Mazzotti, Marco - Eidgenössische Technische Hochschule Zürich - Department of Chemistry and Applied Biosciences

个人简介

Marco Mazzotti, an Italian citizen born in 1960, married, with two children, has been professor of process engineering at ETH Zurich since May 1997 (associate until March 2001 and full professor thereafter). He holds a Laurea (M.S., 1984) and a Ph.D. (1993), both in Chemical Engineering and from the Politecnico di Milano, Italy. Before joining ETH Zurich, he had worked for IBM Italy (1985-1987) and Montefluos (1988-1990), and had been assistant professor at the Politecnico di Milano (1994-1997). His research activity deals with adsorption based separations and chromatography, and with crystallization and precipitation processes. The application areas of interest are the purification of biopharmaceuticals and the development of carbon dioxide capture and storage systems. He teaches classes on Separation Processes, Mathematical Methods for Chemical Engineers and Carbon Dioxide Capture and Storage. Fifteen PhD students have graduated with him and fourteen are currently advised by him. His refereed publications include more than 140 journal articles, 20 articles in books and 6 book chapters. Marco Mazzotti has been coordinating lead author of the IPCC Special Report on Carbon Dioxide Capture and Storage (2002-2005). He is also an active member of the AIChE, of the Working Party on Crystallization of the EFCE, and vice-President of the International Adsorption Society. He was the chair of the 9th International Conference on Fundamentals of Adsorption FOA9 (Italy, May 20-25, 2007), and will be the chair of the 18th International Symposium on Industrial Crystallization (Switzerland, September 15-16, 2011).

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Optimization based adaptive control of Simulated Moving Beds Abel, Stefanie, Mazzotti, Marco, Erdem, Gültekin, Morari, Manfred and Morbidelli, Massimo (2003) In the recent years Simulated Moving Bed (SMB) technology has become more and more attractive for complex separation tasks. To ensure the compliance with product specifications, a robust control is required. In this work a new optimization based adaptive control strategy... Choice of the Focal Point Position Using Lasentec FBRM Worlitschek, Jörg and Mazzotti, Marco (2003) The Focused Beam Reflectance Measurement (FBRM) technique provides on-line and in situ information about the chord length distribution (CLD) of a population of particles in dispersion. The effect of changing the focal point position on the measured CLD is experimentally analyzed by... Measuring and Modeling Supercritical adsorption in porous solids Hocker, Thomas, Rajendran, Arvind and Mazzotti, Marco (2003) Supercritical adsorption of carbon dioxide on 13X zeolite pellets and on silica gel is studied experimentally and theoretically. A gravimetric apparatus with provision for in situ density measurement is used for the measurement of excess adsorption isotherms. The volume of the... Multiobjective optimization of simulated moving bed and Varicol processes using a genetic algorithm Zhang, Ziyang, Mazzotti, Marco and Morbidelli, Massimo (2003) The size of the packing material, the total number of columns and the total feed concentration have significant impacts on the economics of a preparative chromatographic separation, through their effects on column pressure drop, column efficiency and thermodynamics. In this work,... Comparing true countercurrent and Simulated Moving-Bed chromatographic reactors Lode, Florian, Mazzotti, Marco and Morbidelli, Massimo (2003) Simulated Moving Bed reactors (SMBR) combine chemical reaction and adsorptive separation within one single continuous and countercurrent unit. This integration promises substantial improvements in process performance, especially when applied to equilibrium-limited reactions... Precipitation of lysozyme nanoparticles from dimethyl sulfoxide using carbon dioxide as antisolvent Muhrer, Gerhard and Mazzotti, Marco (2003) The protein lysozyme has been precipitated as amorphous nanoparticles from a DMSO solution using dense carbon dioxide as antisolvent, by applying the so-called gas antisolvent recrystallization technique in a 400-mL precipitator. The objective is to investigate the possibility of... Vapor-liquid mass transfer during gas antisolvent recrystallization Lin, Cheng, Muhrer, Gerhard, Mazzotti, Marco and Subramaniam, Bala (2003) In batch gas antisolvent (GAS) recrystallization, the gradual addition of CO2 to a liquid solution containing the solute causes the system pressure to rise and the volume of the liquid phase to expand substantially, eventually resulting in solute precipitation. The expansion rate... Synthesis of methylacetate in a simulated moving-bed reactor Lode, Florian, Francesconi, Gianmario, Mazzotti, Marco and Morbidelli, Massimo (2003) Simulated moving-bed reactors (SMBR) combine chemical reaction and adsorptive separation within one single unit. Toward the design of this rather complex unit, guidelines for the proper choice of the operating parameters, that is, the flow-rate ratios and the Damkohler numbers... PowerFeed operation of simulated moving bed units Zhang, Ziyang, Mazzotti, Marco and Morbidelli, Massimo (2003) A possible way to improve the separation performance of simulated moving bed (SMB) units is to change the internal and external liquid flow-rates during the switching period. This operation mode, referred to as PowerFeed, is examined in this work through a model analysis. Similar... Gas antisolvent recrystallization of an organic compound Muhrer, Gerhard, Mazzotti, Marco and Müller, Martin (2003) An organic pharmaceutical compound has been precipitated from an ethanol solution using dense carbon dioxide as antisolvent. The goals are to analyze the effect of two process parameters, namely antisolvent addition rate and initial solute concentration, on product quality, and to... Model-based optimization of particle size distribution in batch-cooling crystallization of paracetamol Worlitschek, Jörg and Mazzotti, Marco (2004) The control objectives of batch crystallization processes are often defined in terms of particle size distribution (PSD), or properties related to the PSD, viz. average particle size, product filterability, dry solids flow properties, etc. To achieve these control objectives, a... Automatic control of simulated moving beds Erdem, Gültekin, Abel, Stefanie, Morari, Manfred, Mazzotti, Marco, Morbidelli, Massimo and Lee, Jay H. (2004) In recent years, simulated moving bed (SMB) technology has become increasingly attractive for complex separation tasks and emerged as the leading chromatographic separation technique in the fields of pharmaceuticals, fine chemicals, and biotechnology. Extensive usage of SMB... Gas antisolvent recrystallization of paracetamol from acetone using compressed carbon dioxide as antisolvent Fusaro, Francesco and Mazzotti, Marco (2004) Paracetamol was precipitated from solution in acetone using compressed carbon dioxide (CO2) as an antisolvent in a batch gas antisolvent (GAS) recrystallization process. In this study, the effect of specific carbon dioxide addition rate (0.067-6.0 min(-1)), temperature... Analysis of a simulated moving bed operation for three-fraction separations (3F-SMB) Paredes, Galatea, Abel, Stefanie, Mazzotti, Marco, Morbidelli, Massimo and Stadler, Joachim (2004) A three-fraction simulated moving bed (3F-SMB) unit for separating feed mixtures into three fractions is presented. Criteria for the selection of the flow rate ratios in the four sections of the unit under linear chromatographic conditions are developed. These criteria translate... General model for the achiral chromatography of enantiomers forming dimers Baciocchi, Renato, Mazzotti, Marco and Morbidelli, Massimo (2004) Solid-liquid equilibrium of Troger's base enantiomers in ethanol Worlitschek, Jörg, Bosco, Marcello, Huber, Markus, Gramlich, Volker and Mazzotti, Marco (2004) Thermodynamic properties of the enantionters of the Troger's base as crystals and in ethanol solutions have been studied by means of a suite of analytical techniques. We report the melting diagrams of the two enantiomers, providing evidence for the formation of a solid racemic... Solvent gradient operation of simulated moving beds Abel, Stefanie, Mazzotti, Marco and Morbidelli, Massimo (2004) Simulated Moving Bed separations of enantiomers or fine chemicals are usually carried out in the isocratic mode, i.e. by applying the same operating conditions (temperature, pressure, mobile phase composition, pH) in the whole SMB unit. However, it has been recently recognized that... Experimental assessment of PowerFeed chromatography Zhang, Ziyang, Morbidelli, Massimo and Mazzotti, Marco (2004) The PowerFeed process is a modification of the simulated moving bed (SMB) technique, where the flow rates in the unit are allowed to change during a switching period following a predefined pattern. Through multiobjective optimization, using a genetic algorithm, it is shown that... Continuous chromatographic processes with a small number of columns Zhang, Ziyang, Mazzotti, Marco and Morbidelli, Massimo (2004) The Simulated Moving Bed process and its recent extensions called Varicol, PowerFeed and ModiCon are studied, in the case where a small number of columns are used, i.e. from three to five. A multiobjective optimization approach, using genetic algorithms and a detailed model of the... Multi-scale modeling of a reactive mixing process in a semibatch stirred tank Vicum, Lars, Ottiger, Stefan, Mazzotti, Marco, Makowski, Lukasz and Baldyga, Jerzy (2004) In this work the influence of turbulent mixing on the course of two parallel chemical reactions (neutralization of sodium hydroxide and hydrolysis of ethyl chloroacetate) is investigated for a process carried out in a semibatch stirred tank reactor. The multi-scale nature of the...