Jessen, Henning Jacob - University of freiburg - Institute of Organic Chemistry

个人简介

Henning Jessen was born in Hamburg, Germany, where he also studied Chemistry. He received his diploma in 2005 and his doctorate in 2008 in the group of Professor Chris Meier. He then moved for a postdoctoral stay to the group of Professor Karl Gademann, first at the Ecole Polytechnique Federale de Lausanne and later at the University of Basel, Switzerland. In 2011 he moved to the University of Zuerich, Switzerland, to start his Habilitation in the group of Professor Jay Siegel. He was promoted to SNF assistant professor early 2015. Since October 2015 he holds a chair of Bioorganic Chemistry at the University of Freiburg. CURRENT POSITION 2015 – Full Professor of Bio-Organic Chemistry (W3, Chair) Faculty of Chemistry & Pharmacy, University of Freiburg, Germany PREVIOUS POSITION 2015 – 2015 SNSF Assistant Professor Department of Chemistry, University of Zürich, Switzerland FELLOWSHIPS 2011 – 2015 Ambizione Fellowship (SNSF) & Liebig Fellowship (FCI)Department of Chemistry, University of Zürich, Switzerland Mentor: Prof. Dr. Jay S. Siegel 2010 – 2011 DFG Postdoctoral Fellowship, Department of Chemistry, University of Basel,Switzerland with Prof. Dr. Karl Gademann 2008 – 2010 DFG Postdoctoral Fellowship, ISIC/ EPF Lausanne/ Organic Chemistry/Switzerland with Prof. Dr. Karl Gademann EDUCATION 2008 Dr. rer. nat. (summa cum laude)Department of Chemistry, University of Hamburg, Germany 2005 Diploma in Chemistry (Grade: 1.0)Department of Chemistry, University of Hamburg, Germany AWARDS & MAJOR GRANTS 2019 ERC Consolidator Grant 2019 Freiburg Research Institute for Advanced Studies (FRIAS), Senior Fellowship 2016 HFSP Program Grant as PI 2015 Ruzicka Prize and Medal of the ETH Zürich, Switzerland 2015 SNSF Professorship, Switzerland 2010 Klaus-Grohe Award of the GDCh in Medicinal Chemistry, Germany 2008 Best Doctoral Thesis in Chemistry, University of Hamburg, Germany

研究领域

Research in the group is focused on the function and correlation of cellular phosphate conjugates by combining approaches of chemistry and biology.

近期论文

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Jacoby C, Ferlaino S, Bezold D, Jessen HJ, Müller M, Boll M ATP-dependent hydroxylation of an unactivated primary carbon with water 2020 Nat Commun, volume: 11, page: 3906 Qiu D, Wilson MS, Eisenbeis VB, Harmel RC, Riemer E, Haas TM, Wittwer C, Jork N, Gu C, Shears SB, Schaaf G, Kammerer B, Fiedler D, Saiardi A, Jessen HJ Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry 2020 Nat Commun, volume: 11, page: 6035 Li X, Gu C, Hostachy S, Sahu S, Wittwer C, Jessen HJ, Fiedler D, Wang H, Shears SB Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling 2020 P Natl Acad Sci Usa, volume: 117, pages: 3568 - 3574 Bezold D, Dürr T, Singh J, Jessen HJ Cyclotriphosphate: A Brief History, Recent Developments, and Perspectives in Synthesis 2020 Chem-eur J, volume: 26, pages: 2298 - 2308 Azevedo C, Desfougeres Y, Jiramongkol Y, Partington H, Trakansuebkul S, Singh J, Steck N, Jessen HJ, Saiardi A Development of a yeast model to study the contribution of vacuolar polyphosphate metabolism to lysine polyphosphorylation.2020 J Biol Chem, volume: 295, pages: 1439 - 1451 Haas T, Qiu D, Häner M, Angebauer L, Ripp A, Singh J, Koch HG, Jessen-Trefzer C, Jessen HJ Four phosphates at one blow: access to pentaphosphorylated magic spot nucleotides and their analysis by capillary electrophoresis 2020 J Org Chem, volume: 85, pages: 14496 - 14506 Gutacker F, Schmidt-Bohli YI, Strobel T, Qiu D, Jessen HJ, Paululat T, Bechthold A Identification and characterization of a novel N- and O-glycosyltransferase from Saccharopolyspora erythraea 2020 Molecules, volume: 25, page: 3400 Sahu S, Wang Z, Jiao X, Gu C, Jork N, Wittwer C, Li X, Hostachy S, Fiedler D, Wang H, Jessen HJ, Kiledjian M, Shears SB InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics.2020 P Natl Acad Sci Usa, volume: 117, pages: 19245 - 19253 Deng J, Bezold D, Jessen HJ, Walther A Multiple Light Control Mechanisms in ATP‐fueled Non‐Equilibrium DNA Systems 2020 Angew Chem Int Edit, volume: 59, pages: 12084 - 12092 Zong G, Jork N, Hostachy S, Fiedler D, Jessen HJ, Shears SB, Wang H New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1.2020 Faseb J Hauke S, Bittner T, Jessen HJ*, Schultz C*Photo-releasable derivatives of inositol pyrophosphates 2020 Method Enzymol, volume: 641, pages: 53 - 73 Bittner T, Wittwer C, Hauke S, Wohlwend D, Mundinger S, Dutta A, Bezold D, Dürr T, Friedrich T, Schultz C, Jessen HJ Photolysis of caged inositol-pyrophosphate InsP8 directly modulates intracellular Ca2+ oscillations and controls C2AB domain localization 2020 J Am Chem Soc, volume: 142, pages: 10606 - 10611 Ripp A, Singh J, Jessen HJ Rapid Synthesis of Nucleoside Triphosphates and Analogues 2020 Current Protocols in Nucleic Acid Chemistry, volume: 81, page: e108 Wang Z, Jork N, Bittner T, Wang H, Jessen HJ, Shears SB Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode 2020 Chem Sci, volume: 11, pages: 10625 - 10278 Chin AC, Gao Z, Riley AM, Furkert D, Wittwer C, Dutta AK, Rojas T, Semenza ER, Felder RA, Pluznick JL, Jessen HJ, Fiedler D, Potter BVL, Snyder SH, Fu C The inositol pyrophosphate 5-InsP7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α2020 Sci Adv, volume: 6, page: eabb8542 Ma J, Ripp A, Wassy D, Dürr T, Qiu D, Häner M, Haas TM, Popp C, Bezold D, Richert S, Esser B, Jessen HJ Thiocoumarin Caged Nucleotides: Synthetic Access and Their Photophysical Properties 2020 Molecules, volume: 25, page: 5325 Singh J, Steck N, De D, Hofer A, Ripp A, Captain I, Keller M, Wender PA, Bhandari R, Jessen HJ A Phosphoramidite Analog of Cyclotriphosphate Enables Iterative Polyphosphorylations 2019 Angew Chem Int Edit, volume: 58, pages: 3928 - 3933 Laha D, Parvin N, Hofer A, Giehl R, Fernandez-Rebollo N, von Wiren N, Saiardi A, Jessen HJ, Schaaf G Arabidopsis ITPK1 and ITPK2 have an Evolutionary Conserved Phytic Acid Kinase Activity 2019 Acs Chem Biol, volume: 14, pages: 2127 - 2123 Wang H, Jessen HJ, Shears SB Comprehensive snapshots of an unusual reaction cycle for an atypical protein tyrosine phosphatase (PTP)2019 Faseb J, volume: 33 An Y, Jessen HJ, Wang H, Shears S, Kireev D Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine 2019 Structure, volume: 27, pages: 1022 - 1028 Dong J, Ma G, Sui L, Wei M, Satheesh V, Zhang R, Ge S, Li J, Zhang TE, Wittwer C, Jessen HJ, Zhang H, An GY, Chao DY, Liu D, Lei M Inositol Pyrophosphate InsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis 2019 Mol Plant, volume: 12, pages: 1463 - 1473