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个人简介

教育经历: 1983-09-1988-06:吉林大学,理学学士(生物化学); 1994-09-1996-08:首尔国立大学,药学硕士(生物化学); 1996-09-2000-08:首尔国立大学,药学博士(生物化学) 工作经历: 2000-09-2002-08:国立首尔大学综合药物研究所博士后; 2002-09-2004-11:国立首尔大学综合药物研究所资深研究员; 2004-11- 今: 吉林大学生命科学学院教授、博士生导师; 2014-07-2014-12:美国范德堡大学医学院高级研究学者 荣誉称号: 1、第七批"长白慧谷"海外高端领军人才; 2、第七届中国侨界贡献奖(二等) 研究成果: 1、 负责完成了国家自然科学基金6项,省部级项目3项,在研项目5项;发表SCI论文60余篇,被引1000次;授权专利2项,申请专利9项。 2、 阐明了细胞周期依赖性激酶cyclin A-Cdk2通过磷酸化Bcl-2家族蛋白调控细胞凋亡的分子机制,为人类细胞固有的抗癌变机制提供了依据。 3、 系统筛选了人参皂苷的人类靶点,为人参功效的科学解析提供了分子基础,并为人参走向世界提供了科学依据。 4、 首次阐明了人参皂苷Rh2、Rk1、Rg5、CK的人类肿瘤细胞靶点,为人参的抗肿瘤作用提供了科学依据。 5、 成功开发了人参深加工健康食品"安帝康达"。 6、 负责完成云南省科技攻关项目《普洱茶减肥、降血脂作用研究》,为天士力基团成功开发降血脂保健食品《卓清茶》,建立了研究模型和关键数据。

研究领域

肿瘤生物学、人参研究与开发

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1、 Yu-Shi Wang, Hongyan Zhu, He Li, Bing Zhao, Ying-Hua Jin. Ginsenoside compound K inhibits NF-κB by targeting Annexin A2. Journal of Ginseng Research, doi.org/10.1016/j.jgr.2018.04.002 2、 Yu-Shi Wang, He Li, Hongyan Zhu, Yang Li, Ying-Hua Jin* Identification of natural compounds targeting Annexin A2 with an anti-cancer effect Natural compounds targeting Annexin A2, Protein Cell, 2018, 9(6):568-579 (IF:6.228) 3、 Yu-Shi Wang, Yingjia Lin, He Li, Yang Li, Zhiguang Song,Ying-Hua Jin* The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity Scientific Reports 7, 12408 (2017) doi:10.1038/s41598-017-12572-4 (Top 100 Scientific Reports Oncology papers in 2017) 4、 Yingjia Lin, Yang Li, Zhi-Guang Song, Hongyan Zhu, Ying-Hua Jin* The interaction of serum albumin with ginsenoside Rh2 (G-Rh2) resulted in the downregulation of G-Rh2 cytotoxicity J Ginseng Res 2017,41,330-338 (引用1次) 5、 Yuan Shen, Shanshan Liu, Jiao Fan, Yinghua Jin,* , Baolei Tian, Xiaofei Zheng*, Hanjiang Fu*, Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions EMBO Rep. 2017,18(4),536-548 6、 Yingjia Lin,Dan Jiang,Yang Li,Xinye Han,Di Yu,Jeong Hill Park,Ying-Hua Jin*Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells J Ginseng Res 2015,39,22-28 (35次) 7、 Xiao-Xi Guo, Yang Li, Chao Sun, Dan Jiang, Ying-Hua Jin* p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells. Protein Cell 2014, 5, 224 - 234 (IF:6.228,25次) 8、 Liu CY, Jin YH,Yu HS, Sun CK, Zhou SP, Zhu YH, Xu LQ, Yu C, Jin FX. Preparation of przewalskinic acid A from salvianolic acid B using a crude enzyme from an Aspergillus oryzae strain. J Ind Microbiol Biotechnol, 2014, 41, 887-892. 9、 Liu CY, Jin YH, Yu HS, Sun CK, Gao P, Xiao YK, Zhang TY, Xu LQ, Im WT, Jin FX. Biotransformation pathway and kinetics of ginsenosidase type I hydrolyzing 3-O- and 20-O-multi- glucosides of PPD type ginsenosides. Process Biochem, 2014, 49, 813-820. 10、 Xiaoxi Guo, Qiao Guo, Yang Li, Seung ki Lee*, Ying-Hua Jin*, Ginsenoside Rh2 induces human hepatoma cell apoptosis via Bax/Bak triggered cytochrome c release and caspase-9/-caspase-8 activation. Int. J. Mol. Sci. 2012, 13, 15523-15535 (19次) 11、 Zhuo Zhan, Kan He, Yang Li, Ying-Hua Jin* Phosphorylation of Rad9 at Serine 328 by Cyclin A-Cdk2 Triggers Apoptosis via Interfering Bcl-xL. PLoS One. 2012, 7 (9) e44923. 12、 Qing Li, Yang Li, Xiaoyu Wang, Xuexun Fang, Kan He, Xiaoxi Guo, Zhuo Zhan, Chao Sun, and Ying-Hua Jin*, Cotreatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, Bax translocation, and cytochrome c release. Mol Carcinogen 2011, 50,760-769 (31次) 13、 Yang Li , Kan He, Yinghui Huang, Daxin Zheng, Chang Gao, Lin Cui, and Ying-Hua Jin*, Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells. Mol Carcinogen 2010, 49, 630-640. (62次) 14、 Ying-Hua Jin, Kye Jin Yoo, You Hui Lee, and Seung Ki Lee. Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the Cyclin A-Cdk2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J Biol Chem. 2000, 275, 30256-30263. (288次) 15、 Ying-Hua Jin, JoonSeoK Choi, Jeong Hill Park, and Seung Ki Lee*. Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells. Carcinogenesis 2003, 24, 1767-1772. (44次) 16、 Ying-Hua Jin, Hyungshin Yim, Jeong Hill Park, and Seung Ki Lee. Cdk2 activity is associated with depolarization of mitochondria membrane potential during apoptosis. Biochem Biophys Res Commun. 2003, 305, 974-980. (72次) 17、 Ying-Hua Jin, Suk-Jin Lee, Myung Hee Chung, Jeong-Hill Park, Young-In Park, Tae Hyeong Cho and Seung-Ki Lee. Aloesin and Arbutin Inhibit Tyrosinase Activity in a Synergistic Manner via a Different Action Mechanism. Arch Pharm Res 1999, 22, 232-236, (69次)

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