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1. Discrete forms of amylose are synthesized by isoforms of GBSSI in pea
Edwards, Anne, Vincken, Jean-Paul, Suurs, Luc C.J.M., Visser, Richard G.F., Zeeman, Samuel C., Smith, Alison M. and Martin, Cathie (2002)
Amyloses with distinct molecular masses are found in the starch of pea embryos compared with the starch of pea leaves. In pea embryos, a granule-bound starch synthase protein (GBSSIa) is required for the synthesis of a significant portion of the amylose. However, this protein seems...
Journal Items
2. Polymer-TiO2 nanocomposites
Nussbaumer, René J., Caseri, Walter R., Smith, Paul and Tervoort, Theo (2003)
Colloids of TiO2, where rutile was the only crystal modification which could be detected, with ca. 2.5 nm average particle diameter were synthesized by hydrolysis of TiCl4 in acidic solutions. The as-prepared particles were incorporated in polymers such as poly(vinyl alcohol)...
Journal Items
3. 'Latent' ultraviolet light absorbers
Kocher, Christoph, Weder, Christoph and Smith, Paul (2003)
We have synthesized and characterized photo-labile and acid-labile esters of 2-hydroxybenzophenone and 2-hydroxybenzotriazoles, which, upon appropriate treatment, release classical UV absorbers. Two concepts of 'latent' UV absorbers are presented, namely, benzoyl-caged species...
Journal Items
4. "(Hot-)Water-Proof", semiconducting, platinum-based chain structures: Processing, products, and properties
Caseri, W.R., Chanzy, H.D., Feldman, K., Fontana, M., Smith, Paul, Tervoort, T.A., Goossens, J.G.P., Meijer, E.W., Schenning, A.P.H.J., Dolbnya, I.R., Debije, M.G., Haas, Matthijs P. de, Warman, John M., Craats, A.M. van de, Friend, R.H., Sirringhaus, H. and Stutzmann, N. (2003)
A promising solution to the environmental instability of semiconducting organic materials is presented. Thin, highly ordered films (see Figure, a scanning probe microscopy image), fibers, and field-effect transistors (FETs), comprising chain-structures based on the so-called...
Journal Items
5. Design, synthesis, and properties of new biodegradable aromatic/aliphatic liquid crystalline copolyesters
Chen, Yiwang, Wombacher, Ralf, Wendorff, Joachim H., Visjager, Jeroen, Smith, Paul and Greiner, Andreas (2003)
Liquid crystalline copolyesters of high molecular weight were obtained by polycondensation of aromatic diols, diacyl dichlorides, oligolactides, and poly(ethylene glycol)s. Hydrophilicity of the copolyesters was controlled by the content of ethyleneoxy moieties as verified by...
Journal Items
6. The binary system isotactic polypropylene/bis(3,4-dimethylbenzylidene)sorbitol
Kristiansen, Magnus, Werner, Michael, Tervoort, E., Smith, Paul, Blomenhofer, Markus and Schmidt, Hans-Werner (2003)
The phase behavior of the binary system consisting of the commercial nucleating and clarifying agent 1,3:2,4-bis(3,4-dimethyldibenzylidene)sorbitol (DMDBS, Millad 3988) and isotactic polypropylene (i-PP) was investigated over the entire concentration range by means of differential...
Journal Items
7. Polyamides X.34
Ehrenstein, Moritz, Smith, Paul and Weder, Christoph (2003)
Full Paper: A new series of semi-crystalline polyamides (PA), which comprise extended aliphatic segments between the amide moieties and which display an interesting amphiphilic character has been synthesized and characterized. The polymers PA-2.34, PA-4.34, PA-8.34, PA-10.34, and...
Journal Items
8. Synergistic gelation of solutions of isotactic polypropylene and bis-(3,4-dimethyl benzylidene) sorbitol and its use in gel-processing
Kristiansen, Magnus, Tervoort, Theo and Smith, Paul (2003)
We report the synergistic, rapid gelation of solutions of isotactic polypropylene (i-PP) and the nucleating agent 1,3:2,4-bis-(3,4-dimethyl benzylidene) sorbitol (DMDBS) in decalin. Cooling to room temperature of a solution comprising, for instance, 3.0 wt% of a moderately high...
Journal Items
9. Dichroic Ultraviolet Light Filters
Kocher, Christoph, Weder, Christoph and Smith, Paul (2003)
With the intention to produce dichroic filters for use in photoluminescent systems that rely on polarized UV light, we synthesized a number of linear, dichroic dyes, which absorb mainly in the near-UV range of the electromagnetic spectrum. These dyes were designed for compatibility...
Journal Items
10. Hydrolytic and enzymatic degradation of liquid-crystalline aromatic/aliphatic copolyesters
Chen, Yiwang, Jia, Zhihong, Schaper, Andreas, Kristiansen, Magnus, Smith, Paul, Wombacher, Ralf, Wendorff, Joachim H. and Greiner, Andreas (2004)
Aromatic/aliphatic copolyesters containing hydrophilic moieties in the main chain or side chain were synthesized by bulk polycondensation of aromatic monomers without or with solubilizing substituents and aliphatic monomers. Hydrolytic and enzymatic degradation studies were carried...
Journal Items
11. Growth and anisotropic properties of highly oriented films of quasi-one-dimensional platinum compounds
Fontana, Margherita, Chanzy, Henri, Stutzmann, Natalie, Caseri, Walter R. and Smith, Paul (2004)
The semiconductors [Pt(NH(2)dmoc)(4)][PtCl4], where dmoc denotes (S)-3,7-dimethyloctyl, and [Pt(NH(2)eh)(4)][PtCl4], where eh is (R)-2-ethylhexyl, are soluble quasi-one-dimensional compounds with a backbone of linearly arranged platinum atoms. Uniaxially oriented films of those...
Journal Items
12. Facile synthesis of linear poly(dibutylstannane)
Choffat, Fabien, Smith, Paul and Caseri, Walter (2005)
We present a facile, high-yield synthetic route to linear poly( dibutylstannane) of relatively high molecular weight (M-w = 20 x 10(3) g mol(-1)) through dehydropolymerization of dibutylstannane with the catalyst [RhCl(PPh3)(3)]. Unlike previously synthesized polystannanes, the...
Journal Items
13. Crystalline-crystalline block copolymers of regioregular poly(3-hexylthiophene) and polyethylene by ring-opening metathesis polymerization
Radano, Christopher P., Scherman, Oren A., Stingelin-Stutzmann, Natalie, Müller, Christian, Breiby, Dag W., Smith, Paul, Janssen, René A.J. and Meijer, E.W. (2005)
Block copolymers of regioregular poly(3-hexylthiophene) (P3HT) and polyethylene (PE) were synthesized through the chain transfer of olefin-terminated P3HT in the presence of cyclooctene via ring-opening metathesis polymerization (ROMP). Subsequent hydrogenation of the...
Journal Items
14. Mechanical properties of sorbitol-clarified isotactic polypropylene
Kristiansen, Magnus, Tervoort, Theo and Smith, Paul (2005)
The solid-state structure and yield behavior of isotactic polypropylene (i-PP) containing the nucleating/clarifying agent 1,3:2,4-bis(3,4-dimethylbenzylidene)sorbitol (DMDBS) was investigated in the additive concentration range 0-1 wt %. The raise of the crystallization temperature...
Journal Items
15. Polymeric quasi-one-dimensional platinum compounds
Bremi, Juliane, Fontana, Margherita, Caseri, Walter and Smith, Paul (2006)
Magnus' green salt, [Pt(NH3)4][PtCl4], is a quasi-one-dimensional inorganic semiconductor containing linear arrays of platinum atoms. Its use in materials science is limited since it does not melt prior to decomposition and is largely insoluble in water and organic solvents which...
Conference Contributions
16. UniPep
Zhang, Hui, Loriaux, Paul, Eng, Jimmy, Campbell, David, Keller, Andrew, Moss, Pat, Bonneau, Richard, Zhang, Ning, Zhou, Yong, Wollscheid, Bernd, Cooke, Kelly, Yi, Eugene C., Lee, Hookeun, Peskind, Elaine R., Zhang, Jing, Smith, Richard D. and Aebersold, Ruedi (2006)
There has been considerable recent interest in proteomic analyses of plasma for the purpose of discovering biomarkers. Profiling N-linked glycopeptides is a particularly promising method because the population of N-linked glycosites represents the proteomes of plasma, the cell...
Journal Items
17. Multicomponent semiconducting polymer systems with low crystallization-induced percolation threshold
Goffri, Shalom, Müller, Christian, Stingelin-Stutzmann, Natalie, Breiby, Dag W., Radano, Christopher P., Andreasen, Jens W., Thompson, Richard, Janssen, René A.J., Nielsen, Martin M., Smith, Paul and Sirringhaus, Henning (2006)
Blends and other multicomponent systems are used in various polymer applications to meet multiple requirements that cannot be fulfilled by a single material1, 2, 3. In polymer optoelectronic devices it is often desirable to combine the semiconducting properties of the...
Journal Items
18. Phase behavior, nucleation and optical properties of the binary system isotactic polypropylene/N,N′,N″-tris-isopentyl-1,3,5-benzene-tricarboxamide
Kristiansen, Per Magnus, Gress, Anja, Smith, Paul, Hanft, Doris and Schmidt, Hans-Werner (2006)
The phase behavior of the binary system consisting of isotactic polypropylene (i-PP) and N,N′,N″-tris-isopentyl-1,3,5-benzene-tricarboxamide (1)—a selected member of a class of novel, versatile ‘designer’ nucleating/clarifying agents—was investigated over the entire...
Journal Items
19. Electro-spun, semiconducting, oriented fibers of supramolecular quasi-linear platinum compounds
Fontana, Margherita, Caseri, Walter and Smith, Paul (2006)
The semiconducting Magnus’salt derivatives [Pt(NH2eh)4][PtCl4] and [Pt(NH2dmoc)4][PtCl4], with eh = (R)-2-ethylhexyl and dmoc = (S)-3,7-dimethyloctyl, are compounds that exhibit a supramolecular structure comprising a backbone of linear arrays of platinum atoms. These...
Journal Items
20. Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis
Young, Helen S., Summers, Angela M., Read, Ian R., Fairhurst, David A., Plant, Darren J., Campalani, Emanuela, Smith, Catherine H., Barker, Jonathan N.W.N., Detmar, Michael J., Brenchley, Paul E.C. and Griffiths, Christopher E.M. (2006)
Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, + 405 and - 460, are associated with early-onset psoriasis and are close to the functional activator protein-1 site (+ 419) through which...
Journal Items
1. Discrete forms of amylose are synthesized by isoforms of GBSSI in pea
Edwards, Anne, Vincken, Jean-Paul, Suurs, Luc C.J.M., Visser, Richard G.F., Zeeman, Samuel C., Smith, Alison M. and Martin, Cathie (2002)
Amyloses with distinct molecular masses are found in the starch of pea embryos compared with the starch of pea leaves. In pea embryos, a granule-bound starch synthase protein (GBSSIa) is required for the synthesis of a significant portion of the amylose. However, this protein seems...
Journal Items
2. Polymer-TiO2 nanocomposites
Nussbaumer, René J., Caseri, Walter R., Smith, Paul and Tervoort, Theo (2003)
Colloids of TiO2, where rutile was the only crystal modification which could be detected, with ca. 2.5 nm average particle diameter were synthesized by hydrolysis of TiCl4 in acidic solutions. The as-prepared particles were incorporated in polymers such as poly(vinyl alcohol)...
Journal Items
3. 'Latent' ultraviolet light absorbers
Kocher, Christoph, Weder, Christoph and Smith, Paul (2003)
We have synthesized and characterized photo-labile and acid-labile esters of 2-hydroxybenzophenone and 2-hydroxybenzotriazoles, which, upon appropriate treatment, release classical UV absorbers. Two concepts of 'latent' UV absorbers are presented, namely, benzoyl-caged species...
Journal Items
4. "(Hot-)Water-Proof", semiconducting, platinum-based chain structures: Processing, products, and properties
Caseri, W.R., Chanzy, H.D., Feldman, K., Fontana, M., Smith, Paul, Tervoort, T.A., Goossens, J.G.P., Meijer, E.W., Schenning, A.P.H.J., Dolbnya, I.R., Debije, M.G., Haas, Matthijs P. de, Warman, John M., Craats, A.M. van de, Friend, R.H., Sirringhaus, H. and Stutzmann, N. (2003)
A promising solution to the environmental instability of semiconducting organic materials is presented. Thin, highly ordered films (see Figure, a scanning probe microscopy image), fibers, and field-effect transistors (FETs), comprising chain-structures based on the so-called...
Journal Items
5. Design, synthesis, and properties of new biodegradable aromatic/aliphatic liquid crystalline copolyesters
Chen, Yiwang, Wombacher, Ralf, Wendorff, Joachim H., Visjager, Jeroen, Smith, Paul and Greiner, Andreas (2003)
Liquid crystalline copolyesters of high molecular weight were obtained by polycondensation of aromatic diols, diacyl dichlorides, oligolactides, and poly(ethylene glycol)s. Hydrophilicity of the copolyesters was controlled by the content of ethyleneoxy moieties as verified by...
Journal Items
6. The binary system isotactic polypropylene/bis(3,4-dimethylbenzylidene)sorbitol
Kristiansen, Magnus, Werner, Michael, Tervoort, E., Smith, Paul, Blomenhofer, Markus and Schmidt, Hans-Werner (2003)
The phase behavior of the binary system consisting of the commercial nucleating and clarifying agent 1,3:2,4-bis(3,4-dimethyldibenzylidene)sorbitol (DMDBS, Millad 3988) and isotactic polypropylene (i-PP) was investigated over the entire concentration range by means of differential...
Journal Items
7. Polyamides X.34
Ehrenstein, Moritz, Smith, Paul and Weder, Christoph (2003)
Full Paper: A new series of semi-crystalline polyamides (PA), which comprise extended aliphatic segments between the amide moieties and which display an interesting amphiphilic character has been synthesized and characterized. The polymers PA-2.34, PA-4.34, PA-8.34, PA-10.34, and...
Journal Items
8. Synergistic gelation of solutions of isotactic polypropylene and bis-(3,4-dimethyl benzylidene) sorbitol and its use in gel-processing
Kristiansen, Magnus, Tervoort, Theo and Smith, Paul (2003)
We report the synergistic, rapid gelation of solutions of isotactic polypropylene (i-PP) and the nucleating agent 1,3:2,4-bis-(3,4-dimethyl benzylidene) sorbitol (DMDBS) in decalin. Cooling to room temperature of a solution comprising, for instance, 3.0 wt% of a moderately high...
Journal Items
9. Dichroic Ultraviolet Light Filters
Kocher, Christoph, Weder, Christoph and Smith, Paul (2003)
With the intention to produce dichroic filters for use in photoluminescent systems that rely on polarized UV light, we synthesized a number of linear, dichroic dyes, which absorb mainly in the near-UV range of the electromagnetic spectrum. These dyes were designed for compatibility...
Journal Items
10. Hydrolytic and enzymatic degradation of liquid-crystalline aromatic/aliphatic copolyesters
Chen, Yiwang, Jia, Zhihong, Schaper, Andreas, Kristiansen, Magnus, Smith, Paul, Wombacher, Ralf, Wendorff, Joachim H. and Greiner, Andreas (2004)
Aromatic/aliphatic copolyesters containing hydrophilic moieties in the main chain or side chain were synthesized by bulk polycondensation of aromatic monomers without or with solubilizing substituents and aliphatic monomers. Hydrolytic and enzymatic degradation studies were carried...
Journal Items
11. Growth and anisotropic properties of highly oriented films of quasi-one-dimensional platinum compounds
Fontana, Margherita, Chanzy, Henri, Stutzmann, Natalie, Caseri, Walter R. and Smith, Paul (2004)
The semiconductors [Pt(NH(2)dmoc)(4)][PtCl4], where dmoc denotes (S)-3,7-dimethyloctyl, and [Pt(NH(2)eh)(4)][PtCl4], where eh is (R)-2-ethylhexyl, are soluble quasi-one-dimensional compounds with a backbone of linearly arranged platinum atoms. Uniaxially oriented films of those...
Journal Items
12. Facile synthesis of linear poly(dibutylstannane)
Choffat, Fabien, Smith, Paul and Caseri, Walter (2005)
We present a facile, high-yield synthetic route to linear poly( dibutylstannane) of relatively high molecular weight (M-w = 20 x 10(3) g mol(-1)) through dehydropolymerization of dibutylstannane with the catalyst [RhCl(PPh3)(3)]. Unlike previously synthesized polystannanes, the...
Journal Items
13. Crystalline-crystalline block copolymers of regioregular poly(3-hexylthiophene) and polyethylene by ring-opening metathesis polymerization
Radano, Christopher P., Scherman, Oren A., Stingelin-Stutzmann, Natalie, Müller, Christian, Breiby, Dag W., Smith, Paul, Janssen, René A.J. and Meijer, E.W. (2005)
Block copolymers of regioregular poly(3-hexylthiophene) (P3HT) and polyethylene (PE) were synthesized through the chain transfer of olefin-terminated P3HT in the presence of cyclooctene via ring-opening metathesis polymerization (ROMP). Subsequent hydrogenation of the...
Journal Items
14. Mechanical properties of sorbitol-clarified isotactic polypropylene
Kristiansen, Magnus, Tervoort, Theo and Smith, Paul (2005)
The solid-state structure and yield behavior of isotactic polypropylene (i-PP) containing the nucleating/clarifying agent 1,3:2,4-bis(3,4-dimethylbenzylidene)sorbitol (DMDBS) was investigated in the additive concentration range 0-1 wt %. The raise of the crystallization temperature...
Journal Items
15. Polymeric quasi-one-dimensional platinum compounds
Bremi, Juliane, Fontana, Margherita, Caseri, Walter and Smith, Paul (2006)
Magnus' green salt, [Pt(NH3)4][PtCl4], is a quasi-one-dimensional inorganic semiconductor containing linear arrays of platinum atoms. Its use in materials science is limited since it does not melt prior to decomposition and is largely insoluble in water and organic solvents which...
Conference Contributions
16. UniPep
Zhang, Hui, Loriaux, Paul, Eng, Jimmy, Campbell, David, Keller, Andrew, Moss, Pat, Bonneau, Richard, Zhang, Ning, Zhou, Yong, Wollscheid, Bernd, Cooke, Kelly, Yi, Eugene C., Lee, Hookeun, Peskind, Elaine R., Zhang, Jing, Smith, Richard D. and Aebersold, Ruedi (2006)
There has been considerable recent interest in proteomic analyses of plasma for the purpose of discovering biomarkers. Profiling N-linked glycopeptides is a particularly promising method because the population of N-linked glycosites represents the proteomes of plasma, the cell...
Journal Items
17. Multicomponent semiconducting polymer systems with low crystallization-induced percolation threshold
Goffri, Shalom, Müller, Christian, Stingelin-Stutzmann, Natalie, Breiby, Dag W., Radano, Christopher P., Andreasen, Jens W., Thompson, Richard, Janssen, René A.J., Nielsen, Martin M., Smith, Paul and Sirringhaus, Henning (2006)
Blends and other multicomponent systems are used in various polymer applications to meet multiple requirements that cannot be fulfilled by a single material1, 2, 3. In polymer optoelectronic devices it is often desirable to combine the semiconducting properties of the...
Journal Items
18. Phase behavior, nucleation and optical properties of the binary system isotactic polypropylene/N,N′,N″-tris-isopentyl-1,3,5-benzene-tricarboxamide
Kristiansen, Per Magnus, Gress, Anja, Smith, Paul, Hanft, Doris and Schmidt, Hans-Werner (2006)
The phase behavior of the binary system consisting of isotactic polypropylene (i-PP) and N,N′,N″-tris-isopentyl-1,3,5-benzene-tricarboxamide (1)—a selected member of a class of novel, versatile ‘designer’ nucleating/clarifying agents—was investigated over the entire...
Journal Items
19. Electro-spun, semiconducting, oriented fibers of supramolecular quasi-linear platinum compounds
Fontana, Margherita, Caseri, Walter and Smith, Paul (2006)
The semiconducting Magnus’salt derivatives [Pt(NH2eh)4][PtCl4] and [Pt(NH2dmoc)4][PtCl4], with eh = (R)-2-ethylhexyl and dmoc = (S)-3,7-dimethyloctyl, are compounds that exhibit a supramolecular structure comprising a backbone of linear arrays of platinum atoms. These...
Journal Items
20. Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis
Young, Helen S., Summers, Angela M., Read, Ian R., Fairhurst, David A., Plant, Darren J., Campalani, Emanuela, Smith, Catherine H., Barker, Jonathan N.W.N., Detmar, Michael J., Brenchley, Paul E.C. and Griffiths, Christopher E.M. (2006)
Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, + 405 and - 460, are associated with early-onset psoriasis and are close to the functional activator protein-1 site (+ 419) through which...
Journal Items
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Recovery and brain reorganization after stroke in adult and aged rats
Markus, Tiffanie M., Tsai, Shih-Yen, Bollnow, Melanie R., Farrer, Robert G., O'Brien, Timothy E., Kindler-Baumann, Diana R., Rausch, Martin, Rudin, Markus, Wiessner, Christoph, Mir, Anis K., Schwab, Martin and Kartje, Gwendolyn L. (2005)
Stroke is a prevalent and devastating disorder, and no treatment is currently available to restore lost neuronal function after stroke. One unique therapy that improves recovery after stroke is neutralization of the neurite inhibitory protein Nogo-A. Here, we show, in a clinically...
Analysis of lesion development during acute inflammation and remission in a rat model of experimental autoimmune encephalomyelitis by visualization of macrophage infiltration, demyelination and blood-brain barrier damage
Berger, Cedric, Hiestand, Peter, Kindler-Baumann, Diana, Rudin, Markus and Rausch, Martin (2006)
In vivo tracking of macrophage migration is feasible by labeling- cells with ultra-small particles of iron oxide (USPIO). It is demonstrated that it is possible to monitor distinct patterns of inacrophage migration during the early states of inflammation in a rodent model...
Feasibility and Limits of Magnetically Labeling Primary Cultured Rat T Cells with Ferumoxides Coupled with Commonly Used Transfection Agents
Berger, Cedric, Rausch, Martin, Schmidt, Philipp and Rudin, Markus (2006)
Visualization and quantification of inflammatory processes is of high importance for early diagnosis of a multitude of diseases. Magnetic resonance imaging (MRI) using iron oxide (FeO) nanoparticles as contrast agents allows the study of macrophage infiltration during inflammation...
Imaging in Biomedical Research
Folkers, Gerd, Ishai, Alumit, Rudin, Markus, Schubiger, Pius August, Bräutigam, Matthias, Möhler, Hanns and Märki, Hans Peter (2006)
Imaging technologies have experienced rapid progress and are currently used widely both in medical diagnostics and in research. Imaging beyond X-ray and standard MRI became established in recent years. The extended set of imaging methodologies available allows methods to...
Imaging readouts as biomarkers or surrogate parameters for the assessment of therapeutic interventions
Rudin, Markus (2007)
Surrogate markers and biomarkers based on imaging readouts providing predictive information on clinical outcome are of increasing importance in the preclinical and clinical evaluation of novel therapies. They are primarily used in studies designed to establish evidence that the...
In vivo monitoring the fate of Cy5.5-Tat labeled T lymphocytes by quantitative near-infrared fluorescence imaging during acute brain inflammation in a rat model of experimental autoimmune encephalomyelitis
Berger, Cedric, Gremlich, Hans-Ulrich, Schmidt, Philipp, Cannet, Catherine, Kneuer, Rainer, Hiestand, Peter, Rausch, Martin and Rudin, Markus (2007)
T cells and macrophages directed against myelin proteins orchestrate the inflammation process in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). So far, assessment of macrophages infiltration or structural alterations has been achieved by in vivo...
A computational framework for modelling solid tumour growth
Lloyd, Bryan A., Szczerba, Dominik, Rudin, Markus and Székely, Gábor (2008)
The biology of cancer is a complex interplay of many underlying processes, taking place at different scales both in space and time. A variety of theoretical models have been developed, which enable one to study certain components of the cancerous growth process. However,...
A computational framework for modelling solid tumour growth
Lloyd, Bryn A., Szczerba, Dominik, Rudin, Markus and Székely, Gábor (2008)
The biology of cancer is a complex interplay of many underlying processes, taking place at different scales both in space and time. A variety of theoretical models have been developed, which enable one to study certain components of the cancerous growth process. However, most...
Performance of a 200-MHz cryogenic RF probe designed for MRI and MRS of the murine brain
Ratering, David, Baltes, Christof, Nordmeyer-Massner, Jurek, Marek, Daniel and Rudin, Markus (2008)
A cryogenic 200-MHz RF transmit/receive probe (CryoProbe) made of copper and designed for murine brain studies is described. The probe operates at 30K and its performance was compared to a home-made surface coil of equal dimensions and a mouse head volume resonator, both operating...
Functional reorganization in rat somatosensory cortex assessed by fMRI
Sydekum, Esther, Baltes, Christof, Ghosh, Arko, Mueggler, Thomas, Schwab, Martin and Rudin, Markus (2008)
The accuracy at which changes in cortical functional topology can be assessed by functional MRI (fMRI) depends on the quality of the reference coordinate system used for comparison of data sets obtained in different imaging sessions. Current procedures comprise an overlay of...
A portable albumin binder from a DNA-encoded chemical library
Dumelin, Christoph E., Trüssel, Sabrina, Buller, Fabian, Trachsel, Eveline, Bootz, Frank, Zhang, Yixin, Mannocci, Luca, Beck, Susanne C., Drumea-Mirancea, Mihaela, Seeliger, Mathias W., Baltes, Christof, Müggler, Thomas, Kranz, Felicitas, Rudin, Markus, Melkko, Samu, Scheuermann, Joerg and Neri, Dario (2008)
Seeing eye to eye: Plasma-protein binding is effective in improving the pharmacokinetic properties of otherwise short-lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half-life of two widely used contrast...
Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events
Lehmann, Steffi, Stiehl, Daniel P., Honer, Michael, Dominietto, Marco, Keist, Ruth, Kotevic, Ivana, Wollenick, Kristin, Ametamey, Simon, Wenger, Roland H. and Rudin, Markus (2009)
Tumor hypoxia and the hypoxia-inducible factors (HIFs) play a central role in the development of cancer. To study the relationship between tumor growth, tumor hypoxia, the stabilization of HIF-1α, and HIF transcriptional activity, we have established an in vivo imaging tool that...
Functional reorganization in rat somatosensory cortex assessed by fMRI
Sydekum, Esther, Baltes, Christof, Ghosh, Arko, Mueggler, Thomas, Schwab, Martin E. and Rudin, Markus (2009)
The accuracy at which changes in cortical functional topology can be assessed by functional MRI (fMRI) depends on the quality of the reference coordinate system used for comparison of data sets obtained in different imaging sessions. Current procedures comprise an overlay of...
Noninvasive structural, functional, and molecular imaging in drug development
Rudin, Markus (2009)
Modern drug research is mechanism-based and the development of disease modifying therapies involves the identification of molecular key players in the pathological cascade. Today, noninvasive imaging tools enable the visualization and quantitative assessment of the expression of...
Functional and Anatomical Reorganization of the Sensory-Motor Cortex after Incomplete Spinal Cord Injury in Adult Rats
Ghosh, Arko, Sydekum, Esther, Haiss, Florent, Peduzzi, Stefano, Zörner, Björn, Schneider, Regula, Baltes, Christof, Rudin, Markus, Weber, Bruno and Schwab, Martin E. (2009)
A lateral hemisection injury of the cervical spinal cord results in Brown-Sequard syndrome in humans and rats. The hands/forelimbs on the injured side are rendered permanently impaired, but the legs/hindlimbs recover locomotor functions. This is accompanied by increased use of the...
A 'Click Chemistry' Approach to the Efficient Synthesis of Multiple Imaging Probes Derived from a Single Precursor
Mindt, Thomas L., Müller, Cristina, Stuker, Florian, Salazar, Jean-Frederic, Hohn, Alexander, Mueggler, Thomas, Rudin, Markus and Schibli, Roger (2009)
Different imaging modalities can provide complementary information on biological processes at the cellular or molecular level in vitro and in vivo. However, specific molecular probes suitable for a comparison of different imaging modalities are often not readily accessible because...
Micro MRI of the mouse brain using a novel 400 MHz cryogenic quadrature RF probe
Baltes, Christof, Radzwill, Nicole, Bosshard, Simone, Marek, Daniel and Rudin, Markus (2009)
The increasing number of mouse models of human disease used in biomedical research applications has led to an enhanced interest in non-invasive imaging of mice, e.g. using MRI for phenotyping. However, MRI of small rodents puts high demands on the sensitivity of data acquisition....
Molecular neuroimaging in rodents
Mueggler, Thomas, Baltes, Christof and Rudin, Markus (2009)
Multimodal non-invasive neuroimaging in rodents constitutes an attractive tool for studying neurobiological processes in vivo. At present, imaging studies of brain anatomy and function as well as the investigation of structure-function relationships belong to the standard...
Imaging of load induced bone adaptation with in vivo micro-computed tomography and fluorescence molecular tomography
Lambers, Floor, Stuker, Florian, Weigt, Claudia, Schulte, Friederike, Koch, Kathleen, Kuhn, Gisela, Rudin, Markus and Müller, Ralph (2010)
Performance analysis of the two spectroscopic imaging sequences LRE and EPSI
Fischer, Rudolf Fritz, Weiss, Kilian, Baltes, Christof, Rudin, Markus, Bösiger, Peter and Kozerke, Sebastian (2010)
We compare the sensitivity of the two spectroscopic imaging sequences Echo Planar Spectroscopic Imaging (EPSI) and Linear Response Equilibrium (LRE), a steady state free precession sequence with intrinsic suppression of periodic bands. Simulations and phantom experiments were...
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