个人简介

Renato Zenobi is Professor of Analytical Chemistry at the Organic Chemistry Laboratory at ETH Zurich. Born in Zurich in 1961, he received a M.S. degree from the ETH Zurich in 1986, and a Ph.D. at Stanford University in the USA in 1990. This was followed by two postdoctoral appointments at the University of Pittsburgh (1990 - 1991) and at the University of Michigan (1991). Renato Zenobi returned to Switzerland in 1992 as a Werner Fellow at the EPFL, Lausanne, where he established his own research group. He became assistant professor at the ETH in 1995, was promoted to associate professor in 1997, and to full professor in 2000.  He was chairman of the Organic Chemistry Laboratory in 2002-​2003 and 2011-​2012, served as the president of ETH’s university assembly (Hochschulversammlung, HV) from 2006 – 2008, and of the lecturer’s conference (Konferenz des Lehrkörpers, KdL) at ETH Zurich 2006 - 2010. Zenobi was a visiting professor at the Barnett Institute (Boston) in 2004/2005, and at the Institut Curie (Paris) in 2010.  In 2010 he was appointed Associate Editor of Analytical Chemistry (American Chemical Society). He has chaired the 2014 International Mass Spectrometry Conference in Geneva, Switzerland. Renato Zenobi has received many awards for his scientific work, including the Thomas Hirschfeld Award (1989), an Andrew Mellon Fellowship (1990), the Ruzicka Prize (1993), the Heinrich Emanuel Merck-​Prize (1998), the Redwood Lectureship from the Royal Society of Chemistry (2005), the Michael Widmer Award (2006), a honorary Professorship at East China Institute of Technology (2007), the Schulich Graduate Lectureship (2009), a honorary membership of the Israel Chemical Society (2009), honorary professorships at the Chinese Academy of Sciences (Changchun), at Hunan University, and at Changchun University of Chinese Medicine (2010), the Mayent-​Rothschild Fellowship (Institut Curie, Paris; 2010), the Fresenius Lectureship from the German Chemical Society (2012), the Thomson Medal (International Mass Spectrometry Foundation, 2014), the RUSNANO prize (2014), and the Fresenius Prize (German Chemical Society, 2015).

研究领域

Analytical Chemistry

Zenobi’s research areas include laser-based analytical chemistry, electrospray and laser-assisted mass spectrometry, ambient mass spectrometry, and near-field optical microscopy and spectroscopy. He has made important contributions to the understanding of the ion formation mechanism in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, and to ambient ionization methods. He is well known for the development of analytical tools for the nanoscale, in particular TERS (tip-enhanced Raman spectroscopy), a spectroscopic methodology with ≈ 10 nm spatial resolution.

近期论文

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High-​mass MALDI-​MS unravels ligand-​mediated G protein-​coupling selectivity to GPCRs Na Wu, Agnieszka M. Olechwier, Cyrill Brunner, Patricia Edwards, Ching-​Ju Tsai, Christopher G. Tate, Gebhard F.X. Schertler, Gisbert Schneider, Xavier Deupi, Renato Zenobi and Pikyee Ma Proceedings of the National Academy of Sciences of the United States of America, vol. 118: no. 31, pp. e2024146118, Washington, DC: National Academy of Science, 2021. DOI: 10.1073/pnas.2024146118 Screening for potential interaction partners with surface plasmon resonance imaging coupled to MALDI mass spectrometry Ulrike Anders, Maya Gulotti-​Georgieva, Susann Zelger-​Paulus, Fatima-​Ezzahra Hibti, Chiraz Frydman, Detlev Suckau, Roland K.O. Sigel and Renato Zenobi Analytical Biochemistry, vol. 624, pp. 114195, Amsterdam: Elsevier BV, 2021. DOI: 10.1016/j.ab.2021.114195 Immobilization of molecular catalysts on electrode surfaces using host–guest interactions Laurent Sévery, Jacek Szczerbiński, Mert Taskin, Isik Tuncay, Fernanda Brandalise Nunes, Chiara Cignarella, Gabriele Tocci, Olivier Blacque, Jürg Osterwalder, Renato Zenobi, Marcella Iannuzzi and S. David Tilley Nature Chemistry, vol. 13: no. 6, pp. 523-​529, London: Nature Publishing Group, 2021. DOI: 10.1038/s41557-​021-00652-y Atmospheric Pressure Mass Spectrometry Imaging Using Laser Ablation, Followed by Dielectric Barrier Discharge Ionization Qiao Lu, Zhouyi Xu, Xue You, Siyuan Ma and Renato Zenobi Analytical Chemistry, vol. 93: no. 15, pp. 6232-​6238, Washington, DC: American Chemical Society, 2021. DOI: 10.1021/acs.analchem.1c00549 Monitoring peppermint washout in the breath metabolome by secondary electrospray ionization-​high resolution mass spectrometry Jiayi Lan, Amanda Gisler, Tobias Bruderer, Pablo Sinues and Renato Zenobi Journal of Breath Research, vol. 15: no. 2, pp. 026003, Bristol: IOP Publishing, 2021. DOI: 10.1088/1752-​7163/ab9f8a Minimizing ion competition boosts volatile metabolome coverage by secondary electrospray ionization orbitrap mass spectrometry Jiayi Lan, Jérôme Kaeslin, Giorgia Greter and Renato Zenobi Analytica Chimica Acta, vol. 1150, pp. 338209, Amsterdam: Elsevier, 2021. DOI: 10.1016/j.aca.2021.338209 Hallmarks of Alpha-​ And Betacoronavirus non-​structural protein 7+8 complexes Boris Krichel, Ganesh Bylapudi, Christina Schmidt, Clement Blanchet, Robin Schubert, Lea Brings, Martin Koehler, Renato Zenobi, Dmitri I. Svergun, Kristina Lorenzen, Ramakanth Madhugiri, John Ziebuhr and Charlotte Uetrecht Science Advances, vol. 7: no. 10, pp. eabf1004, Washington, DC: American Association for the Advancement of Science, 2021. DOI: 10.1126/sciadv.abf1004 Fluorescence-​Based Detection of the Desolvation Process of Protein Ions Generated in an Aqueous Electrospray Plume Prince Tiwari, Martin F. Czar and Renato Zenobi Analytical Chemistry, vol. 93: no. 7, pp. 3635-​3642, Washington, DC: American Chemical Society, 2021. DOI: 10.1021/acs.analchem.0c05396 Nanoscale hyperspectral imaging of amyloid secondary structures in liquid Ewelina Lipiec, Janina Kaderli, Jan Kobierski, Roland Riek, Katarzyna Skirlinska-​Nosek, Kamila Sofinska, Marke Szymonski and Renato Zenobi Angewandte Chemie. International Edition, vol. 60: no. 9, pp. 4545-​4550, Weinheim: Wiley-​VCH, 2020. DOI: 10.1002/anie.202010331 Competition of Ligands and the 18‐mer Binding Domain of the RHAU Helicase for G‐Quadruplexes: Orthosteric or Allosteric Binding Mechanism? Adrien Henri Marchand, Claire Beauvineau, Marie-​Paule Teulade-​Fichou and Renato Zenobi Chemistry - A European Journal, vol. 27: no. 3, pp. 1113-​1121, Weinheim: Wiley, 2020. DOI: 10.1002/chem.202004040 In-​situ Nanospectroscopic Imaging of Plasmon-​induced Two-​dimensional [4+4]-​Cycloaddition Polymerization on Au(111) Feng Shao, Wei Wang, Weiming Yang, Zhi‐Lin Yang, Yao Zhang, Jinggang Lan, A. Dieter Schlüter and Renato Zenobi Nature Communications, vol. 12, pp. 4557, London: Springer Nature, 2021. DOI: 10.1038/s41467-​021-24856-5 Breaking the brightness barrier: design and characterization of a selected-​ion fluorescence measurement setup with high optical detection efficiency Prince Tiwari, Jonas Bastian Metternich, Martin F. Czar and Renato Zenobi Journal of the American Society for Mass Spectrometry, vol. 32: no. 1, pp. 187-​197, Washington, DC: ACS Publications, 2020. DOI: 10.1021/jasms.0c00264 Rapid Screening and Quantitation of PAHs in Water and Complex Sample Matrices by Solid-​Phase Microextraction Coupled to Capillary Atmospheric Pressure Photoionization-​Mass Spectrometry Mario F. Mirabelli and Renato Zenobi Journal of Mass Spectrometry, vol. 56: no. 1, pp. e4656, Chichester: Wiley, 2020. DOI: 10.1002/jms.4656 Rapid analysis of fragrance allergens by dielectric barrier discharge ionization mass spectrometry Qinlei Liu and Renato Zenobi Rapid Communications in Mass Spectrometry, vol. 35: no. 6, pp. e9021, Hoboken, NJ, USA: Wiley, 2020. DOI: 10.1002/rcm.9021 Quantification of surface composition and segregation on auag bimetallic nanoparticles by maldi ms Suiyang Liao, Zhi Luo, Jonas B. Metternich, Renato Zenobi and Francesco Stellacci Nanoscale, vol. 12: no. 44, pp. 22639-​22644, Cambridge: Royal Society of Chemistry, 2020. DOI: 10.1039/d0nr05061j The MscS-​like channel YnaI has a gating mechanism based on flexible pore helices Vanessa J. Flegler, Akiko Rasmussen, Shanlin Rao, Na Wu, Renato Zenobi, Mark S.P. Sansom, Rainer Hedrich, Tim Rasmussen and Bettina Böttcher Proceedings of the National Academy of Sciences of the United States of America, vol. 117: no. 46, pp. 28754-​28762, Washington, DC: National Academy of Sciences, 2020. DOI: 10.1073/pnas.2005641117 Thermomechanical Nanostraining of Two-​Dimensional Materials Xia Liu, Amit Kumar Sachan, Samuel Tobias Howell, Ana Conde-​Rubio, Armin W. Knoll, Giovanni Boero, Renato Zenobi and Jürgen Brugger Nano Letters, vol. 20: no. 11, pp. 8250-​8257, Washington, DC: American Chemical Society, 2020. DOI: 10.1021/acs.nanolett.0c03358 Tip Recycling for Atomic Force Microscopy-​Based Tip-​Enhanced Raman Spectroscopy Giovanni L. Bartolomeo, Guillaume Goubert and Renato Zenobi Applied spectroscopy, vol. 74: no. 11, pp. 1358-​1364, London: SAGE Publications, 2020. DOI: 10.1177/0003702820916234 Real-​time breath analysis of exhaled compounds upon peppermint oil ingestion by secondary electrospray ionization-​high resolution mass spectrometry: Technical aspects Amanda Gisler, Jiayi Lan, Kapil D. Singh, Jakob Usemann, Urs Frey, Renato Zenobi, Pablo Sinues and Pablo Sinues Journal of Breath Research, vol. 14: no. 4, pp. 046001, Bristol: Institute of Physics, 2020. DOI: 10.1088/1752-​7163/ab9f8b A benchmarking protocol for breath analysis: the peppermint experiment Dorota M. Ruszkiewicz, Max Wilkinson, Jonathan D. Beauchamp, Simona M. Cristescu, Stephen J. Fowler, Dahlia Salman, Fabio Di Francesco, Gudrun Koppen, Jens Langejürgen, Olaf Holz, Andria Hadjithekli, Sergi Moreno, Michele Pedrotti, Pablo Sinues, Gitte Slingers, Michael Wilde, Tommaso Lomonaco, Delphine Zanella, Renato Zenobi, Jean-​François Focant, Stanislas Grassin-​Delyle, Flavio Antonio Franchina, Michaela Màlàskova, Pierre-​Hugues Stefanuto, Giovanni Pugliese, Christopher Mayhew and C. L. Paul Thomas Journal of Breath Research, vol. 14: no. 4, pp. 046008, Bristol: Institute of Physics, 2020. DOI: 10.1088/1752-​7163/aba130