个人简介
Jörn Piel is a full professor of Microbial Interactions at the Institute of Microbiology since February 2013.
He was born in Germany, in 1967.
Jörn Piel studied chemistry at the University of Bonn, Germany. From 1995-1998 he conducted his PhD work in Bonn with Prof. W. Boland, studying biosynthesis and regulation of natural products involved in plant signaling. As an Alexander von Humboldt postdoctoral fellow (1998-1999) he worked on biosynthetic pathways of marine bacteria in the laboratory of Prof. B. S. Moore and Prof. H. G. Floss at the University of Washington, Seattle. From 1999-2004 he headed a junior research group at the Max Planck Institute of Chemical Ecology, Jena, Germany, and obtained the habilitation at the University of Jena in 2004. In the same year he was appointed a C3 (Assistant) Professor at the Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Germany.
研究领域
Jörn Piel's research focuses on the origin, ecology, and activity of natural products. Using biological and chemical methods, his research group investigates how organisms such as bacterial communities in marine sponges synthesize these often complex substances. This knowledge is then applied in Synthetic Biology to produce compounds that are difficult to obtain from Nature. Such natural products are of great interest for the development of drugs used in antiinfective or anticancer therapy.
近期论文
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Metagenomic Approaches for Exploiting Uncultivated Bacteria as a Resource for Novel Biosynthetic Enzymology Wilson, Micheal C.; Piel, Jörn (2013) Chemistry & Biology
The hidden enzymology of bacterial natural product biosynthesis Scott, Thomas A.; Piel, Jörn (2019)
Enzyme from an Uncultivated Sponge Bacterium Catalyzes S-Methylation in a Ribosomal Peptide Helf, Maximilian J.; Jud, Aurelia; Piel, Jörn (2017) ChemBioChem
Biosynthesis of polyketides by trans-AT polyketide synthases Helfrich, Eric J.N.; Piel, Jörn (2016)
Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnological Production Bhushan, Agneya; Peters, Eike E.; Piel, Jörn (2017)Progress in molecular and subcellular biology ~ Blue Biotechnology
Evolution-guided engineering of nonribosomal peptide synthetase adenylation domains Crüsemann, Max; Kohlhaas, Christoph; Piel, Jörn (2013) Chemical Science
Biosynthetic Insights of Calyculin- and Misakinolide-Type Compounds in “Candidatus Entotheonella sp.” Uria, Agustinus R.; Piel, Jörn; Wakimoto, Toshiyuki (2018)Methods in Enzymology ~ Marine Enzymes and Specialized Metabolism - Part A
Erratum to "Recent advances in genome-based polyketide discovery" Helfrich, Eric J.N.; Reiter, Silke; Piel, Jörn (2014)Current Opinion in Biotechnology
Aranazoles: Extensively Chlorinated Nonribosomal Peptide–Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339 Moosmann, Philipp; Ueoka, Reiko; Gugger, Muriel; et al. (2018)
Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis Helf, Maximilian J.; Freeman, Michael F.; Piel, Jörn (2019)Journal of Industrial Microbiology and Biotechnology
Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria Freeman, Michael F.; Vagstad, Anna L.; Piel, Jorn (2016)Current Opinion in Chemical Biology
Genome Mining-guided and MALDI Imaging-assisted Discovery of New Antibiotics Probst, Silke I.; Vogel, Christine; Vorholt, Julia A.; et al. (2018)
Radical S-Adenosylmethionine Peptide Epimerases: Detection of Activity and Characterization of D-Amino Acid Products Morinaka, Brandon I.; Vagstad, Anna L.; Piel, Jörn (2018)Methods in Enzymology ~ Marine Enzymes and Specialized Metabolism - Part A
An Orthogonal D2O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases Morinaka, Brandon I.; Verest, Marjan; Freeman, Michael F.; et al. (2017) Angewandte Chemie. International Edition
Fe2+ chelator proferrorosamine A: A gene cluster of Erwinia rhapontici P45 involved in its synthesis and its impact on growth of erwinia amylovora CFBP1430 Born, Yannick; Remus-Emsermann, Mitja N.P.; Bieri, Marco; et al. (2016)
Biosynthesis of Phenylnannolone A, a Multidrug Resistance Reversal Agent from the Halotolerant Myxobacterium Nannocystis pusilla B150 Bouhired, Sarah M.; Crüsemann, Max; Almeida, Celso; et al. (2014) ChemBioChem
Introduction of D-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-L-Methionine Radical Epimerase Vagstad, Anna L.; Kuranaga, Takefumi; Püntener, Salome; et al. (2019) Angewandte Chemie. International Edition
Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor Brachmann, Alexander O.; Garcie, C.; Wu, V.; et al. (2015) Chemical Communications
Fast direct detection of natural dyes in historic and prehistoric textiles by flowprobe™-ESI-HRMS Kramell, Annemarie E.; Brachmann, Alexander O.; Kluge, Ralph; et al. (2017) RSC Advances
A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution Fuchs, Sebastian W.; Lackner, Gerald; Morinaka, Brandon I.; et al. (2016) Angewandte Chemie. International Edition
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