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个人简介

关爽,1973年生,副教授,博士生导师。毕业于吉林大学,获得药理学博士学位,康奈尔大学访问学者。主讲《食品毒理学》、《食品免疫学》、《食品质量与安全》和《分子毒理学》(研究生课)。近年来主持或参加多项省部级科研课题及企业课题,以第一作者或通讯作者发表SCI论文30多篇。 受教育经历 1992-1996 长春中医学院 中药系 学士 2007-2009 吉林大学 军需科技学院食品科学系 硕士 2009-2011 吉林大学 畜牧兽医学院基础兽医系 博士 研究工作经历 2000-2009 吉林亚泰药业 新药研发部 研究员 2012-2015 吉林大学军需科技学院食品质量与安全系 讲师 2015-现在 吉林大学食品科学与工程学院 副教授 2013/03-2013/11 美国康奈尔大学 农业与生命学院 食品系 访问学者 2012-2016 吉林大学 畜牧兽医学院(动物科学学院)生物化学与分子生物学 博士后 科研项目 主持国家自然科学基金面上项目,1,3-二氯丙醇通过抑制自噬诱导肝细胞脂质蓄积的作用机制研究,NO. 32072315, 2021-2024 58万元; 主持国家自然科学国际合作项目子课题,抗沙门氏菌三型分泌系统天然化合物的筛选,2017-2021 149.75万元; 主持十二五科技支撑项目子课题,林蛙骨补钙制剂的研究及相关产品开发,2013-2017,80万元; 主持国家教育部博士点基金项目(新教师类),3-氯-1,2-丙二醇抑制小鼠T淋巴细胞的毒性,2014-2017,4万元; 主持博士后科学基金面上项目,苯并芘对小鼠T淋巴细胞的抑制作用,2013-2016,10万元; 主持企业项目,林蛙多肽口服液技术开发(委托)项目,2013-2017,10万; 参加吉林省科技厅重点项目,林蛙综合深加工技术研究开发,2018-2020,80万; 参加吉林省世行贷款项目,吉林省养殖鱼类常见细菌性病害新药筛选,2012-2014,25万元; 参加吉林省科技厅重点项目,玉米汁中农药残留快速检测及控制技术的研究,2012-2014,14万元;

研究领域

主要从事食品营养和毒理机制研究及安全评价研究、长白山特色资源综合开发研究。

近期论文

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Jing Lu,Jianing Lu , Yan Chen, Zhe Feng, Shuang Liu, Guan Shuang(*). 3-Chloro-1, 2-propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells. FOOD AND CHEMICAL TOXICOLOGY. 2020(144):111575. Jing Lu, Zhuoqun Meng, Yan Chen, Liangli Yu,,Boyan Gao, Yangjie Zheng, Guan Shuang(*). Apigenin induced autophagy and stimulated autophagic lipid degradation. Food & Function.2020, DOI: 10.1039/d0fo00949k Shuang Guan , SiYu Tao, YiXuan Huang, YingLi Jin, YuTing Hu, Jing Lu. Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux. Ecotoxicology and Environmental Safety. 2020(205)111062. Cheng, BJ; Lu, J ; Li, TJ ; Meng, ZQ ; Liu, MT; Guan Shuang(*). 1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells. FOOD AND CHEMICAL TOXICOLOGY. 2018(122):143-150 Lu J, Cheng B, Meng Z, Fang B, Li T, Sun M, Liu M, Guan Shuang(*). Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.Life Sci. 2018 Feb 15;195:19-24. Lu J, Cheng B, Fang B, Meng Z, Zheng Y, Tian X, Guan Shuang(*). Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells.Biomed Pharmacother. 2017 Dec;96:1411-1417. Lu J, Fang B, Zheng Y, Yu X, Huang G, Wang Z, Deng X, Guan Shuang(*).1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors.Environ Toxicol Pharmacol. 2017 Oct;55:118-126. Guan, Shuang ; Zheng, Yiying; Yu, Xin; Lu, Jing. Ellagic acid protects against LPS-induced acute lung injury through inhibition of nuclear factor kappa B, proinflammatory cytokines and enhancement of interleukin-10. FOOD AND AGRICULTURAL IMMUNOLOGY,2017:28(6):1347-1361 Guan, Shuang ; Yu, Xin; Fang, Baochen; Lu, JingThe toxicity of 3-monochloro-1,2-propanediol (+) to activated T cells in mice. AGRICULTURAL IMMUNOLOGY:28(4):612-624. Guan S, Huang Y, Feng Z, Xu L, Jin Y, Lu J. The toxic effects of benzo[a]pyrene on activated mouse T cells in vitro. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):117-123. Lu J, Wang Z, Ren M, Huang G, Fang B, Bu X, Liu Y, Guan Shuang(*).Antibacterial Effect of Gallic Acid against Aeromonas hydrophila and Aeromonas sobria Through Damaging Membrane Integrity.Curr Pharm Biotechnol. 2016;17(13):1153-1158. Jin Y, Wang Y, Zhao D, Ma S, Lu J, Guan Shuang(*).Pristimerin attenuates ovalbumin-induced allergic airway inflammation in mice.Immunopharmacol Immunotoxicol. 2016 Jun;38(3):221-7 jing lu (#),Ren Mengrou(#),Fang Baochen,Huang Guoren,Zhang Shuang,Wang Yi,Deng Xuming(*),Guan Shuang(*),Nonalcoholic fatty liver disease induced by 13-week oral administration of 1,3-dichloro-2-propanol in C57BL/6J mice,Environ Toxicol Pharmacol,2015,39(3):1115-1121 jing lu (#) ,Wang Zhenning,Ren Mengrou,Feng Guangxin,Ye Beining,Wang Yi,Fang Baochen,Deng Xuming,Guan Shuang(*),A 4-week study of four 3-monochloropropane-1,2-diol diesters on lipid metabolism in C57BL/6J mice,Environ Toxicol Pharmacol,2015.9.01,40(2):453-458 Lu Jing,Huang, Guoren,Hu, Sizhuo,Wang, Zhenning,Guan, Shuang(*),1,3-Dichloro-2-propanol induced hyperlipidemia in C57BL/6J mice via AMPK signaling pathway,Food and Chemical Toxicology,2014,64:403~409 Jing Lu (#),Guoren Huang(#), Bocui Song,Zhenning Wang,Linli Xu,Shuonan Zhang,Shuang Guan(*),The inhibition of 2,3-dichloro-1-Propanol on T cell in vitro and in vivo,International Immunopharmacology,2013,17(2):321~328 Jing Lu (#) ,Guoren Huang,Zhenning Wang,Shuang Zhuang,Linli Xu,Bocui Song,Ying Xiong,Shuang Guan (*),Tyrosol exhibits negative regulatory effects on LPS response and endotoxemia,Food and Chemical Toxicology,2013,62:172~178 Bocui Song (#),Shuang Guan(#),Jing Lu (#),Zhibao Chen,Guoren Huang,Gen Li,Ying Xiong,Shuang Zhang,Zhanpeng Yue(*),Xuming Deng(*),Suppressive effects of fisetin on mice T lymphocytes in vitro and in vivo,Journal of Surgical Research,2013.11.01,185(1):399~409 Ying Xiong(#),Shuang Zhang(#),Jing Lu (#) ,Shicheng Sun,Bocui Song,Linli Xu,Zhenguo Yang(*),Shuang Guan(*),Investigation of effects of farrerol on suppression of murine T lymphocyte activation in vitro and in vivo,International Immunopharmacology,2013,16(2):313~321 Jing Lu (#),Wenhui Qian(#),Linli Xu ,Guoren Huang,Wen Cong,Zhenning Wang,Xuming Deng,Dacheng Wang,Shuang Guan(*),Phytochemical composition andtoxicity of an antioxidant extract from Pimpinella brachycarpa (Kom.) Nakai,Environmental Toxicology and Pharmacology,2012,34(2):409~415 Guan Shuang, Song Yu, Guo Weixiao, Chu Xiao, Zhang Xiaozhe, Wang Dacheng, Lu Jing, Deng Xuming. Immunosuppressive activity of tilmicosin on the immune responses in mice. Immunopharmacol Immunotoxicol, 33(2), 323-8, 2011. Shuang Guan, Yu Songa, Weixiao Guoa, Zhenguo Yang, Jing Lu,Xuming Deng. Immunosuppressive activity of Florfenicolon on the immune responses in mice. Immunological Investigations, 40(4), 356-66, 2011. Guan Shuang, Feng Haihua, Song Bocui, Guo Weixiao, Xiong Ying, Huang Guoren, Zhong Weiting, Huo Meixia, Chen Na,Lu, Jing, Deng Xuming. Salidroside attenuates LPS-induced pro-inflammatory cytokine responses and improves survival in murine endotoxemia. International immunopharmacology,11(12), 2194-2199, 2011. Shuang Guan, Lu Jing, Weixiao Guo, Xuming Deng. Adjuvant effects of salidroside from Rhodiola rosea L.on the immune responses to ovalbumin in mice. Immunopharmacology And Immunotoxicology, 33 (4), 738-743, 2011. Shuang Guan,Jing Lu, Wenhui Qian, Jingbo Liu, Xuming Deng. Florfenicol impairs the immune responses to vaccination against foot-and-mouth disease in mice. Immunopharmacology and immunotoxicology, 33 (4), 609-613, 2011. Guan S, Wang W, Lu J, Qian W, Huang G, Deng X, Wang X. Salidroside attenuates hydrogen peroxide-induced cell damage through a cAMP-dependent pathway. Molecules,16(4), 3371-9, 2011. Shuang Guan, Ying Xiong, Bocui Song, Yu Song , Dacheng Wang, Xiao Chu, Na Chen, Meixia Huo, Xuming Deng , Jing Lu. Protective Effects of salidroside from Rhodiola rosea on LPS-Induced Acute Lung Injury in Mice. Immunopharmacology and immunotoxicology, 34(4), 667-672, 2012. Lanan Wassy Soromou, Rongtao Li , Weixiao Guo , Weiting Zhong, Na Chen, Meixia Huo, Jing Lu, Shuang Guan*, Xuming Deng, Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-O-methylnaringenin. Molecules. 2011. Shuang Guan, Jing Lu, Xue Shen, Wenhui Qian, Guoren Huang, Dacheng Wang, Xuming Deng, Guanghong Xie. Immunosuppressive activity of 8-gingerol on the immune responses in mice.Molecules,16(3), 2636-45, 2011. Guan Shuang,Lu Jing , Liu Jingbo, Guo Na, Shen Xue, Qian Wenhui, Deng Xuming. In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice. Lat. Am. J.Pharm, 30 (1), 112-118, 2010. Jing Lu, Wenhui Qian, Linli Xua, Guoren Huang, Wen Cong, Zhenning Wang, Xuming Deng, Dacheng Wang, Shuang Guan*. Phytochemical composition and toxicity of an antioxidant extract from Pimpinella brachycarpa (Kom.) Nakai. Environmental toxicology andpharmacology, 34, 409-415, 2012.

学术兼职

中国毒理学会会员、吉林省食品学会会员。

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