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教育经历(按时间倒排序) 2004/9 - 2007/6,吉林大学,预防兽医学,博士 2000/9 - 2003/6,解放军军需大学,植物病理学,硕士 1996/9 - 2000/6,解放军军需大学,农学,学士 工作经历(按时间倒排序) 2017/9 - 至 今,吉林大学,动物科学学院,教授 2011/9 – 2017/09,吉林大学,畜牧兽医学院/动物科学学院,副教授 2015/9 – 2016/09,新加坡国立大学微生物与免疫学系,访问学者 2006/9 - 2011/09,吉林大学,畜牧兽医学院,讲师 2003/7 - 2006/09,解放军军需大学/吉林大学,畜牧兽医学院,助教 主讲课程 本科生课程:分子生物学,基因工程原理 研究生课程:基因表达技术 主持科研项目及人才计划项目情况(按时间倒排序) 1.吉林省教育厅十三五科学技术项目,JJKH20190172KJ,猪源髓细胞核分化抗原对PCV2感染的影响,2.5万元,2019.01-2020.12,主持,运行 2.国家自然科学基金面上项目,31772747,HMG-CoA还原酶调节网络在猪圆环病毒2型感染过程中的功能研究,2018.01-2021.12,60万,运行,主持 3.2017年国家重点研发计划“畜禽重大疫病防控与高效安全养殖综合技术研发”专项------“畜禽重要疫病病原学与流行病学研究”项目,2017YFD0500103,重要病毒持续性感染及宿主调控病毒复制的分子机制,52万,运行,分题主持 4.转基因生物新品种培育重大专项,2016ZX08006-003-001,克隆猪抗病性能检测,2017.01-2019.12,90万元,运行,主持 5.吉林省科技发展计划重点科技攻关项目,20150204077NY,应用病毒感染报告细胞筛选猪瘟靶向药物及弱毒疫苗的研究,2015.01-2017.12,17万元,结题,主持 6.吉林省科技发展计划自然科学基金面上项目,20140101123JC,猪圆环病毒2型高敏感细胞系的建立及全病毒灭活疫苗的制备,2014.01-2016.12,8万元,结题,主持 7.吉林大学自然科学基本科研业务费择优资助项目,450060501753,猪瘟病毒感染报告细胞的构建,2014.07-2016.07,10万元,已结题,主持 8.吉林大学自然科学基本科研业务费资助项目,450060488104,羟甲基戊二酸单酰辅酶A还原酶对猪圆环病毒2型复制的影响,2013.01-2014.12,2万元,已结题,主持 9.吉林大学自然科学基本科研业务费资助项目,450060445276,几种宿主蛋白对猪繁殖与呼吸综合征病毒感染的影响,2011.05-2013.05,5万元,已结题,主持 10.转基因生物新品种培育重大专项,3D6090106201,抗猪瘟转基因猪新品种培育,2008.01-2010.12,50万元,已结题,分题主持 11.转基因生物新品种培育重大专项、3D5100016201、节粮型高瘦肉率转基因猪新品种培育、2008/01-2010/12、10万、已结题、分题主持. 专利: [1] 一种猪伪狂犬病毒的抑制细胞系. 发明人:任林柱, 彭志园, 欧阳婷, 马腾,陈心容, 陈福旺, 逄大欣, 欧阳红生. 申请号:201610001039.4;申请日:2016.1.5; 专利权人:吉林大学;专利号:ZL201610001039.4;授权公告日:2019.01.09(已授权) [2] 利用生殖特异性启动子表达cre的重组酶载体. 发明人:逄大欣,宋宇宁,李占军,王勇,欧阳红生,赖良学,张明军,焦虎平,唐小春,任林柱. 申请号:2015106034311;申请日:2015.09.22;专利权人:吉林大学; [3] 一种基于LAMP方法快速检测肉类掺假的试剂盒. 发明人:唐小春,卢新,冉光耀,谢俊平,逄大欣,梁科,任林柱,欧阳红生. 申请号:201410660271X;申请日:2014.11.18;专利权人:广东达元绿洲食品安全科技股份有限公司;专利号:ZL201410660271X;授权公告日:2016.09.21(已授权) [4] 一种用于检测猪瘟病毒感染的报告细胞系. 发明人:任林柱,陈福旺,杨鑫,欧阳红生,逢大欣;申请号:2014102738570;申请日:2014.06.19;专利权人:吉林大学;专利号:ZL201410273857.0;授权公告号:CN104017904B;授权公告日:2015.06.24。(已授权) [5] 一种猪圆环病毒2型高敏感细胞系的制备方法. 发明人:任林柱,陈福旺,杨鑫,欧阳红生,逄大欣,曹宇航,张明军,董美辰;申请号:2013104814803;申请日:2013.10.16;专利权人:吉林大学;专利号:ZL201310481480.3;授权公告号:CN103497932B;授权公告日:2015.01.07。(已授权) [6] 2012年,叶点霉发酵液中蒽醌类物质的提取,潘风光 王楠 任林柱 宫新统,申请号:201210549187.1 申请日:2012-12-06 [7] 2012年,猪繁殖与呼吸综合症病毒受体CD163敲除猪及培育方法,赖良学、逄大欣、欧阳红生、任林柱、宋娜、于飞飞、杨鑫、陈福旺、曹宇航、李莉,申请号:201210135794.3 [8] 饲料中牛羊源成分检测方法及试剂盒. 发明人:逄大欣,欧阳红生,郑文文,李小平,高飞,王铁东,任林柱,李莉,张明军,张英。申请号:200910218081.1;申请日:2009.12.23; 专利权人:吉林大学;专利号:ZL200910218081.1;授权公告日: 2013.03.13(已授权) [9] 玉米丝黑穗病菌PCR检测试剂盒及其制备方法申报专利. 发明人:任林柱,李莉,白容霖。申请号:200910066923.6;申请日:2009.05.08; 专利权人:吉林大学;专利号:ZL200910066923.6;授权公告日: 2012.02.01(已授权) [10] 2009年,一种用于制备人类疾病动物模型的转基因猪及其培育方法,欧阳红生,逄大欣,陈立梅,李莉,李占军,王铁东,张明军,任林柱,闫森,宋娜。,申请号:200910066584.1 [11] 一种检测Cre位点特异重组酶活性转基因报告猪重构胚构建的方法. 发明人:欧阳红生,逄大欣,李莉,王铁东,陈立梅,赖良学,任林柱,张明军,李占军。申请号:200910066596.4;专利权人:吉林大学;专利号:ZL200910066596.4;授权公告日: 2011.09.14(已授权)

研究领域

基因表达调控,病毒与宿主相互作用

近期论文

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[1] Ouyang T, Niu G, Zhang Y, Liu X, Zhang X, Zhang S, Geng Y, Pang D, Ouyang H, Ren L*. Porcine HMGCR Inhibits Porcine Circovirus Type 2 Infection by Directly Interacting with the Viral Proteins. Viruses-basel 2019, 11(6), 544. (IF: 3.811) [2] Ouyang T*, Niu G*, Liu X, Zhang X, Zhang Y, Ren L*. Recent progress on porcine circovirus type 3. Infect Genet Evol. 2019 May 13, 73: 227-233. (IF: 2.611) [3] Dong H, Su A, Lv D, Ma L, Dong J, Guo N, Ren L, Jiao H, Pang D, Ouyang H. Development of whole-porcine monoclonal antibodies with potent neutralization activity against classical swine fever virus (CSFV) from single B cells. ACS Synth Biol. 2019 May 17;8(5):989-1000. (IF: 5.571) [4] Liu X, Ouyang T, Ouyang H, Liu XH, Niu G, Huo W, Yin W, Pang D, Ren L*. Human cells are permissive for the productive infection of porcine circovirus type 2 in vitro. Sci Rep. 2019 Apr 4;9(1):5638. (IF: 4.011) [5]Du S, Jiang Y, Xu W, Bai J, Tian M, Wang M, Wang Y, Cao T, Song L, Jiang Y, Chen J, Fu T, Hao P, Li T, Wu S, Ren L*(Co-corresponding), Jin N*, Li C*. Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro. Int J Biol Macromol., 2019 Mar 23;131:925-932. (IF: 4.784) [6]Ouyang T, Zhang X, Liu X, Ren L*. Co-infection of swine with porcine circovirus type 2 and other swine viruses. Viruses-basel, 2019, 11(2), 185. (IF: 3.811) [7] Yang Y, Cheng Y, Li N, Cheng S, Guo L, Zhou Y, Zhang H, Zhang X, Ren L*. Mink Circovirus Can Infect Minks, Foxes and Raccoon Dogs. Virol Sin. 2018 Dec 4. 33(6), 561-564. (IF:2.415) [8] Ouyang T, Liu X, Ouyang H, Ren L*. Recent trends in click chemistry as a promising technology for virus-related research, Virus Res, 2-SEP-2018, 256: 21-28. (IF: 2.484) [9] Ren L, Peng Z, Ouyang T, Liu X, Chen X, Ye L, Fan J, Ouyang H, Pang D, Bai J. Subculturing cells have no effect on CRISPR/Cas9‐mediated cleavage of UL30 gene in pseudorabies virus. Animal Models and Experimental Medicine, 19 April 2018: 74-77. https://doi. org/ 10.1002/ame2.12006 Indexed by Pubmed [10] Ouyang T, Liu X, Ouyang H, Ren L*. Mouse models of porcine circovirus 2 infection. Animal Models and Experimental Medicine, 19 April 2018: 23-28. https://doi.org/10.1002/ ame2.12009 Indexed by Pubmed [11] Liu X, Ouyang T, Ma T, Ouyang H, Pang D, Ren L*. Immunogenicity evaluation of inactivated virus and purified proteins of porcine circovirus type 2 in mice. BMC Vet Res, 2018, 14:137. (IF: 1.958) [12] 欧阳婷,刘晓慧,任林柱*. 抗DNA病毒信号通路cGAS-STING的研究进展.中国比较医学杂志,2018年3月第28卷第3期,103-107 [13]Chen X, Ye L, Fan J, Li C, Tang F, Liu W, Ren L(第一作者导师), Bai J*. Detection of Kobe-type and Otsu-type Babesia microti in wild rodents in China’s Yunnan Province. Epidemiol Infect. 2017 Aug 14:1-7.(IF: 2.044) [14] Liu X, Ouyang T, Ouyang H, Ren L*. Single particle labeling of RNA virus in live cells. Virus Res, 12 May 2017, 237: 14–21.(IF: 2.484) [15] Ma T, Chen X, Ouyang H, Liu X, Ouyang T, Peng Z, Yang X, Chen F, Pang D, Bai J, Ren L*. HMGCR inhibits the early stage of PCV2 infection, while PKC enhances the infection at the late stage. Virus Res, 2017, 229: 41-47. (IF: 2.484) [16] Ma T, Ouyang T, Ouyang H, Chen F, Peng Z, Chen X, Pang D, Ren L*. Porcine circovirus 2 proliferation can be enhanced by stably expressing porcine IL-2 gene in PK-15 cell. Virus Res, 2017 Jan 2, 227: 143-149. (IF: 2.484) [17] Peng Z, Ma T, Pang D, Su D, Chen F, Chen X, Guo N, Ouyang T, Ouyang H, Ren L*. Expression, purification and antibody preparation of PCV2 Rep and ORF3 proteins. Int J Biol Macromol. 2016, 86:277-281. (IF: 3.671) [18] Peng Z, Ouyang T, Pang D, Ma T, Chen X, Guo N, Chen F, Yuan Lin, Ouyang H, Ren L*. Pseudorabies virus can escape from CRISPR-Cas9-mediated inhibition. Virus Res, 2016, 223: 197-205. (IF: 2.628) [19] Ran G, Ren L (并列第一), Han X, Liu X, Li Z, Pang D, Ouyang H, Tang X. Development of a Rapid Method for the Visible Detection of Pork DNA in Halal Products by Loop-Mediated Isothermal Amplification. Food Anal Method, 2016, 9:565–570.(IF: 2.167) [20] Ren L*, Peng Z, Chen X, Ouyang H. Live cell reporter systems for positive-sense single strand RNA viruses. Appl Biochem Biotech, 2016, 178: 1567-85. (IF: 1.606) [21] Ren L*, Chen X, Ouyang H. Interactions of porcine circovirus 2 with its hosts. Virus genes, 2016, 52: 437-444. (IF: 1.431) [22] Chen F, Jiang J, Ouyang H, Ma T, Peng Z, Ma Y, Chen X, Pang D, Lin S, Ren L*. Markerless deletion system for Escherichia coli using short homologous sequences and positive-negative selectable cassette. Appl Biochem Biotech, 2015 Jul;176(5):1472-81.(IF: 1.606) [23]Chen F, Yang X, Pang D, Peng Z, Ma T, Ouyang H, Ren L*. A dark-to-bright reporter cell for classical swine fever virus infection. Antiviral Res, 2015, 117: 44-51. (IF: 4.909) [24] Yang X, Ma T, Ouyang H, Chen F, Peng Z, Li C, Ma Y, Chen X, Li B, Pang D, Ren L*. Effect of atovastatin treatment on porcine circovirus 2 infectionin BALB/c mice. Clin Exp Pharmacol Physiol, 2015, 42(8): 817-21(IF: 2.004) [25] Yang X, Ouyang H, Chen F, Ma T, Dong M, Wang F, Pang D, Peng Z, Ren L*. Inhibition of HMG-CoA reductase increases the expression of IFN-responsive genes. Clin Exp Pharmacol Physiol, 2014, 41: 950-955. IF: 2.372) [26] Yang X, Ouyang H, Chen F, Pang D, Dong M, Yang S, Liu X, Peng Z, Wang F, Zhang X, Ren L*. HMG CoA reductase is negatively associated with PCV2 infection and PCV2-induced apoptotic cell death. J Gen Virol, 2014, 95: 1330-1337.(IF: 3.183) [27] Chen F, Yang X, Pang D, Peng Z, Dong M, Liu X, Ouyang H, Ren L*. Expression, purification and antibody preparation using different constructs of PCV2 capsid protein. Int J Biol Macromol, 2014, 67: 289-294.(IF: 2.858) [28]Yang X, Chen F, Cao Y, Pang D, Ouyang H*, Ren L*. Comparative analysis of different methods to enhance porcine circovirus 2 replication. J Virol Methods, 2013, 187: 368-371 (IF: 1.883) [29] Lin X, Yang X, Chen F, Cao Y, Meng X, Jiang J, Pang D, Zhao Y, Ouyang H, Ren L*. Porcine CD4 promoters and enhancers can direct foreign gene expression in human cells. Biotechnol Lett, 2013, 35: 663-669.(IF: 1.736) [30] Yang X, Chen F, Cao Y, Pang D, Ouyang H*, Ren L*. Complete Genome Sequence of Porcine Circovirus 2b Strain CC1. J Virol, 2012, 86: 9536.(IF: 5.076) [31] Tan G, Ren L (co-author), Huang Y, Tang X, Zhou Y, Zhou Y, Li D, Song H, Ouyang H*, Pang D*. Isolation and culture of embryonic stem-like cells from pig nuclear transfer blastocysts of different days. Zygote, 2012, 20: 347-352.(IF:1.5) [32] Lin S, Meng X, Jiang J, Pang D, Jones G, Ouyang H*, Ren L*. Site-directed mutagenesis and over expression of aroG gene of Escherichia coli K-12. Int J Biol Macromol, 2012,51: 915-919. (IF: 2.596) [33] Zhao Y, Pang D, Wang T, Yang X, Wu R, Ren L, Yuan T, Huang Y, Ouyang H*. Human MxA protein inhibits the replication of classical swine fever virus. Virus Res, 2011, 156:151-155.(IF: 2.941) [34] Linzhu Ren, Daxin Pang, Mingjun Zhang, Li Li, Tiedong Wang, Hongsheng Ouyang*,Aimin Li. Comparative analysis of the activity of two promoters in insect cells. Afr J Biotechnol, 2011, 10: 8930-8941.(IF: 0.573) [35] Linzhu Ren, Lin Wang, Yunzhi Ma, Xinglong Wang*. Genetic characterization of food-and-mouth disease virus WFL strain. Afr J Microbiol Res, 2011, 5: 2661-2666.(IF: 0.539) [36] Zhou Y, Ren L (co-author), Zhu J, Yan S, Wang H, Song N, Li L, Ouyang H*, Pang D*. Construction of a recombinant human FGF1 expression vector for mammary gland-specific expression in human breast cancer cells. Mol Cell Biochem, 2011, 354: 39-46.(IF: 2.057) [37] Wang Y, Dang Y, Wang X*, Lu H, Wang X, Lang X, Li X, Feng S, Zhang F, Ren L. Comparative Proteomic Analyses of Streptococcus suis Serotype 2 Cell Wall-Associated Proteins. Curr Microbiol, 2011, 62: 578-588.(IF: 1.51) [38] Linzhu Ren*. Molecular characterization of a Chinese variant of the Flury-LEP strain. Virol J, 2010, 7:80. (IF: 2.546) [39] Cao Y, Ouyang H, Zhang M, Chen F, Yang X, Pang D, Ren L*. Analysis of molecular variation in porcine reproductive and respiratory syndrome virus in China between 2007 and 2012. Virol Sin, 2014, 29: 183-188 (indexed by Pubmed) [40] 曹宇航,王斐,刘晓云,张潇,逄大欣,张明军*,任林柱*. HSP27和Annexin A2蛋白对PRRSV感染的影响. 中国兽医学报, 2014, 34(04): 618-621. [41] 陈福旺,于飞飞,曹宇航,杨鑫,任林柱(通信). 猪圆环病毒Ⅱ型Cap、Rep基因原核表达质粒的构建与表达. 中国农学通报, 2012,28(第20期7月): 98-101. [42] 于飞飞,陈福旺,宋娜,杨鑫,曹宇航,张娟,傅震洲,王安峰,任林柱(通信).猪繁殖与呼吸综合症病毒受体CD163基因敲除载体的建立. 动物医学进展,2012,33(9):27-30. [43] 邢士博,曹宇航,张田,朱琳,陈玉珏,任林柱(通信). 猪Annexin A2 基因真核表达载体的构建及表达. 吉林农业大学学报,2012,34(5):571-574. [44] 林晓晨,杨鑫,曹宇航,焦丽,戴甄,任林柱(通信),逄大欣. 慢病毒介导的猪CD4启动子在白血病Jurkat细胞中的启动作用,吉林大学学报(医学版),2012, 02: 20-24.

学术兼职

1.中国畜牧兽医学会动物传染病学分会理事 2.中国畜牧兽医学会高级会员 3.Animal models and experimental medicine 编委委员 4.吉林大学青年科技工作者协会会员 5.吉林大学动物科学学院教学委员会委员 6.Molecular Therapy-Nucliec Acids、Antiviral research、BMC Veterinary Research、Virus Research、Virologica Sinica、病毒学报、畜牧兽医学报等国内外期刊审稿专家

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