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个人简介

教育经历: 1991~1995,四川大学,理学学士 1997~2000,长春生物制品所,医学免疫学硕士 2001~2005,吉林大学,生物化学和分子生物学博士 工作经历: 1、2006~2009,美国杜克大学,博士后 2、2001至今,吉林大学,生命科学学院、艾滋病疫苗国家工程实验室,讲师、教授 近五年发表SCI收入论文50多篇,获授权发明专利7项。主持“十二五”国家科技重大专项子课题1项,国家自然科学面上基金1项,吉林省科技厅重大科技攻关招标项目、重点项目及产业化项目各1项,长春市产学研协同创新示范点建设专项1项,累计到款科研经费超过500万。获得省部级科研学术奖励3项。

研究领域

1、病原微生物致病分子机制研究 2、新型疫苗研究与开发

近期论文

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1: Shi W, Kou Y, Xiao J, Zhang L, Gao F, Kong W, Su W, Jiang C, Zhang Y. Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants. Vaccine. 2018 Aug 9;36(33):5020-5029. doi: 10.1016/j.vaccine.2018.07.006. Epub 2018 Jul 7. PubMed PMID: 30037417. 2: Kou Y, Wan M, Shi W, Liu J, Zhao Z, Xu Y, Wei W, Sun B, Gao F, Cai L, Jiang C. Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis. J Microbiol Biotechnol. 2018 Jun 28;28(6):1022-1029. doi: 10.4014/jmb.1712.12064. PubMed PMID: 29847865. 3: Song H, Giorgi EE, Ganusov VV, Cai F, Athreya G, Yoon H, Carja O, Hora B, Hraber P, Romero-Severson E, Jiang C, Li X, Wang S, Li H, Salazar-Gonzalez JF, Salazar MG, Goonetilleke N, Keele BF, Montefiori DC, Cohen MS, Shaw GM, Hahn BH, McMichael AJ, Haynes BF, Korber B, Bhattacharya T, Gao F. Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection. Nat Commun. 2018 May 15;9(1):1928. doi: 10.1038/s41467-018-04217-5. PubMed PMID: 29765018; PubMed Central PMCID: PMC5954121. 4: Shi W, Kou Y, Jiang H, Gao F, Kong W, Su W, Xu F, Jiang C. Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant. Immunol Lett. 2018 Jun;198:26-32. doi: 10.1016/j.imlet.2018.03.012. Epub 2018 Mar 27. PubMed PMID: 29601940. 5: Dai W, Wu Y, Bi J, Wang S, Li F, Kong W, Barbier J, Cintrat JC, Gao F, Gillet D, Su W, Jiang C. Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo. Viruses. 2018 Mar 9;10(3). pii: E119. doi: 10.3390/v10030119. PubMed PMID: 29522484; PubMed Central PMCID: PMC5869512. 6: Wang D, Lu J, Yu J, Hou H, Leenhouts K, Van Roosmalen ML, Gu T, Jiang C, Kong W, Wu Y. A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like Particles Provides Broad Protection Against Pneumococcal Pneumonia in Mice. Immunol Invest. 2018 May;47(4):403-415. doi: 10.1080/08820139.2018.1439505. Epub 2018 Mar 2. PubMed PMID: 29498560. 7: Du X, Zhang X, Jiang C, Zhang W, Yang L. The Trace Detection of Nitrite Ions Using Neutral Red Functionalized SH-β-Cyclodextrin @Au Nanoparticles. Sensors (Basel). 2018 Feb 25;18(3). pii: E681. doi: 10.3390/s18030681. PubMed PMID: 29495331; PubMed Central PMCID: PMC5877208. 8: Zhao D, Sun B, Sun S, Fu B, Liu C, Liu D, Chu Y, Ma Y, Bai L, Wu Y, Zhou Y, Su W, Hou A, Cai L, Xu F, Kong W, Jiang C. Characterization of human enterovirus71 virus-like particles used for vaccine antigens. PLoS One. 2017 Jul 21;12(7):e0181182. doi: 10.1371/journal.pone.0181182. eCollection 2017. PubMed PMID: 28732070; PubMed Central PMCID: PMC5521781. 9: Kou Y, Xu Y, Zhao Z, Liu J, Wu Y, You Q, Wang L, Gao F, Cai L, Jiang C. Tissue plasminogen activator (tPA) signal sequence enhances immunogenicity of MVA-based vaccine against tuberculosis. Immunol Lett. 2017 Oct;190:51-57. doi: 10.1016/j.imlet.2017.07.007. Epub 2017 Jul 17. PubMed PMID: 28728855. 10: Dai W, Wu Y, Bi J, Lu X, Hou A, Zhou Y, Sun B, Kong W, Barbier J, Cintrat JC, Gao F, Gillet D, Su W, Jiang C. Antiviral effects of Retro-2(cycl) and Retro-2.1 against Enterovirus 71 in vitro and in vivo. Antiviral Res. 2017 Aug;144:311-321. doi: 10.1016/j.antiviral.2017.07.001. Epub 2017 Jul 5. PubMed PMID: 28688753. 11: Zhou Y, Wang Z, Xu Y, Zhang Z, Hua R, Liu W, Jiang C, Chen Y, Yang W, Kong W. Optimized DNA Vaccine Enhanced by Adjuvant IL28B Induces Protective Immune Responses Against Herpes Simplex Virus Type 2 in Mice. Viral Immunol. 2017 Oct;30(8):601-614. doi: 10.1089/vim.2017.0033. Epub 2017 Jun 26. PubMed PMID: 28650722. 12: Su W, Li X, Chen M, Dai W, Sun S, Wang S, Sheng X, Sun S, Gao C, Hou A, Zhou Y, Sun B, Gao F, Xiao J, Zhang Z, Jiang C. Synonymous codon usage analysis of hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015. Infect Genet Evol. 2017 Sep;53:212-217. doi: 10.1016/j.meegid.2017.06.004. Epub 2017 Jun 15. PubMed PMID: 28602802. 13: Wang C, Jiang C, Gao N, Zhang K, Liu D, Wang W, Cong Z, Qin C, Ganusov VV, Ferrari G, LaBranche C, Montefiori DC, Kong W, Yu X, Gao F. Immunologic and Virologic Mechanisms for Partial Protection from Intravenous Challenge by an Integration-Defective SIV Vaccine. Viruses. 2017 Jun 2;9(6). pii: E135. doi: 10.3390/v9060135. PubMed PMID: 28574482; PubMed Central PMCID: PMC5490812. 14: Lu J, Hou H, Wang D, Leenhouts K, Roosmalen MLV, Sun T, Gu T, Song Y, Jiang C, Kong W, Wu Y. Systemic and mucosal immune responses elicited by intranasal immunization with a pneumococcal bacterium-like particle-based vaccine displaying pneumolysin mutant Plym2. Immunol Lett. 2017 Jul;187:41-46. doi: 10.1016/j.imlet.2017.05.003. Epub 2017 May 6. PubMed PMID: 28487097. 15: Xi H, Zhang K, Yin Y, Gu T, Sun Q, Li Z, Cheng Y, Jiang C, Kong W, Wu Y. Engineering of a novel zipFv using leucine zipper motif against rabies virus glycoprotein G with improved protection potency in vivo. Immunol Lett. 2017 Jun;186:9-14. doi: 10.1016/j.imlet.2017.04.001. Epub 2017 Apr 4. PubMed PMID: 28389318. 16: Liu W, Zhou Y, Wang Z, Zhang Z, Wang Q, Su W, Chen Y, Zhang Y, Gao F, Jiang C, Kong W. Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice. Microbiol Immunol. 2017 May;61(5):176-184. doi: 10.1111/1348-0421.12482. PubMed PMID: 28378925. 17: Jin J, Li R, Jiang C, Zhang R, Ge X, Liang F, Sheng X, Dai W, Chen M, Wu J, Xiao J, Su W. Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells. BMC Genomics. 2017 Jan 25;18(Suppl 1):933. doi: 10.1186/s12864-016-3253-6. PubMed PMID: 28198671; PubMed Central PMCID: PMC5310284. 18: Xi H, Zhang K, Yin Y, Gu T, Sun Q, Shi L, Zhang R, Jiang C, Kong W, Wu Y. Fusion Peptide Improves Stability and Bioactivity of Single Chain Antibody against Rabies Virus. J Microbiol Biotechnol. 2017 Apr 28;27(4):718-724. doi: 10.4014/jmb.1611.11062. PubMed PMID: 28068664. 19: Shen Z, Bowen RA, Ge P, Yu J, Shen Y, Kong W, Jiang C, Wu J, Zhu C, Xu Y, Wei W, Rudenko L, Kiseleva I, Xu F. Evaluation of a candidate live attenuated influenza vaccine prepared in Changchun BCHT (China) for safety and efficacy in ferrets. Vaccine. 2016 Nov 21;34(48):5953-5958. doi: 10.1016/j.vaccine.2016.09.059. Epub 2016 Oct 26. PubMed PMID: 27997342. 20: Wang D, Di X, Fu L, Li Y, Han X, Wu H, Cai L, Meng X, Jiang C, Kong W, Su W. Analysis of serum β-amyloid peptides, α2-macroglobulin, complement factor H, and clusterin levels in APP/PS1 transgenic mice during progression of Alzheimer's disease. Neuroreport. 2016 Oct 19;27(15):1114-9. doi: 10.1097/WNR.0000000000000661. PubMed PMID: 27541273. 21: Xi H, Yuan R, Chen X, Gu T, Cheng Y, Li Z, Jiang C, Kong W, Wu Y. Purification and on-column refolding of a single-chain antibody fragment against rabies virus glycoprotein expressed in Escherichia coli. Protein Expr Purif. 2016 Oct;126:26-32. doi: 10.1016/j.pep.2016.05.004. Epub 2016 May 5. PubMed PMID: 27157441. 22: Li X, Fan P, Jiang C, Ma T, Yu X, Kong W, Gao F. High-Frequency Illegitimate Strand Transfers of Nascent DNA Fragments During Reverse Transcription Result in Defective Retrovirus Genomes. J Acquir Immune Defic Syndr. 2016 Aug 1;72(4):353-62. doi: 10.1097/QAI.0000000000000952. PubMed PMID: 26885810. 23: Gong X, Yin H, Shi Y, Guan S, He X, Yang L, Yu Y, Kuai Z, Jiang C, Kong W, Wang S, Shan Y. Conserved stem fragment from H3 influenza hemagglutinin elicits cross-clade neutralizing antibodies through stalk-targeted blocking of conformational change during membrane fusion. Immunol Lett. 2016 Apr;172:11-20. doi: 10.1016/j.imlet.2016.02.006. Epub 2016 Feb 10. PubMed PMID: 26875772. 24: Jiang L, Fan R, Sun S, Fan P, Su W, Zhou Y, Gao F, Xu F, Kong W, Jiang C. A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice. Vaccine. 2015 Nov 27;33(48):6596-603. doi: 10.1016/j.vaccine.2015.10.104. Epub 2015 Oct 31. PubMed PMID: 26529072. 25: Cheng Y, Li Z, Xi H, Gu T, Yuan R, Chen X, Jiang C, Kong W, Wu Y. A VL-linker-VH Orientation Dependent Single Chain Variable Antibody Fragment Against Rabies Virus G Protein with Enhanced Neutralizing Potency in vivo. Protein Pept Lett. 2016;23(1):24-32. PubMed PMID: 26497316. 26: Sun B, Zhao D, Zhang X, Gu T, Yu X, Sun S, Zhao X, Wei L, Liu D, Yan H, Meng X, Kong W, Xu F, Yang P, Jiang C. Development a scalable production process for truncated human papillomavirus type-6 L1 protein using WAVE Bioreactor and hollow fiber membrane. Appl Microbiol Biotechnol. 2016 Feb;100(3):1231-40. doi: 10.1007/s00253-015-6974-6. Epub 2015 Oct 8. PubMed PMID: 26446387. 27: Li Z, Cheng Y, Xi H, Gu T, Yuan R, Chen X, Jiang C, Kong W, Wu Y. A novel variable antibody fragment dimerized by leucine zippers with enhanced neutralizing potency against rabies virus G protein compared to its corresponding single-chain variable antibody fragment. Mol Immunol. 2015 Dec;68(2 Pt A):168-75. doi: 10.1016/j.molimm.2015.06.027. Epub 2015 Aug 29. PubMed PMID: 26325475. 28: Qi Y, Zhang F, Zhang L, Harrison TJ, Huang W, Zhao C, Kong W, Jiang C, Wang Y. Hepatitis E Virus Produced from Cell Culture Has a Lipid Envelope. PLoS One. 2015 Jul 10;10(7):e0132503. doi: 10.1371/journal.pone.0132503. eCollection 2015. PubMed PMID: 26161670; PubMed Central PMCID: PMC4498737. 29: Zang Y, Du D, Li N, Su W, Liu X, Zhang Y, Nie J, Wang Y, Kong W, Jiang C. Eliciting neutralizing antibodies against the membrane proximal external region of HIV-1 Env by chimeric live attenuated influenza A virus vaccines. Vaccine. 2015 Jul 31;33(32):3859-64. doi: 10.1016/j.vaccine.2015.06.072. Epub 2015 Jun 28. PubMed PMID: 26126669. 30: Lu J, Sun T, Wang D, Dong Y, Xu M, Hou H, Kong FT, Liang C, Gu T, Chen P, Sun S, Lv X, Jiang C, Kong W, Wu Y. Protective Immune Responses Elicited by Fusion Protein Containing PsaA and PspA Fragments. Immunol Invest. 2015;44(5):482-96. doi: 10.3109/08820139.2015.1037956. PubMed PMID: 26107747. 31: Sun S, Gao F, Mao Q, Shao J, Jiang L, Liu D, Wang Y, Yao X, Wu X, Sun B, Zhao D, Ma Y, Lu J, Kong W, Jiang C, Liang Z. Immunogenicity and protective efficacy of an EV71 virus-like particle vaccine against lethal challenge in newborn mice. Hum Vaccin Immunother. 2015;11(10):2406-13. doi: 10.1080/21645515.2015.1053675. PubMed PMID: 26036916; PubMed Central PMCID: PMC4635907. 32: Fan P, Li X, Su W, Kong W, Kong X, Wang Z, Wang Y, Jiang C, Gao F. Enhanced Sensitivity for Detection of HIV-1 p24 Antigen by a Novel Nuclease-Linked Fluorescence Oligonucleotide Assay. PLoS One. 2015 Apr 27;10(4):e0125701. doi: 10.1371/journal.pone.0125701. eCollection 2015. PubMed PMID: 25915630; PubMed Central PMCID: PMC4410951. 33: Chen Y, Li N, Zhang T, Huang X, Cai F, Vandergrift N, Xin R, Meng Z, Zhang X, Jiang C, Xu X, Montefiori DC, Gao F, Wu H. Comprehensive Characterization of the Transmitted/Founder env Genes From a Single MSM Cohort in China. J Acquir Immune Defic Syndr. 2015 Aug 1;69(4):403-12. doi: 10.1097/QAI.0000000000000649. PubMed PMID: 25886933; PubMed Central PMCID: PMC4482776. 34: Fan P, Li X, Sun S, Su W, An D, Gao F, Kong W, Jiang C. Identification of a common epitope between enterovirus 71 and human MED25 proteins which may explain virus-associated neurological disease. Viruses. 2015 Mar 27;7(4):1558-77. doi: 10.3390/v7041558. PubMed PMID: 25826188; PubMed Central PMCID: PMC4411665. 35: Qi Y, Fan J, Huang W, Zhao C, Wang Y, Kong FT, Kong W, Jiang C. Expression and characterization of hepatitis E virus-like particles and non-virus-like particles from insect cells. Biotechnol Appl Biochem. 2016 May;63(3):362-70. doi: 10.1002/bab.1379. Epub 2015 Jul 6. Review. PubMed PMID: 25824972. 36: Zang Y, Du D, Ge P, Xu Y, Liu X, Zhang Y, Su W, Kiseleva I, Rudenko L, Xu F, Kong W, Jiang C. Development of one-step real-time PCR assay for titrating trivalent live attenuated influenza vaccines. Hum Vaccin Immunother. 2014;10(12):3642-8. doi: 10.4161/hv.34453. PubMed PMID: 25483696; PubMed Central PMCID: PMC4514063. 37: Sun S, Jiang L, Liang Z, Mao Q, Su W, Zhang H, Li X, Jin J, Xu L, Zhao D, Fan P, An D, Yang P, Lu J, Lv X, Sun B, Xu F, Kong W, Jiang C. Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice. Hum Vaccin Immunother. 2014;10(10):2885-95. doi: 10.4161/hv.29823. PubMed PMID: 25483672; PubMed Central PMCID: PMC5443096. 38: Xu L, Su W, Jin J, Chen J, Li X, Zhang X, Sun M, Sun S, Fan P, An D, Zhang H, Zhang X, Kong W, Ma T, Jiang C. Identification of luteolin as enterovirus 71 and coxsackievirus A16 inhibitors through reporter viruses and cell viability-based screening. Viruses. 2014 Jul 17;6(7):2778-95. doi: 10.3390/v6072778. PubMed PMID: 25036464; PubMed Central PMCID: PMC4113793. 39: Lu J, Sun T, Hou H, Xu M, Gu T, Dong Y, Wang D, Chen P, Wu C, Liang C, Sun S, Jiang C, Kong W, Wu Y. Detoxified pneumolysin derivative Plym2 directly protects against pneumococcal infection via induction of inflammatory cytokines. Immunol Invest. 2014;43(7):717-26. doi: 10.3109/08820139.2014.930478. Epub 2014 Jul 14. PubMed PMID: 25020076. 40: Zhang H, An D, Liu W, Mao Q, Jin J, Xu L, Sun S, Jiang L, Li X, Shao J, Ma H, Huang X, Guo S, Chen H, Cheng T, Yang L, Su W, Kong W, Liang Z, Jiang C. Analysis of cross-reactive neutralizing antibodies in human HFMD serum with an EV71 pseudovirus-based assay. PLoS One. 2014 Jun 25;9(6):e100545. doi: 10.1371/journal.pone.0100545. eCollection 2014. PubMed PMID: 24964084; PubMed Central PMCID: PMC4070950. 41: Zang Y, Bi J, Du D, Liu X, Zhang Y, Su W, Wu J, Shan Y, Wang S, Kong W, Qiu A, Jiang C. Development of a Norovirus P particle platform for eliciting neutralizing antibody responses to the membrane proximal external region of human immunodeficiency virus type 1 envelope. Protein Pept Lett. 2014;21(12):1230-9. PubMed PMID: 24939661. 42: Xiang Y, Liu W, Chen Y, Zhang C, Su W, Zhang Y, Sun J, Gao F, Jiang C. The variable loop 3 in the envelope glycoprotein is critical for the atypical coreceptor usage of an HIV-1 strain. PLoS One. 2014 Jun 4;9(6):e98058. doi: 10.1371/journal.pone.0098058. eCollection 2014. PubMed PMID: 24897520; PubMed Central PMCID: PMC4045670. 43: Duan Y, Gu T, Zhang X, Jiang C, Yuan R, Li Z, Wang D, Chen X, Wu C, Chen Y, Wu Y, Kong W. Negative effects of a disulfide bond mismatch in anti-rabies G protein single-chain antibody variable fragment FV57. Mol Immunol. 2014 Jun;59(2):136-41. doi: 10.1016/j.molimm.2014.01.006. Epub 2014 Mar 2. PubMed PMID: 24598312. 44: Zhang L, Jiang C, Zhang H, Gong X, Yang L, Miao L, Shi Y, Zhang Y, Kong W, Zhang C, Shan Y. A novel modified peptide derived from membrane-proximal external region of human immunodeficiency virus type 1 envelope significantly enhances retrovirus infection. J Pept Sci. 2014 Jan;20(1):46-54. doi: 10.1002/psc.2587. Epub 2013 Nov 19. PubMed PMID: 24254845. 45: Yuan R, Chen X, Chen Y, Gu T, Xi H, Duan Y, Sun B, Yu X, Jiang C, Liu X, Wu C, Kong W, Wu Y. Preparation and diagnostic use of a novel recombinant single-chain antibody against rabies virus glycoprotein. Appl Microbiol Biotechnol. 2014 Feb;98(4):1547-55. doi: 10.1007/s00253-013-5351-6. Epub 2013 Nov 16. PubMed PMID: 24241896. 46: Zheng DD, Pan D, Zha X, Wu Y, Jiang C, Yu X. In vitro monitoring of the formation of pentamers from the monomer of GST fused HPV 16 L1. Chem Commun (Camb). 2013 Oct 4;49(76):8546-8. doi: 10.1039/c3cc44986f. PubMed PMID: 23945594. 47: Li X, Fan P, Jin J, Su W, An D, Xu L, Sun S, Zhang Y, Meng X, Gao F, Kong W, Jiang C. Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2. Virol J. 2013 Aug 6;10:250. doi: 10.1186/1743-422X-10-250. PubMed PMID: 23919614; PubMed Central PMCID: PMC3765843. 48: Zhang L, Miao L, Gong X, Zhang H, Yang L, Shi Y, Kong W, Jiang C, Shan Y. Multiple antigen peptide mimetics containing gp41 membrane-proximal external region elicit broad neutralizing antibodies against human immunodeficiency virus type 1 in guinea pigs. J Pept Sci. 2013 Aug;19(8):491-8. doi: 10.1002/psc.2526. Epub 2013 Jun 21. PubMed PMID: 23794478. 49: Sun B, Yu X, Yin Y, Liu X, Wu Y, Chen Y, Zhang X, Jiang C, Kong W. Large-scale purification of pharmaceutical-grade plasmid DNA using tangential flow filtration and multi-step chromatography. J Biosci Bioeng. 2013 Sep;116(3):281-6. doi: 10.1016/j.jbiosc.2013.03.015. Epub 2013 May 7. PubMed PMID: 23660074. 50: Jin J, Ma H, Xu L, An D, Sun S, Huang X, Kong W, Jiang C. Development of a Coxsackievirus A16 neutralization assay based on pseudoviruses for measurement of neutralizing antibody titer in human serum. J Virol Methods. 2013 Feb;187(2):362-7. doi: 10.1016/j.jviromet.2012.11.014. Epub 2012 Nov 20. PubMed PMID: 23178532.

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