詹杨 - 吉林大学 - 生命科学学院

个人简介

教育经历： 1999年9月--2003年7月：山东大学生命科学学院学士 2003年9月--2006年12月：吉林大学生命科学学院硕士 2007年9月--2013年5月：吉林大学生命科学学院博士美国杜兰大学访问学者工作经历： 2013年5月--2016年8月：美国杜兰大学结构及细胞生物学系博士后 2017年3月-至今：吉林大学生命科学学院副教授

研究领域

1. 去势抵抗性前列腺癌(CRPC)的治疗 2. 雄激素受体剪切突变体(AR-Vs)的产生机制及在CRPC发展过程中的作用

近期论文

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1.Yang Zhan, Guanyi Zhang, Xiaojie Wang, Yanfeng Qi, Shanshan Bai1, Dongying Li, Tianfang Ma, Oliver Sartor, Erik K. Flemington, Haitao Zhang, Peng Lee, and Yan Dong, Interplay Between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediate Castration Resistance, Molecular Cancer Research, 2016,15(1): 59-68 2. Xinyu Wu*, Yang Zhan*, Xin Li, Jianjun Wei, Larion Santiago, Garrett Daniels, Fangming Deng, Xuelin Zhong, Luis Chiriboga, Ross Basch, Yan Dong, Xinmin Zhang and Peng Lee, Nuclear TBLR1 as an ER corepressor promotes cell proliferation, migration and invasion in breast and ovarian cancer, American Journal of Cancer Research, 2016, 6(10): 2351-2360, (co-first author) 3. Duo Xu*, Yang Zhan*, Yanfeng Qi, Bo Cao, Shanshan Bai, Wei Xu, Sanjiv S. Gambhir, Peng Lee, Oliver Sartor, Erik K. Flemington, Haitao Zhang, Chang-Deng Hu and Yan Dong, Androgen receptor splice variants dimerize to transactivate target genes. Cancer Research, 2015, 75 (17): 3663-3671 (co-first author) 4. Yang Zhan, Bin Yu, Zhen Wang, Yu Zhang, Hai-Hong Zhang, Hao Wu, Xiao Feng, Ran-Shen Geng, Wei Kong and Xiang-Hui Yu, A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells, International Journal Clinical Experimental Pathology, 2014, 7 (6):2850-2860 5. Yang Zhan, Bo Cao, Yanfeng Qi, Shuang Liu, Wei Kong, Haitao Zhang and Yan Dong, Methylselenol Prodrug Enhances MDV3100 Efficacy for Treatment of Castration-Resistant Prostate Cancer. International Journal of Cancer, 2013, 133: 2225–2233 6. Subing Cao, Yang Zhan, Ruijuan Gao and Yan Dong, Emerging data on androgen receptor splice variants in prostate cancer (review), Endocrine-Related Cancer, (2016 Dec;23(12):T199-T210) 7. Bo Cao, Yanfeng Qi, Guanyi Zhang, Duo Xu, Yang Zhan, Xavier Alvarez, Zhiyong Guo, Xueqi Fu, Stephen R. Plymate, Oliver Sartor, Haitao Zhang and Yan Dong, Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy, Oncotarget, 2014, 5 (6): 1646-1656 8. Haitao Zhang, Yang Zhan, Xichun Liu, Yanfeng Qi, Guanyi Zhang, Oliver Sartor and Yan Dong, Splicing variants of androgen receptor in prostate cancer (review), American Journal of Clinical and Experimental Urology, 2013, 1(1):18-24 9.Bin Yu, Jianing Dong, Chu Wang, Yang Zhan, Haihong Zhang, Jiaxin Wu, Wei Kong and Xianghui Yu. Characteristics of neutralizing antibodies to adenovirus capsid proteins in human and animal sera. Virology, 2013, 437:118-123 10. Book：Ruijuan Gao, Xichun Liu, Bo Cao, Yang Zhan, Yanfeng Qi, Haitao Zhang, Yan Dong, The Role of Selenium in Prostate Cancer Therapy. Chapter in Prostate Cancer Cells: Detection, Growth and Treatment, Nova Science Publishers, Inc, NY, 2013, 197-208. 11. Bin Yu, Yu Zhang, Yang Zhan, Wei Kong and Xianghui Yu，Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects. Oncology Reports, 2011, 26: 255-264.