Kast, Peter A. - Eidgenössische Technische Hochschule Zürich - Department of Chemistry and Applied Biosciences

研究领域

Function & Evolution of Biocatalysts

近期论文

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J. Spielmann-Ryser; M. Moser; P. Kast; H. Weber, Mol. Gen. Genet. 1991, 226, 441-448. Factors determining the frequency of plasmid cointegrate formation mediated by insertion sequence IS3 from Escherichia coli. P. Kast; H. Hennecke, J. Mol. Biol. 1991, 222, 99-124. Amino acid substrate specificity of Escherichia coli phenylalanyl-tRNA synthetase altered by distinct mutations. P. Kast; C. Wehrli; H. Hennecke, FEBS Lett. 1991, 293, 160-163. Impaired affinity for phenylalanine in Escherichia coli phenylalanyl-tRNA synthetase mutant caused by Gly-to-Asp exchange in motif 2 of class II tRNA synthetases. P. Kast; B. Keller; H. Hennecke, J. Bacteriol. 1992, 174, 1686-1689. Identification of the pheS5 mutation, which causes thermosensitivity of Escherichia coli mutant NP37. B. Keller; P. Kast; H. Hennecke, FEBS Lett. 1992, 301, 83-88. -- Erratum: FEBS Lett.1992, 310, 204. Cloning and sequence analysis of the phenylalanyl-tRNA synthetase genes (pheST) from Thermus thermophilus. P. Kast, Gene 1994, 138, 109-114. pKSS — A second-generation general purpose cloning vector for efficient positive selection of recombinant clones. M. Ibba; P. Kast; H. Hennecke, Biochemistry 1994, 33, 7107-7112. Substrate specificity is determined by amino acid binding pocket size in Escherichia coli phenylalanyl-tRNA synthetase. P. Kast; J. D. Hartgerink; M. Asif-Ullah; D. Hilvert, J. Am. Chem. Soc. 1996, 118, 3069-3070. Electrostatic catalysis of the Claisen rearrangement: probing the role of Glu78 in Bacillus subtilis chorismate mutase by genetic selection. P. Kast; M. Asif-Ullah; D. Hilvert, Tetrahedron Lett. 1996, 37, 2691-2694. Is chorismate mutase a prototypic entropy trap? — Activation parameters for the Bacillus subtilis enzyme. P. Kast; M. Asif-Ullah; N. Jiang; D. Hilvert, Proc. Natl. Acad. Sci. USA 1996, 93, 5043-5048. Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis. P. Kast; D. Hilvert, Pure Appl. Chem. 1996, 68, 2017-2024. Genetic selection strategies for generating and characterizing catalysts. P. Kast; D. Hilvert, Curr. Opin. Struct. Biol. 1997, 7, 470-479. 3D structural information as a guide to protein engineering using genetic selection. P. Kast; Y. B. Tewari; O. Wiest; D. Hilvert; K. N. Houk; R. N. Goldberg, J. Phys. Chem. B 1997, 101, 10976-10982. Thermodynamics of the conversion of chorismate to prephenate: Experimental results and theoretical predictions. C. Grisostomi; P. Kast; R. Pulido; J. Huynh; D. Hilvert, Bioorg. Chem. 1997, 25, 297-305. Efficient in vivo synthesis and rapid purification of chorismic acid using an engineered Escherichia coli strain. G. MacBeath; P. Kast, Biotechniques 1998, 24, 789-794. UGA read-through artifacts — when popular gene expression systems need a pATCH. G. MacBeath; P. Kast; D. Hilvert, Protein Sci. 1998, 7, 325-335. Exploring sequence constraints on an interhelical turn using in vivo selection for catalytic activity. G. MacBeath; P. Kast; D. Hilvert, Science 1998, 279, 1958-1961. Redesigning enzyme topology by directed evolution. G. MacBeath; P. Kast; D. Hilvert, Biochemistry 1998, 37, 10062-10073. A small, thermostable, and monofunctional chorismate mutase from the archeon Methanococcus jannaschii. G. MacBeath; P. Kast; D. Hilvert, Protein Sci. 1998, 7, 1757-17657. Probing enzyme quaternary structure by combinatorial mutagenesis and selection. P. Mattei; P. Kast; D. Hilvert, Eur. J. Biochem. 1999, 261, 25-32. Bacillus subtilis chorismate mutase is partially diffusion-controlled.