, G. Yeo, Y. Mu, G. Chen, F. H. Gage, and A. R. Muotri. (2010) A model for neural development and treatment of Rett Syndrome using human induced pluripotent stem cells. Cell 143: 527-539. Gu, J., C. W. Lee, Y. Fan, D. Komlos, X. Tang, C. Sun, K. Yu, H. C. Hartzell, G. Chen, J. R. Bamburg, and J. Q. Zheng. (2010) ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity. Nature Neuroscience 13: 1208-1215.